EX DUO 50 Tablet 10's
Netmeds First Membership
Quick Links
Introduction About EX DUO 50 TABLET
EX DUO 50 TABLET is a combination medication containing Sacubitril and Valsartan. It is primarily used in the management of heart failure and hypertension. This innovative drug helps to improve heart function and manage high blood pressure, leading to better overall cardiovascular health.
EX DUO 50 TABLET can be taken with or without food. For optimal results, take it at the same time every day. Your doctor will determine the appropriate dose and frequency, which may vary based on your response to the medication. It is important to take the tablets consistently as prescribed and avoid missing any doses to achieve the best outcome. Even if you are feeling better, do not stop taking the medication, as it helps prevent future complications.
Common side effect of this medication includes dizziness, lightheadedness, fatigue, low blood pressure, elevated potassium levels, angioedema (swelling under the skin) and cough. To help minimize the risk of dizziness caused by low blood pressure, try rising gradually from a sitting or lying position. If these or any other side effects become severe or persist, inform your doctor.
Before taking this medication, inform your doctor if you are currently taking any other medications for blood pressure or heart conditions, or if you have kidney or liver disease. Additionally, make sure to share all other medications you are using, as they may interact with this medicine. This medication is not recommended during pregnancy and should be avoided while breastfeeding. While taking this medication, your doctor may recommend regular monitoring of blood pressure and kidney function.
Uses Of EX DUO 50 TABLET
- Heart failure
- Hypertension
Benefits of EX DUO 50 TABLET
- Improves Heart Function: The combination of Sacubitril and Valsartan helps reduce strain on the heart and improves its pumping ability, which is crucial in heart failure management.
- Reduces Blood Pressure: Valsartan, an angiotensin receptor blocker (ARB), works to lower high blood pressure, reducing the risk of heart attack and stroke.
- Reduce Hospitalization: Regular use of EX DUO 50 TABLET may reduce the frequency of heart failure-related hospitalizations, improving quality of life for patients.
- Supports Better Survival Rates: The medication can increase survival rates in patients suffering from chronic heart failure.
How EX DUO 50 TABLET Works
EX DUO 50 TABLET, a combination of sacubitril and valsartan that works by improving heart function in patients with heart failure. Sacubitril is a neprilysin inhibitor that prevents the breakdown of natriuretic peptides, which help dilate blood vessels, reduce fluid retention, and lower blood pressure. Valsartan, an angiotensin II receptor blocker (ARB), further supports this by blocking the effects of angiotensin II, a hormone that constricts blood vessels and raises blood pressure. Together, these two components help relax blood vessels, reduce fluid buildup, and ease the heart's workload, ultimately improving heart function and reducing symptoms of heart failure.
How to use EX DUO 50 TABLET
Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage.
How to Take EX DUO 50 TABLET?
- Take one tablet daily with or without food.
- Swallow the tablet whole with a glass of water. Do not crush or chew the medication.
- For best results, take the tablet at the same time each day.
Recommended Dosage of EX DUO 50 TABLET:
- The recommended starting dose of EX DUO 50 TABLET for most patients is one 50mg tablet once a day.
- However, your doctor may adjust the dosage based on your medical condition and how you respond to the medication.
- Always follow the specific instructions provided by your doctor.
What if I forgot to take EX DUO 50 TABLET
- If you forget to take your dose, take it as soon as you remember.
- Do not take two doses to make up for a missed dose. This could increase your risk of side effects.
- If it is almost time for your next dose, skip the missed dose and take your regular dose at the usual time.
Overdose
- Taking more than the prescribed dose of EX DUO 50 TABLET could lead to serious side effects. Symptoms of an overdose might include low blood pressure (hypotension), dizziness, or fainting.
- If you suspect an overdose: Contact your doctor immediately. It is important to get help right away if you experience severe symptoms like dizziness, fainting, or confusion.
Side Effects Of EX DUO 50 TABLET
Like all medicines, EX DUO 50 TABLET may cause certain side effects in some individuals, although not everybody gets them.
