Espin AT Tablet 10'S
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Introduction About ESPIN AT TABLET
ESPIN AT TABLET is a combination of S(-)Amlodipine and Atenolol which belongs to the group of medicine called Antihypertensive agents. It is used to manage hypertension (also known as high blood pressure) and angina pectoris (chest pain caused due to lack of oxygen supply to the heart). It can also be used to reduce the risk of heart attack (myocardial infarction) among heart patients.
Take ESPIN AT TABLET as advised by your physician. Avoid drinking grapefruit juice while taking ESPIN AT TABLET, as it could further decrease your blood pressure and may make you feel dizzier, drowsier or faint.
Before taking ESPIN AT TABLET, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have asthma, diabetes, overactive thyroid gland or low blood volume as a precaution.
ESPIN AT TABLET is not recommended for use in patients with other severe heart problems apart from hypertension and angina (such as heart failure). It is also not suitable for use in patients with severe hypotension (low blood pressure).
Consult your doctor before taking ESPIN AT TABLET if you are pregnant or breastfeeding. The most common side effects of taking ESPIN AT TABLET are swelling of ankles or other body parts, headache, dizziness, sleepiness, tiredness, racing heartbeat, indigestion, constipation, muscle cramps, cold hands and feet and slow heartbeat. Contact your doctor if any of these side effects trouble you.
Uses Of ESPIN AT TABLET
- Manage hypertension (high blood pressure)
- Manage angina (chest pain)
- Prevents heart attack
How ESPIN AT TABLET Works
ESPIN AT TABLET contains two medicines namely S(-)Amlodipine and Atenolol. Atenolol blocks the effects of certain hormones (adrenaline) in the body that naturally increases heart rate. This slows down the heartbeat and makes the heart to pump blood with a lesser force.
S(-)Amlodipine is a vasodilator. It relaxes the blood vessels supplying the heart which improves blood flow and oxygen supply to the heart muscles. Collectively, they reduce the strain on the heart and improves heart functions.
How to use ESPIN AT TABLET
Take ESPIN AT TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. ESPIN AT TABLET can be taken with or without meals.
Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Continue to take ESPIN AT TABLET for the stipulated duration instructed by your doctor to achieve better results.
Side Effects Of ESPIN AT TABLET
Common
- edema (swelling of the ankles or other body parts)
- headache, dizziness, sleepiness
- palpitations (fast heartbeat)
- flushing (redness and warmth of the skin)
- stomach pain, nausea, diarrhea, constipation, indigestion
- changes in bowel habit
- tiredness, weakness
- visual disturbances, double vision
- muscle pains
- cold hands and feet
- slow heartbeat
Uncommon
- anxiety, depression
- insomnia (sleeplessness)
- changes in taste
- tingling sensation in limbs, loss of pain sensation
- ringing in the ears
- low blood pressure
- increased sweating
- increased urination at night
- inability to obtain an erection, enlargement of the breasts in men
- joint pain, back pain
- weight gain or decrease in weight
Rare
- confusion
Stop taking ESPIN AT TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth or throat which can lead to difficulty in breathing or swallowing)
- severe skin reactions (such as skin rash with itching and redness, blistering and peeling of skin, skin swelling and inflammation of mucous membrane)
- chest pain, shortness of breath (signs of heart attack)
- inflammation of pancreas (causing severe stomach pain that radiates to the back side of the body)
How To Manage Side Effects
Nausea and vomiting:
Take ESPIN AT TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Constipation:
Eat plenty of fibre rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Warning & Precautions
Pregnancy
ESPIN AT TABLET should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before taking it.
Breastfeeding
ESPIN AT TABLET should be used with caution in breastfeeding women as it may pass through the breast milk to the nursing infant. Therefore, consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any heavy tools or machines if you feel dizzy after taking ESPIN AT TABLET.
Alcohol
Avoid consumption of alcohol while taking ESPIN AT TABLET as it could make you feel dizzier.
Kidney
ESPIN AT TABLET should be used with caution in patients with kidney problems (such as dialysis). Therefore, consult your doctor before taking it.
Liver
ESPIN AT TABLET should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.
Allergy
Do not take ESPIN AT TABLET if you are allergic to Atenolol, S(-)Amlodipine or to any other beta blockers (such as propranolol) or calcium antagonists (such as nifedipine, diltiazem).
Lungs
ESPIN AT TABLET should be used with caution in patients who have or previously had any breathing problems such as asthma. Therefore, consult your doctor before taking it.
