Encorate Chrono 300mg Tablet 10'S

Introduction About ENCORATE CHRONO 300MG TABLET

Encorate Chrono 300mg Tablet is an anticonvulsant medication containing sodium valproate and valproic acid. It is commonly used to support the management of epilepsy by helping stabilize abnormal electrical activity in the brain. Additionally, this medicine is prescribed for certain mood-related conditions such as bipolar disorder and may assist in lowering the frequency of migraine headaches when recommended by a healthcare professional.

It is recommended to take Encorate Chrono 300mg Tablet with food to help reduce stomach discomfort. Your doctor will prescribe the appropriate dose tailored to your needs, which may be gradually increased until your condition stabilizes.

Consistent use is essential, as the medicine may take several weeks to achieve its full effect. Continue taking the tablet regularly, even if you start feeling better, unless your doctor advises otherwise. Stopping the medication suddenly without medical guidance can lead to an increase in seizure episodes or may negatively impact the management of bipolar disorder.

The most common side effects of these medicines are nausea, weight gain, drowsiness, hair loss, vomiting, loss of appetite, gum swelling, headache, tremors, liver-related symptoms, and upper abdominal pain. These side effects often subside over time. However, if any side effects persist or cause discomfort, it is important to consult your healthcare provider. There are ways to manage or minimize these effects with professional guidance to support your well-being during management.

Before taking Encorate Chrono 300mg Tablet, inform your healthcare provider if you have any kidney or liver conditions, a history of meningitis, depression, or thoughts of self-harm. It is also essential to disclose all other medications you are currently taking, including contraceptive pills, as some drugs may interact with this medicine.

If you are pregnant or breastfeeding, this medication may be used only when clearly needed, with doses adjusted by your doctor to ensure safety.

Avoid driving, operating heavy machinery, or riding a bicycle if you experience drowsiness or dizziness while taking this medicine. Additionally, regular blood tests may be required to monitor your response and ensure safe use of the medication.

Avoid consuming alcohol during your course of Encorate Chrono 300mg Tablet, as it can increase the risk of side effects such as dizziness, drowsiness, and other unwanted reactions. To help manage potential weight gain associated with this medicine, maintain a healthy, balanced diet, limit high-calorie snacks, and engage in regular physical activity.

Additionally, it is crucial to inform your healthcare provider promptly if you experience any unusual mood or behavior changes, including new or worsening symptoms of depression or thoughts of self-harm. Monitoring your mental health during management supports safer use of the medication.

Uses Of ENCORATE CHRONO 300MG TABLET

• Epilepsy (fits)

Benefits of ENCORATE CHRONO 300MG TABLET

01)Effective Seizure Management:

Encorate Chrono 300mg Tablet helps control seizures by stabilizing abnormal electrical activity in the brain. This supports improved daily safety and confidence during normal activities.

02)Mood Stability Support:

This medicine assists in maintaining mood balance for certain conditions like bipolar disorder when taken as prescribed under medical supervision.

03)Migraine Management Aid:

It may help reduce how often migraine attacks occur and their severity for some patients, based on professional healthcare recommendations.

04)Extended-Release Formulation:

Available as an extended-release (chrono) tablet, it delivers the medication steadily throughout the day, ensuring consistent effects and convenient dosing.

How ENCORATE CHRONO 300MG TABLET Works

Encorate Chrono 300mg Tablet is designed to help control seizures and stabilize mood by acting directly on the brain's electrical activity. It contains sodium valproate and valproic acid, both well-known anticonvulsant agents used in epilepsy and certain mood conditions.

Mechanism of Action of Encorate Chrono 300mg

The key action of this medicine is to reduce excessive and abnormal brain activity. It achieves this by increasing the amount of gamma-aminobutyric acid (GABA) is a natural, calming neurochemical in the brain. Higher GABA levels help dampen overly active nerve signals, making the brain less likely to generate sudden bursts that cause seizures or mood instability.

Role of Sodium Valproate and Valproic Acid

Both sodium valproate and valproic acid work together to boost GABA production. Sodium valproate acts as a precursor to valproic acid, ensuring a consistent supply in the body. Their combined action leads to more effective, reliable control of seizure activity and supports mood balance in conditions such as bipolar disorder.

