DULEZ 20 Capsule 10's
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Introduction About DULEZ 20 CAPSULE
DULEZ 20 CAPSULE is used in adults to manage major depressive disorders and generalized anxiety disorder. It can also be used to manage diabetic neuropathic pain and stress urinary incontinence in women.
It contains Duloxetine which is an antidepressant medicine which controls depression by altering the levels of certain brain chemicals that causes depression and urinary incontinence.
DULEZ 20 CAPSULE is not recommended for use in patients having liver or kidney disease. Before taking it, inform your doctor if you have heart disease, fits, mania, bipolar disorder, glaucoma, low sodium levels or a history of bleeding disorder. Alcohol should be consumed with caution.
DULEZ 20 CAPSULE should be used in pregnant women only if the potential benefits justify the risks to the baby. It is not recommended for use breastfeeding women and in children and adolescents (under 18 years of age).
While taking DULEZ 20 CAPSULE, call your doctor right away if you have thoughts of harming or killing yourself. The most common side effects are nausea, dry mouth, extreme tiredness, trouble sleeping, headache, decreased sex drive, blurred eyesight, etc.
Uses Of DULEZ 20 CAPSULE
DULEZ 20 CAPSULE is used to manage:
- major depressive disorders
- diabetic neuropathic pain
- generalized anxiety disorder
- stress urinary incontinence in women
How DULEZ 20 CAPSULE Works
DULEZ 20 CAPSULE works by increasing the amount of serotonin and norepinephrine (natural substances in the brain that help maintain mental balance and stop the movement of pain signals), resulting in relief of anxiety, pain and depression. DULEZ 20 CAPSULE helps in managing stress urinary incontinence by increasing the strength of the muscle responsible for holding back urine when you laugh, sneeze or perform physical activities.
How to use DULEZ 20 CAPSULE
- Take DULEZ 20 CAPSULE as advised by your physician.
- Swallow it with water. Do not crush or chew the medicine.
- You may find it easier to take DULEZ 20 CAPSULE at the same times daily to help you remember to take it.
- Your doctor will decide the right dose and duration of depending upon your age, body weight and severity of the disease.
- Do not stop taking DULEZ 20 CAPSULE unless your doctor advises you to stop.
Side Effects Of DULEZ 20 CAPSULE
Common Side Effects of DULEZ 20 CAPSULE:
- nausea, dry mouth, constipation, loss of appetite, gas
- diarrhea, heartburn, indigestion, stomach pain, vomiting
- trouble sleeping, agitation, decreased sex drive, anxiety, difficulty or failure to gain orgasm, unusual dreams
- headache, dizziness, feeling sluggish, sleepiness, shaking, numbness, pricking or tingling of the skin
- blurred eyesight, spinning sensation
- increased blood pressure, flushing, throbbing sensation
- increased sweating, weakness, shivering
- ringing in ears
- increased yawning, extreme tiredness
- itchy rash
- muscle pain or spasm
- painful or frequent urination
- trouble getting an erection, changes in ejaculation
- falls
- weight loss
Stop taking DULEZ 20 CAPSULE and contact your doctor immediately if you experience any of the following side effects:
- sensing restlessness or unable to sit or stand still
- thoughts of harming or killing self
Warning & Precautions
Pregnancy
Consult your doctorDULEZ 20 CAPSULE should be used in pregnant women only after discussing the potential benefits and risks to your unborn child with your doctor.
Breastfeeding
ContraindicatedDULEZ 20 CAPSULE is not recommended for use in breastfeeding mothers.
Driving and Using Machines
Use with CautionDo not drive or use machineries if you feel dizzy or sleepy after taking DULEZ 20 CAPSULE.
Alcohol
Use with CautionAlcohol should be consumed with caution while taking DULEZ 20 CAPSULE.
Kidney
Consult your doctorDULEZ 20 CAPSULE is not recommended for use in patients with severe kidney disease. DULEZ 20 CAPSULE should be used with caution in other kidney diseases.
Liver
ContraindicatedDULEZ 20 CAPSULE is not recommended for use in patients with liver disease.
Allergy
ContraindicatedDo not take DULEZ 20 CAPSULE if you are allergic to Duloxetine or any of the other ingredients of this medicine.
Heart Disease
Use with CautionDULEZ 20 CAPSULE should be used with caution in patients with high blood pressure or other heart diseases.
Use In Pediatrics
ContraindicatedDULEZ 20 CAPSULE is generally not recommended for use in children (below 18 years of age).
Use In Geriatrics
Use with CautionDULEZ 20 CAPSULE should be used with caution in elderly patients as they are more prone to certain side effects.
