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Introduction About DYTOR E 20MG COMBI KIT
DYTOR E 20MG COMBI KIT is a combination of Eplerenone and Torsemide which belongs to the group of medicines called Diuretics. It is used in adults to manage high blood pressure and edema (swelling due to fluid retention) related to heart failure.
Hypertension is defined as persistently increased blood pressure, that can show symptoms like headache, sweating, fast heartbeat or throbbing sensation. Fluid regularly drains into body tissues from the blood. When this fluid isn’t removed from the tissue, fluid retention (edema) occurs, causing symptoms like swelling and aching of affected body parts such as feet, ankles or hands.
During course of the management your doctor might regularly monitor your kidney or liver function test to avoid any untoward side effects.
Before taking DYTOR E 20MG COMBI KIT, inform your doctor if you have any kidney, heart or liver problems, high or low blood potassium levels, diabetes, low blood volume or difficulty in passing urine.
DYTOR E 20MG COMBI KIT is not recommended for use in pregnant and breastfeeding women, so consult your doctor before taking it. It is not recommended for use in children and adolescents due to lack of safety and effectiveness.
The most common side effects of taking DYTOR E 20MG COMBI KIT are muscle cramps, diarrhoea, nausea, dizziness, headache and constipation. Consult your doctor if any of the above side effects worsen.
Uses Of DYTOR E 20MG COMBI KIT
- Manage high blood pressure and edema related to heart failure
How DYTOR E 20MG COMBI KIT Works
DYTOR E 20MG COMBI KIT lowers edema where eplerenone blocks aldosterone, which is a mineralocorticoid acting on epithelial (e.g., kidney) and nonepithelial (e.g., heart and blood vessels) receptors to cause sodium and water reabsorption, and torsemide induces excretion of sodium, chloride and water by inhibiting sodium and chloride reabsorption in kidney tubules.
How to use DYTOR E 20MG COMBI KIT
Take DYTOR E 20MG COMBI KIT as advised by your physician. Swallow DYTOR E 20MG COMBI KIT with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking DYTOR E 20MG COMBI KIT unless your doctor advises you to stop.
Side Effects Of DYTOR E 20MG COMBI KIT
Common
- dizziness, fainting, headache
- difficulty sleeping
- heart complaints like irregular heartbeat and heart failure
- cough
- constipation
- nausea, vomiting, diarrhea, loss of appetite, upper abdominal pain
- rash, itching
- back pain
- weakness, extreme tiredness
- muscle spasm
Uncommon
- dehydration
- inflammation of the gall bladder
- decreased blood pressure that can make you feel dizzy upon standing
- blood clot in the leg
- sore throat
- flatulence
- reduced sense of touch
- too much sweating
- musculoskeletal pain
- feeling generally unwell
- kidney inflammation
- enlargement of breasts in men
- urinary retention, bladder dilation
Rare
Stop taking DYTOR E 20MG COMBI KIT and consult your doctor immediately if you experience any of the following side effects:
- angioneurotic edema (swollen face, tongue or throat, hives, trouble swallowing and breathing)
How To Manage Side Effects
Nausea and vomiting:
Take this medicine with or just after a meal or a snack and stick to simple meals and do not eat oil rich or spicy food. Consult your doctor if the symptom does not improve.
Headache:
Take rest and drink plenty of water. Avoid taking alcohol and skipping meals. Do not strain your eyes by watching the screen for long time. Consult your doctor if the symptom persists for long or gets worsened.
Dizziness:
Lie down until dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol and drugs. Consult your doctor if the symptom gets worse.
Constipation:
Try to eat more high-fiber foods such as fresh fruit, vegetables, cereals and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate managements for constipation.
Diarrhea:
Drink lot of fluids such as water or fruit juice to keep yourself hydrated. Do not consume any medicine other than DYTOR E 20MG COMBI KIT without consulting your doctor.
Warning & Precautions
Pregnancy
DYTOR E 20MG COMBI KIT is not recommended for use in pregnant women, as it is not known if it causes any potential harm to the unborn baby. Consult your doctor before taking DYTOR E 20MG COMBI KIT.
