Estrabet 2mg Tablet 28'S

Introduction About ESTRABET 2MG TABLET

Estrabet 2mg Tablet contains estradiol, a form of estrogen hormone used as hormone replacement therapy (HRT) in postmenopausal women. It is prescribed to help relieve symptoms associated with menopause, particularly in women who have not had a natural menstrual period for at least 6 months. It may also be recommended for selected postmenopausal women to help maintain bone strength and reduce the risk of osteoporosis when other options are not suitable.

Take Estrabet 2mg Tablet exactly as prescribed by your doctor. Swallow the tablet whole with water, with or without food, preferably at the same time each day. The dose and duration of therapy depend on your medical history, symptom severity, and individual response. Your doctor may advise regular check-ups, including breast and pelvic examinations, while you are receiving hormone replacement therapy.

Do not use Estrabet 2mg Tablet if you are allergic to estradiol or have a history of breast cancer, cancer of the womb lining (endometrial cancer), unexplained vaginal bleeding, untreated endometrial hyperplasia, blood clots, pulmonary embolism, heart attack, stroke, severe liver disease, or certain liver tumours. Before starting treatment, inform your doctor if you have uterine fibroids, endometriosis, epilepsy, asthma, kidney problems, migraine, high blood pressure, diabetes, high cholesterol, gallbladder disease, or a family history of blood clots or hormone-sensitive cancers.

Common side effects of Estrabet 2mg Tablet may include headache, nausea, abdominal or pelvic pain, leg cramps, vaginal spotting or breakthrough bleeding, weakness, rash, or itching. Seek immediate medical attention if you experience symptoms such as chest pain, sudden shortness of breath, swelling or pain in one leg, severe headache, vision changes, yellowing of the skin or eyes, or unusual vaginal bleeding, as these may require prompt medical evaluation. Since this medicine is intended for postmenopausal women, it is not recommended during pregnancy, breastfeeding, or in children and adolescents. Elderly women, especially those aged 60 years and above, should use this medicine only under close medical supervision due to an increased risk of certain cardiovascular complications.

Uses Of ESTRABET 2MG TABLET

• Provides relief from symptoms that occur after menopause in postmenopausal women
• Prevents osteoporosis in post-menopausal women

Benefits of ESTRABET 2MG TABLET

Estrabet 2mg Tablet for Menopausal Symptoms

Estrabet 2mg Tablet helps relieve symptoms that commonly occur after menopause due to reduced estrogen levels. It contains estradiol, a form of estrogen hormone replacement therapy (HRT). By restoring estrogen levels, it may help reduce hot flushes, night sweats, vaginal dryness, mood changes, and sleep disturbances. Estrabet 2mg should be taken exactly as prescribed by a doctor.

Estrabet 2mg Tablet for Postmenopausal Osteoporosis

After menopause, lower estrogen levels can lead to bone loss and increase the risk of osteoporosis. Estrabet 2mg helps slow bone loss by replacing the estrogen the body no longer produces. It may be prescribed for postmenopausal women at increased risk of fractures when other osteoporosis medicines are not suitable. Use only under medical supervision.

Estrabet 2mg Tablet for Estrogen Replacement Therapy

Estrabet 2mg is used as part of hormone replacement therapy to restore estrogen levels in women with estrogen deficiency after menopause or following certain medical conditions affecting hormone production. Restoring estrogen levels helps support overall well-being and may improve symptoms associated with estrogen deficiency. Regular follow-up with your doctor is important while using this medicine

How ESTRABET 2MG TABLET Works

Mechanism of Estrabet 2mg Tablet

Estrabet 2mg contains estradiol, which belongs to the group of medicines called estrogens. It works by replacing the estrogen that the body produces in lower amounts after menopause. Restoring estrogen levels helps reduce menopausal symptoms and supports the maintenance of healthy bones.

How Does Estradiol Work in the Body?

Estradiol binds to estrogen receptors present in different tissues, including the reproductive organs, bones, brain, and blood vessels. After binding to these receptors, it helps regulate the activity of genes involved in maintaining normal body functions. This action helps reduce menopausal symptoms such as hot flushes and vaginal dryness while also slowing the loss of bone mineral density associated with menopause.

How to use ESTRABET 2MG TABLET

• Swallow Estrabet 2mg Tablet whole with a glass of water. Do not crush, chew, or break the tablet.
• Take the medicine at the same time each day, with or without food, as prescribed by your doctor.
• Continue taking the medication regularly, even if your menopausal symptoms improve, unless your doctor advises you to stop.
• If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not take a double dose.
• Attend regular follow-up appointments, as your doctor may monitor your response to treatment and adjust the dose if needed.
• Periodic health checks, including breast examinations, pelvic examinations, and blood pressure monitoring, may be recommended during treatment.
• Inform your doctor immediately if you notice unusual vaginal bleeding, breast changes, severe headache, chest pain, leg swelling, or sudden vision changes.
• Do not stop taking Estrabet 2mg Tablet without consulting your doctor, as your treatment plan may need to be reviewed before discontinuation.

