EGOLIX 150 Tablet 10's

Introduction About EGOLIX 150 TABLET

EGOLIX 150 TABLET is indicated for the management of moderate to severe pain associated with endometriosis. It contains a medicine called Elagolix which works by blocking the action of gonadotropin-releasing hormone (GnRH), reducing estrogen levels and thereby decreasing inflammation and pain caused by endometrial tissue outside the uterus.

Unlike traditional hormonal treatments, Elagolix offers rapid symptom relief and a customizable dosing regimen, making it a preferred choice for women seeking non-surgical management of endometriosis-related discomfort.

Patients should take Elagolix at the same time each day, with or without food, and use non-hormonal contraception during treatment due to potential effects on fertility. Long-term use should be carefully monitored due to the risk of bone mineral density loss.

Elagolix provides a convenient and effective alternative to surgery or injectable hormone therapies for endometriosis management. It reduces pain and improves quality of life, allowing women to manage their symptoms while maintaining daily activities.

However, caution is advised for those with osteoporosis, mood disorders, liver disease, or pregnancy, and interactions with certain medications should be assessed before use. Regular follow-ups with a doctor are essential to ensure safe and optimal treatment outcomes.

Uses Of EGOLIX 150 TABLET

• Management of moderate to severe pain associated with endometriosis

Benefits of EGOLIX 150 TABLET

• Effective Pain Relief: Helps reduce pelvic pain, menstrual cramps, and pain during intercourse (dyspareunia) by lowering estrogen levels.
• Rapid Symptom Control: Starts working within a few weeks, providing faster relief compared to other hormonal treatments.
• Flexible Dosing Options: Available in different doses to suit individual needs and symptom severity.
• Non-Surgical Option: Offers an alternative to surgery for managing endometriosis-related pain.
• Short-Term, Reversible Effects: Unlike surgical removal of ovaries, Elagolix allows temporary estrogen suppression, and normal hormone levels return after stopping the medication.
• Convenient Oral Therapy: Taken as a simple daily tablet, with or without food, for ease of use.

While Elagolix is effective for symptom relief, it is important to monitor bone health and discuss long-term treatment plans with a doctor.

How EGOLIX 150 TABLET Works

EGOLIX 150 TABLET works by blocking a hormone called gonadotropin-releasing hormone (GnRH) in the brain. GnRH normally signals the body to produce estrogen and progesterone, hormones that regulate the menstrual cycle.

By partially blocking this signal, Elagolix lowers estrogen levels, which helps reduce the growth and activity of endometrial tissue. This, in turn, relieves pain and other symptoms associated with endometriosis. However, since estrogen is important for bone health, long-term use of Elagolix may lead to bone density loss.

How to use EGOLIX 150 TABLET

How To Take EGOLIX 150 TABLET?

1. Confirm Pregnancy Status: Ensure you are not pregnant before starting EGOLIX 150 TABLET. If starting during your menstrual cycle, begin within the first 7 days of your period.
2. Dosage Timing: Take Elagolix at the same time each day, with or without food, to maintain consistent drug levels in your body.
3. Use the Lowest Effective Dose: Your doctor will determine the best dosage based on the severity of your symptoms and treatment goals.
4. Duration of Use: Do not exceed the prescribed duration, as long-term use may lead to bone density loss.

Recommended Dosage:

• For Normal Liver Function or Mild Hepatic Impairment:
  • 150 mg once daily for up to 24 months
  • 200 mg twice daily for up to 6 months (if you have dyspareunia or severe symptoms)
• For Moderate Hepatic Impairment:
  • 150 mg once daily for up to 6 months

Additional Considerations:

• Use non-hormonal contraception while taking Elagolix and for one week after stopping treatment.
• If you experience severe side effects, such as mood changes or unusual bleeding, contact your doctor immediately.
• Follow up with your doctor regularly to monitor bone health and treatment effectiveness.

What if I forgot to take EGOLIX 150 TABLET

If you miss a dose, take it as soon as you remember on the same day. If it's almost time for the next dose, skip the missed one and continue your regular schedule. Do not take extra doses to make up for a missed one.

Side Effects Of EGOLIX 150 TABLET

Like all medicines, EGOLIX 150 TABLET may cause certain side effects, although not everybody gets them.

