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Introduction About EASYSIX INJECTIONPFS
EASYSIX INJECTIONPFS is a combination of Haemophilus Influenza Type B Conjugate, Inactivated Poliomyelitis Trivalent Vaccine, Purified Diphtheria Toxoid, Purified Tetanus Toxoid, Recombinant Hepatitis B, and Whole Cell Pertussis which belongs to the group of medicines called Vaccines. It is used in infants and children (below 7 years) to manage diseases caused by certain bacteria and viruses such as haemophilus influenzae type B, poliomyelitis, diphtheria, tetanus, hepatitis B, or pertussis.
Haemophilus influenzae type B causes a serious bacterial infection characterised by symptoms such as meningitis (inflammation of membranes covering the brain) or inflammation of the lungs, tissue under the skin, joints, bones, and throat.
Poliomyelitis is a viral disease that generally causes paralysis of the legs. It can be fatal if it affects the muscles that help with breathing and swallowing. Hepatitis B is a viral disease that causes inflammation of the liver tissues. This virus may also cause liver cancer in some patients.
Diphtheria is a bacterial disease that first causes pain and swelling in the throat, which may result in suffocation. It may also cause the production of a toxin in the body that can damage the heart, kidneys, and nerves.
Tetanus is a bacterial infection that develops in penetrating, deep wounds. The disease can be very dangerous because the bacteria may produce a toxin that may trigger the spasms of the back muscles and airway muscles, resulting in breathing difficulties and even suffocation.
Pertussis, or whooping cough, affecting mostly infants and young children, is a bacterial infection that primarily affects the airways. It is characterised by symptoms such as a severe cough with a ‘whoop’ noise that can last even for weeks.
EASYSIX INJECTIONPFS is not recommended for use if your child has previously experienced problems of the nervous system, such as encephalopathy within 7 days following a pertussis vaccination, infection with a high fever (more than 38 °C), an uncontrolled neurologic disorder such as uncontrolled epilepsy, or breathing difficulties, particularly in the children who are prematurely born. EASYSIX INJECTIONPFS is not recommended for use by pregnant or breastfeeding women. EASYSIX INJECTIONPFS is also not recommended for use in children (aged 7 years or above).
The common side effects associated with the use of EASYSIX INJECTIONPFS are pain, tenderness, fever, swelling, redness, irritability, or restlessness. Consult your doctor if any of the conditions worsen.
Uses Of EASYSIX INJECTIONPFS
- Prevent diseases such as haemophilus influenzae type B, poliomyelitis, diphtheria, tetanus, hepatitis B, or pertussis
How EASYSIX INJECTIONPFS Works
EASYSIX INJECTIONPFS stimulate our body to produce disease specific antibodies (disease fighting proteins) that manage these viruses and bacteria from causing the infection in the future.
How to use EASYSIX INJECTIONPFS
EASYSIX INJECTIONPFS will be given to you only by a doctor or a nurse subcutaneously under the skin or intramuscularly into the muscle (antero-lateral aspect of thigh). EASYSIX INJECTIONPFS is not recommended to administer EASYSIX INJECTIONPFS under the skin (subcutaneously), or vein (intravenously). Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of EASYSIX INJECTIONPFS
Common
- pain
- tenderness
- fever
- swelling
- redness
- irritability
- restlessness
- fussiness
- vomiting
- loss of appetite lost
- excessive sleepiness
Uncommon
- nervousness
- diarrhoea
- fever higher than 39.5°C
- itching
- reactions at the site of injection such as induration or swelling (> 50 mm)
- drowsiness
- upper respiratory tract infection such as sore throat, common cold
- weakness
- cough
- diffuse swelling of the administrated leg which can involve adjacent joint
Rare
- reaction at the site of injection (larger than > 10 cm) including pain, tenderness, and swelling
- rashes
- signs of bronchitis (inflammation in the lungs) such as wet cough and noisy breathing
- poor eating
Stop receiving EASYSIX INJECTIONPFS and contact your doctor if you experience any of the following side effects:
- difficulty in breathing
- a rash
- swelling of the face or throat
- signs of low blood pressure such as dizziness or collapse
- loss of consciousness or awareness
- fits (with or without fever)
How To Manage Side Effects
Diarrhea
Drink lots of fluids, such as water, to keep yourself hydrated. Try to avoid taking any medicine on your own to manage diarrhoea, and consult your doctor if the symptom gets worse.