Impact on Brain Electrical Activity

By enhancing the inhibitory effect of GABA, Encorate Chrono 300mg Tablet stabilizes the brain's electrical signals. This helps prevent sudden changes that trigger seizures and allows patients to feel more stable in their everyday activities.

Understanding GABA’s Role in Seizure Control

GABA is the brain’s main "calming" neurotransmitter. When its levels are increased, the brain is better protected against sudden electrical surges. This is especially important for patients with epilepsy or mood disorders, as it reduces the risk of uncontrolled episodes and promotes overall neurological health.

Why Extended-Release Formulation Matters

Encorate Chrono 300mg Tablet uses an extended-release (chrono) technology. This means the medicine is released steadily over time, maintaining consistent therapeutic levels in the body throughout the day. As a result, patients enjoy fewer dosing times, fewer side effect peaks, and better seizure control.

Neurological Effects of Encorate Chrono 300mg Tablet

This tablet not only helps reduce the frequency and severity of seizures but also supports mood stabilization and, for some, a reduction in migraine attacks. By regulating brain chemistry, it helps patients experience improved daily functioning and emotional well-being.

Important Information on Neurochemical Action

Encorate Chrono 300mg Tablet’s dual-action formula is specifically designed to regulate neurochemical activity. Its effect on GABA makes it an effective choice for reducing seizures, balancing mood, and maintaining stable brain function when taken as prescribed. Regular use, under medical supervision, offers the most benefit with ongoing monitoring for safety.

How to use ENCORATE CHRONO 300MG TABLET

Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage.

Recommended Dosage and Administration

Encorate Chrono 300mg Tablet is typically prescribed by your doctor in doses tailored to your condition, age, and body weight.

• Adults: Usually start with 600 mg per day, divided into two doses taken preferably after food. The dose may be increased by 200 mg every 3 days based on response, up to a maximum of 2.5 grams daily.
• Children: Dosing depends on weight of the children over 20 kg may start at 400 mg daily in divided doses, increasing as needed with medical supervision. Children under 20 kg usually start at 20 mg/kg daily in divided doses.
  Always follow your healthcare provider’s instructions and do not adjust the dose without consulting them.

How to Take Encorate Chrono 300mg Effectively

• Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet to maintain the extended-release effect.
• Take the tablet with food or immediately after meals to reduce stomach discomfort.
• Maintain a consistent dosing schedule, taking it at the same times daily helps maintain steady medication levels.

Important Dosage Instructions

• Do not skip doses, even if you feel better, as this may lead to worsening seizures or mood instability.
• In case of dose adjustment, changes should be gradual and supervised by your doctor.
• The medication may take several weeks to reach its full effect; continued use as prescribed is essential.

Best Practices for Taking Encorate Chrono 300mg

• Store tablets in a cool, dry place away from direct sunlight and out of reach of children.
• Use a pill organizer or set reminders to help with medication adherence.
• Avoid alcohol, as it can enhance side effects like dizziness or drowsiness.
• Maintain a healthy diet and regular exercise to manage potential weight gain associated with this medicine.

Special Tips for Dosing and Safety

• Inform your doctor of any other medications you are taking to avoid drug interactions, especially with contraceptives or other anticonvulsants.
• Avoid driving or operating heavy machinery if you feel drowsy or dizzy after taking the tablet.
• Regular blood tests may be needed to monitor liver function and blood counts during treatment.

Administration Guide for Children and Adults

• For children, dosing is weight-based and should always be supervised closely by a healthcare professional.
• Adults should follow the prescribed dose and not alter it without consulting their doctor.
• Caregivers should help ensure children take their medication as directed and watch for any side effects.

Swallowing and Food Instructions

• Always swallow Encorate Chrono 300mg Tablet whole with water, do not chew or crush.
• Taking with food can help reduce nausea or stomach upset sometimes associated with this medicine.
• If you experience stomach discomfort, discuss with your doctor for possible dietary adjustments or timing changes.

