Duphalac Lemon Flavour Oral Solution 450ml

Introduction About DUPHALAC LEMON FLAVOUR ORAL SOLUTION

Duphalac Lemon Flavour Oral Solution 450ml is a gentle osmotic laxative formulated to support regular bowel movements in people dealing with constipation. It contains lactulose, a synthetic sugar that works by drawing water into the intestine, softening stools, and making them easier to pass. This action helps reduce discomfort, bloating, and straining. Its pleasant lemon flavour makes it more acceptable for both adults and children compared to traditional formulations. 

Duphalac is especially useful for individuals who require safe and gradual relief from constipation, including the elderly, post-surgical patients, people with piles (haemorrhoids), and children under medical supervision. It may also be prescribed in certain liver-related conditions where reducing toxins in the body is important. The syrup can be taken directly or mixed with water, juice, or milk, and should be consumed at the same time each day for the best results. It generally works within 24–48 hours, making it suitable for routine and long-term use under medical advice.

When taking Duphalac, it is important to follow the prescribed dose carefully. Overuse may lead to bloating, cramps, or diarrhea. Patients should drink plenty of fluids throughout the day to enhance its effectiveness. Those with diabetes, lactose intolerance, or existing bowel obstruction should use it only under medical guidance. It should be stored in a cool, dry place and not frozen.

Duphalac is usually considered safe during pregnancy and breastfeeding when recommended by a doctor, as it acts locally in the gut and is not absorbed into the bloodstream in significant amounts. Common side effects may include mild gas, abdominal discomfort, or loose stools, which often improve as the body adjusts. If symptoms persist or become severe, medical advice should be sought promptly.

Uses Of DUPHALAC LEMON FLAVOUR ORAL SOLUTION

• For constipation
• Used to manage regular bowel patterns
• Used to manage digestive discomfort
• Used to manage certain liver-related conditions

Benefits of DUPHALAC LEMON FLAVOUR ORAL SOLUTION

Duphalac Syrup for Bowel Movement Support

Duphalac Syrup is widely used to support smooth and regular bowel movements. It works by softening the stool and increasing its water content, which makes it easier to pass. This gentle action helps individuals who experience irregularity or difficulty in passing stools. Regular use under medical guidance can improve bowel routine, reduce straining, and enhance overall digestive comfort.

Duphalac Syrup for Digestion

Duphalac Syrup contributes to better digestion by promoting the growth of healthy gut bacteria. It contains lactulose, a prebiotic that supports the natural balance of intestinal flora. This action not only eases bowel movement but also helps in improving gut health and reducing bloating. With its mild and non-irritant effect, Duphalac can be considered as a digestive aid in conditions linked with sluggish bowel activity.

Duphalac Syrup for Constipation

Duphalac Syrup is commonly recommended for managing constipation. It works by drawing water into the intestines, softening stools, and making them easier to pass. This results in relief from hard stools, straining, and discomfort. Suitable for both short-term and long-term use under medical advice, it provides gentle relief without causing dependency. For best results, it should be taken regularly as prescribed, along with adequate fluid intake.

How DUPHALAC LEMON FLAVOUR ORAL SOLUTION Works

Duphalac Mechanism of Action

Duphalac contains lactulose, a synthetic sugar that works mainly in the large intestine. After reaching the colon, it is broken down by gut bacteria into organic acids. These acids increase the water content in the intestine and lower the pH level. As a result, stool becomes softer, and bowel movements occur more smoothly. This process also helps stimulate natural bowel activity, making it easier for the body to pass stools without straining.

Duphalac Role in Softening Stools

Duphalac plays an important role in managing constipation by drawing water into the intestine and softening hard stools. The increased water content adds bulk and makes stools easier to pass, reducing discomfort, bloating, or straining. By promoting a gentle and natural bowel movement, Duphalac supports healthy digestion and regularity. This makes it especially useful for individuals dealing with chronic constipation, post-surgery bowel irregularities, or conditions where straining must be avoided.

How to use DUPHALAC LEMON FLAVOUR ORAL SOLUTION

Duphalac – How to Take

• Duphalac syrup should be taken orally using the measuring cup or spoon provided.
• It can be taken directly or mixed with water, juice, or milk to improve taste.
• Take it at the same time every day for the best results.
• Swallow the dose slowly instead of drinking it in one gulp.
• Always follow the dosage as advised by your doctor or pharmacist.

Duphalac Syrup Dosage Instructions

• The dose of Duphalac may vary depending on age, condition, and medical advice.
• In adults, the dose usually starts higher and may be adjusted gradually.
• For children, only use the syrup under medical supervision with age-appropriate dosing.
• Do not exceed the recommended amount, as it may cause bloating or diarrhea.
• Consistency is important – take Duphalac daily at the prescribed dose to maintain regular bowel movements.