Dizziness Or Drowsiness
Lie down until the drowsiness passes and get up slowly. Do not bend down suddenly. Get a lot of rest. Walk slowly and carefully. Take plenty of fluids. Avoid drinking coffee, alcohol, or smoking. Consult your doctor if the condition persists for a long time or gets worse.
Nausea And Vomiting
Stick to simple meals. Avoid eating rich or spicy food. Eat slowly. Prefer to eat small and frequent meals. Avoid mixing hot and cold foods. Consult your doctor if the symptom gets worse.
Skin rash Or Itching
Gently pat the itchy skin instead of scratching it, and place something like a damp towel on the itchy area. Prefer wearing loose cotton clothing. Avoid wearing tight clothes and using perfumed soaps, deodorants, or moisturisers.
Warning & Precautions
Pregnancy
ContraindicatedEASYSIX INJECTIONPFS is not recommended for use in pregnancy. Consult your doctor before receiving the medicine.
Breastfeeding
ContraindicatedEASYSIX INJECTIONPFS is not recommended for use in breast feeding. Consult your doctor before receiving the medicine.
Kidney
Use with CautionEASYSIX INJECTIONPFS is used with caution in patients planned for kidney transplant. Consult your doctor before receiving it.
Liver
Use with CautionEASYSIX INJECTIONPFS should be used with caution in patients with chronic liver diseases. Consult your doctor before receiving it.
Allergy
Consult your doctorEASYSIX INJECTIONPFS is not recommended for use if you are allergic to vaccine or any injection containing diphtheria, tetanus, pertussis, hepatitis B, poliovirus, or haemophilus influenzae type B, or any other ingredients of this medicine. It should be given with caution if your child has known allergies. Consult your doctor before receiving it.
Use In Pediatrics
ContraindicatedEASYSIX INJECTIONPFS is not recommended for use in children (aged 7 years or above). Consult your doctor before receiving it.
Use In Geriatrics
ContraindicatedEASYSIX INJECTIONPFS is not recommended for use in any age group (aged 7 years or above). Consult your doctor before receiving it.
Others
EASYSIX INJECTIONPFS is not recommended for use if your child:
- has previously experienced problems of the nervous system such as encephalopathy within 7 days following a pertussis vaccination
- has an infection with a high fever (more than 38°C)
- has breathing difficulties particularly in the children who are prematurely born
- uncontrolled neurologic disorder such as uncontrolled epilepsy
Before receiving EASYSIX INJECTIONPFS, inform your doctor if your child:
- has any problem such as high fever (40.0°C or more), collapse (shock like state), or persistent crying for 3 hours or more) within 48 hours
- had fits (with or without a fever) within 3 days of this vaccination or any another vaccine against pertussis (whooping cough)
- has a weak immunity such as HIV infection
- has history of convulsions with fever
- have a family history of convulsions, SIDS (Sudden Infant Death Syndrome), or adverse event following this vaccination
- is suffering from neurological disorders such as infantile spasms, or progressive encephalopathy (disease of brain)
- has bleeding problem or bruises easily
- has a high fever (more than 38°C)
- has any serious health problem
- has history of fainting with previous injections
Interactions
A. Drug-Drug Interactions:
Before receiving EASYSIX INJECTIONPFS, inform your doctor, if you are receiving any of the following medicine:
- pneumococcal polysaccharide conjugated vaccines (vaccine for the management of pneumococcal infection)
- measles-mumps-rubella vaccines (vaccine for the management of measles, mumps, or rubella infection)
- rotavirus vaccines (vaccine for the management of rotavirus infection)
- immunosuppressant drugs (medicines that lower the immune response of the body) Ex. tacrolimus, cyclosporine
- anticoagulants (medicine that delays blood clotting) Ex. warfarin, heparin
Overdosage:
EASYSIX INJECTIONPFS will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, if you experience any unusual symptoms, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Haemophilus Influenza Type B Conjugate, Inactivated Poliomyelitis Trivalent Vaccine, Purified Diphtheria Toxoid, Purified Tetanus Toxoid, Recombinant Hepatitis B, and Whole Cell Pertussis |
| Pharmacological Category | : | Vaccine |
| Therapeutic Indication | : | Prevent Haemophilus Influenza Type B Conjugate,Inactivated Poliomyelitis Trivalent Vaccine, Purified Diphtheria Toxoid, Purified Tetanus Toxoid, Recombinant Hepatitis B, and Whole Cell Pertussis |
| Dosage Forms | : | Injection |
More Information
- Keep the medicine out of reach of children
- Store EASYSIX INJECTIONPFS at room temperature
FAQs About EASYSIX INJECTIONPFS
Q: What is EASYSIX INJECTIONPFS used for?