Dosage Adjustment and Monitoring

• Your doctor will monitor your response to the medication and adjust the dose as necessary to achieve seizure control or symptom stability.
• Routine blood tests to check liver health and blood cell counts may be required to ensure safe use.
• Never stop or change your dose suddenly without medical advice to prevent seizure worsening or mood destabilization.

What if I forgot to take ENCORATE CHRONO 300MG TABLET

• Take the missed dose as soon as you remember unless it is almost time for the next scheduled dose.
• Do not double the dose to make up for a missed one.
• Inform your healthcare provider if you frequently miss doses for advice on managing your schedule.

Side Effects Of ENCORATE CHRONO 300MG TABLET

Like all medicines, Encorate Chrono 300mg Tablet may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking Encorate Chrono 300mg Tablet are:

• Nausea
• Weight gain
• Drowsiness
• Hair loss
• Vomiting
• Loss of appetite
• Gum swelling
• Headache
• Tremors
• Liver-related symptoms
• Upper abdominal pain

When to consult your doctor?

• Signs of severe liver damage such as yellowing of the skin or eyes (jaundice), severe upper abdominal pain, persistent nausea or vomiting, unusual fatigue, or dark urine.
• Severe allergic reactions including rash, itching, swelling of the face, lips, tongue, or throat, difficulty breathing or swallowing.
• Unusual mood or behavior changes such as sudden worsening depression, suicidal thoughts, aggression, or confusion.
• Severe bleeding or unexplained bruising, bleeding gums, or prolonged bleeding indicating blood disorders.
• Symptoms of low blood cell counts like persistent weakness, dizziness, frequent infections, or unusual tiredness.
• Sudden severe abdominal pain, fever, or persistent diarrhea.
• Worsening or increased frequency of seizures despite medication.
• Loss of consciousness, severe dizziness, muscle weakness, or neurological decline.

How To Manage Side Effects

Headache

• Rest in a Quiet, Dark Room: Find a calm, quiet space away from bright lights and loud noises. Lie down and close your eyes.
• Hydrate: Dehydration can contribute to headaches, so drink plenty of water.
• Apply a Cold or Warm Compress: A cold pack on your forehead may reduce pain, or a warm compress on your neck or shoulders can relieve tension.
• Over-the-Counter Pain Relief: You can take over-the-counter pain relievers like acetaminophen or ibuprofen if appropriate for you. Follow the recommended dosage.
• Practice Relaxation Techniques: Deep breathing exercises, meditation, or gentle stretching can help reduce stress and alleviate headache symptoms.

Nausea And Vomiting

• Rest in a Calm Environment: Sit or lie down in a quiet, comfortable place away from strong smells or bright lights that may worsen nausea.
• Stay Hydrated: Sip small amounts of clear fluids frequently, such as water, oral rehydration solutions, or herbal teas, to prevent dehydration caused by vomiting.
• Eat Light and Easy-to-Digest Foods: When able to eat, choose bland and soft foods like crackers, toast, bananas, or rice, avoiding greasy, spicy, or heavy meals.
• Apply a Cool Compress: Placing a cool cloth on your forehead can provide soothing relief and help ease nausea symptoms.
• Over-the-Counter Remedies: If suitable, anti-nausea medications or remedies like ginger supplements may help, always follow dosing instructions and consult your doctor if unsure.
• Practice Deep Breathing and Relaxation: Gentle breathing exercises and relaxation techniques can help calm your stomach and reduce discomfort.

Warning & Precautions

Pregnancy

Contraindicated

Encorate Chrono 300mg Tablet is generally not recommended during pregnancy as it may pose risks to the developing baby. Use only if clearly needed and prescribed by your doctor. Women of childbearing age should use effective contraception while on this medication. Consult your doctor before taking this medication.

Breastfeeding

Consult your doctor

Encorate Chrono passes into breast milk in small amounts. Consult your doctor before use during breastfeeding to ensure safety for both mother and child.

Driving and Using Machines

Use with Caution

Encorate Chrono may cause drowsiness or dizziness or impaired concentration. Avoid driving or operating machinery until you know how this medicine affects you.