Duphalac Syrup – Before or After Meals

• Duphalac syrup can be taken with or without food.
• Taking it with meals may help reduce stomach discomfort or gas in some individuals.
• Ensure you drink plenty of fluids during the day to enhance its effectiveness.
• If advised by your doctor, stick to the recommended timing (before or after meals).

What if I forgot to take DUPHALAC LEMON FLAVOUR ORAL SOLUTION

• Take the missed dose as soon as you remember.
• If it’s almost time for your next dose, skip the missed one and continue your regular schedule.
• Do not take a double dose to make up for the missed dose.
• Try to take the solution at the same time each day to build a routine.
• If you frequently forget doses, set a reminder or alarm to help stay consistent.

Overdose

If you or someone else accidentally takes more than the recommended amount of Duphalac Lemon Flavour Oral Solution 450ml, consult your doctor immediately or visit the nearest hospital. Symptoms of overdose may include diarrhoea, abdominal pain, bloating, or electrolyte imbalance. Prompt medical attention is important to manage possible complications.

Side Effects Of DUPHALAC LEMON FLAVOUR ORAL SOLUTION

Common Side Effects of Duphalac Lemon Flavour Oral Solution 450ml

• Bloating or abdominal distension
• Flatulence (passing gas)
• Stomach cramps or discomfort
• Nausea
• Mild diarrhoea, especially with higher doses
• Polydipsia

When to Seek Medical Attention?

Stop taking Duphalac Lemon Flavour Oral Solution 450ml and contact your doctor immediately if you experience any of the following side effects:

• Severe or persistent diarrhoea
• Intense abdominal pain or cramping
• Blood in stools or rectal bleeding
• Severe bloating or swelling of the abdomen
• Signs of allergic reaction (such as rash, itching, swelling of face/lips/tongue, difficulty breathing)
• Unusual weakness, confusion, or muscle cramps (possible signs of electrolyte imbalance)

How To Manage Side Effects

Nausea And Vomiting

• Eat Small, Frequent Meals: Instead of three large meals, opt for 5–6 smaller meals throughout the day to reduce stomach discomfort and help prevent nausea.
• Choose Bland, Easy-to-Digest Foods: Foods like crackers, toast, rice, bananas, or applesauce are less likely to trigger nausea and can settle your stomach.
• Stay Hydrated: Sip water or clear fluids slowly throughout the day. Small, frequent sips are better than drinking large amounts at once.
• Avoid Strong Odors: Stay away from foods or environments with strong smells, as these can worsen nausea. Try to keep rooms well-ventilated and avoid cooking smells when possible.
• Rest in an Upright Position: After eating, avoid lying down immediately. Sitting upright for at least 30 minutes after meals can help minimize nausea.
• Try Ginger: Ginger in the form of tea, candy, or supplements may help relieve mild nausea. However, consult a healthcare provider before trying herbal remedies.

Stomach Discomfort

• Warm Compress or Heating Pad: Applying gentle heat on the abdomen helps relax muscles, reduce cramps, and ease bloating-related pain.
• Ginger Tea: Ginger has natural digestive properties that can calm the stomach and reduce discomfort caused by gas or indigestion.
• Peppermint: Drinking peppermint tea or sucking on peppermint lozenges may help relax intestinal muscles and ease stomach spasms.
• Chamomile Tea: Known for its soothing effect, chamomile tea can relieve abdominal cramps and promote relaxation.
• Hydration: Drinking warm water throughout the day aids digestion and reduces bloating, which often contributes to abdominal pain.
• Light Diet: Opt for easily digestible foods such as rice, bananas, or toast to give your stomach rest. Avoid spicy, oily, or heavy meals until the pain subsides.
• Gentle Movement: Light walking or stretching can improve digestion and help release trapped gas, relieving discomfort.

Warning & Precautions

Pregnancy

Consult your doctor

Duphalac Lemon Flavour Oral Solution should be used during pregnancy only if clearly advised by a healthcare professional. Discuss potential risks and benefits before use.

Breastfeeding

Safe

Use during breastfeeding is generally considered safe in recommended doses. However, consult your doctor for personalised guidance.

Driving and Using Machines

Use with Caution

Duphalac is not known to affect alertness, but if you experience bloating, cramps, or discomfort, avoid driving or operating machinery until you feel well.

Alcohol

Contraindicated

Alcohol may aggravate digestive discomfort. It is best to limit or avoid alcohol while using Duphalac Lemon Flavour Oral Solution.

Liver

Consult your doctor

If you have liver problems, use Duphalac only as directed by your doctor, as it may be prescribed in certain liver-related conditions.

Allergy

Contraindicated

Avoid this product if you are allergic to lactulose or any of its ingredients.