Others
Before taking DULEZ 20 CAPSULE, inform your doctor if you:
- had fits
- had mania
- have bipolar disorder
- have eye problems (Ex. glaucoma)
- had any bleeding disorders in the past (tendency to develop bruises)
- are at risk of low sodium levels (Ex. if you are taking water tablets or are elderly)
Interactions
A. Drug - Drug interactions:
Before taking DULEZ 20 CAPSULE, inform your doctor if you are taking any of the following medicines:
- medicines used as antidepressants (Ex. moclobemide, paroxetine, fluoxetine, venlafaxine, clomipramine, amitriptyline, pethidine, St John’s Wort)
- linezolid (used to manage bacterial infections)
- Anxiolytics (Ex. alprazolam, clonazepam)
- Pain killers (Ex. tramadol, buprenorphine)
- Antipsychotic agents (Ex. olanzapine, quetiapine, phenobarbital)
- medicines used to manage allergic conditions (Ex. loratadine, cetirizine)
- medicines used to manage migraine (Ex. sumatriptan, naratriptan)
- tryptophan (used for protein synthesis in the body)
- medicines used to manage blood clots (Ex. warfarin, rivaroxaban)
Overdosage:
If you or anyone else accidentally take too much of DULEZ 20 CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of DULEZ 20 CAPSULE overdosage are sleepiness, serotonin syndrome (a rare reaction causing feelings of great happiness, drowsiness, clumsiness, restlessness, feeling drunk, fever, sweating, rigid muscles), fits, vomiting and fast heartrate.
Synopsis
| Drug | : | Duloxetine |
| Pharmacological Category | : | Selective serotonin and norepinephrine reuptake inhibitors |
| Therapeutic Indication | : | Depression, Generalized anxiety disorder, Diabetic neuropathic pain, Stress Urinary Incontinence (in women) |
| Dosage Forms | : | Tablet, Capsule |
More Information
For more information on Duloxetine:
FAQs About DULEZ 20 CAPSULE
Q: What if I miss a dose of DULEZ 20 CAPSULE?
A: If you forget a dose of DULEZ 20 CAPSULE, take it as soon as you remember. However, if it is time for your next dose, skip the forgotten one and take only a single dose as usual. Leave out the missed dose if it's almost time for the next one. Do not take more than the daily amount of DULEZ 20 CAPSULE that has been prescribed for you in a day.
Q: Can I stop taking DULEZ 20 CAPSULE on my own?
A: No. Do not stop taking DULEZ 20 CAPSULE without your doctor’s advice even if you feel better. Your doctor may gradually reduce the dose before stopping management altogether. If you stop taking DULEZ 20 CAPSULE suddenly, you may have symptoms such as dizziness, tingling feelings or electric shock-like feelings, sleep disturbances, extreme tiredness, sleepiness, restlessness, agitation, anxiety, nausea, vomiting, shaking, headaches, muscle pain, irritability, diarrhoea, excessive sweating or spinning sensation.
Q: How soon can I see the effects of DULEZ 20 CAPSULE?
A: DULEZ 20 CAPSULE starts to work in most people with depression or anxiety within two weeks of starting management, but it may take 2-4 weeks before you feel better. Your doctor may continue to give you DULEZ 20 CAPSULE when you are feeling better to manage your depression or anxiety from returning. In people with diabetic neuropathic pain, it can take a few weeks before you feel better.
Q: Can DULEZ 20 CAPSULE be given to children?
A: No. DULEZ 20 CAPSULE is used for adults and generally not recommended for children and adolescents below 18 years of age. Your doctor may prescribe DULEZ 20 CAPSULE for patients under 18 if decided that this is in their best interests. If your doctor has prescribed DULEZ 20 CAPSULE for your child and you want to discuss this, please go back to your doctor. Inform your doctor if you see your child experiencing any symptoms like suicide attempt or ideas, aggression, oppositional behaviour and anger.
Q: Can DULEZ 20 CAPSULE make me have suicidal thoughts?
A: During initial management with DULEZ 20 CAPSULE, you might have suicidal thoughts. In such case, call your doctor or go to a hospital straight away. You may find it helpful to confront a relative or close friend and ask them to tell you if they think your depression or anxiety is worsening or if they are concerned about changes in your behaviour.
Q: Can I take DULEZ 20 CAPSULE on an empty stomach?
A: Take DULEZ 20 CAPSULE as advised by your doctor. You can take DULEZ 20 CAPSULE with or without food. Try taking DULEZ 20 CAPSULE at same time each day which will help you in remembering your dose.
References
1. KD Tripathi. Drugs Used in Mental Illness. Essentials of Medical Pharmacology. Eighth Edition. 2019. Page – 490.
2. David J Goldstein. Duloxetine in the treatment of major depressive disorder. NIH National Library of Medicine. National center for biotechnology information. Pubmed.gov. April 2007. [Accessed on 6th June 2024] click here
3. Trevor R Norman, James S Olver. Duloxetine in the treatment of generalized anxiety disorder. NIH National Library of Medicine. National center for biotechnology information. Pubmed Central. December 2009. [Accessed on 6th June 2024] click here
4. Wolfgang Jost, Parvaneh Marsalek. Duloxetine: mechanism of action at the lower urinary tract and Onuf's nucleus. NIH National Library of Medicine. National center for biotechnology information. Pubmed.gov. August 2004. [Accessed on 6th June 2024] click here
5. Dr. Reddy’s Laboratories (UK) Ltd. Electronic Medicines Compendium (EMC). [Revised in April 2024] [Accessed on 6th June 2022] click here
6. Pharmadox Healthcare Ltd. Electronic Medicines Compendium (EMC). [Revised in May 2021] [Accessed on 6th June 2024] click here
7. Icon Lifesciences. Dulotin (Duloxetin 10mg). [Accessed on 6th June 2024] click here
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