The most common side effects of taking EX DUO 50 TABLET are:
- Dizziness
- Lightheadedness
- Fatigue
- Low blood pressure
- Elevated potassium levels
- Angioedema (swelling under the skin)
- Cough
When to consult your doctor?
- Severe allergic reaction symptoms such as angioedema (swelling of the face, lips, tongue, or throat), difficulty breathing or swallowing
- Severe low blood pressure (hypotension) symptoms such as dizziness, fainting, or feeling lightheaded
- Hyperkalemia (high potassium levels) symptoms such as muscle weakness, irregular heartbeats, or numbness
- Kidney problems symptoms such as changes in urination (like reduced urine output), swelling in the legs or feet, and confusion
- Liver problems symptoms such as yellowing of the skin or eyes (jaundice), dark urine, or upper abdominal pain
- Infection or blood disorder symptoms such as fever, sore throat, or unusual tiredness
- Heart problems symptoms such as dizziness, fainting, or rapid heartbeat
How To Manage Side Effects
Dizziness Or Drowsiness
- Sit or Lie Down: If you feel dizzy, sit down or lie down immediately to prevent falling. Keep your head still and close your eyes if needed.
- Hydrate: Dehydration can cause dizziness, so drink water or electrolyte-replenishing drinks like sports drinks.
- Avoid Sudden Movements: When standing or sitting, do so slowly to avoid triggering dizziness. Take your time when getting up.
- Eat Small, Regular Meals: Low blood sugar can cause dizziness, so eat small meals throughout the day and avoid skipping meals.
- Fresh Air: Sometimes dizziness can be alleviated by taking slow, deep breaths in a well-ventilated area.
Warning & Precautions
Pregnancy
ContraindicatedEX DUO 50 TABLET is not recommended for use in pregnant women. It is important to consult your doctor before taking this medication.
Breastfeeding
ContraindicatedEX DUO 50 TABLET is not recommended for use in breast-feeding women. It is important to consult your doctor before taking this medication.
Driving and Using Machines
Use with CautionAvoid driving or operating any machinery while taking EX DUO 50 TABLET, as it may cause dizziness or fatigue.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking EX DUO 50 TABLET as it may cause low blood pressure further and worsen side effects.
Kidney
Use with CautionEX DUO 50 TABLET should be used with caution in patients with severe kidney disease and with narrowed kidney artery. Consult your doctor before taking it.
Liver
Consult your doctorEX DUO 50 TABLET is not recommended for use in patients with severe liver disease and should be used with caution in patients with liver disease. Consult your doctor before taking it.
Allergy
ContraindicatedDo not take this medication if you are allergic to Sacubitril or Valsartan or any other ingredients of this medicine.
Use In Pediatrics
ContraindicatedEX DUO 50 TABLET is not recommended for use in children and adolescents (aged below 18 years). Consult your pediatrician before giving it.
Use In Geriatrics
Use with CautionEX DUO 50 TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking it.
Other Warnings for EX DUO 50 TABLET
Before taking EX DUO 50 TABLET inform your doctor if you have:
- History of angioedema
- Low blood pressure
- Vomiting or diarrhea
- Dehydration
- Hallucinations, paranoia, or changes in sleeping pattern
Who should not take [GBNKEYWORD
EX DUO 50 TABLET is not recommended for use, if you have:
- Diabetes or impaired kidney function (and being managed with aliskiren (blood pressure lowering medicine))
- Personal or family history of angioedema (when taking angiotensin receptor blockers (ARB) such as valsartan, telmisartan)
Safety Advice
- Take one tablet daily with or without food.
- Swallow the tablet whole with a glass of water. Do not crush or chew the medication.
- For best results, take the tablet at the same time each day.
- It is important to remain active with light walking and stretching, and follow a healthy, low-sodium diet while taking this medication.
- It could increase the potassium levels in your blood. Avoid taking potassium supplements and consuming potassium-rich foods like bananas and broccoli.
- Let your doctor know if you have kidney problems or liver problems
- This medication is not recommended during pregnancy and breastfeeding.
- Alcohol can lower blood pressure further and worsen side effects. It is advisable to limit alcohol intake while taking EX DUO 50 TABLET.
