DOXYRIL 10mg Tablet 10's

Introduction About DOXYRIL 10MG TABLET

DOXYRIL 10MG TABLET contains Doxepin which belongs to the group of medicines called Tricyclic Antidepressants. It is used to manage depression (mood disorder with the symptoms of sadness, loss of interest and suicidal thoughts) and difficulty in sleeping because of depression.

Avoid consumption of alcohol while taking DOXYRIL 10MG TABLET as it can cause drowsiness. DOXYRIL 10MG TABLET is not suitable for use in patients with severe liver disease, who suffer from a type of mood disorder called mania (abnormally elevated mood state), have glaucoma (increased eye pressure), or have difficulty in passing urine.

Before taking DOXYRIL 10MG TABLET inform your doctor if you have suicidal thoughts or have attempted suicide in the past, have kidney, heart problems or had a heart attack recently, intolerant to certain sugars, have epilepsy (fits), are going to have an operation or dental surgery. If you have thoughts of harming or killing yourself (increased when first starting antidepressants, since these medicines take time to work) inform your doctor immediately.

DOXYRIL 10MG TABLET is not recommended for use in pregnant or breast-feeding women, consult your doctor for advice. It is not recommended for use in children and adolescents under 18 years of age and caution to be exercised in elderly patients. The most common side effects of taking DOXYRIL 10MG TABLET are drowsiness, dry mouth and constipation Consult your doctor if the symptom worsens.

Uses Of DOXYRIL 10MG TABLET

• it is used to manage depression associated with symptoms of feeling sad, tearful, unable to enjoy life, or difficulty in sleeping

How DOXYRIL 10MG TABLET Works

DOXYRIL 10MG TABLET works by increasing the concentration of the neurotransmitter called serotonin (a chemical that acts as a messenger between nerve cells of brain and throughout the body) and norepinephrine (a neurotransmitter that plays an important role in body’s fight-flight response) in the brain as these substances are found to be low in the depressed and anxiety patients.

How to use DOXYRIL 10MG TABLET

Take DOXYRIL 10MG TABLET as advised by your physician.

For Tablet, Capsule: Swallow DOXYRIL 10MG TABLET with a glass of water. Do not crush or chew the medicine.

For Dispersible Tablet: Disperse DOXYRIL 10MG TABLET in the specified quantity of water as mentioned on the label. Consume the mixture immediately after reconstitution.

Take this medicine while standing or sitting upright. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Side Effects Of DOXYRIL 10MG TABLET

How To Manage Side Effects

Constipation:

Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly. Consult your doctor if symptoms don't improve.

Drowsiness:

When you feel drowsy, lie, or sit down immediately. If you're experiencing a severe episode of vertigo, lie in a dark and quiet place with eyes closed. Vehicle driving should be avoided if you experience frequent drowsiness without warning. Talk to your doctor if the symptoms worsen.

Dry mouth:

Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes that contain alcohol because they can be drying. Consult your doctor if symptoms don't improve.

Warning & Precautions

Pregnancy

DOXYRIL 10MG TABLET is not recommended for use in pregnancy or women planning to have a baby. Consult your doctor before taking DOXYRIL 10MG TABLET.

Breastfeeding

DOXYRIL 10MG TABLET is not recommended for use in breastfeeding women. Consult your doctor for advice before taking it.

Driving and Using Machines

Do not drive or operate any machines if you feel sleepy after taking this medicine. Consult your doctor before taking DOXYRIL 10MG TABLET.

Alcohol

Avoid consumption of alcohol while taking DOXYRIL 10MG TABLET as it may cause drowsiness.

Kidney

DOXYRIL 10MG TABLET should be taken with caution in patients with kidney problems. Dose will be adjusted by your doctor. Consult your doctor before taking it.

Liver

DOXYRIL 10MG TABLET is not recommended for use in patients with severe liver problems. Consult your doctor before taking it.

Allergy

DOXYRIL 10MG TABLET is not recommended for use if you are allergic to Doxepin or any other ingredients of this medicine.

Heart Disease

DOXYRIL 10MG TABLET should be taken with caution in patients who had a heart attack recently or have any other heart problems. Before taking DOXYRIL 10MG TABLET consult with your doctor.

