Durogesic 25Mcg Patch 3'S

Introduction About DUROGESIC 25MCG PATCH

DUROGESIC 25MCG PATCH contains Fentanyl which belongs to the group of medicine called Opioid Analgesics. It is used to manage severe long-lasting pain. It can also be used in the management of chronic cancer pain and other severe pains that is not controlled by conventional pain killers.

DUROGESIC 25MCG PATCH is suitable for use both in adults and in children (aged 2 years or above) who need continuous pain management. Before using DUROGESIC 25MCG PATCH inform your doctor if you have any liver, kidney or heart problems.

You must also inform your doctor if you have asthma or any other breathing problems, low blood pressure, mental health problems, chronic alcoholism or a previous history of drug abuse as a precaution.

DUROGESIC 25MCG PATCH is not recommended for use in pregnant or breastfeeding women due to increased risk of side effects. When DUROGESIC 25MCG PATCH is used in children, carefully monitor your child’s health condition. Make sure that they do not peel the patch or accidentally swallow the medicine, as it could lead to fatal outcomes.

Be cautious of storing the medicine strictly out of reach of children. Adults using DUROGESIC 25MCG PATCH should make sure that the medicine is not accidentally stuck to their children or to other family members while coming in close contact.

Repeated or long-term use of DUROGESIC 25MCG PATCH may make the medicine less effective for you as it may make you more dependent on it. Therefore, if you notice that your medicine becomes less effective, consult your doctor.

The most common side effects of using DUROGESIC 25MCG PATCH are nausea, vomiting, constipation, excessive sleepiness, drowsiness and dizziness, headache, mood changes (high or low), muscle spasms, shortness of breath, dry mouth and excessive sweating. Consult your doctor if any of these side effect worsens.

You must also inform your doctor immediately if you experience excessive drowsiness or breathing difficulties after using this medicine.

Uses Of DUROGESIC 25MCG PATCH

• Manage chronic severe pain
• Helps in managing chronic cancer pain

How DUROGESIC 25MCG PATCH Works

DUROGESIC 25MCG PATCH is a pain-relieving medication. It works by blocking the transmission of pain signals between the affected sites and the brain which helps in reducing pain sensation.

How to use DUROGESIC 25MCG PATCH

Use DUROGESIC 25MCG PATCH as advised by your physician. It is for external use only. Clean and dry the skin sites where patch needs to be applied. Carefully peel the shiny plastic backing away from the patch and place the sticky side of the patch onto the skin.

Make sure that the patch sticks well, especially the edges. Wash your hands before and after handling the patch.

Do not use soap, soap or any other cleansers, creams, moisturisers, oils or talc before applying the patch. Do not stick the patch on the skin straight after a hot bath or shower.

Your doctor will decide the correct dose, duration of therapy and skin sites where the patch has to be stuck based on your age, body weight and health condition. Inform your doctor immediately if the patch falls off or tears before it needs changing.

Avoid having long hot baths, hot spa baths, sunbaths or exposing the patch towards direct heat sources (such heating pads, hot-water bottles or heat or tanning lamps) as it may increase the amount of medicine released from the patch. Do not stop using DUROGESIC 25MCG PATCH without consulting your doctor.

Side Effects Of DUROGESIC 25MCG PATCH

How To Manage Side Effects

Constipation

Eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Consult your doctor if your dizziness worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Nausea And Vomiting

Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if nausea worsens.

Warning & Precautions

Pregnancy

Monitoring required

DUROGESIC 25MCG PATCH should not be used during pregnancy unless considered necessary by the physician. Inform your doctor before using this medicine, if you are pregnant, or think you may be pregnant. DUROGESIC 25MCG PATCH should not be used during childbirth as it may affect the baby’s breathing.

Breastfeeding

Contraindicated

DUROGESIC 25MCG PATCH may pass through breast milk. Therefore, it is not recommended to breastfeed the infant for at least 3 days after using this medicine.

Driving and Using Machines

Use with Caution

DUROGESIC 25MCG PATCH may cause dizziness and sleepiness. Therefore, do not drive or operate any heavy tools or machines until the effects of this medicine wears off completely.