Diet and Lifestyle Advice
What are some heart-healthy diet, exercise, and lifestyle changes for heart failure patients that can complement the use of EX DUO 50 TABLET?
|
Category |
Tip |
Details |
|
Diet |
Low-sodium diet |
Reduce sodium intake to less than 2,300 mg per day to prevent fluid retention and lower blood pressure. Avoid processed foods, canned foods, and high-salt snacks. |
|
|
Heart-healthy fats |
Include sources of unsaturated fats such as olive oil, avocados, and nuts. Limit saturated fats and trans fats found in red meat, butter, and fried foods. |
|
|
Increase fiber intake |
Eat more fruits, vegetables, and whole grains to help lower cholesterol and maintain healthy blood pressure. Fiber-rich foods also support digestion and weight management. |
|
|
Limit refined sugars |
Avoid sugary snacks, sodas, and desserts that can contribute to weight gain, high blood sugar, and increase the risk of cardiovascular complications. |
|
|
Lean protein sources |
Include lean meats, poultry, fish, legumes, and plant-based proteins to support muscle function and heart health while minimizing the intake of unhealthy fats. |
|
Exercise |
Low-impact aerobic exercises |
Engage in activities like walking, swimming, or cycling to improve cardiovascular health without overloading the heart. Aim for at least 150 minutes of moderate-intensity exercise weekly. |
|
|
Strength training |
Incorporate light resistance training (e.g., using weights or resistance bands) 2-3 times a week to build muscle strength and improve overall fitness. |
|
|
Stretching and flexibility |
Stretching exercises can help improve mobility, prevent stiffness, and promote relaxation, which can benefit heart failure patients. |
|
|
Pacing and monitoring intensity |
Start slowly and gradually increase the intensity of exercise. Always listen to your body and consult with a doctor about safe exercise limits. |
|
Lifestyle Changes |
Weight management |
Maintaining a healthy weight helps reduce strain on the heart. Focus on gradual, sustainable weight loss through diet and exercise, aiming for a BMI within the healthy range. |
|
|
Stress management |
Practice relaxation techniques like meditation, deep breathing, or yoga to manage stress, which can exacerbate heart failure symptoms. |
|
|
Quit smoking |
Smoking increases heart disease risk and worsens heart failure symptoms. Seek support to quit smoking and avoid exposure to secondhand smoke. |
|
|
Limit alcohol intake |
Excessive alcohol can weaken the heart and interfere with medications. Limit alcohol consumption to moderate levels or avoid it altogether based on doctor’s advice. |
|
|
Regular monitoring and check-ups |
Keep track of weight, blood pressure, and symptoms. Regular check-ups with a healthcare provider are essential for managing heart failure effectively and adjusting treatment as needed. |
|
|
Adequate sleep |
Aim for 7-9 hours of quality sleep each night to support heart health and reduce fatigue. Sleep apnea should be addressed if present, as it can worsen heart failure. |
What dietary restrictions should be followed while taking EX DUO 50 TABLET, particularly regarding high potassium foods and fluid intake management?