Interactions

A. Drug - Drug interactions:

Before taking DOXYRIL 10MG TABLET, inform your doctor if you are taking any of the following medicines:

• monoamine oxidase inhibitors like isocarboxazid, phenelzine (medicines used to manage depression)
• barbiturates like phenobarbital, pentobarbital (medicines used to manage insomnia) or other sleeping medicines like triazolam, zolpidem
• medicines like telmisartan, losartan. captopril used to lower blood pressure
• sympathomimetics, such as nasal decongestants (Ex. oxymetazoline, phenylephrine, pseudoephedrine) and bronchodilators (Ex. salmeterol, albuterol) both are used for cold and hay fever
• medicines like fluticasone, beclomethasone used to manage asthma
• cimetidine (medicine used to manage ulcers and other stomach complaints)
• thyroid hormones like thyroxine (medicine used to manage thyroid disorders)
• chlorpromazine (medicine used to manage mental illness)
• sublingual nitrates like nitro-glycerine (used to manage angina and heart failure)
• buprenorphine/opioids (medicine used to manage opioid overdose)

Overdosage:

If you or anyone else accidentally takes too much of DOXYRIL 10MG TABLET, consult your doctor immediately or visit the nearby hospital. Signs and symptoms of overdose include drowsiness, stupor (nearly unconscious), blurred vision and excessive dryness of the mouth. Severe overdose may cause loss of consciousness, reduced breathing rate, convulsions (fits), low blood pressure, unusually fast heartbeat, or palpitations.

Synopsis

More Information

• Keep DOXYRIL 10MG TABLET out of reach of children
• Store at room temperature

FAQs About DOXYRIL 10MG TABLET

How does DOXYRIL 10MG TABLET work?

DOXYRIL 10MG TABLET works by increasing the concentration of the neurotransmitter called serotonin (a chemical that acts as a messenger between nerve cells of brain and throughout the body) and norepinephrine (a neurotransmitter that plays an important role in body’s fight-flight response) in the brain as these substances are found to be low in the depressed and anxiety patients.

What is DOXYRIL 10MG TABLET used for?

DOXYRIL 10MG TABLET is used to manage depression (mood disorder with the symptoms of sadness, loss of interest and suicidal thoughts) and difficulty in sleeping because of depression.

Does DOXYRIL 10MG TABLET cause drowsiness?

Yes, this medicine may cause drowsiness in some people. When you feel drowsy, lie, or sit down immediately. If you're experiencing a severe episode of vertigo, lie in a dark and quiet place with eyes closed. Talk to your doctor if the symptoms worsen.

Can DOXYRIL 10MG TABLET be taken with Zolpidem?

No, taking DOXYRIL 10MG TABLET along with Zolpidem may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Consult your doctor before taking this medicine.

Is DOXYRIL 10MG TABLET addictive?

No, DOXYRIL 10MG TABLET is one of the few medicines used to manage insomnia that doesn’t cause addiction or dependency. Consult your doctor for more information on safety measures.

References

1. KD. Tripathi. Antidepressants and Anti-Anxiety Drugs. Essentials of medical pharmacology. Eighth edition. 2019. Page –481-489.

2. Marie Rosa Mews, CandMed, Felicitas Rombold, MSc, and Arnim Quante, MD. Efficacy and Safety of Low-Dose Doxepin in Depressed Patients Suffering From Insomnia: A Retrospective, Naturalistic Case Series Analysis. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. January 2014. [Accessed 27th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048140/

3. Anasheh Almasi; Carlos E. Meza. Doxepin. NIH National Library of Medicine, National center for biotechnology information. Statpearls. January 2022. [Accessed 27th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK542306/

4. Recipharm Uppsala AB. Electronic Medicines Compendium (EMC). [Revised in August 2021]. [Accessed 27th May 2022] https://www.medicines.org.uk/emc/files/pil.13073.pdf

5. Morningside Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Revised in May 2021]. [Accessed 27th May 2022] https://www.medicines.org.uk/emc/files/pil.13350.pdf.

6. Mylan Pharmaceuticals Inc. U.S. Food & Drug Administration [Revised in May 2014] [Accessed 27th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/070791s027lbl.pdf

7. Dailymed. Doxepin (3mg). [Revised in January 2022] [Accessed 27th May 2022] DailyMed - DOXEPIN HYDROCHLORIDE tablet (nih.gov)

Author Details

Written By Dr. Shruthi M R - BDS

Reviewed For Accuracy By Dr. Aravindan Balachandran - MBBS, MD (Psychiatry)

Last updated on 12 Jan 2023 | 11:36 AM(IST)