Emeset Injection 4ml

Introduction About EMESET INJECTION

Emeset Injection contains ondansetron, a 5-HT3 receptor antagonist used in the management of nausea and vomiting. It is particularly useful for patients experiencing nausea and vomiting associated with cancer chemotherapy and surgery, and ondansetron injection is indicated for prevention of chemotherapy-induced and postoperative nausea and vomiting. In clinical practice, ondansetron may also be used in other situations when considered appropriate by a healthcare professional.

Emeset Injection is generally suitable for patients who require rapid antiemetic treatment in a hospital or supervised healthcare setting, including patients receiving emetogenic chemotherapy or undergoing surgery. The injection is administered intravenously or intramuscularly by a qualified healthcare professional, with the dose and timing determined according to the patient's age, indication, clinical condition, and other medicines being used. Patients should not self-administer the injection or alter the prescribed dose. People with severe liver impairment may require dose limitation, while renal impairment generally does not require routine dose adjustment.

Before administration, the healthcare professional should be informed about any previous allergy to ondansetron or other 5-HT3 antagonists, heart rhythm problems, electrolyte abnormalities, liver disease, or medicines being taken. Ondansetron can prolong the QT interval, so particular caution and ECG monitoring may be appropriate in patients with congenital long-QT syndrome, electrolyte disturbances, bradyarrhythmias, heart failure, or concomitant use of other QT-prolonging medicines. Concomitant use with apomorphine is contraindicated, and caution is required with serotonergic medicines because serotonin syndrome has been reported.

During pregnancy, ondansetron should be used only after discussion with a healthcare professional, because available epidemiological studies have reported inconsistent findings and do not allow definitive conclusions about pregnancy safety. For breastfeeding, available data indicate that ondansetron passes into breast milk at low levels, and clinically relevant exposure in breastfed infants is considered unlikely at intravenous doses up to 4 mg/day; available studies have not reported adverse effects attributed to exposure through breast milk. Common adverse effects include headache, constipation, diarrhoea, and fatigue/malaise; injection-site reactions may also occur. Patients should seek prompt medical attention for symptoms such as severe allergic reactions, abnormal heartbeat, fainting, chest pain, or symptoms suggestive of serotonin syndrome.

Uses Of EMESET INJECTION

• Management of nausea and vomiting

Benefits of EMESET INJECTION

Provides Relief from Nausea and Vomiting

Emeset Injection contains ondansetron, which helps reduce nausea and vomiting by blocking serotonin signals involved in the vomiting reflex. It can provide relief when nausea and vomiting occur in situations where ondansetron is clinically indicated.

Helps Manage Chemotherapy- and Surgery-Related Nausea and Vomiting

Emeset Injection is used to help prevent and control nausea and vomiting associated with chemotherapy and surgery. By reducing these symptoms, it can help patients tolerate their treatment or recover more comfortably after a procedure.

How EMESET INJECTION Works

Blocks 5-HT3 Serotonin Receptors

Ondansetron selectively blocks 5-HT3 serotonin receptors in the gastrointestinal tract and central nervous system. This reduces the activation of pathways involved in triggering nausea and vomiting.

Reduces Serotonin-Mediated Vomiting Signals

Ondansetron reduces the transmission of serotonin-mediated signals from the gut and vomiting centre of the brain. By limiting these signals, it helps control nausea and vomiting, particularly those associated with chemotherapy and surgery.

How to use EMESET INJECTION

• Emeset 4 mg Injection should be administered only by a qualified healthcare professional.
• It may be given by intravenous (IV) or intramuscular (IM) injection, as prescribed.
• The dose and frequency should be based on the patient’s condition and treatment requirements.
• Do not self-administer the injection or change the prescribed dose.
• Follow the healthcare professional’s instructions regarding the rate and method of administration.
• Inform the healthcare professional about any other medicines you are taking before receiving the injection.
• Seek medical advice if nausea or vomiting continues despite treatment.

What if I forgot to take EMESET INJECTION

If you miss a scheduled dose of Emeset 4 mg Injection, inform your doctor or nurse as soon as possible. They will advise when the next dose should be given based on your treatment schedule. Do not receive a double dose to make up for the missed injection.