Common Side Effects of EGOLIX 150 TABLET:

• hot flushes and night sweats
• headache, nausea
• insomnia (lack of sleep)
• amenorrhea (lack of periods)
• anxiety,
• joint pain, bone weakness

When To Seek Medical Attention?

Stop taking EGOLIX 150 TABLET and inform your doctor immediately if you experience any of the following side effects such as:

• depression-related adverse reactions
• mood changes

Warning & Precautions

Pregnancy

Contraindicated

EGOLIX 150 TABLET is contraindicated during pregnancy, as early exposure may increase the risk of early pregnancy loss. If you become pregnant while taking this medicine, discontinue use immediately and consult your doctor.

Breastfeeding

Consult your doctor

The presence of Elagolix in human milk, its effects on the breastfed child, or its impact on milk production are not well understood. Therefore, it's advisable to weigh the benefits of breastfeeding against the potential risks of taking EGOLIX 150 TABLET while nursing.

Driving and Using Machines

Use with Caution

EGOLIX 150 TABLET may cause side effects such as dizziness, fatigue, or mood changes, which can impair your ability to drive or operate heavy machinery. If you experience these symptoms, refrain from such activities and discuss them with your doctor.?

Alcohol

Consult your doctor

While there are no specific warnings against alcohol consumption with EGOLIX 150 TABLET, combining alcohol with medications can potentially exacerbate side effects like dizziness or liver strain. It is prudent to limit or avoid alcohol while on this medication.

Kidney

Consult your doctor

No dosage adjustment of Elagolix is required in women with any degree of renal impairment or end-stage renal disease, including those on dialysis.

Liver

Consult your doctor

EGOLIX 150 TABLET is not recommended for use in patients with severe hepatic (liver) impairment due to the risk of bone loss. For those with moderate hepatic impairment, a reduced dosage may be necessary. Always inform your doctor of any existing liver conditions before starting therapy.

Allergy

Contraindicated

Inform your doctor about any known allergies, especially to medications. If you experience signs of an allergic reaction, such as rash, itching, swelling, or difficulty breathing, seek medical attention promptly.?

Use In Pediatrics

Contraindicated

EGOLIX 150 TABLET is not recommended for use in children and adolescents under 18 years of age, as its safety and effectiveness have not been established in this age group. Since Elagolix affects hormone levels and bone mineral density, it may interfere with normal growth and bone development in younger patients.

Use In Geriatrics

Contraindicated

EGOLIX 150 TABLET is not indicated for use in elderly patients (65 years and older), as endometriosis is a condition that primarily affects women of reproductive age. Additionally, older adults may have a higher risk of bone loss, liver impairment, or drug interactions, making Elagolix unsuitable for routine use in this population.

Other Warnings for EGOLIX 150 TABLET

Before taking EGOLIX 150 TABLET, inform your doctor if you have:

• Bone loss
• Reduced ability to recognise pregnant
• Suicidal ideation and mood disorders
• Hepatic transaminase elevations
• Estrogen-Containing Contraceptives

Who should not take [GBNKEYWORD

EGOLIX 150 TABLET is not recommended for use in patients with:

• Known history of osteoporosis, as it can increase the risk of fractures
• Pregnancy

Drug - Drug interaction

• CYP3A Substrates: Elagolix may decrease plasma concentrations of drugs that are substrates of CYP3A (e.g, digoxin), as it is a weak to moderate inducer of this enzyme.
• P-glycoprotein (P-gp) Substrates: Elagolix may increase plasma concentrations of drugs that are substrates of P-gp (e.g., digoxin) because it inhibits this efflux transporter.
• Hormonal Contraceptives: Elagolix may reduce the efficacy of estrogen-containing contraceptives. Use non-hormonal contraception during management and for one week after discontinuing Elagolix.

FAQs About EGOLIX 150 TABLET

References

1. Elagolix. Prescribing Information. U. S. Food and Drug Administration. [Revised in July 2018]. [Accessed on 27th March 2025].
2. Elagolix 150 & 200 mg Tablet. Incepta Pharmaceuticals Ltd. [Accessed on 27th March 2025].

Useful Diagnostic Tests

• Estrogen/Progesterone Receptor (ER/PR)
• Female Hormones Package
• Female Hormones Profile

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Venkatesh Poludasu - MBBS

Last updated on 28 Mar 2025 | 12:46 PM(IST)