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Introduction About ENZYL 80MG CAPSULE
ENZYL 80MG CAPSULE contains Enzalutamide, which belongs to the group of medicines called Androgen receptor inhibitors. It is used to manage adult men with prostate cancer who no longer respond to hormone therapy or surgical management or if the cancer, despite responding to management, has spread to other parts of the body.
Prostate cancer occurs in the prostate gland (a gland in males that produces the seminal fluid to transport sperm). Symptoms include problems while urinating (difficulty, decreased force, or blood in the urine), blood in the semen, bone pain, erectile dysfunction, and weight loss.
Enzalutamide acts by blocking the activity of hormones called androgens (such as testosterone). By blocking androgens, it stops the growth of prostate cancer cells and can further induce cancer cell death and tumour regression.
Before taking ENZYL 80MG CAPSULE, inform your doctor if you have kidney problems, liver problems, or heart conditions like arrhythmia (heart rhythm problem). ENZYL 80MG CAPSULE is not recommended for use by pregnant and breastfeeding women. ENZYL 80MG CAPSULE is not recommended for use in children and adolescents. Consult your doctor before taking it.
The most common side effects of taking ENZYL 80MG CAPSULE are tiredness, broken bones, hot flushes, high blood pressure, headaches, feeling anxious, dry skin, itching, difficulty remembering, and breast enlargement in men. Consult your doctor if any of the symptoms worsen.
Uses Of ENZYL 80MG CAPSULE
- To manage prostate cancer
How ENZYL 80MG CAPSULE Works
ENZYL 80MG CAPSULE works by blocking the activity of hormones called androgens (such as testosterone). By blocking androgens, it stops the growth of prostate cancer cells and can induce cancer cell death and tumour regression.
How to use ENZYL 80MG CAPSULE
Take ENZYL 80MG CAPSULE as advised by your physician. Swallow it with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.
Side Effects Of ENZYL 80MG CAPSULE
Common
- Tiredness and falling
- Broken bones
- Hot flushes, high blood pressure, blockage of the arteries in the heart (ischemic heart disease)
- Headaches
- Feeling anxious, symptoms of restlessness
- An uncontrollable urge to move a part of the body, usually the legs
- Dry skin and itching
- Difficulty remembering, reduced concentration, and forgetfulness
- Change in sense of taste
- Breast enlargement in men (gynecomastia)
Uncommon
- Hallucinations
- Difficulty thinking clearly
- Low white blood cell count
Rare
- Posterior reversible encephalopathy syndrome (a reversible condition involving the brain)
Stop taking it and contact your doctor immediately if you experience:
- Seizures
How To Manage Side Effects
Headache
Drink enough water and avoid bright lights. A cold compress will also have a soothing effect.
Warning & Precautions
Pregnancy
ContraindicatedENZYL 80MG CAPSULE is not recommended for use by pregnant women. Consult your doctor before taking it. Women who are or may become pregnant should not handle broken or damaged medicine without wearing protection like gloves.
Breastfeeding
ContraindicatedENZYL 80MG CAPSULE is not recommended for breastfeeding women. Consult your doctor before taking it.
Driving and Using Machines
Use with CautionENZYL 80MG CAPSULE may have a moderate influence on the ability to drive and use machines, so avoid driving or handling machines while on ENZYL 80MG CAPSULE.
Kidney
Use with CautionENZYL 80MG CAPSULE should be taken with caution in patients with severe kidney disease. Consult your doctor before taking it.
Liver
Use with CautionENZYL 80MG CAPSULE should be used with caution in patients with severe liver disease. Consult your doctor before taking it.
Allergy
ContraindicatedDo not take ENZYL 80MG CAPSULE if you are allergic to enzalutamide.
Heart Disease
Use with CautionENZYL 80MG CAPSULE should be taken with caution in patients with heart or blood vessel conditions, including heart rhythm problems (arrhythmia). Consult your doctor before taking it.
Use In Pediatrics
ContraindicatedENZYL 80MG CAPSULE is not recommended for use in children and adolescents. Consult your doctor before taking it.
Use In Geriatrics
Consult your doctorYour doctor will give you the right dose depending on your age, body weight, and disease condition. Consult your doctor before taking ENZYL 80MG CAPSULE.
Others
Before taking ENZYL 80MG CAPSULE, inform your doctor if you:
- Have seizures or fits
Interactions
A. Drug-drug interactions:
Before taking ENZYL 80MG CAPSULE, inform your doctor if you are taking any of the following medicines:
- Anticoagulants (Ex. warfarin, acenocoumarol, and clopidogrel)
- Medicines used to manage asthma and other respiratory diseases (Ex. aminophylline, theophylline).