Alcohol

Consult your doctor

Avoid consumption of alcohol while undergoing management with DUROGESIC 25MCG PATCH as it may increase your drowsiness.

Kidney

Use with Caution

DUROGESIC 25MCG PATCH should be used with caution in patients with kidney problems. Therefore, consult your doctor before using it.

Liver

Use with Caution

DUROGESIC 25MCG PATCH should be used with caution in patients with liver problems. Therefore, consult your doctor before using it.

Allergy

Contraindicated

Do not use DUROGESIC 25MCG PATCH if you are allergic to Fentanyl or to any other opioid analgesic medications.

Lungs

Consult your doctor

DUROGESIC 25MCG PATCH is not recommended for use in patients with asthma, shallow breathing or other breathing difficulties. It should be used with caution in patients with other lung diseases. Therefore, consult your doctor before using it.

Heart Disease

Use with Caution

DUROGESIC 25MCG PATCH should be used with caution in patients with low blood pressure or other heart problems. Therefore, consult your doctor before using it.

Use In Pediatrics

Use with Caution

DUROGESIC 25MCG PATCH should be used with caution in children and adolescents (aged below 18 years). Proper dose adjustments and careful monitoring are required in such patients.

Use In Geriatrics

Use with Caution

DUROGESIC 25MCG PATCH should be used with caution in elderly patients. Therefore, consult your doctor before using it. Proper dose adjustments and careful monitoring are required in such patients.

Interactions

A. Drug-Drug interactions:

Before using DUROGESIC 25MCG PATCH, inform your doctor if you are taking any of the following medicines:

• other medicines used for pain relief (such as buprenorphine, nalbuphine, pentazocine, gabapentin and pregabalin)
• medicines that reduce anxiety and helps you fall asleep (such as temazepam, zaleplon, zolpidem, alprazolam, clonazepam, diazepam, hydroxyzine, lorazepam)
• medicines used for mental conditions (such as aripiprazole, haloperidol, olanzapine, risperidone or chlorpromazine)
• medicines used for relaxing muscles (such as cyclobenzaprine or diazepam)
• medicines used to manage depression (such as isocarboxazid, phenelzine, selegiline, tranylcypromine, citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, or venlafaxine)
• antihistamines (medicines used to manage allergic conditions) such as cetirizine, levocetirizine, chlorpheniramine, clemastine, cyproheptadine, diphenhydramine, or hydroxyzine
• antibiotics used to manage infection (Ex. erythromycin or clarithromycin)
• medicines used to manage fungal infection (Ex. itraconazole, ketoconazole, fluconazole, or voriconazole)
• medicines used to manage HIV infection (Ex. ritonavir)
• medicines used to manage an irregular heartbeat (Ex. amiodarone, diltiazem or verapamil)
• medicines to manage tuberculosis (Ex. rifampicin)
• medicines used to manage epilepsy (Ex. carbamazepine, phenobarbital, or phenytoin)
• medicines used to manage nausea or motion sickness (such as promethazine)
• medicines used to manage heartburn or ulcers (Ex. cimetidine)
• medicines used to manage angina or high blood pressure (such as nicardipine)
• medicines used to manage blood cancer (such as idelalisib)
• general anaesthetic (used to cause loss of consciousness) such as etomidate

Overdosage:

If you accidentally overdosed or swallowed DUROGESIC 25MCG PATCH, contact your doctor immediately.

Synopsis

More Information

• Keep DUROGESIC 25MCG PATCH strictly out of reach of children
• Store DUROGESIC 25MCG PATCH at room temperature
• Careful dispose the patch as instructed by your doctor or pharmacist
• Make sure that the disposed patch or used patch is not in reach of children

FAQs About DUROGESIC 25MCG PATCH

Q: What is DUROGESIC 25MCG PATCH used for?

A: DUROGESIC 25MCG PATCH is used to manage severe long-lasting pain. It can also be used in the management of chronic cancer pain and other severe pains that is not controlled by conventional pain killers.