A: EASYSIX INJECTIONPFS is used in infants and children (below 7 years) to manage diseases caused by certain bacteria and viruses, such as haemophilus influenzae type B, poliomyelitis, diphtheria, tetanus, hepatitis B, or pertussis.
Q: What side effects are seen with EASYSIX INJECTIONPFS?
A: The common side effects associated with the use of EASYSIX INJECTIONPFS are pain, tenderness, fever, swelling, redness, irritability, or restlessness. Consult your doctor if any of the conditions worsen.
Q: Who should avoid receiving EASYSIX INJECTIONPFS?
A: EASYSIX INJECTIONPFS is not recommended for use if your child has previously experienced problems of the nervous system, such as encephalopathy within 7 days following a pertussis vaccination, infection with a high fever (more than 38 °C), an uncontrolled neurologic disorder such as uncontrolled epilepsy, or breathing difficulties, particularly in the children who are prematurely born. EASYSIX INJECTIONPFS is also not recommended for use in children (aged 7 years or above). Consult your doctor before receiving it.
Q: How does EASYSIX INJECTIONPFS work?
A: EASYSIX INJECTIONPFS stimulates our body to produce disease-specific antibodies (disease fighting proteins) that manage these viruses and bacteria from causing infection in the future.
Q: What is the method of receiving EASYSIX INJECTIONPFS?
A: EASYSIX INJECTIONPFS will be given to you only by a doctor or a nurse, subcutaneously under the skin or intramuscularly into the muscle (antero-lateral aspect of the thigh). It is not recommended to administer this medicine in a vein (intravenously) or under the skin (subcutaneously). Your doctor will determine the correct dose and duration for you depending upon your age, body weight, and disease condition.
Q: What happens if you take more EASYSIX INJECTIONPFS than your required dose?
A: EASYSIX INJECTIONPFS will be given to you only by a doctor or nurse in a hospital, and so it is unlikely that you will receive an overdose. However, if you experience any unusual symptoms, consult your doctor immediately or visit the nearby hospital.
Q: How often should EASYSIX INJECTIONPFS be received?
A: EASYSIX INJECTIONPFS is administered via three intramuscular injections with an interval of four weeks between doses, starting at 6 weeks of age. According to the Indian Academy of Paediatrics (IAP) recommendation, this vaccine must be administered at the ages of 6, 10, and 14 weeks after birth. A booster dose is recommended to be administered at the age of 15–18 months. A reinforcing injection of this combination vaccine should be administered at age 5. Consult your doctor for advice.
Q: What if you missed a dose of EASYSIX INJECTIONPFS for your child?
A: If your child misses any scheduled dose of EASYSIX INJECTIONPFS, it is important that you discuss this with the doctor. Your doctor will decide when to give the missed dose. It is important to follow the instructions of the doctor to complete your child’s course of injections.
References
1. KD Tripathi. Vaccines And Sera. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 925.
2. Intissar Haddiya. Current Knowledge of Vaccinations in Chronic Kidney Disease Patients. National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. July 2020. [Assessed 23rd July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394503/
3. Panacea Biotec Ltd. EasySix. [Revised in April 2018] [Assessed 23rd July 2022] https://media.panaceabiotec.com/documents/2019/7/24/Easysix-PMPIS05903.pdf
4. GlaxoSmithKline Inc. INFANRIX hexa. [Revised in August 2021] [Assessed 23rd July 2022] https://ca.gsk.com/media/6247/infanrix-hexa.pdf
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