What if I forgot to take ESTRABET 2MG TABLET

• If you miss a dose of Estrabet 2mg Tablet, take it as soon as you remember.
• If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do not take two tablets together to make up for the missed dose.
• Missing doses occasionally may reduce the effectiveness of hormone replacement therapy in controlling menopausal symptoms.
• Try to take Estrabet 2mg Tablet at the same time every day to help you remember your dose. 

Overdose

If an overdose of Estrabet 2mg Tablet occurs, seek immediate medical attention or contact your doctor without delay. Prompt medical evaluation is important, as excessive estradiol may increase the risk of side effects and requires appropriate assessment and supportive care.

Side Effects Of ESTRABET 2MG TABLET

Common side effects of Estrabet 2mg Tablet

• headache
• nausea
• cramps in legs
• abdominal/pelvic pain
• unscheduled bleeding/spotting
• asthenia (feeling of weakness)
• changes in weight
• rash/itching

When to Seek Medical Attention?

Stop taking Estrabet 2mg Tablet and inform your doctor immediately if you experience any of the following:

• Signs of a severe allergic reaction, such as skin rash, itching, hives, swelling of the face, lips, tongue, or throat, or difficulty breathing or swallowing.
• Symptoms of a blood clot, such as sudden pain or swelling in one leg, chest pain, sudden shortness of breath, or coughing up blood.
• Signs of a stroke, including sudden weakness or numbness on one side of the body, difficulty speaking, severe headache, dizziness, or vision changes.
• Symptoms of a heart attack, such as severe chest pain or pressure that may spread to the arm, neck, jaw, or back, along with sweating, nausea, or shortness of breath.
• Yellowing of the skin or eyes (jaundice), severe abdominal pain, or dark urine, which may indicate liver problems.
• Unusual vaginal bleeding, especially after menopause, or any new breast lump or changes in the breast.

Severe skin reactions, including widespread rash, blistering, peeling of the skin, or sores in the mouth, eyes, or genitals (which may indicate Stevens-Johnson syndrome or toxic epidermal necrolysis).

How To Manage Side Effects

Headache

• Stay Hydrated: Dehydration is a common cause of headaches. Drink enough water throughout the day and avoid excess caffeine or alcohol.
• Cold or Warm Compress: Apply a cold pack on your forehead for tension or migraine-type headaches. Use a warm compress or heating pad on the back of the neck for stress-related headaches.
• Rest in a Quiet, Dark Room: Bright light and noise can worsen headaches. Resting in a calm, dark room often helps reduce discomfort.
• Massage and Relaxation: Gently massage your temples, neck, and shoulders to ease tension. Practice deep breathing, yoga, or meditation for relaxation.
• Ginger Tea: Ginger has natural anti-inflammatory properties that may reduce headache pain. Drink a cup of warm ginger tea for soothing relief.
• Peppermint Oil or Balm: Applying diluted peppermint oil on the temples or forehead can give a cooling effect. This may help in reducing tension headaches.
• Follow a Regular Sleep Schedule: Poor or irregular sleep often triggers headaches. Maintain a consistent bedtime and avoid late-night screen use.

Skin rash Or Itching

• Cold Compress: Apply a clean, cold, damp cloth or ice pack wrapped in a towel to the rash for 10–15 minutes. This helps reduce itching, swelling, and redness.
• Aloe Vera Gel: Fresh aloe vera has cooling and healing properties. Apply a thin layer to the rash area to soothe irritation.
• Oatmeal Bath: Add a cup of finely ground oatmeal to lukewarm bath water. Soaking in it for 15–20 minutes helps calm itching and inflammation.
• Coconut Oil: Virgin coconut oil works as a natural moisturizer. It can soothe dry, irritated skin and reduce mild redness.
• Chamomile or Green Tea Compress: Soak a cloth in cooled chamomile or green tea and apply to the rash. This can relieve irritation and promote skin healing.
• Avoid Irritants: Do not use strong soaps, detergents, or perfumes on the affected area. Wear loose cotton clothing to avoid friction and sweating.
• Keep Skin Moisturized: Apply gentle, fragrance-free moisturizers to prevent dryness. Hydrated skin heals faster and itches less.

Warning & Precautions

Pregnancy

Contraindicated

Estrabet 2mg Tablet is not recommended during pregnancy or in women planning to become pregnant. It is intended for use only in postmenopausal women. If you become pregnant or think you may be pregnant while taking this medicine, stop taking it and contact your doctor immediately.

Breastfeeding

Contraindicated

Estrabet 2mg Tablet is not recommended during breastfeeding, as it is intended for postmenopausal women. Consult your doctor before using this medicine.