- Medicines used to manage certain psychiatric disorders such as depression and schizophrenia (Ex. clozapine, olanzapine, chlorpromazine, mesoridazine, thioridazine, amitriptyline, desipramine, doxepin, imipramine, maprotiline, risperidone, ziprasidone, bupropion, lithium, mirtazapine, diazepam, midazolam, and haloperidol)
- Medicines used to manage cholesterol (Ex. gemfibrozil, atorvastatin, simvastatin)
- Medicines used to manage pain (Ex. fentanyl, tramadol, pethidine, methadone)
- Medicines used to manage cancer (Ex. cabazitaxel, docetaxel)
- Medicines used to manage epilepsy (Ex. carbamazepine, clonazepam, phenytoin, primidone, and valproic acid)
- Medicines used to manage sleep disorders (Ex. zolpidem)
- Medicines used to manage heart conditions or lower blood pressure (Ex. bisoprolol, digoxin, diltiazem, felodipine, nicardipine, nifedipine, propranolol, and verapamil), to manage heart conditions or strokes (Ex. dabigatran etexilate), to manage heart rhythm problems (Ex. quinidine, procainamide, amiodarone, and sotalol)
- Medicines used to manage serious diseases related to inflammation (Ex. dexamethasone, prednisolone)
- Medicines used to manage HIV infection (Ex. indinavir, ritonavir)
- Medicines used to manage bacterial infections (Ex. clarithromycin, doxycycline)
- Medicines used to manage thyroid disorders (Ex. levothyroxine)
- Medicines used to manage gout (Ex. colchicine)
- Medicines used to manage stomach disorders (Ex. omeprazole)
- Medicines used to manage organ rejection (Ex. tacrolimus)
- Moxifloxacin (a medicine used to manage bacterial infections)
Overdosage:
If you or anyone else accidentally takes too much of ENZYL 80MG CAPSULE, consult your doctor immediately or visit the nearby hospital. The symptoms of an overdose are seizures.
Synopsis
| Drug | : | Enzalutamide |
| Pharmacological Category | : |
Androgen receptor inhibitors |
| Therapeutic Indication | : | Prostate cancer |
| Dosage Forms | : | Tablet |
More Information
Storage
- Keep ENZYL 80MG CAPSULE out of reach of children
- Store below 30°C
FAQs About ENZYL 80MG CAPSULE
Q: Can ENZYL 80MG CAPSULE cause confusion?
A: Yes, ENZYL 80MG CAPSULE can develop a condition involving the brain called posterior reversible encephalopathy syndrome. If you have seizures, an increasing headache, confusion, blindness, or vision problems, please contact your doctor as soon as possible.
Q: What if I forget to take ENZYL 80MG CAPSULE?
A: If you forget to take ENZYL 80MG CAPSULE at the usual time, take it as soon as you remember. If you forget it for the whole day, take it the following day. If you forget to take the medicine for more than one day, talk to your doctor immediately. Do not take a double dose.
Q: Is ENZYL 80MG CAPSULE a chemotherapy drug?
A: No, ENZYL 80MG CAPSULE is not a chemotherapy drug, despite being used in the management of cancer. It is a type of hormone therapy that works to inhibit prostate cancer cells from growing and spreading by blocking the action of a group of hormones called androgens.
Q: Can ENZYL 80MG CAPSULE be taken by a woman?
A: No. ENZYL 80MG CAPSULE is not recommended for women. It is used to manage prostate cancer in men.
Q: What is ENZYL 80MG CAPSULE used for?
A: ENZYL 80MG CAPSULE is used to manage adult men with prostate cancer who no longer respond to hormone therapy or surgical management or if the cancer, despite responding to management, has spread to other parts of the body.
Q: How does ENZYL 80MG CAPSULE work?
A: ENZYL 80MG CAPSULE works by blocking the activity of hormones called androgens (such as testosterone). By blocking androgens, it stops the growth of prostate cancer cells and can induce cancer cell death and tumour regression.
Q: How should I take ENZYL 80MG CAPSULE?
A: Take ENZYL 80MG CAPSULE as advised by your physician. Swallow it with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.
Q: When to stop taking ENZYL 80MG CAPSULE?
A: Always take ENZYL 80MG CAPSULE as advised by your doctor. Stop taking it and contact your doctor immediately if you experience seizures.
Q: What are the side effects of ENZYL 80MG CAPSULE?
A: The most common side effects of taking ENZYL 80MG CAPSULE are tiredness, broken bones, hot flushes, high blood pressure, headaches, feeling anxious, dry skin, itching, difficulty remembering, and breast enlargement in men. Consult your doctor if any of the symptoms worsen.
Q: Is ENZYL 80MG CAPSULE safe for pregnant women?
A: ENZYL 80MG CAPSULE is not recommended for use by pregnant women. Consult your doctor before taking it. Women who are or may become pregnant should not handle broken or damaged medicine without wearing protection like gloves.
References
1. Jean Hoffman, Wm. Kevin Kelly. Enzalutamide: a novel antiandrogen for patients with castrate-resistant prostate cancer. [Revised on March 2013] [Accessed on 29th July 2024] https://pubmed.ncbi.nlm.nih.gov/23300275/
2. Astellas Pharma Europe B.V. Electronic Medicines Compendium (EMC). [Revised in April 2022] [Accessed on 29th July 2024] https://www.medicines.org.uk/emc/files/pil.10318.pdf
3. Enzalutamide. Mayo Clinic. [Revised in June 2021] [Accessed on 29th July 2024] https://www.mayoclinic.org/diseases-conditions/prostate-cancer/diagnosis-treatment/drc-20353093
Useful Diagnostic Tests
- Complete Blood Count (CBC)/ Hemogram
- Urine Routine & Microscopy
- Prostate Specific Antigen - Psa (Total)
- Prostate Specific Antigen - Psa (Free)
- Healthians Prostate Cancer Package
- Prostatic Acid Phosphatase (Pap)
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