ESPRA DSR Capsule 15's

Introduction About ESPRA DSR CAPSULE

ESPRA DSR CAPSULE is a highly effective medication used for the management of acid reflux, gastroesophageal reflux disease (GERD), and stomach ulcers. The active ingredient, Domperidone and Esomeprazole, helps to reduce stomach acid and promotes healing in the digestive system.

ESPRA DSR CAPSULE should be taken without food, following the dosage and duration prescribed by your doctor. The dosage will depend on your condition and how you respond to the medication. It is important to continue taking the medicine for the full duration recommended by your doctor. Stopping management prematurely may cause your symptoms to return or worsen your condition. Be sure to inform your healthcare team about any other medications you are taking, as some may interact with this medication.

Common side effect of this medication includes headache, abdominal pain, and diarrhea, flatulence, dryness in the mouth. Most of these side effects are temporary and typically improve with time. However, if you are concerned about any side effects, contact your doctor immediately. This medication may also cause drowsiness and dizziness, so refrain from driving or engaging in activities that require focus until you are aware of how it affects you. It is best to avoid alcohol while taking this medicine, as it can increase drowsiness. Making lifestyle changes, such as drinking cold milk and avoiding hot tea, coffee, spicy foods, or chocolate, can help improve your results.

Before taking this medication, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Additionally, let your doctor know if you have any liver conditions so they can determine the appropriate dose for you.

Uses Of ESPRA DSR CAPSULE

• Acid reflux
• Gastroesophageal reflux disease (GERD)
• Stomach ulcers

Benefits of ESPRA DSR CAPSULE

1.Reduces Acid Reflux and GERD Symptoms: Esomeprazole, a proton pump inhibitor (PPI), helps reduce the amount of stomach acid produced, effectively relieving symptoms of acid reflux and GERD (Gastroesophageal Reflux Disease). This alleviates heartburn, chest pain, and regurgitation.

2.Promotes Healing of Stomach Ulcers: The combination of Esomeprazole and Domperidone works together to decrease stomach acid and promote gastric motility. This aids in healing peptic ulcers by reducing irritation from stomach acid and speeding up recovery.

3.Effective in Managing Chronic Acid-Related Conditions: It helps manage conditions like Zollinger-Ellison syndrome and other acid-related disorders by reducing stomach acid production over an extended period, providing relief from symptoms and preventing complications.

How ESPRA DSR CAPSULE Works

ESPRA DSR CAPSULE contains two active ingredients: Domperidone and Esomeprazole. Domperidone helps by increasing the movement of the stomach and intestines, which helps relieve symptoms like nausea and vomiting. Esomeprazole reduces the amount of acid produced in the stomach, helping to treat acid reflux, heartburn, and ulcers. Together, these medicines work to improve digestion, reduce acid-related problems, and prevent discomfort in the stomach and esophagus.

How to use ESPRA DSR CAPSULE

Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage.

How to Take ESPRA DSR CAPSULE?

• Take one capsule daily, preferably before a meal in the morning
• Swallow the tablet whole with a glass of water. Do not crush or chew the medication.
• For best results, take the tablet at the same time each day.

What if I forgot to take ESPRA DSR CAPSULE

If you forget to take a dose, take it as soon as you remember unless it is almost time for your next dose. In that case, skip the missed dose, do not take two doses at once to make up for a missed dose.

Overdose

If you or anyone else accidentally took more ESPRA DSR CAPSULE, contact your doctor immediately or go to a hospital straight away. Symptoms of overdosage might include sleepiness, confusion, uncontrollable body movements (including eye and tongue), twisted neck and abnormal posture.

Side Effects Of ESPRA DSR CAPSULE

Like all medicines, ESPRA DSR CAPSULE may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking ESPRA DSR CAPSULE

• Headache
• Abdominal pain
• Diarrhea
• Flatulence
• Dryness in the mouth

When to consult your doctor?