Kidney

Use with Caution

Use Estrabet 2mg Tablet with caution if you have kidney disease or reduced kidney function. Your doctor may recommend regular monitoring during treatment. 

Liver

Contraindicated

Do not use Estrabet 2mg Tablet if you have active liver disease, a history of certain liver disorders (such as benign liver tumors), or abnormal liver function tests, unless advised by your doctor.

Allergy

Contraindicated

Do not take Estrabet 2mg Tablet if you are allergic to estradiol or any of the other ingredients in the medicine. Seek immediate medical attention if you develop signs of an allergic reaction.

Lungs

Consult your doctor

Estrabet 2mg Tablet is not recommended if you have or have had a pulmonary embolism (blood clot in the lungs). Use it with caution if you have other lung conditions, such as asthma, after consulting your doctor.

Heart Disease

Consult your doctor

Do not use Estrabet 2mg Tablet if you have a history of heart attack or certain serious heart conditions unless your doctor specifically recommends it. Estrogen therapy may increase the risk of blood clots, stroke, or other cardiovascular events in some women.

Use In Pediatrics

Contraindicated

Estrabet 2mg Tablet is not recommended for children or adolescents, as it is intended only for postmenopausal women.

Use In Geriatrics

Use with Caution

Women 60 years of age and older should use Estrabet 2mg Tablet with caution, as the risk of heart disease, stroke, and blood clots may increase with age. Regular medical follow-up is recommended during treatment.

Other Warnings for ESTRABET 2MG TABLET

Before taking Estrabet 2mg Tablet inform your doctor if you:

• Have, have had, or are suspected to have breast cancer.
• Have or are suspected to have cancer of the womb (endometrial cancer).
• Have unexplained vaginal bleeding.
• Have untreated endometrial hyperplasia (thickening of the womb lining).
• Have or have had blood clots in the veins, such as deep vein thrombosis (DVT).
• Have inherited blood clotting disorders (such as protein C, protein S, or antithrombin deficiency).
• Have recently had or currently have a stroke or other arterial blood clot.
• Have inherited porphyria (a rare blood disorder).

Who should not take ESTRABET 2MG TABLET

Estrabet 2mg Tablet not recommended if you:

• Have uterine fibroids or endometriosis.
• Have a history of endometrial hyperplasia.
• Are at increased risk of developing blood clots.
• Have a strong family history of estrogen-sensitive cancers, such as breast cancer.
• Have high blood pressure, diabetes, gallstones, or migraine.
• Have systemic lupus erythematosus (SLE).
• Have epilepsy.
• Have otosclerosis or hereditary/acquired angioedema.
• Are scheduled to undergo surgery, as temporary discontinuation of hormone therapy may be recommended.

Safety Advice

• Attend Regular Check-ups: Regular follow-up visits are important while taking Estrabet 2mg Tablet. Your doctor may recommend breast examinations, pelvic examinations, blood pressure monitoring, and other health checks based on your individual risk factors.
• Do Not Self-Medicate: Do not start, stop, or combine Estrabet 2mg Tablet with other hormone replacement therapies or estrogen-containing medicines without your doctor's advice.
• Watch for Serious Symptoms: Stop taking the tablet and seek immediate medical attention if you notice signs of a blood clot (leg pain or swelling, chest pain, sudden shortness of breath), stroke, severe allergic reactions, or unusual vaginal bleeding.
• Take Exactly as Prescribed: Take Estrabet 2mg Tablet at the dose and duration recommended by your doctor. Do not change the dose or discontinue treatment without medical advice.
• Inform Your Doctor About Any New Symptoms: Tell your doctor if you develop breast changes, persistent headaches, vision changes, yellowing of the skin or eyes, or worsening migraine during treatment.
• Maintain a Healthy Lifestyle: Regular exercise, a balanced diet, maintaining a healthy weight, avoiding smoking, and limiting alcohol intake may help support overall health during hormone replacement therapy.
• Inform Before Surgery or Prolonged Immobilization: Tell your doctor or surgeon that you are taking Estrabet 2mg Tablet, as it may need to be stopped several weeks before major surgery or prolonged bed rest to reduce the risk of blood clots.