Overdose

Emeset 4 mg Injection should be administered only in the prescribed dose by a healthcare professional. An overdose may increase the risk of serious adverse effects, including heart rhythm abnormalities. If an overdose is suspected, seek immediate medical attention for appropriate monitoring and treatment. Do not take any additional dose unless advised by your healthcare professional.

Side Effects Of EMESET INJECTION

Common Side Effects :

• headache
• flushing (feeling of warmth)
• constipation
• Dizziness
• Diarrhea
• fits (seizures)
• irregular heartbeat (fast or slow)
• low blood pressure
• hiccups

Stop receiving Emeset Injection and contact your doctor if you experience any of the following side effects:       

• sudden wheezing, chest pain or tightness
• swelling of eyelids, face, lips, mouth or tongue
• skin rash, red spots or lumps under your skin (hives) or anywhere on the body

How To Manage Side Effects

Constipation

• Drink adequate water and other fluids unless your healthcare professional has advised fluid restriction.
• Include fibre-rich foods such as fruits, vegetables, whole grains, and pulses in your diet.
• Stay physically active, as gentle walking may help promote regular bowel movements.
• Do not ignore the urge to pass stools, and try to maintain a regular toilet routine.
• Consult your healthcare professional if constipation is severe, persistent, or associated with abdominal pain or vomiting.

Diarrhea

• Drink plenty of fluids to replace fluid lost through frequent loose stools and reduce the risk of dehydration.
• Take small, frequent meals and choose light, easily digestible foods while symptoms continue.
• Avoid foods that may worsen diarrhea, such as very spicy, greasy, or highly processed foods.
• Maintain good hand hygiene to reduce the risk of spreading or acquiring gastrointestinal infections.
• Seek medical advice if diarrhea is severe or persistent, or if you develop blood in the stool, fever, dizziness, or signs of dehydration.

Headache

• Rest in a quiet, comfortable environment and avoid excessive screen time or bright light.
• Drink adequate fluids throughout the day to help maintain hydration.
• Maintain regular meals and avoid skipping food if it worsens the headache.
• Avoid taking pain-relieving medicines without consulting your healthcare professional, especially if you are taking other medicines.
• Contact your healthcare professional if the headache is severe, persistent, or keeps recurring.

Warning & Precautions

Pregnancy

Consult your doctor

Pregnant women should only use Emeset Injection if prescribed by a doctor, after assessing the benefits and risks.

Breastfeeding

Consult your doctor

Limited data is available on the use of ondansetron during breastfeeding. While no harmful effects have been reported in breastfed infants, ondansetron is excreted in breast milk. Therefore, breastfeeding mothers should consult a doctor before using this medicine to ensure its safety for their baby.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizzy or uneasy after receiving Emeset Injection

Liver

Use with Caution

Emeset Injection should be used with caution in patients with liver problems. Consult your doctor before receiving Emeset Injection

Allergy

Contraindicated

Do not take Emeset Injection if you are allergic to ondansetron, granisetron or palonosetron or to any other ingredients of this medicine.

Heart Disease

Use with Caution

Emeset Injection should be used with caution in patients with heart diseases such as uneven heartbeats (arrhythmias) or congestive heart failure.

Use In Pediatrics

Consult your doctor

Emeset Injection can be used in children if prescribed by the physician.

Use In Geriatrics

Consult your doctor

Emeset Injection can be used in elderly patients if prescribed by the physician.

Other Warnings for EMESET INJECTION

Before receiving Emeset Injection, inform your doctor if you:

• have a blockage in your gut
• have constipation
• have problems with the levels of salts in the blood (such as potassium, sodium and magnesium)
• are intolerant to some sugars (Ex. lactose intolerance)

Safety Advice

• Ondansetron may prolong the QT interval, so use caution in patients with heart rhythm disorders.
• ECG monitoring may be needed in patients with electrolyte abnormalities or other risk factors for QT prolongation.
• Do not use with apomorphine, as serious hypotension and loss of consciousness may occur.
• Inform the doctor about medicines such as SSRIs, SNRIs, tramadol, fentanyl, or other serotonergic drugs because of the risk of serotonin syndrome.
• Seek immediate medical attention if breathing difficulty, swelling, wheezing, or other signs of severe allergy occur.
• Patients with severe liver impairment require dose adjustment and should not receive more than 8 mg per day.
• The injection should be administered only by a healthcare professional using the recommended dose and route.
• Ondansetron may mask symptoms of intestinal obstruction, particularly in patients after abdominal surgery or receiving chemotherapy.