Alcohol

Consult your doctor

Avoid alcohol consumption while taking this medicine, as it can increase side effects such as dizziness and drowsiness and may reduce management effectiveness.

Kidney

Monitoring required

Inform your doctor if you have any kidney problems. Dose adjustments are rarely needed but close monitoring is essential. Consult your doctor before taking this medication.

Liver

Use with Caution

Encorate Chrono 300mg Tablet should be used with caution in patients with liver problems or a history of liver problems. Regular liver function tests are recommended to reduce potential liver damage. Consult your doctor before taking this medication.

Allergy

Contraindicated

Do not take Encorate Chrono if you are allergic to sodium valproate or valproic acid, or any other ingredients of this medicine.

Use In Pediatrics

Use with Caution

Encorate Chrono 300mg Tablet should be used with special caution in children, particularly those under 3 years of age, as they have a higher risk of liver toxicity. Pediatric doses are calculated based on body weight and must be administered under strict medical supervision. Consult your pediatrician before giving it.

Use In Geriatrics

Use with Caution

Encorate Chrono 300mg Tablet should be used with caution in elderly patients (aged 65 years or older). Older adults may be more sensitive to side effects such as dizziness or drowsiness, increasing risk of falls. Dose adjustments and monitoring are advised. Consult your doctor before taking this medication.

Other Warnings for ENCORATE CHRONO 300MG TABLET

Before taking Encorate Chrono 300mg Tablet, inform your doctor if you have:

• Depression, suicidal thoughts, or any unusual mood or behavior changes.
• Other serious medical illnesses.

Who should not take [GBNKEYWORD

Encorate Chrono 300mg Tablet is not recommended for use if you have:

• Pancreatitis or a history of pancreas problems.
• Certain metabolic disorders affecting how your body processes urea or other metabolic wastes.
• Severe blood disorders or bleeding problems.

Diet and Lifestyle Advice

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking Encorate Chrono 300mg Tablet:

1. Antiepileptic Drugs (e.g., Phenobarbital, Phenytoin, Lamotrigine, Topiramate)
   • Interaction: Encorate Chrono (sodium valproate) can alter the metabolism of other antiepileptics, potentially increasing or decreasing their blood levels.
   • Effects: Increased risk of side effects such as dizziness, drowsiness, or impaired seizure control. Possible changes in seizure frequency.
   • Management: Regular monitoring of blood levels and clinical response; dose adjustments may be necessary under doctor supervision.
2. Anticoagulants (e.g., Warfarin, Aspirin)
   • Interaction: Sodium valproate may enhance the effects of blood thinners by inhibiting their metabolism.
   • Effects: Increased risk of bleeding, bruising, or prolonged clotting time.
   • Management: Frequent blood clotting tests (INR/PT); dose modification of anticoagulants may be required.
3. Antihypertensive Drugs (e.g., Amlodipine, Atenolol, Enalapril)
   • Interaction: Co-administration may enhance the blood pressure-lowering effects.
   • Effects: Risk of excessive hypotension, dizziness, or fainting.
   • Management: Monitor blood pressure regularly; adjust antihypertensive dose as needed under medical guidance.
4. Contraceptive Pills (Hormonal Contraceptives)
   • Interaction: Encorate Chrono may reduce the effectiveness of hormonal contraceptives.
   • Effects: Increased risk of unintended pregnancy.
   • Management: Use additional contraceptive methods (barrier methods); consult your doctor regarding birth control options.
5. Other CNS Depressants (e.g., Benzodiazepines, Opioids)
   • Interaction: Combined use may increase sedation and respiratory depression.
   • Effects: Excessive drowsiness, respiratory difficulty, impaired cognition.
   • Management: Use cautiously with close monitoring; dose adjustments may be required.
6. Drugs Affecting Liver Enzymes (e.g., Carbamazepine, Rifampicin)
   • Interaction: These may alter the metabolism of sodium valproate, reducing or increasing its blood levels.
   • Effects: Possible decreased seizure control or increased toxicity.
   • Management: Regular clinical and laboratory monitoring; dose adjustments as advised by your doctor.