Breastfeeding
DYTOR E 20MG COMBI KIT is not recommended for use in breastfeeding women as it is not known if it passes into breast milk. Consult your doctor before taking DYTOR E 20MG COMBI KIT.
Driving and Using Machines
Do not drive or use any machine if you feel dizzy after taking DYTOR E 20MG COMBI KIT.
Kidney
DYTOR E 20MG COMBI KIT is not recommended for use in patients with kidney problems. It should be used with caution in patients with kidney disease. Consult your doctor before taking DYTOR E 20MG COMBI KIT.
Liver
DYTOR E 20MG COMBI KIT is not recommended for use in patients with liver problems. It should be used with caution in patients with liver disease. Consult your doctor before taking DYTOR E 20MG COMBI KIT.
Allergy
Do not take DYTOR E 20MG COMBI KIT if you are allergic to Eplerenone, Torsemide or any other ingredients of this medicine.
Heart Disease
DYTOR E 20MG COMBI KIT is not recommended for use in patients having low blood pressure or irregular heartbeats. Consult your doctor before taking DYTOR E 20MG COMBI KIT.
Others
DYTOR E 20MG COMBI KIT is not recommended for use if you:
- have low volume of blood
- have high blood potassium levels
Before taking DYTOR E 20MG COMBI KIT, inform your doctor if you:
- have low levels of potassium or sodium in your blood
- have difficulty with micturition (passing urine) including prostatic hypertrophy
- have diabetes
Use in pediatrics:
DYTOR E 20MG COMBI KIT is not recommended for use in children and adolescents as its safety and effectiveness have not been established. Consult your child’s doctor for advice.
Use in geriatrics:
Your doctor will prescribe the right dose of DYTOR E 20MG COMBI KIT depending on your age, body weight and health condition.
Interactions
A. Drug - Drug interactions:
Before taking DYTOR E 20MG COMBI KIT, inform your doctor if you are taking any of the following medicines:
- medicines used to manage fungal infections (Ex. itraconazole, ketoconazole, fluconazole, miconazole)
- medicines used to manage HIV (Ex. ritonavir, nelfinavir, saquinavir)
- medicines used to manage bacterial infections (Ex. clarithromycin, telithromycin, erythromycin, trimethoprim, rifampicin, streptomycin, gentamycin, cephalexin, ceftriaxone)
- medicines used to manage depression (Ex. nefazodone, amitriptyline, amoxapine, St. John’s Wort)
- drugs which help you to excrete excess body fluid (Ex. spironolactone, amiloride)
- medicines used to manage heart conditions like high blood pressure or heart insufficiency (Ex. lisinopril, enalapril, olmesartan, candesartan, prazosin, alfuzosin, digoxin, amiodarone, diltiazem, verapamil)
- lithium (used to manage bipolar disorder)
- medicines used after organ transplantation (Ex. cyclosporin, tacrolimus)
- medicines used to relieve pain, stiffness, and inflammation (Ex. aspirin, ibuprofen, indomethacin)
- medicines used to manage psychiatric disorders (Ex. chlorpromazine, haloperidol)
- medicines used during cancer chemotherapy (Ex. amifostine, cisplatin)
- baclofen (used to manage muscle spasm)
- medicines used to manage inflammation and certain skin conditions (Ex. hydrocortisone, prednisone, dexamethasone)
- tetracosactide (used in diagnosis and management of adrenal cortex disorders)
- medicines used to manage fits (Ex. carbamazepine, phenytoin, phenobarbital)
- medicines used to manage high blood sugar (Ex. chlorpropamide, glibenclamide, glipizide, tolbutamide)
- adrenaline (used to manage low blood pressure)
- cholestyramine (used to manage high blood cholesterol levels)
- medicines used to manage constipation (Ex. methylcellulose, psyllium)
- probenecid (used to manage gout)
- theophylline (used to manage asthma)
- oxandrolone (used to promote weight gain)
- substances used to enhance the visibility of internal structures in CT scan and other tests (Ex. iodinated contrast media, ionic iodinated contrast media)
Overdosage:
If you or anyone else accidentally takes too much of DYTOR E 20MG COMBI KIT, contact your doctor immediately or visit the nearby hospital. Symptoms of DYTOR E 20MG COMBI KIT overdose includes low blood pressure (signs include light-headedness, dizziness, blurred vision, weakness, acute loss of consciousness), high blood potassium levels (signs include muscle cramps, diarrhea, nausea, dizziness, headache), passing a lot of urine, sleepiness, confusion, fainting or dizzy and stomach upset.