Q: Is DUROGESIC 25MCG PATCH addictive?

A: Repeated or long-term use of DUROGESIC 25MCG PATCH may make the medicine less effective for you, as it may make you more dependent on it. Therefore, if you notice that your medicine becomes less effective, consult your doctor.

Q: What are the side effects of DUROGESIC 25MCG PATCH?

A: The most common side effects of using DUROGESIC 25MCG PATCH are nausea, vomiting, constipation, excessive sleepiness, drowsiness and dizziness, headache, mood changes (high or low), muscle spasms, shortness of breath, dry mouth and excessive sweating. Consult your doctor if any of these side effect worsens.

Q: Can a person using DUROGESIC 25MCG PATCH breastfeed?

A: DUROGESIC 25MCG PATCH may pass through breast milk. Therefore, it is not recommended to breastfeed the infant for at least 3 days after receiving this medicine.

Q: Is DUROGESIC 25MCG PATCH safe?

A: DUROGESIC 25MCG PATCH is safe at doses prescribed by the physician.

Q: How DUROGESIC 25MCG PATCH works?

A: DUROGESIC 25MCG PATCH is a pain-relieving medication. It works by blocking the transmission of pain signals between the affected sites and the brain which helps in reducing pain sensation.

Q: Can I stop using DUROGESIC 25MCG PATCH once my pain is relieved?

A: Do not stop using DUROGESIC 25MCG PATCH without consulting your doctor as it may cause withdrawal symptoms such as restlessness, difficulty in sleeping, feeling anxious, agitated or irritated, palpitations, increased blood pressure, nausea or vomiting, diarrhoea, loss of appetite, shaking, shivering and/or sweating.

Q: Can I drive a car after using DUROGESIC 25MCG PATCH?

A: DUROGESIC 25MCG PATCH may cause dizziness and sleepiness. Therefore, do not drive or operate any heavy tools or machines until the effects of this medicine wears off completely.

Q: How to use DUROGESIC 25MCG PATCH?

A: Use DUROGESIC 25MCG PATCH as advised by your physician. It is for external use only. Clean and dry the skin sites where patch needs to be applied. Carefully peel the shiny plastic backing away from the patch and place the sticky side of the patch onto the skin. Make sure that the patch sticks well, especially the edges. Wash your hands before and after handling the patch.

Q: What should I do if I forgot to use DUROGESIC 25MCG PATCH?

A: If you forgot to use DUROGESIC 25MCG PATCH at the stipulated time, apply it as soon as you remember. However, it is time for next application, skip the missed application and continue with next application at regular times. Do not apply too much of medicine at a time with a view of compensating the missed application, as this could lead to overdose.

References

1. KD. Tripathi. General Anesthetics. Opioid Analgesics and Antagonists. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 384, 385 & 475.

2. Carlos F. Ramos-Matos, Karlyle G. Bistas; Wilfredo Lopez-Ojeda. Fentanyl. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. May 2022. [Accessed on 24th March 2023] https://www.ncbi.nlm.nih.gov/books/NBK459275/#:~:text=Fentanyl%20is%20a%20potent%20synthetic,approximately%2010%20mg%20of%20morphine.

3. Durogesic® DTrans® 12mcg, 25mcg, 50mcg, 75mcg, 100mcg transdermal patch. Janssen Pharmaceutica NV. European Medicines Compendium. [Revised in March 2022]. [Accessed on 24th March 2023] https://www.medicines.org.uk/emc/files/pil.6941.pdf

4. Fentanyl Skin Patches. MHRA. Regulating Medicines and Medical Devices. [Revised in October 2018]. [Accessed on 24th March 2023] https://assets.publishing.service.gov.uk/media/5bbdfd58ed915d732b992548/Fent-patient-sheet-FINAL.pdf

5. Central Drugs Standard Control Organization. Fentanyl Transdermal Patch. January 1999. [Accessed on 24th March 2023] https://cdscoonline.gov.in/CDSCO/Drugs

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 25 Mar 2023 | 06:16 PM(IST)