Heart Disease
ESPIN AT TABLET is not recommended for use in patients with severe heart problems such as heart failure, aortic stenosis (narrowing of arteries) or cardiogenic shock (inability of heart to pump blood). It should be used with caution in patients having a history of heart attack or heart failure in the recent days. Therefore, consult your doctor before taking it.
Others
ESPIN AT TABLET is not recommended for use if you:
- have severe low blood pressure (hypotension)
- have a very poor blood circulation
- have unmanageed phaeochromocytoma (a tumor present in the adrenal gland)
- have metabolic acidosis (high acid levels in the blood)
Before taking ESPIN AT TABLET, inform your doctor if you:
- have severe uncontrollable increase in blood pressure (hypertensive crisis)
- have diabetes
- have low blood volume (loss of fluids from the body due to vomiting or diarrhea)
- have thyrotoxicosis (increased activity of the thyroid gland)
- have psoriasis (an autoimmune skin condition causing white patches)
- any scheduled for any operations or procedures
Use in pediatrics:
ESPIN AT TABLET is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor for advice.
Use in geriatrics:
ESPIN AT TABLET should be used with caution in the elderly patients. Therefore, consult your doctor before taking it.
Interactions
A. Drug-Drug interactions:
Before taking ESPIN AT TABLET, inform your doctor if you are taking any of the following medicines such as:
- other medicines used to manage high blood pressure and angina (such as nifedipine, verapamil, diltiazem, enalapril, ramipril, metoprolol, clonidine)
- ketoconazole, itraconazole (used to manage fungal infections)
- ritonavir, indinavir, nelfinavir (used in management of HIV infections)
- rifampicin, erythromycin, clarithromycin (used to manage bacterial infections)
- dantrolene (a medicine used to manage muscle spasms)
- medicines used to control elevated cholesterol levels (Ex. simvastatin)
- medicines used to manage graft rejection and to suppress immune functions (such as tacrolimus, sirolimus, temsirolimus, everlimus, cyclosporine)
- St. John’s wort (an herbal medicine used to manage depression)
- medicine used to manage irregular heartbeat (Ex. amiodarone, digoxin, quinidine or disopyramide)
- adrenaline (a medicine used to stimulate the heart)
- indomethacin or ibuprofen (medicines used for pain relief)
- medicines used to manage nose or sinus congestion and other cold remedies (such as montelukast, levocetirizine)
- medicines used to manage diabetes (Ex. insulin, metformin, glimepiride)
B. Drug-Food interaction:
Avoid drinking grapefruit juice while taking ESPIN AT TABLET, as it could lead to further decrease your blood pressure and may make you feel dizzier, drowsier or faint.
Overdosage:
If you or anyone else accidentally took more ESPIN AT TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include dizziness, fainting, light-headedness, weakness, shock, cool or clampy skin and shortness of breath.
Synopsis
| Drug | : | S(-)Amlodipine, Atenolol |
| Pharmacological Category | : | Calcium Channel Blocker, Beta blockers |
| Therapeutic Indication | : | Hypertension, Angina pectoris |
| Dosage Forms | : | Tablet |
More Information
- Keep ESPIN AT TABLET out of the sight and reach of children
- Store ESPIN AT TABLET at room temperature
FAQs About ESPIN AT TABLET
Q: What are the uses of ESPIN AT TABLET?
A: ESPIN AT TABLET is used to manage hypertension and angina. It can also be used to manage heart attack among heart patients.
Q: What type of a medicine is ESPIN AT TABLET?
A: ESPIN AT TABLET is an antihypertensive medicine. It relaxes blood vessels which improves blood flow and oxygen supply to the heart. It also slows down the heartbeat which makes the heart to pump more blood with lesser force.
Q: What happens when I stop taking ESPIN AT TABLET?
A: Do not stop taking ESPIN AT TABLET without consulting your doctor as your blood pressure may raise once again. Make sure to take ESPIN AT TABLET for the stipulated duration recommended by your doctor to achieve maximum benefits.
Q: What is the best time to take ESPIN AT TABLET?
A: ESPIN AT TABLET can be taken with or without meals. Your doctor will decide the best time for you to take ESPIN AT TABLET based on your age, body weight and disease condition.
Q: What to do if I forgot to take a dose of ESPIN AT TABLET?
A: If you have missed a dose of ESPIN AT TABLET, take it as soon as you remember. However, if it is time for the next dose of ESPIN AT TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of ESPIN AT TABLET to compensate the missed ones.
Q: What precautions should be followed while taking ESPIN AT TABLET?
