Endoxan 50mg Tablet 10'S

INTRODUCTION ABOUT ENDOXAN 50MG TABLET

ENDOXAN 50MG TABLET contains Cyclophosphamide, which belongs to a group of medicines called Cytotoxic agents or Anti-cancer agents. It is indicated for malignant diseases in adults and children (such as malignant lymphomas, Hodgkin’s disease, Non-Hodgkin’s lymphoma, lymphocytic lymphoma mixed-cell type lymphoma, histiocytic lymphoma, Burkitt’s lymphoma, multiple myeloma, chronic lymphocytic leukemia, chronic granulocytic leukemia, acute myelogenous and monocytic leukemia, acute lymphoblastic leukemia, mycosis fungoides, neuroblastoma, adenocarcinoma of the ovary, retinoblastoma, Ewing’s sarcoma, breast cancer. It is also used for minimal change nephrotic syndrome in children.

ENDOXAN 50MG TABLET is not recommended for use in patients with acute infections, bone-marrow aplasia, urinary tract infections like cystitis, acute urothelial toxicity from cytotoxic chemotherapy or radiation therapy, urinary outflow obstruction, or unmanageed infections. Before taking ENDOXAN 50MG TABLET inform your doctor if you have allergic or anaphylactic reactions, bone marrow suppression, neutropenic fever, serious infections, severe immune suppression, concomitant chemotherapy and/or radiation therapy, urinary tract and renal diseases, heart diseases, pneumonitis, pulmonary fibrosis, pulmonary veno-occlusive disease, respiratory failure, pneumonitis and secondary malignancies, veno-occlusive liver disease, SIADH (syndrome of inappropriate secretion of antidiuretic hormone), rare hereditary problems of fructose intolerance, galactose intolerance, glucose-galactose malabsorption, Lapp lactase deficiency, sucrase-isomaltase insufficiency, adrenal insufficiency, diabetes and poor general health.

ENDOXAN 50MG TABLET is not recommended for use by pregnant women. It is generally not recommended for use in breastfeeding women as it may pass through the breast milk. ENDOXAN 50MG TABLET should be used with caution in children and adolescents. It should be used with caution in elderly patients. The most common side effects of taking ENDOXAN 50MG TABLET are nausea, vomiting, weight loss, alopecia, hematuria and leukopenia. Contact your doctor if any of your symptoms gets worse or persists for a long duration.

USES OF ENDOXAN 50MG TABLET

It is used for:

• malignant diseases in adults and children
• minimal change nephrotic syndrome in children

HOW ENDOXAN 50MG TABLET WORKS

ENDOXAN 50MG TABLET works by interfering with the malignant cell growth by cross-linking of cancer cells DNA. ENDOXAN 50MG TABLET also transfers alkyl groups to DNA during the process of cell division, thus managing the normal synthesis of DNA. Therefore works against the growth and multiplication of cancer cells.

DIRECTIONS FOR USE

Take ENDOXAN 50MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

SIDE EFFECTS OF ENDOXAN 50MG TABLET

HOW TO MANAGE SIDE EFFECTS

Diarrhea

Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not take any medicine on your own for managing diarrhea. Contact your doctor if the symptom did not improve.

Headache

Rest and relax. Drink plenty of fluids such as water and electrolytes. Apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom did not improve.

Nausea And Vomiting

Take the medicine, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food.

WARNING & PRECAUTIONS

PREGNANCY

Contraindicated

ENDOXAN 50MG TABLET is generally not recommended for use in pregnant women. Consult your doctor before taking ENDOXAN 50MG TABLET.

BREASTFEEDING

Contraindicated

ENDOXAN 50MG TABLET is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking ENDOXAN 50MG TABLET.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or operate any machinery if you feel dizziness, blurred vision, and visual impairment after taking ENDOXAN 50MG TABLET.

ALCOHOL

Consult your doctor

Avoid consumption of alcohol while taking ENDOXAN 50MG TABLET as it increases nausea and vomiting caused by ENDOXAN 50MG TABLET.