|
Dietary Concern |
Foods to Avoid |
Explanation/Reason |
|
High Potassium Foods |
- Bananas |
EX DUO 50 TABLET can affect potassium levels in the body, leading to potential hyperkalemia. |
|
|
- Oranges & orange juice |
High potassium can cause heart arrhythmias or other complications. |
|
|
- Potatoes (especially baked or fried) |
Excess potassium can build up and be dangerous. |
|
|
- Tomatoes & tomato-based products |
High-potassium content should be monitored. |
|
|
- Spinach & other leafy greens |
Can contribute to elevated potassium levels. |
|
|
- Dried fruits (e.g., apricots, raisins, prunes) |
Dried fruits are high in potassium and should be consumed cautiously. |
|
High-Sodium Foods |
- Processed meats (e.g., bacon, sausage, deli meats) |
Sodium can exacerbate fluid retention and increase blood pressure. |
|
|
- Canned soups or vegetables (high in sodium) |
Sodium can increase strain on the kidneys and worsen fluid retention. |
|
|
- Fast food and salty snacks (chips, pretzels) |
Excess sodium can cause imbalances in fluid and electrolytes. |
|
Excessive Fluid Intake |
- Avoid drinking excessive fluids (especially if kidney function is impaired) |
EX DUO 50 TABLET may affect kidney function, so excessive fluid intake can strain kidneys. |
|
|
- Limit intake of caffeinated beverages or alcohol, which can increase dehydration |
These can dehydrate the body and worsen kidney function or fluid balance. |
|
High-Protein Foods |
- Avoid excessive consumption of red meats (e.g., steak, burgers) |
High-protein intake can stress the kidneys, especially with kidney disease. |
|
|
- Limit dairy products (especially full-fat versions) |
High-protein and high-fat dairy products can have similar effects on the kidneys. |
|
Foods with High Phosphorus |
- Processed cheese, cola drinks, and packaged foods (e.g., fast food) |
High phosphorus levels can be problematic for kidney function when taking EX DUO 50 TABLET. |
Drug - Drug interaction
Inform your physician if you are taking any of the following medicine before taking EX DUO 50 TABLET:
1. Angiotensin-Converting Enzyme (ACE) Inhibitors or Angiotensin Receptor Blockers (ARBs):
- Interaction: EX DUO 50 TABLET combines valsartan, an ARB, with sacubitril, an neprilysin inhibitor. Concomitant use with ACE inhibitors or other ARBs (like losartan) can increase the risk of hyperkalemia (high potassium levels) and renal impairment.
- Effect: There is an increased risk of angioedema, hypotension, and renal dysfunction. Sacubitril can potentiate the effects of ACE inhibitors, which can lead to adverse effects, especially in the early stages of treatment.
- Management: Avoid the concurrent use of ACE inhibitors and sacubitril-containing products. If switching from an ACE inhibitor to EX DUO 50 TABLET, wait at least 36 hours before starting the drug to minimize risk.
2. Potassium-Sparing Diuretics (e.g., Spironolactone):
- Interaction: Potassium-sparing diuretics (or potassium supplements) may interact with EX DUO 50 TABLET, increasing the risk of hyperkalemia.
- Effect: Elevated potassium levels can cause serious heart problems.
- Management: Monitor potassium levels regularly. Consider adjusting the dose of potassium-sparing diuretics or avoiding their use in combination with EX DUO 50 TABLET.
3. Lithium:
- Interaction: The combination of EX DUO 50 TABLET and lithium can increase lithium concentrations in the blood, enhancing the risk of lithium toxicity.
- Effect: Symptoms of lithium toxicity include nausea, vomiting, diarrhea, tremors, confusion, and in severe cases, kidney damage.
- Management: Regular monitoring of lithium levels is essential. If necessary, adjust the lithium dose under medical supervision.
4. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs):
- Interaction: The use of NSAIDs along with EX DUO 50 TABLET may impair kidney function, especially in patients with preexisting kidney issues, and reduce the antihypertensive effect of valsartan.
- Effect: There is a risk of worsening renal function and increasing blood pressure.
- Management: Avoid prolonged use of NSAIDs in patients on EX DUO 50 TABLET. Regular kidney function monitoring is recommended. If NSAID use is necessary, lower doses and close monitoring should be considered.
5. Diuretics (Thiazide Diuretics, Loop Diuretics):
- Interaction: Diuretics can amplify the hypotensive effect of EX DUO 50 TABLET, leading to excessive lowering of blood pressure, particularly in patients who are volume-depleted.
- Effect: This can lead to dizziness, fainting, or electrolyte disturbances.
- Management: Monitor blood pressure and electrolyte levels regularly. Consider adjusting the diuretic dose if blood pressure drops significantly.
6. Drugs Affecting the Renin-Angiotensin-Aldosterone System (RAAS):
- Interaction: Any drugs that modulate RAAS (such as aliskiren) can increase the risk of hyperkalemia and kidney damage when used in combination with EX DUO 50 TABLET.
- Effect: There is an increased risk of renal failure, hyperkalemia, and severe hypotension.