• Allergic reactions symptoms such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat.
• Heart problems symptoms such as chest pain, irregular heartbeats, or feeling faint.
• Severe digestive problems symptoms such as persistent abdominal pain, nausea, or vomiting.
• Electrolyte imbalance symptoms such as muscle spasms or tremors
• Clostridium difficile infection (a serious gastrointestinal infection) symptoms such as severe diarrhea
• Severe Skin Reactions symptoms such as blisters, peeling skin, or rashes.
• Excessive Drowsiness or Fatigue
• Liver problems symptoms such as yellowing of the skin or eyes (jaundice), dark urine, or unusual fatigue.

How To Manage Side Effects

Warning & Precautions

Other Warnings for ESPRA DSR CAPSULE

Before taking ESPRA DSR CAPSULE inform your doctor if you:

• have osteoporosis
• have vitamin B12 deficiency (sore tongue, mouth ulcers, pale skin, depression)
• are going to test Chromogranin A level

Who should not take ESPRA DSR CAPSULE

ESPRA DSR CAPSULE is not recommended for use if you:

• have bloody stools or bleeding in the gut
• have blockage or tear in the intestines
• have severe fluid or electrolyte disturbances
• have prolactinoma (a non-cancerous tumor of pituitary gland)
• have low blood potassium or magnesium levels
• have hyperkalemia (high blood potassium levels)

Safety Advice

• Follow your doctor's instructions regarding the exact dosage.
• Do not exceed the recommended daily dosage. 
• Take one capsule daily, preferably before a meal in the morning.
• Swallow the tablet whole with a glass of water. Do not crush or chew the medication.
• For best results, take the tablet at the same time each day.
• Do not take ESPRA DSR CAPSULE or change your dosage without talking to your doctor, especially if you have not been diagnosed with a condition that needs this management.
• If you have a history of allergies to Esomeprazole, Domperidone, or similar medications, make sure to inform your doctor before taking this capsule.
• If you have impaired kidney or liver function, it is important to consult your doctor before using ESPRA DSR CAPSULE. Your doctor may modify your dosage or recommend a different medication.
• Let your doctor know If you are pregnant or planning to become pregnant or breastfeeding women.
• Let your doctor know about any other medications you are taking, including over-the-counter medicines and herbal supplements. Some medications, such as antifungal drugs, antibiotics, or blood thinners, may interact with ESPRA DSR CAPSULE.
• Long-term use of Esomeprazole (a key component) may raise the risk of bone fractures or vitamin B12 deficiency. If you need to use it for an extended period, it is important to undergo regular monitoring.
• Domperidone can sometimes cause dizziness or drowsiness. If you feel lightheaded or sleepy, avoid driving or operating heavy machinery until you feel better.
• It is best to limit alcohol consumption while on ESPRA DSR CAPSULE, as it may increase the risk of stomach irritation or side effects.
• If you do not feel better after taking it for 14 days, let your doctor know, as it could indicate another underlying issue that requires attention

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking ESPRA DSR CAPSULE

1. Clopidogrel (Antiplatelet Drug)

• Interaction: Esomeprazole, the proton pump inhibitor (PPI) component of ESPRA DSR CAPSULE, can reduce the activation of clopidogrel in the liver.
• Effect: This may decrease the effectiveness of clopidogrel, leading to a higher risk of cardiovascular events.
• Management: If clopidogrel and ESPRA DSR CAPSULE must be co-administered, it's generally recommended to choose a different PPI or closely monitor for signs of cardiovascular issues.

2. Warfarin (Anticoagulant)

• Interaction: Esomeprazole can alter the metabolism of warfarin, potentially leading to increased blood levels of warfarin.
• Effect: Increased INR (International Normalized Ratio), raising the risk of bleeding.
• Management: Regular monitoring of INR is advised when using these drugs together. The warfarin dose may need adjustment.

3. Diazepam (Benzodiazepine)

• Interaction: Esomeprazole can increase the concentration of diazepam in the blood.
• Effect: This can lead to an increased sedative effect, resulting in drowsiness, dizziness, and impaired motor skills.
• Management: Dose adjustments of diazepam may be required. Close monitoring for signs of excessive sedation is essential.