KIDNEY

Consult your doctor

ENDOXAN 50MG TABLET is not recommended if you have kidney or bladder problems as a result of previous chemotherapy or radiotherapy. It should be used with caution in patients with kidney diseases. Contact your doctor before taking ENDOXAN 50MG TABLET.

LIVER

Use with Caution

ENDOXAN 50MG TABLET should be used with caution in patients with liver diseases. Contact your doctor before taking ENDOXAN 50MG TABLET.

ALLERGY

Contraindicated

Do not take ENDOXAN 50MG TABLET if you are allergic to Cyclophosphamide or any other ingredients of this medicine.

LUNGS

Use with Caution

[GBNEYWORD] should be used with caution in patients with lung diseases such as pneumonia, pulmonary fibrosis, pulmonary venous-occlusive disease, respiratory failure, and pneumonitis. Contact your doctor before taking ENDOXAN 50MG TABLET.

HEART DISEASE

Use with Caution

ENDOXAN 50MG TABLET should be used with caution in patients with heart disease such as myocarditis, myopericarditis, and pericardial effusion including cardiac tamponade, congestive heart failure, ventricular arrhythmias. Contact your doctor before taking ENDOXAN 50MG TABLET.

USE IN PEDIATRICS

Use with Caution

ENDOXAN 50MG TABLET should be used with caution in children. Contact your doctor before taking ENDOXAN 50MG TABLET.

USE IN GERIATRICS

Use with Caution

ENDOXAN 50MG TABLET should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking ENDOXAN 50MG TABLET.

INTERACTIONS

A. Drug-Drug interactions:

Before taking ENDOXAN 50MG TABLET, inform your doctor if you are taking any of the following medicine:

• Medicines used for cancer (Ex. paclitaxel, Busulfan, thiotepa)
• Depolarizing muscle relaxants Ex. succinylcholine (a medicine used in anaesthesia)
• Aprepitant
• Ciprofloxacin, chloramphenicol, sulfadiazine, sulfasalazine, sulfamethoxazole, Rifampin (medicines used to manage bacterial infections)
• Fluconazole, itraconazole, Amphotericin-B (medicines used for fungal infections)
• Prasugrel (medicines used to thin the blood)
• Allopurinol (medicines used for gout)
• Azathioprine (medicines used to reduce the activity of the immune system)
• Chloral hydrate (medicines used for insomnia)
• Medicines used to manage stomach ulcers (Ex. cimetidine)
• Disulfiram (medicines used for alcoholism)
• Glyceraldehyde (medicines used for warts)
• Protease inhibitors Ex. atazanavir, darunavir, Zidovudine (medicines used to manage viral infection)
• Ondansetron  
• Medicines used to manage epilepsy or seizures (Ex. carbamazepine, phenobarbital, phenytoin)
• St. John’s wort (used for depression)
• Corticosteroids (medicines used for inflammation)
• Carbimazole (medicines used for an overactive thyroid)
• Medicines used for multiple sclerosis Ex. natalizumab
• Medicines used to manage high blood pressure (enalapril, thiazide diuretics such as hydrochlorothiazide or chlorthalidone)
• Amiodarone (medicines used to manage irregular heartbeat)
• Medicine used to increase white blood cell numbers after chemotherapy (Ex. GM-CSF, G-CSF)
• Indomethacin (medicines used to manage pain and inflammation)
• Etanercept (medicines used for rheumatoid arthritis)
• Metronidazole (medicines used for bacterial or protozoal infections)
• Bupropion (medicines used to manage depression)
• Digoxin, β-acetyl digoxin (medicines used for heart conditions)
• Vaccines Ex. BCG vaccine, anthrax vaccine (used to manage infections)
• Verapamil (medicines used to manage high blood pressure, angina or irregular heartbeat)
• Clozapine (medicines used to manage psychotic disorders)

Overdosage:

If you or anyone else accidentally takes too much ENDOXAN 50MG TABLET consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are myelosuppression (leukopenia, neutropenia, thrombocytopenia, and anaemia), bone marrow failure, and severe immunosuppression.