A: Before taking ESPIN AT TABLET, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have severe high or low blood pressure, or other heart problems (such as narrowing of the arteries, cardiogenic shock or a recent heart attack). Consult your doctor before taking ESPIN AT TABLET if you are pregnant and breastfeeding. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail.
Q: Can I consume alcohol while taking ESPIN AT TABLET?
A: Avoid consumption of alcohol while taking ESPIN AT TABLET as it might make you feel dizzier and drowsier.
Q: What happens if I accidentally take more ESPIN AT TABLET?
A: If you or anyone else accidentally took more ESPIN AT TABLET, consult your doctor immediately. Symptoms of overdosage might include dizziness, fainting, light-headedness, weakness, shock, cool or clampy skin and shortness of breath.
Q: Can I take ESPIN AT TABLET daily?
A: Take ESPIN AT TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take ESPIN AT TABLET every day or not.
Q: Can ESPIN AT TABLET cause ankle swelling?
A: ESPIN AT TABLET may cause edema or swelling of ankles in few patients. If you experience ankle swelling, keep your legs on a table or slightly elevated from the ground level. If this symptom bothers you, contact your doctor.
Q: What are the side effects of ESPIN AT TABLET?
A: The most common side effects of taking ESPIN AT TABLET are swelling of ankles or other body parts, headache, dizziness, sleepiness, tiredness, racing heartbeat, indigestion, constipation, muscle cramps, cold hands and feet and slow heartbeat. Contact your doctor if any of these side effects trouble you.
Q: Can I stop taking ESPIN AT TABLET once my symptoms subside?
A: No. Do not stop taking ESPIN AT TABLET without consulting your doctor. As hypertension is a chronic condition, long term management may be necessary to control its symptoms. Therefore, take ESPIN AT TABLET as advised by your doctor for the stipulated duration. Premature discontinuation of therapy may increase your blood pressure once again.
Q: Can ESPIN AT TABLET be taken during pregnancy?
A: ESPIN AT TABLET should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before taking it.
Q: Can the use of ESPIN AT TABLET affect the liver?
A: Yes. ESPIN AT TABLET may affect the way your liver work. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before taking it.
Q: Can ESPIN AT TABLET cause erectile dysfunction?
A: ESPIN AT TABLET may cause problems in erection in few individuals. Consult your doctor if it bothers you.
References
1. KD. Tripathi. Antiadrenergic agents and drugs for glaucoma. Antianginal and Other Anti-ischaemic Drugs, Antihypertensive Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 149, 549 & 562-563.
2. Gerald G. Briggs and Roger K. Freeman. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 196-198 and 306-316.
3. Gang Ling, Ai-jun Liu, Fu-ming Shen, Guo-jun Cai, Jian-guo Liu & Ding-feng Su. Effects of combination therapy with atenolol and amlodipine on blood pressure control and stroke prevention in stroke-prone spontaneously hypertensive rats. Acta Pharmacologica Sinica. November 2007. [Accessed on 3rd January 2023] https://www.nature.com/articles/aps2007215
4. Kishen G. Bulsara; Manouchkathe Cassagnol. Amlodipine. StatPearls. NIH. National Library of Medicine, National Center for biotechnology information. PMC. PubMed Central. January 2022. [Accessed on 3rd January 2023] https://www.ncbi.nlm.nih.gov/books/NBK519508/
5. Dr. Reddy’s Laboratories (UK) Ltd. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 3rd January 2023] https://www.medicines.org.uk/emc/files/pil.3478.pdf
6. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2021] [Accessed on 3rd January 2023] https://www.medicines.org.uk/emc/files/pil.13960.pdf
7. Accord Healthcare Limited, Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on 3rd January 2023] https://www.medicines.org.uk/emc/files/pil.6025.pdf
8. Torrent Pharmaceuticals Ltd. Esam AT. (Atenolol and S-Amlodipine Besylate Tablets). [Revised in January 2016] [Accessed on 3rd January 2023] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1998.pdf
9. Central Drugs Standard Control Organization. S(-) Amlodipine-2.5mg/2.5mg +Atenolol 25/50mg tablet. October 2002. S(-) Amlodipine 2.5mg/5mg + Atenolol 8mg/8mg Tablet. July 2003. S (-) Amlodipine 2.5mg/5mg+Atenolol 50mg/50mg tablet. March 2003. S(-) Amlodipine 5mg+Atenolol 50mg tablet. July 2003. [Accessed on 3rd January 2023] https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
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