4. Methotrexate (Chemotherapy and Immunosuppressive Drug)

• Interaction: High doses of esomeprazole may increase methotrexate levels by inhibiting its elimination.
• Effect: This can increase the risk of methotrexate toxicity, leading to severe side effects like kidney damage or bone marrow suppression.
• Management: Temporarily discontinuing ESPRA DSR CAPSULE during high-dose methotrexate therapy may be advised. Alternatively, a dose reduction of methotrexate may be considered.

5. Itraconazole / Ketoconazole (Antifungal Drugs)

• Interaction: Esomeprazole reduces stomach acid production, which can affect the absorption of certain antifungals, like itraconazole and ketoconazole.
• Effect: Decreased absorption of these antifungals, leading to reduced efficacy.
• Management: Take antifungals at a different time of day than ESPRA DSR CAPSULE, or consider using a different PPI or alternative antifungals if necessary.

6. Cyclosporine (Immunosuppressant)

• Interaction: Esomeprazole may increase blood levels of cyclosporine, as it inhibits its metabolism.
• Effect: Higher cyclosporine levels can lead to kidney toxicity or other side effects associated with immunosuppression.
• Management: Monitor cyclosporine levels regularly and adjust its dose accordingly.

7. Digoxin (Heart Medication)

• Interaction: Domperidone (the prokinetic agent in ESPRA DSR CAPSULE) may increase the absorption of digoxin.
• Effect: Elevated digoxin levels can cause toxicity, leading to heart arrhythmias or other serious effects.
• Management: Monitor digoxin levels regularly and adjust the dose as needed.

8. HIV Protease Inhibitors (e.g., Atazanavir, Lopinavir)

• Interaction: Esomeprazole may reduce the effectiveness of protease inhibitors by decreasing their absorption due to lower stomach acidity.
• Effect: Decreased plasma concentrations of protease inhibitors, leading to reduced antiviral efficacy.
• Management: Avoid combining these drugs with ESPRA DSR CAPSULE if possible. If necessary, monitor viral load and consider alternative treatments.

9. Phenytoin (Anti-Seizure Drug)

• Interaction: Esomeprazole can increase blood levels of phenytoin by inhibiting its metabolism.
• Effect: Increased phenytoin levels, leading to the risk of toxicity (e.g., nystagmus, ataxia).
• Management: Regularly monitor phenytoin levels and adjust its dosage accordingly.

10. Antacids or H2-receptor antagonists (e.g., Ranitidine)

• Interaction: Combining ESPRA DSR CAPSULE with other acid-reducing drugs may further reduce stomach acidity.
• Effect: This could decrease the effectiveness of ESPRA DSR CAPSULE and lead to increased gastric pH.
• Management: Avoid combining ESPRA DSR CAPSULE with other PPIs or H2-receptor antagonists. If necessary, adjust the timing between doses to avoid interactions.

11.Antibiotics (e.g., Clarithromycin)

• Interaction: Esomeprazole can increase the blood levels of certain antibiotics like Clarithromycin, which is often used for bacterial infections.
• Effect: This may increase the risk of side effects from the antibiotic, including QT prolongation (a heart rhythm disturbance), especially in individuals with pre-existing heart conditions.
• Management: Monitor for signs of heart problems, including irregular heartbeats. If you are using Clarithromycin or similar antibiotics, the dosage of Esomeprazole may need adjustment. Alternative antibiotics should be considered in some cases.

12.Blood Pressure Medication (e.g., Amlodipine)

• Interaction: Esomeprazole can increase the absorption of Amlodipine (a calcium channel blocker used for controlling blood pressure), potentially increasing its effects.
• Effect: This may lead to excessive lowering of blood pressure, causing symptoms like dizziness, fainting, or light-headedness.
• Management: If you experience symptoms of low blood pressure, consult your healthcare provider. Your doctor may adjust the dosage of Amlodipine or consider a different blood pressure medication.