- Management: Avoid combining EX DUO 50 TABLET with other RAAS inhibitors. Monitor kidney function and electrolytes closely.
7. Other Antihypertensive Agents:
- Interaction: EX DUO 50 TABLET has a strong antihypertensive effect, and combining it with other blood pressure-lowering drugs can lead to excessive lowering of blood pressure.
- Effect: Patients may experience symptoms like dizziness, lightheadedness, or fainting.
- Management: Carefully monitor blood pressure. If blood pressure drops too low, adjust or discontinue other antihypertensive medications.
8. Other Medications Metabolized by CYP Enzymes:
- Interaction: Valsartan is minimally metabolized by cytochrome P450 enzymes, but any drug that affects liver enzymes could theoretically alter the concentration of EX DUO 50 TABLET.
- Effect: Though the interaction is limited, drugs like rifampin (an enzyme inducer) could potentially lower the effect of EX DUO 50 TABLET.
- Management: If using drugs that impact liver metabolism, monitor for effectiveness and side effects.
Drug - Food interaction
High-Salt Diet:
- Interaction: A high-salt diet can counteract the blood-pressure-lowering effect of valsartan.
- Effect: The effectiveness of EX DUO 50 TABLET in controlling blood pressure may be reduced.
- Management: Encourage a balanced, low-sodium diet for patients taking EX DUO 50 TABLET to optimize its effectiveness.
Synopsis
|
Drug |
: |
Sacubitril and Valsartan |
|
Pharmacological Category |
: |
Neprilysin Inhibitor, Angiotensin II Receptor Blocker |
|
Therapeutic Indication |
: |
Heart failure |
|
Dosage Forms |
: |
Tablet |
More Information
Product Comparison:
|
Medication |
Key Ingredients |
Mechanism of Action |
Benefits |
Common Side Effects |
Effectiveness |
Standout Features of EX DUO 50 TABLET |
|
EX DUO 50 TABLET |
Sacubitril (24mg) + Valsartan (26mg) |
- Sacubitril: Neprilysin inhibitor, enhances natriuretic peptides to reduce fluid retention and improve vascular tone. |
- Effective for heart failure with reduced ejection fraction (HFrEF). |
- Hyperkalemia |
- Proven to reduce mortality in heart failure. |
Dual action (sacubitril + valsartan), offering a broader and more comprehensive effect for heart failure management. Superior to standard ARBs/ACE inhibitors in reducing heart failure complications. |
|
ACE Inhibitors |
Captopril, Enalapril, Lisinopril, etc. |
Inhibit the enzyme that converts angiotensin I to angiotensin II, helping to relax blood vessels and reduce blood pressure. |
- Effective in lowering blood pressure. |
- Persistent dry cough |
- Effective in reducing blood pressure and improving symptoms of heart failure. |
Standard therapy for hypertension and heart failure but lacks the dual-action mechanism for heart failure that EX DUO 50 TABLET offers. |
|
ARBs (Angiotensin II Receptor Blockers) |
Losartan, Irbesartan, Olmesartan |
Block the receptors for angiotensin II, lowering blood pressure and reducing heart strain. |
- Effective in managing hypertension. |
- Hyperkalemia |
- Similar in efficacy to ACE inhibitors for hypertension and heart failure. |
Preferred for those who cannot tolerate ACE inhibitors, but lacks the added benefits of sacubitril (neprilysin inhibitor) for heart failure patients. |
|
Beta-blockers |
Metoprolol, Carvedilol, Bisoprolol |
Block beta-adrenergic receptors, reducing heart rate and blood pressure, and improving heart efficiency. |
- Effective in reducing heart rate and controlling hypertension. |
- Fatigue |
- Particularly beneficial for heart failure patients with symptoms of left ventricular dysfunction and arrhythmias. |
Effective for managing arrhythmias and post-heart attack recovery, but lacks the multi-faceted effect of EX DUO 50 TABLET for heart failure-related issues. |
FAQs About EX DUO 50 TABLET
Q: What is EX DUO 50 TABLET used for?
