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Introduction About DOXINATE PLUS TABLET
DOXINATE PLUS TABLET is a combination of Doxylamine Succinate, Folic acid and Pyridoxine which belongs to the group of medicines called Antihistamines and Vitamins respectively. It is used to manage nausea and vomiting in pregnant women when changes in diet or other non-medicine managements have not worked.
Before taking DOXINATE PLUS TABLET inform your doctor if you have ever had asthma, glaucoma, stomach ulcer, blockages in the bladder or intestine. DOXINATE PLUS TABLET is safe to use in pregnant women. It is not recommended for use in breastfeeding mothers. Contact you are doctor before taking it.
The most common side effects of taking DOXINATE PLUS TABLET are anorexia, nausea, constipation, abdominal distension, flatulence, dry mouth, drowsiness etc. Consult your doctor if any of the above symptoms worsen.
Uses Of DOXINATE PLUS TABLET
- Used to manage nausea and vomiting in pregnant women
How DOXINATE PLUS TABLET Works
DOXINATE PLUS TABLET is a combination of Doxylamine Succinate, Pyridoxine and Folic Acid, works by suppressing the activation of a chemical messenger called histamine that alert our brain about the sense of discomfort or suppress the signals that create the feeling of nausea or vomiting, dizziness in a pregnant woman.
How to use DOXINATE PLUS TABLET
Take DOXINATE PLUS TABLET as advised by your physician. It should be taken on an empty stomach. Swallow DOXINATE PLUS TABLET with a glass of water and do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of DOXINATE PLUS TABLET
Common
- Anorexia
- Nausea, constipation, abdominal distension, flatulence
- Dry mouth
- Drowsiness
- Tiredness
- Light-headedness
Stop taking DOXINATE PLUS TABLET and contact your physician immediately if you experience the following side effects:
- Allergic reactions (symptoms include erythema, rash, itching, urticaria, difficulty breathing, anaphylactic reactions (including shock)
How To Manage Side Effects
Bloating
Eat smaller and frequent meals. Eat and drink slowly and exercise regularly. If the flatulence does not improve, contact your doctor.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling drowsy. Do not drink alcohol, as it can aggravate your drowsiness. Contact your doctor if your drowsiness did not improve.
Dry Mouth
Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes that contain alcohol because they can be drying. Consult your doctor if the dry mouth gets worse.
Nausea And Vomiting
Take DOXINATE PLUS TABLET, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if your nausea did not improve.
Stomach Pain
Try to rest and relax. Eat small meals but take frequently. Keep a heat pad on your stomach. Contact your doctor if the stomach pain worsens.
Warning & Precautions
Pregnancy
SafeDOXINATE PLUS TABLET is safe to use in pregnant women. Consult your doctor before taking it.
Breastfeeding
ContraindicatedDOXINATE PLUS TABLET is not recommended for use in breastfeeding mothers due to the effects of this medicine on the brain in nursing infants. Contact you are doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you feel dizziness or drowsiness after taking DOXINATE PLUS TABLET.
Alcohol
Consult your doctorAvoid alcohol consumption while using DOXINATE PLUS TABLET as it leads to excessive drowsiness.
Allergy
ContraindicatedDo not take DOXINATE PLUS TABLET if you are allergic to Doxylamine Succinate, Pyridoxine, Folic Acid or other antihistamines (such as diphenhydramine) or to other ingredients of this medicine.
Lungs
Consult your doctorBefore taking DOXINATE PLUS TABLET inform your doctor if you have ever had asthma.
Others
Before taking DOXINATE PLUS TABLET, inform your doctor if you have:
- Pernicious anaemia (Vitamin B 12 deficiency)
- Malignant (cancerous) disease
- Narrow-angle glaucoma (increased eye pressure)
- Stomach ulcer
- Blockage between your stomach and small intestine
- Folate-dependent tumour
- Blockages in the bladder
- Any disease that reduces the amount of vitamin B12 in the body
Interactions
A. Drug-Drug interactions:
Before taking DOXINATE PLUS TABLET, inform your physician if you are taking any of the following medicine:
- Medicines used to manage depression (monoamine oxidase inhibitors) (Ex. Isocarboxazid, Phenelzine)
- Medicines used for colds, cough (Ex. cetirizine, chlorpheniramine)
- Sleeping medicines (medicines help you to sleep) (Ex. diazepam, alprazolam)
- Medicines used to manage pain (Ex. morphine)
- Medicines used to manage epilepsy (Ex. phenytoin, phenobarbital, primidone, sodium valproate and carbamazepine)
- Medicines used to manage infections (Ex. trimethoprim, chloramphenicol and cotrimoxazole)
- Sulfasalazine (a medicine used to manage ulcerative colitis, Crohn’s disease or rheumatoid arthritis)
- Methotrexate (a medicine used to manage Crohn’s disease, psoriasis or rheumatoid arthritis)
Overdosage:
If you or anyone else accidentally use too much of DOXINATE PLUS TABLET, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Doxylamine Succinate, Folic acid, Pyridoxine |
| Pharmacological Category | : | Antihistamines, Vitamin B9, Vitamin B6 |
| Therapeutic Indication | : | Used to manage nausea and vomiting in pregnant women |
| Dosage Forms | : | Tablet, Capsule |
More Information
Storage
- Keep DOXINATE PLUS TABLET out of sight and reach of children
- Store DOXINATE PLUS TABLET below 30°C
FAQs About DOXINATE PLUS TABLET
Q: Is DOXINATE PLUS TABLET safe in pregnant women?