Diet and Lifestyle Advice

• Eat a Balanced, Calcium-Rich Diet: Include calcium- and vitamin D-rich foods such as low-fat dairy products, leafy green vegetables, fortified foods, and nuts to help support bone health, especially after menopause.
• Stay Physically Active: Engage in regular weight-bearing and muscle-strengthening exercises such as walking, dancing, yoga, or light resistance training to help maintain bone strength and overall well-being.
• Maintain a Healthy Weight: Achieving and maintaining a healthy body weight may help reduce the risk of certain health conditions associated with menopause and hormone therapy.
• Avoid Smoking: Smoking may reduce the benefits of estrogen therapy and increase the risk of heart disease, blood clots, and osteoporosis. Quitting smoking is recommended.
• Limit Alcohol Intake: Excessive alcohol consumption may increase the risk of certain side effects and affect overall health. Consume alcohol only in moderation, if at all, after discussing it with your doctor.
• Stay Hydrated: Drink enough water throughout the day to support your overall health and help maintain normal body functions.
• Attend Regular Health Screenings: Have routine breast examinations, pelvic examinations, blood pressure checks, and bone health assessments as recommended by your doctor while using Estrabet 2mg Tablet.
• Report Any Unusual Symptoms Promptly: Contact your doctor if you notice unusual vaginal bleeding, breast changes, severe headaches, vision problems, leg swelling, chest pain, or sudden shortness of breath, as these may require immediate medical evaluation.

1. Estrabet 2mg Tablet vs. Tibolone for Menopausal Symptom Management

Drug - Drug interaction

1. Blood thinners (e.g., Warfarin)

• Interaction: Estrogen therapy may alter the effect of blood thinners, which can affect blood clotting control.
• Management: If you are taking warfarin or another anticoagulant, your doctor may monitor your blood clotting tests (INR) more frequently and adjust the dose if needed.

2. Thyroid medicines (e.g., Levothyroxine)

• Interaction: Estrabet 2mg Tablet may increase the amount of thyroid-binding proteins, reducing the effectiveness of thyroid replacement therapy.
• Management: Your doctor may monitor your thyroid function and adjust your levothyroxine dose if required.

3. Anti-seizure medicines (e.g., Carbamazepine, Phenytoin, Phenobarbital)

• Interaction: These medicines may reduce the effectiveness of Estrabet 2mg Tablet by increasing the breakdown of estradiol in the body.
• Management: Your doctor may adjust your treatment or monitor your symptoms more closely.

4. Antibiotics for tuberculosis (e.g., Rifampicin, Rifabutin)

• Interaction: These medicines can reduce estradiol levels, making hormone replacement therapy less effective.
• Management: Inform your doctor if you are prescribed these medicines, as an alternative treatment or dose adjustment may be needed.

5. Antifungal medicines (e.g., Ketoconazole, Itraconazole)

• Interaction: Certain antifungal medicines may increase estradiol levels in the body, increasing the likelihood of side effects.
• Management: Your doctor may monitor you for side effects and adjust treatment if necessary.

6. HIV or Hepatitis C medicines (e.g., Ritonavir, Nelfinavir)

• Interaction: These medicines can either increase or decrease estradiol levels, depending on the combination used.
• Management: Tell your doctor about all antiviral medicines you are taking so appropriate monitoring can be arranged.

7. Herbal products (e.g., St. John's Wort)

• Interaction: St. John's Wort may reduce the effectiveness of Estrabet 2mg Tablet by increasing estradiol metabolism.
• Management: Avoid taking St. John's Wort unless your doctor advises otherwise.

Drug - Food interaction

1. Grapefruit and grapefruit juice

• Interaction: Grapefruit may increase the level of estradiol in the body, potentially increasing the risk of side effects.
• Management: Avoid or limit grapefruit and grapefruit juice while taking Estrabet 2mg Tablet unless your doctor advises otherwise.

2. Alcohol

• Interaction: Excessive alcohol intake may increase estrogen levels and may also increase the risk of certain side effects such as liver problems or breast tenderness.
• Management: Limit alcohol consumption and discuss safe intake with your doctor.  

Synopsis

More Information

• Keep ESTRABET 2MG TABLET out of reach of children
• Store ESTRABET 2MG TABLET at room temperature

FAQs About ESTRABET 2MG TABLET

References

1. K.D. Tripathi. Estrogens, Progestins and Contraceptives. Essentials of Medical Pharmacology. seventh edition. 2013. Page – 306.

2. Nosek, M., Kennedy, H.P. and Gudmundsdottir, M. Distress during the menopause transition: a rich contextual analysis of midlife women’s narratives. [Accessed on 23rd July 2026] 

3. Estradiol. NIH National Library of Medicine. National centre for biotechnology information. PubChem. July 2022. [Accessed on 23rd July 2026] 

4. TTK Healthcare Limited. Primiwal Tablet. [Revised in February 2021] [Accessed on 23rd July 2026] 

5. Abbott Biologicals BV. Electronic Medicines Compendium (EMC) [Revised in August 2025] [Accessed on 23rd July 2026] 

Useful Diagnostic Tests

• Liver Function Test (LFT)

Author Details

Written By Dr. K .AZEEM HUSSAIN - B.D.S

Reviewed For Accuracy By Dr. M N Himaja - MBBS

Last updated on 11 Jan 2023 | 06:53 PM(IST)