SYNOPSIS

MORE INFORMATION

• Keep ENDOXAN 50MG TABLET out of the sight and reach from children
• Store ENDOXAN 50MG TABLET below 25°C

FAQs ABOUT ENDOXAN 50MG TABLET

Q: What are the side effects of taking ENDOXAN 50MG TABLET?

A: The most common side effects of taking ENDOXAN 50MG TABLET are nausea, vomiting, weight loss, alopecia, hematuria, and leukopenia. Contact your doctor if any of the symptoms worsen.

Q: How does ENDOXAN 50MG TABLET work?

A: ENDOXAN 50MG TABLET works by interfering with malignant cell growth by cross-linking cancer cells DNA. ENDOXAN 50MG TABLET also transfers alkyl groups to DNA during the process of cell division, thus managing the normal synthesis of DNA. Therefore works against the growth and multiplication of cancer cells.

Q: Who should avoid taking ENDOXAN 50MG TABLET?

A: ENDOXAN 50MG TABLET is not recommended for use in patients with pregnancy, breast-feeding, allergies to cyclophosphamide or any of its metabolites, acute infections, bone-marrow aplasia, urinary tract infections like cystitis, acute urothelial toxicity from cytotoxic chemotherapy or radiation therapy, urinary outflow obstruction, or unmanageed infections. Contact your doctor before taking ENDOXAN 50MG TABLET.

Q: Can ENDOXAN 50MG TABLET used for nephrotic syndrome?

A: Yes. ENDOXAN 50MG TABLET is used to manage nephrotic syndrome in paediatric patients who fail to adequately respond to or are unable to tolerate adrenocorticosteroid therapy. Contact your doctor before taking ENDOXAN 50MG TABLET.

Q: Can I take alcohol while taking ENDOXAN 50MG TABLET?

A: No. Avoid consumption of alcohol while taking ENDOXAN 50MG TABLET as it may increase nausea and vomiting caused by ENDOXAN 50MG TABLET.

REFERENCES

1. Skidmore. Cyclophosphamide. Mosby’s 2021 Nursing Drug Reference. 34th edition. 2021. Page - 330-332.

2. Robert j. Kizior, Keith j. Hodgson. Cyclophosphamide. Saunder’s Nursing Drug Handbook 2021. 29th edition. 2021. Page -283-285.

3. Ogino MH, Tadi P. Mechanism of Cyclophosphamide. National Institute of Health. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. April 2022. [Accessed on November 6th, 2023] https://www.ncbi.nlm.nih.gov/books/NBK553087/

4. Baxter Healthcare Ltd. Electronic Medicines Compendium (EMC). [Revised on December 2016] [Accessed on November 6th, 2023] https://www.medicines.org.uk/emc/medicine/30161#gref

5. Baxter Healthcare Corporation. U.S. Food & Drug Administration. [Revised on May 2013] [Accessed on November 6th, 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/012141s090,012142s112lbl.pdf

6. Baxter Holding B.V. Health Products Regulatory Authority (HPRA). [Revised on December 2018] [Accessed on November 6th, 2023] https://www.hpra.ie/img/uploaded/swedocuments/Licence_PA2299-027-003_21122018112109.pdf

7. Baxter International Inc. Cyclophosphamide. [Revised on November 2018] [Accessed on November 6th, 2023] https://5.imimg.com/data5/SELLER/Doc/2021/4/QA/YA/XN/8801618/cyclophosphamide.pdf

USEFUL DIAGNOSTIC TESTS

• Complete blood count
• Peripheral smear count
• Prothrombin time
• Triglycerides
• Urine albumin

AUTHOR DETAILS

Written By Dr. Janet.C - Pharm.D

Last updated on 21 Nov 2023 | 03:19 PM(IST)