Synopsis
| Drug | : | Eplerenone, Torsemide |
| Pharmacological Category | : | Potassium sparing and loop diuretic |
| Therapeutic Indication | : | Hypertension, Edema in heart failure |
| Dosage Forms | : | Tablet |
More Information
- Keep DYTOR E 20MG COMBI KIT out of reach of children
- Store DYTOR E 20MG COMBI KIT at room temperature
FAQs About DYTOR E 20MG COMBI KIT
Q: Can DYTOR E 20MG COMBI KIT be used in children?
A: DYTOR E 20MG COMBI KIT is not recommended for use in children and adolescents as its safety and effectiveness have not been established. Your doctor will decide the correct dose or select a suitable alternative therapy for your child.
Q: Is DYTOR E 20MG COMBI KIT safe during pregnancy?
A: DYTOR E 20MG COMBI KIT is not recommended for use in pregnant women, as it is not known if it causes any potential harm to the unborn baby. If you are pregnant, think you may be pregnant or are planning to get pregnant, inform your doctor before taking DYTOR E 20MG COMBI KIT.
Q: What precautions do I need to follow while taking DYTOR E 20MG COMBI KIT?
A: Patients taking DYTOR E 20MG COMBI KIT must inform their doctor if they have diabetes, kidney, liver or heart problems, if they are pregnant, breast-feeding, having any allergies, high or low blood potassium levels, low blood volume or difficulty in passing urine. Contact your doctor immediately if you have any unusual symptoms while taking DYTOR E 20MG COMBI KIT.
Q: Can DYTOR E 20MG COMBI KIT cause constipation?
A: Yes, constipation is a common side effect of DYTOR E 20MG COMBI KIT. In such case, eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals and drink plenty of water and exercise more regularly. Tell your doctor if your constipation doesn’t resolve.
Q: Is DYTOR E 20MG COMBI KIT safe to use in patients with kidney problems?
A: DYTOR E 20MG COMBI KIT is not recommended for use in patients with kidney problems. It should be used with caution in patients with kidney disease. Consult your doctor before taking it.
References
1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Hypertension. Pharmacotherapy Handbook. Ninth edition. Page-87
2. Tejaswi Kanderi; Pradeep Vaitla. Torsemide. StatPearls [Internet]. July 2021. [Accessed on 3rd June 2022] https://www.ncbi.nlm.nih.gov/books/NBK559175/#:~:text=Go%20to%3A-,Mechanism%20of%20Action,K%2B%2F2Cl%2D%20cotransport%20mechanism
3. Jonathan C. Hughes; Manouchkathe Cassagnol. Eplerenone. StatPearls [Internet]. May 2022. [Accessed on 3rd June 2022] https://www.ncbi.nlm.nih.gov/books/NBK553100/#article-21264.s3
4. S.C.Zentiva S.A. Electronic Medicines Compendium (EMC). [Revised in May 2021] [Accessed on 3rd June 2022] https://www.medicines.org.uk/emc/files/pil.3665.pdf
5. MEDA Pharma GmBH and Co. KG. Electronic Medicines Compendium (EMC). [Revised in August 2019] [Accessed on 3rd June 2022] https://www.medicines.org.uk/emc/files/pil.6663.pdf
6. Torsemide. DailyMed; National Library of Medicine; National Institute of Health. [Revised in February 2022] [Accessed on 3rd June 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=55e88727-864e-4313-860c-31a6ca45168f#Section_5.3
7. Eplerenone. DailyMed; National Library of Medicine; National Institute of Health. [Revised in March 2022] [Accessed on 3rd June 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d953457e-0aff-6c38-e053-2995a90a7d32
Useful Diagnostic Tests
- Kidney function test
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