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Introduction About ETOVEL 100 INJECTION
ETOVEL 100 INJECTION contains Etoposide which belongs to the group of medicines called Anticancer agents. It is used to manage various types of cancer such as lung cancer, blood cancer, lymph cancer, ovarian cancer and testicular cancer.
ETOVEL 100 INJECTION should be used under careful medical supervision. During management with ETOVEL 100 INJECTION, your doctor will periodically monitor your heart, liver, kidney functions as a precaution.
Before receiving ETOVEL 100 INJECTION, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have any serious infections, low albumin levels in blood or recently received any vaccine or radiotherapy or chemotherapy as a precaution.
Do not receive ETOVEL 100 INJECTION without consulting your doctor if you are pregnant or breastfeeding. Both men and women undergoing therapy with this medicine, must use a suitable contraceptive to stop pregnancy during and until 6 months after stopping the therapy.
The most common side effects of receiving ETOVEL 100 INJECTION are blood disorders, loss of appetite, constipation, pigmentation on the skin, temporary hair loss, weakness, tiredness and sore lips, mouth or throat ulcers. Consult your doctor if any of these side effects worsen.
Uses Of ETOVEL 100 INJECTION
It is used to manage various types of cancer such as:
- Small cell lung cancer
- Blood cancer (Ex. acute myeloid leukaemia)
- Lymph cancer (Ex. Hodgkin’s lymphoma, non-Hodgkin’s lymphoma)
- Ovarian cancer
- Testicular cancer
How ETOVEL 100 INJECTION Works
ETOVEL 100 INJECTION is an anticancer agent. It works by blocking the abnormal actions of certain cellular proteins (topoisomerase 2) that triggers cancer cell formation. As a result, it reduces cancer formation and stops its further growth within the body.
How to use ETOVEL 100 INJECTION
ETOVEL 100 INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Side Effects Of ETOVEL 100 INJECTION
Common
- blood disorders
- loss of appetite, constipation, stomach pain, diarrhea
- changes in skin colour (pigmentation)
- temporary hair loss
- weakness, tiredness
- liver damage
- blood cancer
- irregular heartbeat
- high blood pressure
- sore lips, mouth or throat ulcers
- dizziness
- skin rash or itching
Uncommon
- tingling or numbness in hands and feet
Rare
- acid reflux
- flushing
- difficulty in swallowing
- taste changes
- fits
Stop receiving ETOVEL 100 INJECTION and contact your doctor immediately if you experience any of the following side effects:
- signs of allergic reactions (such as skin rash, itching, swelling of the face, lips, tongue and throat causing difficulty in breathing or swallowing)
How To Manage Side Effects
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Consult your doctor if your dizziness worsens.
Nausea And Vomiting
Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if nausea worsens.
Skin rash Or Itching
Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.
Warning & Precautions
Pregnancy
ContraindicatedETOVEL 100 INJECTION is not recommended for use in pregnant women. Therefore, consult your doctor for advice before receiving it. Women of childbearing potential must use a suitable contraceptive method to stop pregnancy while receiving ETOVEL 100 INJECTION and until 6 months after stopping the therapy.
Breastfeeding
ContraindicatedETOVEL 100 INJECTION may pass through breast milk. Therefore, it is not recommended for use in breast-feeding women. Kindly consult your doctor before receiving it.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if your ability is affected by ETOVEL 100 INJECTION.
Alcohol
Consult your doctorAvoid consumption of alcohol while receiving ETOVEL 100 INJECTION to avoid unwanted reactions.
Kidney
Use with CautionETOVEL 100 INJECTION should be used with caution in patients with kidney diseases. Therefore, consult your doctor before receiving it.
Liver
Use with CautionETOVEL 100 INJECTION should be used with caution in patients with liver diseases. Therefore, consult your doctor before receiving it.
Allergy
ContraindicatedTalk to your doctor before receiving ETOVEL 100 INJECTION if you are allergic to Etoposide.
Use In Pediatrics
Monitoring requiredETOVEL 100 INJECTION should be used in children and adolescents (aged below 18 years) only if prescribed by a physician. Therefore, consult your child’s doctor before administration of ETOVEL 100 INJECTION.
