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Introduction About EDAVON INJECTION
EDAVON INJECTION contains Edaravone which belongs to group of medicines called Antioxidants. EDAVON INJECTION is used to manage amyotrophic lateral sclerosis (nervous system disease that weakens muscles and impacts physical function) in affected individuals.
EDAVON INJECTION is not recommended for use if you are allergic to Edaravone.
Before receiving EDAVON INJECTION, inform your doctor if you have lung problems (such as asthma), kidney problems (such as impaired renal insufficiency), and/or liver problems (such as mild/moderate/severe hepatic insufficiency).
EDAVON INJECTION should be used with caution in pregnant and breastfeeding women only if it is clearly necessary since there is no adequate data to determine safety and efficacy of the medicine.
EDAVON INJECTION is not recommended for use in children and adolescents (below 18 years) as there is no adequate data to determine the safety and efficacy of the medicine in children. It is advised to be used with caution in elderly patients (aged 65 years/above) after consulting the doctor.
The most common side effects of receiving EDAVON INJECTION are confusion, gait disturbance, headache, dermatitis, eczema, and/or tinea infection (fungal infection of skin). Consult and inform your doctor if any of these symptoms worsen.
Uses Of EDAVON INJECTION
- Manage amyotrophic lateral sclerosis in affected individuals
How EDAVON INJECTION Works
EDAVON INJECTION works by relieving the effects of oxidative stress (condition that occurs due to imbalance of free radicals and antioxidants in the body during ageing process) which results in delayed nerve damage associated with the symptoms of amyotrophic lateral sclerosis condition thus preserving the motor function and managing the associated symptoms of the condition in affected individuals.
How to use EDAVON INJECTION
EDAVON INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of EDAVON INJECTION
Common
- confusion
- gait disturbance
- headache
- dermatitis
- eczema
- signs of glycosuria (condition marked by excess sugar in urine) such as extreme hunger, accidental urination, nighttime urination
- tinea infection (fungal infection of skin)
Rare
Stop receiving EDAVON INJECTION and contact your doctor immediately if you have:
- signs of hypersensitivity reactions (immune mediated response to an allergen) such as red itchy welts, breathing problems, itching, swelling of lips/tongue/face, dizziness, wheezing, and/or fainting
- signs of sulfite allergic reactions such as asthma attack (in people with a history of asthma), red itchy welts, breathing problems, itching, swelling of lips/tongue/face, dizziness, wheezing, and/or fainting
How To Manage Side Effects
Headache:
If EDAVON INJECTION causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking EDAVON INJECTION. If it lasts more than a week or severe, inform your doctor.
Warning & Precautions
Pregnancy
EDAVON INJECTION should be used with caution during pregnancy and in women planning for pregnancy only if it clearly necessary since there is no adequate data to determine safety and efficacy of the medicine. Consult your doctor before receiving the medicine.
Breastfeeding
EDAVON INJECTION should be used with caution in breastfeeding women only if it is clearly necessary as there is no data to determine its safety and efficacy. Consult your doctor before receiving the medicine.
Kidney
EDAVON INJECTION should be used with caution in patients with kidney problems such as renal insufficiency. Consult your doctor before receiving the medicine.
Liver
EDAVON INJECTION should be used with caution in patients with liver problems such as mild/moderate/severe hepatic insufficiency. Consult your doctor before receiving the medicine.
Allergy
Do not receive EDAVON INJECTION if you are allergic to edaravone, and/or any other ingredients of this medicine. It should be used with caution in patients allergic to sulfites. Consult and inform your doctor before receiving the medicine.
Lungs
EDAVON INJECTION should be used with caution in patients with lung problems such as asthma. Consult your doctor before receiving the medicine.
Others
Use in Pediatrics:
EDAVON INJECTION is not recommended for use in children and adolescents (below 18 years) as there is no adequate data to determine the safety and efficacy of the medicine in children. Consult your doctor before administering the medicine to the child.
Use in Geriatrics:
EDAVON INJECTION should be received with caution in elderly patients (aged above 65 years). Consult and inform your doctor before receiving the medicine.
Interactions
A. Drug-Drug interactions:
Before taking EDAVON INJECTION, inform your doctor if you are taking:
- CYP enzyme inhibitors (medicines that inhibit cyp enzyme which is responsible for cholesterol & steroid production) Ex. clarithromycin, diltiazem, erythromycin, itraconazole
- UGT inhibitors (medicines that inhibit metabolism of drugs) Ex. diclofenac, phenylbutazone
Over dosage:
EDAVON INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Synopsis
| Drug | : | Edaravone |
| Pharmacological Category | : | Antioxidants |
| Therapeutic Indication | : | Amyotrophic lateral sclerosis |
| Dosage Forms | : | Injection |
More Information
- Keep EDAVON INJECTION out of reach of children
- Store EDAVON INJECTION below 25°C
FAQs About EDAVON INJECTION
What are the uses of EDAVON INJECTION?
EDAVON INJECTION is used to manage amyotrophic lateral sclerosis in affected individuals which is a progressive neuro muscular disease that weakens muscles and impacts physical function, generally characterized by symptoms such as difficulty while walking, tripping & falling, weakness in legs/feet/ankles, slurred speech, and/or trouble swallowing.
What are the side effects of EDAVON INJECTION?
The most common side effects of receiving EDAVON INJECTION are confusion, gait disturbance, headache, dermatitis, eczema, and/or tinea infection (fungal infection of skin). Contact your doctor if any of these symptoms worsen.
Is EDAVON INJECTION safe to be used in pregnant and breastfeeding women?
Yes, EDAVON INJECTION can be used but with caution during pregnancy only if it is clearly necessary. It is also advised to be used with caution in breast feeding only if needed since it is unknown whether the medicine may get excreted through breastfed milk. Consult your doctor before receiving the medicine.
How EDAVON INJECTION works?
EDAVON INJECTION works by relieving the effects of oxidative stress (condition that occurs due to imbalance of free radicals and antioxidants in the body during ageing process) which results in delayed nerve damage associated with the symptoms of amyotrophic lateral sclerosis condition thus preserving the motor function and managing the associated symptoms of the condition in affected individuals.
How much dose can EDAVON INJECTION be received in a day?
EDAVON INJECTION is generally given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration depending on your age, body weight and disease condition.
References
1. Patrick A. Lewis, Jennifer E. Spillane. The motor neuron diseases and amyotrophic lateral sclerosis. The Molecular and Clinical Pathology of Neurodegenerative Disease. Edition 2018. Page: 178.
2. R Bhandari, A Kuhad. Edaravone: a new hope for deadly amyotrophic lateral sclerosis. NIH National Library of medicine. National Center for Biotechnology Information. PubMed.gov. [Revised in June 2018] [Accessed on 19th May 2022] https://pubmed.ncbi.nlm.nih.gov/29998226/
3. Martin Paspe Cruz. Edaravone (Radicava). NIH National Library of medicine. National Center for Biotechnology Information. PMC PubMed Central. January 2018. [Accessed on 19th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737249/
4. Mitsubishi Tanabe Pharma Corporation. Drug and Health Product Register (HRES). [Revised in October 2018] [Accessed on 19th May 2022] https://pdf.hres.ca/dpd_pm/00047612.PDF
5. Taj Pharma. Edaravone Injection. [Accessed on 19th May 2022] https://tajpharma.in/portfolio-item/edaravone-injection-1-5mg/
Useful Diagnostic Tests
- Blood test
- Magnetic Resonance Imaging (MRI)
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