A: EX DUO 50 TABLET is used to manage heart failure with reduced ejection fraction. It helps reduce the risk of heart failure hospitalization and cardiovascular death.
Q: How does EX DUO 50 TABLET work?
A: Sacubitril inhibits neprilysin, which helps reduce fluid buildup and improve heart function. Valsartan is an ARB that lowers blood pressure and reduces strain on the heart. Together, they help the heart pump more effectively and reduce symptoms of heart failure.
Q: What happens if I miss a dose of EX DUO 50 TABLET?
A: If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Do not take two doses at once to make up for the missed dose. If you're unsure, consult your doctor.
Q: How should I store EX DUO 50 TABLET?
A: Store EX DUO 50 TABLET in a cool, dry place at room temperature, away from direct sunlight, and out of the reach of children. Keep it in its original packaging to protect from moisture.
Q: Can I take EX DUO 50 TABLET on an empty stomach?
A: Yes, you can take EX DUO 50 TABLET on an empty stomach or with food. However, try to take it at the same time each day to help remember.
Q: How effective is EX DUO 50 TABLET for heart failure?
A: EX DUO 50 TABLET is very effective for managing heart failure with reduced ejection fraction. It improves heart function, reduces fluid retention, and lowers the risk of hospitalization or cardiovascular death.
Q: How long does it take for EX DUO 50 TABLET to work?
A: You may start noticing improvements in a few weeks, but it can take a few months to see the full benefits, especially in terms of heart function and reduced hospitalizations.
Q: Is EX DUO 50 TABLET suitable for young adults?
A: EX DUO 50 TABLET is typically prescribed for adults with heart failure. Its use in young adults would depend on individual health conditions and the doctor’s recommendation.
Q: Is EX DUO 50 TABLET safe for long-term use?
A: Yes, EX DUO 50 TABLET is safe for long-term use under a doctor's supervision. Your doctor will monitor for potential side effects like changes in kidney function or potassium levels.
Q: Can I take EX DUO 50 TABLET with other medications?
A: You can take EX DUO 50 TABLET with some other medications, but always inform your doctor about all the medications you are taking, especially other blood pressure or heart failure medications, as they may interact.
Q: Is it safe to take EX DUO 50 TABLET while pregnant or breastfeeding?
A: EX DUO 50 TABLET should not be used during pregnancy as it can harm the fetus. It is also not recommended while breastfeeding. Consult your doctor for safer alternatives during pregnancy or breastfeeding.
Q: What are the benefits of EX DUO 50 TABLET over other heart failure drugs?
A: EX DUO 50 TABLET combines Sacubitril, a neprilysin inhibitor, and Valsartan, an ARB, to provide superior benefits over other heart failure medications. This combination is more effective in reducing heart failure symptoms, reducing hospitalizations, and lowering the risk of cardiovascular death than ACE inhibitors or ARBs alone.
Q: Where can I buy EX DUO 50 TABLET online?
A: You can buy EX DUO 50 TABLET online at Netmeds. Just visit their website and search for the product, and you will find options to purchase it directly from there.
References
- KD Tripathi MD. Cardiovascular drugs. Essentials of Medical Pharmacology. Seventh Edition. New Delhi, May 2013. Page-508.
- Loretta Fala. Entresto (Sacubitril/Valsartan): First-in-Class Angiotensin Receptor Neprilysin Inhibitor FDA Approved for Patients with Heart Failure. NCBI; PMC. Pubmed Central. National Library of Medicine, National Institute of Health. September 2018. [Accessed on 27th May 2025]
- Peter Khalil, Ghazal Kabbach, Sarmad Said and Debabrata Mukherje. Entresto, a New Panacea for Heart Failure. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2018. [Accessed on 27th May 2025]
- Novartis Pharmaceuticals UK Ltd. Electronic Medicines Compendium (EMC) [Revised in May 2021] [Accessed on 27th May 2025]
- Cipla Ltd. Azmarda Tablets (Sacubitril/Valsartan). Ciplamed. [Revised in March 2017] [Accessed on 27th May 2025]
Author Details