Synopsis

More Information

FAQs About ENCORATE CHRONO 300MG TABLET

Q: What is Encorate Chrono 300mg Tablet used for?

A: Encorate Chrono 300mg Tablet is primarily used to manage epilepsy (seizures), control manic episodes associated with bipolar disorder, and prevent migraine headaches. It works by stabilizing abnormal electrical activity in the brain to reduce seizure frequency and mood swings.

Q: How should I take Encorate Chrono 300mg Tablet?

A: Take the tablet whole with water, preferably after meals, to reduce stomach upset. Do not crush or chew it, as it is an extended-release formulation. Follow your doctor's dosage instructions carefully, and do not stop the medicine abruptly.

Q: What are common side effects of Encorate Chrono 300mg Tablet?

A: Common side effects include nausea, vomiting, headache, weight gain, drowsiness, tremors, hair loss, and stomach discomfort. If side effects persist or worsen, consult your healthcare provider.

Q: Can I drink alcohol while taking Encorate Chrono 300mg Tablet?

A: Avoid consuming alcohol during treatment with Encorate Chrono 300mg, as it can increase side effects like dizziness, drowsiness, and may raise the risk of seizures.

Q: Is Encorate Chrono 300mg Tablet safe during pregnancy and breastfeeding?

A: It is generally not recommended during pregnancy due to potential risks to the baby and should only be used if clearly needed under medical advice. Small amounts may pass into breast milk, so consult your doctor before using while breastfeeding.

Q: What should I inform my doctor before taking Encorate Chrono 300mg Tablet?

A: Inform your doctor if you have any kidney or liver problems, blood disorders, pancreatitis, mood disorders such as depression or suicidal thoughts, allergies to sodium valproate, or if you are pregnant or breastfeeding. Also disclose all other medicines you are taking.

Q: What should I do if I miss a dose of Encorate Chrono 300mg Tablet?

A: Take the missed dose as soon as you remember unless it is almost time for the next dose. Do not double the dose to make up for a missed one. Contact your healthcare provider for advice if you frequently miss doses.

Q: Can Encorate Chrono 300mg Tablet cause serious side effects? When should I seek immediate medical help?

A: Yes, serious side effects requiring urgent care include signs of liver damage (yellow skin or eyes, severe nausea), allergic reactions (rash, swelling, difficulty breathing), severe mood changes, bleeding or bruising, and worsening seizures. Seek immediate medical attention if these occur.

Q: Are there any important lifestyle tips while taking Encorate Chrono 300mg Tablet?

A: Yes, avoid alcohol, maintain a balanced diet to prevent weight gain, exercise regularly, avoid driving or operating machinery if drowsy, and attend regular lab tests to monitor liver function and blood counts.

Q: Is Encorate Chrono 300mg Tablet safe for children?

A: Encorate Chrono 300mg Tablet can be used in children under medical supervision. Extra caution is needed for children under 3 years of age due to an increased risk of certain side effects, especially liver toxicity. Always follow your doctor’s guidance regarding pediatric use.

Q: Can I drive after taking Encorate Chrono 300mg Tablet?

A: Encorate Chrono may cause drowsiness, dizziness, or impaired alertness in some people. It is advised to avoid driving, operating heavy machinery, or performing activities requiring full concentration until you know how the medicine affects you.

References

1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 4053-4069.

2. Natalia N Nalivaeva 1, Nikolai D Belyaev, Anthony J Turner. Sodium valproate: an old drug with new roles. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Oct 2009. [Accessed 06 Aug 2025] 

3. Peter M. Jeavons and Jean E. Clark. Sodium Valproate in Management of Epilepsy. US National Library of Medicines, National Institutes of Health. 15 Jun 1974. [Accessed 06 Aug 2025] 

4. Sanofi-aventis S.A; Electronic Medicines Compendium (EMC); [Revised on Nov 2019] [Accessed 06 Aug 2025] 

Useful Diagnostic Tests

• EEG
• MRI Scan
• CT Scan

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 08 Aug 2025 | 02:56 PM(IST)