Synopsis

Drug	:	Domperidone, Esomeprazole
Pharmacological Category	:	Dopamine antagonist, Proton-pump inhibitor
Therapeutic Indication	:	GERD, Peptic ulcer, Zollinger-Ellison syndrome Acidity, Heartburn, Indigestion
Dosage Forms	:	Tablet, Capsule

More Information

01.Why Choose ESPRA DSR CAPSULE for GERD and Ulcers?

• Reduces Stomach Acid Production: ESPRA DSR CAPSULE works by reducing the production of stomach acid, which is beneficial in managing conditions like GERD, where acid reflux can cause heartburn and irritation of the esophagus, or ulcers, where acid can worsen the condition.
• Heals Ulcers: For gastric and duodenal ulcers, reducing the acid levels helps promote healing by creating a less acidic environment, which can help protect the stomach lining.
• Relieves GERD Symptoms: In GERD, ESPRA DSR CAPSULE helps alleviate symptoms such as heartburn, regurgitation, and discomfort by preventing stomach acid from flowing back into the esophagus.
• Effective and Well-Tolerated: ESPRA DSR CAPSULE is well-tolerated by many people and has a good safety profile when used as directed for acid-related conditions.
• Long-Lasting Effects: The 40mg dosage of ESPRA DSR CAPSULE provides significant relief for up to 24 hours with just one dose per day, making it convenient for patients.

02. Alternative to ESPRA DSR CAPSULE:

ESPRA DSR CAPSULE (esomeprazole with domperidone) is commonly prescribed for managing conditions such as gastroesophageal reflux disease (GERD), acid reflux, and certain stomach disorders. I have included some of the top alternative medications for the ESPRA DSR CAPSULE

1. For GERD and Acid Reflux (Proton Pump Inhibitors & Antacids):

• Omeprazole: A common PPI, works similarly to ESPRA DSR CAPSULE to reduce stomach acid.
• Pantoprazole: Another PPI, often used for similar conditions.
• Lansoprazole: Also a PPI, similar to ESPRA DSR CAPSULE in terms of reducing acid production.
• Rabeprazole: Another proton pump inhibitor, effective in reducing gastric acid.

2. For Nausea and Gastric Motility (Prokinetics):

• Metoclopramide: A prokinetic agent similar to domperidone, it helps in increasing stomach motility and reducing nausea.
• Cisapride: Another prokinetic, though it's less commonly used due to potential side effects.

3. Antacids:

• Ranitidine: Though now less commonly used due to safety concerns, it's an H2 blocker that reduces acid production.
• Antacids like Tums, Mylanta, or Gelusil: Provide immediate relief for acid reflux but do not address long-term acid reduction.

4. Herbal Alternatives:

• Ginger: Known for reducing nausea and improving digestion.
• Chamomile: Can help soothe an irritated stomach.
• Licorice root: Sometimes used to soothe stomach ulcers and esophageal issues.

If you are looking for a specific alternative for your condition, it would be best to consult with your doctor to choose the most appropriate medication or management, as they can vary in effectiveness and safety based on individual health conditions.

FAQs About ESPRA DSR CAPSULE

Q: What is ESPRA DSR CAPSULE used for?

A: ESPRA DSR CAPSULE is primarily used to manage acid-related stomach conditions like gastroesophageal reflux disease (GERD), peptic ulcers, and other digestive issues. It helps reduce excess stomach acid and provides relief from symptoms like heartburn, acid reflux, and stomach discomfort.

Q: How does ESPRA DSR CAPSULE work?

A: ESPRA DSR CAPSULE contains Esomeprazole and Domperidone. Esomeprazole is a proton pump inhibitor that reduces stomach acid production, while Domperidone is a prokinetic agent that helps with stomach emptying and relieves nausea and vomiting.

Q: What is the recommended dosage of ESPRA DSR CAPSULE?

A: The usual dosage of ESPRA DSR CAPSULE is one capsule daily, taken before meals. However, the exact dosage and duration should be prescribed by your doctor based on your condition.

Q: Can I take ESPRA DSR CAPSULE on an empty stomach?

A: Yes, it is recommended to take ESPRA DSR CAPSULE on an empty stomach, about 30 to 60 minutes before a meal, to maximize its effectiveness in reducing stomach acid.