Diet and Lifestyle Advice

• Drink adequate fluids to help prevent dehydration, especially after repeated vomiting.
• Take small, frequent meals rather than large meals if nausea continues.
• Choose light, easily digestible foods such as rice, toast, porridge, bananas, and clear soups.
• Avoid oily, fried, spicy, or heavily seasoned foods if they worsen nausea.
• Limit foods and drinks with strong smells, as these may trigger nausea in some patients.
• Avoid excessive caffeine and alcohol, particularly when experiencing nausea or vomiting.
• If vomiting improves, gradually return to your normal balanced diet.
• Maintain adequate rest and sleep during recovery.
• Follow the dietary advice given by your doctor or dietitian, particularly during chemotherapy or recovery after surgery.

1. Emeset Injection vs Metoclopramide Injection

Drug - Drug interaction

1. Apomorphine
   Interaction: Concomitant use with ondansetron may cause profound hypotension and loss of consciousness.
   Management: The combination is contraindicated and should not be administered together.
2. QT-prolonging medicines
   Interaction: Ondansetron may prolong the QT interval, and combining it with other QT-prolonging medicines can further increase the risk of serious cardiac arrhythmias.
   Management: Use cautiously and consider ECG monitoring, particularly in patients with heart disease or electrolyte abnormalities.
3. SSRIs, SNRIs and other serotonergic medicines
   Interaction: Concomitant use may increase the risk of serotonin syndrome, although this is uncommon.
   Management: Monitor for changes in mental status, excessive sweating, tremor, muscle rigidity, or other symptoms suggestive of serotonin syndrome.
4. Tramadol
   Interaction: Ondansetron may reduce the analgesic effect of tramadol, which can result in inadequate pain relief.
   Management: Monitor the patient's response to pain treatment and consider alternative analgesia if clinically appropriate.
5. Phenytoin, carbamazepine and rifampicin
   Interaction: These medicines can increase the metabolism of ondansetron and may reduce its plasma concentration and antiemetic effect.
   Management: Monitor the clinical response to ondansetron and adjust treatment if required based on the patient's condition.
6. Other medicines affecting ondansetron metabolism
   Interaction: Medicines that induce or inhibit CYP3A4, CYP2D6, or CYP1A2 enzymes may alter ondansetron exposure.
   Management: Review concomitant medicines and monitor therapeutic response, particularly when multiple interacting medicines are being used.

Drug - Food interaction

1. Alcohol

Interaction: Alcohol may worsen nausea, vomiting, dizziness, or drowsiness and can make recovery more difficult.

Management: It is advisable to avoid or limit alcohol while receiving treatment, particularly when the patient is already experiencing nausea or weakness.

Synopsis

More Information

FAQs About EMESET INJECTION

References

1. KD. Tripathi. Section 11, Gastrointestinal Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 661.

2. LTS Lohmann Therapie-Systeme AG Lohmannstrasse. Andernach GERMANY [Revised April 2022] [Accessed on 18th September 2026]

3. Koland M, Sandeep V, Charyulu N. Fast Dissolving Sublingual Films of Ondansetron Hydrochloride: Effect of Additives on in vitro Drug Release and Mucosal Permeation. J Young Pharm. 2010 Jul;2(3):216-22. [Accessed on 18th September 2026]

4. Kumria R, Gupta V, Bansal S, Wadhwa J, Nair AB. Oral buccoadhesive films of ondansetron: Development and evaluation. Int J Pharm Investig. 2013 Apr;3(2):112-8. [Accessed on 18th September 2026]

5. Ondansetron Soluble Films. [Accessed on 18th September 2026]

Useful Diagnostic Tests

• Complete blood count