Use In Geriatrics
Use with CautionETOVEL 100 INJECTION should be used with caution in elderly patients (aged 65 years or older). Therefore, consult your doctor before receiving it.
Others
ETOVEL 100 INJECTION is not recommended for use if you:
- are recently vaccinated with live vaccines (including yellow fever vaccine)
Before receiving ETOVEL 100 INJECTION, inform your doctor if you:
- have any serious infections
- recently had radiotherapy or chemotherapy
- have low albumin levels in blood
Interactions
A. Drug - Drug interactions:
Before receiving ETOVEL 100 INJECTION inform your doctor if you are taking any of the following medicines such as:
- live vaccines (including yellow fever vaccine)
- ciclosporin (a medicine used to suppress immune function and to stop graft rejection post-transplant)
- cisplatin (another medicine used to manage cancer)
- medicines used to manage epilepsy (such as phenytoin, carbamazepine)
- warfarin (a medicine used to manage blood clot formation)
- medicines used for pain relief (such as phenylbutazone, sodium salicylate, or aspirin)
- other medicines used for cancer such as anthracyclines (Ex. doxorubicin, epirubicin, daunorubicin)
Over dosage:
ETOVEL 100 INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, contact your doctor if you experience any unusual side effects.
Synopsis
| Drug | : | Etoposide |
| Pharmacological Category | : | Topoisomerase-2 Inhibitors |
| Therapeutic Indication | : | Blood cancer, lymph cancer, ovarian cancer, testicular cancer, small cell lung cancer |
| Dosage Forms | : | Capsule, Injection |
More Information
- Keep ETOVEL 100 INJECTION out of reach of children
- Store ETOVEL 100 INJECTION in a refrigerator between 2-8°C
FAQs About ETOVEL 100 INJECTION
Q: How does ETOVEL 100 INJECTION works?
A: ETOVEL 100 INJECTION is an anticancer agent. It works by blocking the abnormal actions of certain cellular proteins (topoisomerase 2) that triggers cancer cell formation. As a result, it reduces cancer formation and stops its further growth within the body.
Q: Can I receive ETOVEL 100 INJECTION during breastfeeding?
A: No. ETOVEL 100 INJECTION is not recommended for use in breast-feeding women. Therefore, consult your doctor before receiving.
Q: Can ETOVEL 100 INJECTION increase the risk of infections?
A: ETOVEL 100 INJECTION may cause a drop in the number of white blood cells in the body and may weaken your immune system. As a result, you may be at a greater risk of getting infected while receiving ETOVEL 100 INJECTION. To avoid this, your doctor will regularly monitor your blood counts as a precaution. However, inform your doctor if you experience any signs of infection such as fever.
Q: Can the use of ETOVEL 100 INJECTION make me feel tired?
A: Yes. ETOVEL 100 INJECTION may make you feel tired easily. This is because, it reduces the levels of red blood cells in your blood and may make you anaemic. Consult your doctor if you experience tiredness after receiving ETOVEL 100 INJECTION. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while receiving this medicine.
Q: Can I drive a car after receiving ETOVEL 100 INJECTION?
A: ETOVEL 100 INJECTION may make you feel tired or dizzy. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by ETOVEL 100 INJECTION.
Q: How ETOVEL 100 INJECTION is administered?
A: ETOVEL 100 INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously).
Q: How to control nausea caused due to ETOVEL 100 INJECTION?
A: Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with ETOVEL 100 INJECTION. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-manage nausea.
References
1. KD. Tripathi. Anticancer Drugs. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 866.
2. Gizem Reyhanoglu; Prasanna Tadi. Etoposide. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2022. [Accessed on 6th November 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336826/
3. Neon Healthcare Limited. ETOPOPHOS™ 100 mg Powder for Solution for Injection Etoposide (as phosphate). Electronics Medicines Compendium. [Revised in February 2022]. [Accessed on 6th November 2023] https://www.medicines.org.uk/emc/files/pil.10514.pdf
4. Central Drugs Standard Control Organization. Etoposide Capsule and Injection. March 1988. [Accessed on 6th November 2023] https://cdscoonline.gov.in/CDSCO/Drugs
Useful Diagnostic Tests
- Beta Human Chorionic Gonadotropin, Tumour marker
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