Other Warnings for DUPHALAC LEMON FLAVOUR ORAL SOLUTION

Before taking this Talk to your doctor before taking this medicine, if you:

• Have galactosaemia
• Have unexplained abdominal pain
• Have diabetes
• Have low-galactose/low-lactose diet
• Have electrolyte imbalance

Safety Advice

• Use only as directed by your healthcare professional.
• Measure the dose accurately using the provided cup or spoon.
• Drink plenty of water during use to support effectiveness.
• Avoid prolonged use without medical supervision.
• Do not use if the seal is broken or the solution appears discoloured.
• Consult your doctor if symptoms persist or worsen.

Diet and Lifestyle Advice

• Include fibre-rich foods like fruits, vegetables, and whole grains in your meals.
• Drink 6–8 glasses of water daily to support softer stools.
• Engage in regular physical activity, such as walking or light exercise.
• Establish a consistent time for meals and bathroom routines.
• Limit intake of processed foods, fried foods, and refined sugars.
• Avoid excessive caffeine and alcohol, as they may cause dehydration.
• Manage stress through relaxation techniques like yoga or meditation.

1. Duphalac Lemon Flavour Oral Solution 450ml vs. Cremaffin Syrup – Which is Gentler for Constipation Relief 

2. Duphalac Lemon Flavour Oral Solution 450ml vs. Lactihep Syrup – Which Works Faster in Softening Stools 

3. Duphalac Lemon Flavour Oral Solution 450ml vs. Cremaffin Plus – Which Option is Safer for Elderly Patients

Drug - Drug interaction

1. Antacids containing magnesium or aluminium

• Interaction: May reduce the effectiveness of lactulose if taken together.
• Management: Take Duphalac at least 2 hours before or after such antacids.

2. Broad-spectrum antibiotics (e.g., neomycin)

• Interaction: May reduce the breakdown of lactulose in the colon, decreasing its stool-softening effect.
• Management: Doctor may adjust the dose or monitor effectiveness closely.

3. Diuretics (water tablets)

• Interaction: When combined with Duphalac, may increase the risk of electrolyte imbalance due to fluid loss.
• Management: Regular monitoring of electrolyte levels may be advised.

4. Digoxin

• Interaction: Electrolyte changes (especially potassium levels) caused by long-term or high-dose Duphalac may affect digoxin’s action.
• Management: Doctor may check potassium levels and adjust digoxin dose if needed.

5. Other laxatives

• Interaction: Using multiple laxatives with Duphalac may cause excessive diarrhoea and electrolyte loss.
• Management: Avoid combining unless specifically recommended by a healthcare professional.

Drug - Food interaction

1. High-sugar foods and beverages

• Interaction: Duphalac contains small amounts of sugar and combining it with high-sugar foods may raise overall sugar intake. This may be a concern for people with diabetes.
• Management: Limit intake of sugary foods and drinks and monitor blood sugar levels as advised by your doctor.

2. Low-fluid diets

• Interaction: Not drinking enough fluids while taking Duphalac may reduce its effectiveness and increase the risk of bloating or discomfort.
• Management: Drink 6–8 glasses of water daily unless otherwise advised by your healthcare provider.

3. High-fibre foods (excessive intake)

• Interaction: While fibre is beneficial, a sudden large increase along with Duphalac may cause excessive gas or bloating.
• Management: Increase fibre gradually and balance with adequate water intake.

Synopsis

More Information

FAQs About DUPHALAC LEMON FLAVOUR ORAL SOLUTION

References

1. K.D. Tripathi, Osmotic Laxatives – Lactulose. Essentials of Medical Pharmacology. 7th edition 2013. Page no 899.

2. Wesselius-De Casparis, A., Braadbaart, S., Bergh-Bohlken, G. E., and Mimica, M. Treatment of chronic constipation with lactulose syrup: results of a double-blind study. NIH National Library of Medicine, National Centre for Biotechnology Information. PubMed Central. [ Revised in February 1968]. [Accessed on 18th August 2025] 

3. Institute of Liver and Biliary Sciences, India. To Compare Efficacy and Safety of Lactulose Versus Polyethylene Glycol for Treatment of Overt Hepatic Encephalopathy in Cirrhotics. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in 28th  February 2018] [Accessed on 18th  August 2025] 

4. Braintree Laboratories, Inc., U.S. Food & Drug Administration. [Revised in February 2020] [Accessed on 18th August 2025] 

5. Fresenius Kabi Austria GmbH. Health Products Regulatory Authority (HPRA). [Revised in June 2022] [Accessed on 18th August 2025] 

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Vrushabhakumar Jitendra Shah. - MBBS

Last updated on 25 Aug 2025 | 03:11 PM(IST)