A: DOXINATE PLUS TABLET is safe and well-tolerated by pregnant women. It helps to manage nausea and vomiting in pregnant women. Inform your doctor if you have any history of organ damage before taking this medication. This medication may include inactive ingredients that may cause an allergic response. Consult your doctor immediately if you experience any side effects.
Q: How often can I take DOXINATE PLUS TABLET?
A: Take DOXINATE PLUS TABLET as advised by your physician. It should be taken on an empty stomach and take two tablets or as directed by your doctor. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Q: Is DOXINATE PLUS TABLET safe for breastfeeding women?
A: Due to the CNS (Central Nervous System) effects of Doxylamine succinate present in this medicine on nursing infants, women should not breastfeed while taking DOXINATE PLUS TABLET. Consult your doctor before taking it.
Q: What is the best time to take DOXINATE PLUS TABLET?
A: Usually DOXINATE PLUS TABLET prescribed at bedtime. Take as advised by your doctor. Your doctor will decide the correct dose and duration of DOXINATE PLUS TABLET for you depending on your age, weigh and disease condition.
Q: What to do if I forget to take DOXINATE PLUS TABLET?
A: If you forget to take a dose of DOXINATE PLUS TABLET, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take the usual prescribed dose. Do not take a double dose to make up for a forgotten dose. As this may increases the chances of getting unwanted side effects.
Q: Can I stop taking DOXINATE PLUS TABLET if I feel better?
A: Do not stop taking DOXINATE PLUS TABLET, even though you feel better. Your symptoms may come back if you stop taking DOXINATE PLUS TABLET. Inform your doctor before stopping it.
Q: Does DOXINATE PLUS TABLET cause dry mouth?
A: Yes, this medicine may cause dry mouth as a side effect. Drink plenty of water and avoid foods that are salty, acidic or spicy in this case. Consult your doctor if dry mouth persists.
References
1. Laurence L. Brunton, Randa Hilal-Dandan, Bjorn C. Knollmann. Gastrointestinal Motility and Water Flux, Emesis and Biliary and Pancreatic Disease. Hematopoietic Agents: Growth Factors, Minerals and Vitamins. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. 2018. Page-938 and 764.
2. Gideon Koren, Shannon Clark, Gary D V Hankins, Steve N Caritis, Jason G Umans, Menachem Miodovnik, Donald R Mattison and Ilan Matok. Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial. BMC Pregnancy and Childbirth. March 2015. [Accessed on 30th January 2023] https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-015-0488-1
3. Nina Nuangchamnong and Jennifer Niebyl. Doxylamine succinate–pyridoxine hydrochloride (Diclegis) for the management of nausea and vomiting in pregnancy: an overview. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. April 2014. [Accessed on 30th January 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990370/
4. James A Greenberg, Stacey J Bell, Yong Guan and Yan-hong Yu. Folic Acid Supplementation and Pregnancy: More Than Just Neural Tube Defect Prevention. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. 2011 [Accessed on 30th January 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218540/
5. Mapra Laboratories Private Limited. Doxylamine Succinate, Pyridoxine Hydrochloride and Folic Acid. [Revised in August 2021] [Accessed on 30th January 2023] https://www.mapra.com/pdf/Dol%20B6%20Tablets.pdf
6. Pregfy (Doxylamine Succinate, Pyridoxine Hydrochloride and Folic Acid). Aden Healthcare. [Accessed on 30th January 2023] https://www.adenhealthcare.com/product/doxylamine-succinate-20mg-pyridoxine-hcl-20mg-folic-acid-5mg
7. Sinate (Doxylamine Succinate, Pyridoxine Hydrochloride and Folic Acid. Serum Institute of India Pvt Ltd. [Accessed on 30th January 2023] https://www.seruminstitute.com/product_ind_sinate.php
8 DPF-Forte (Doxylamine Succinate, Pyridoxine Hydrochloride and Folic Acid). Apikos Pharma. [Accessed on 30th January 2023] https://www.apikospharma.com/product/dpf-forte/
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