Q: Are there any side effects of ESPRA DSR CAPSULE?

A: Common side effects may include nausea, headache, dizziness, abdominal pain, or dry mouth. If you experience severe side effects like allergic reactions, difficulty breathing, or chest pain, contact your doctor immediately.

Q: Can I take ESPRA DSR CAPSULE if I am pregnant or breastfeeding?

A: Consult your doctor before taking ESPRA DSR CAPSULE if you are pregnant, planning to become pregnant, or breastfeeding. Your doctor will assess whether the benefits outweigh any potential risks.

Q: Can I drink alcohol while taking ESPRA DSR CAPSULE?

A: It is advisable to avoid alcohol while taking ESPRA DSR CAPSULE, as alcohol can increase the risk of side effects like stomach irritation and may interfere with the medication's effectiveness.

Q: What should I do if I miss a dose of ESPRA DSR CAPSULE?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose, do not take two doses at once.

Q: Can ESPRA DSR CAPSULE interact with other medications?

A: Yes, ESPRA DSR CAPSULE can interact with certain medications, including antifungal drugs, blood thinners, and certain antibiotics. Always inform your doctor about all the medications you are currently taking.

Q: How long should I take ESPRA DSR CAPSULE?

A: The duration of management with ESPRA DSR CAPSULEdepends on the condition being managed. For chronic conditions, your doctor may recommend long-term use, while short-term management may be sufficient for acute issues.

Q: Can I stop taking ESPRA DSR CAPSULE suddenly?

A: It is not recommended to stop ESPRA DSR CAPSULE suddenly, especially after long-term use, as this may cause a rebound increase in stomach acid. Speak with your doctor before discontinuing the medication.

Q: Does long-term use of ESPRA DSR CAPSULE affect bone health?

A: Yes, extended use of ESPRA DSR CAPSULE may affect bone density due to its impact on calcium absorption. To reduce the risk of fractures, your doctor may suggest calcium and vitamin D supplementation or other bone health measures.

Q: How long does it take for ESPRA DSR CAPSULE to work?

A: ESPRA DSR CAPSULE typically starts to work within 1 to 2 hours after taking the capsule, with its full effects usually felt within a few days of consistent use, especially for conditions like acid reflux or GERD. However, for optimal results, it may take up to 1-2 weeks for full symptom relief. Always follow the dosage instructions provided by your doctor.

References

1. KD. Tripathi. Antiemetic, Prokinetic and Digestant drugs & Drugs for Peptic Ulcer and Gastroesophageal Reflux Disease. Essentials of medical pharmacology. Seventh edition. 2013. Page-666 & 651-653.

2. Keith A. Sharkey and John L. Wallace. Treatment of disorders of bowel motility and water flux; Antiemetics; Agents used in biliary and pancreatic disease and Pharmacotherapy of gastric acidity, peptic ulcer, and gastroesophageal reflux disease. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page-1326 & 1311-1313.

3. Gerald G. Briggs and Roger K. Freeman. D & E. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page-1232 & 1427-1431.

4. KY Marakhouski, GA Karaseva, DN Ulasivich and Y Kh Marakhouski. Omeprazole-Domperidone Fixed Dose Combination vs Omeprazole Monotherapy: A Phase 4, Open-Label, Comparative, Parallel Randomized Controlled Study in Mild to Moderate Gastroesophageal Reflux Disease. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. May 2017. [Accessed on 7th May 2026] 

5. TORRENT PHARMACEUTICALS LTD. IZRA D. Torrentian.com. [Revised in February 2022] [Accessed on 7th May 2026] 

6. Cipla Ltd. ESOMAC-D Capsules (Esomeprazole magnesium + Domperidone). Ciplamed. [Revised in April 2020] [Accessed on 7th May 2026] 

7. Sun Pharmaceutical Industries Europe B.V., and Terapia SA. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 7th May 2026] 

8. Vibcare Pharma Pvt Ltd. ESOVIB DSR. [Accessed on 7th May 2026]