Doxin 10mg Capsule 10'S

Introduction About DOXIN 10MG CAPSULE

DOXIN 10MG CAPSULE contains Doxepin which belongs to the group of medicines called Tricyclic Antidepressants. It is used to manage depression (mood disorder with the symptoms of sadness, loss of interest and suicidal thoughts) and difficulty in sleeping because of depression.

Avoid consumption of alcohol while taking DOXIN 10MG CAPSULE as it can cause drowsiness. DOXIN 10MG CAPSULE is not suitable for use in patients with severe liver disease, who suffer from a type of mood disorder called mania (abnormally elevated mood state), have glaucoma (increased eye pressure), or have difficulty in passing urine.

Before taking DOXIN 10MG CAPSULE inform your doctor if you have suicidal thoughts or have attempted suicide in the past, have kidney, heart problems or had a heart attack recently, intolerant to certain sugars, have epilepsy (fits), are going to have an operation or dental surgery. If you have thoughts of harming or killing yourself (increased when first starting antidepressants, since these medicines take time to work) inform your doctor immediately.

DOXIN 10MG CAPSULE is not recommended for use in pregnant or breast-feeding women, consult your doctor for advice. It is not recommended for use in children and adolescents under 18 years of age and caution to be exercised in elderly patients. The most common side effects of taking DOXIN 10MG CAPSULE are drowsiness, dry mouth and constipation Consult your doctor if the symptom worsens.

Uses Of DOXIN 10MG CAPSULE

• it is used to manage depression associated with symptoms of feeling sad, tearful, unable to enjoy life, or difficulty in sleeping

How DOXIN 10MG CAPSULE Works

DOXIN 10MG CAPSULE works by increasing the concentration of the neurotransmitter called serotonin (a chemical that acts as a messenger between nerve cells of brain and throughout the body) and norepinephrine (a neurotransmitter that plays an important role in body’s fight-flight response) in the brain as these substances are found to be low in the depressed and anxiety patients.

How to use DOXIN 10MG CAPSULE

Take DOXIN 10MG CAPSULE as advised by your physician.

For Tablet, Capsule: Swallow DOXIN 10MG CAPSULE with a glass of water. Do not crush or chew the medicine.

For Dispersible Tablet: Disperse DOXIN 10MG CAPSULE in the specified quantity of water as mentioned on the label. Consume the mixture immediately after reconstitution.

Take this medicine while standing or sitting upright. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Side Effects Of DOXIN 10MG CAPSULE

How To Manage Side Effects

Constipation:

Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly. Consult your doctor if symptoms don't improve.

Drowsiness:

When you feel drowsy, lie, or sit down immediately. If you're experiencing a severe episode of vertigo, lie in a dark and quiet place with eyes closed. Vehicle driving should be avoided if you experience frequent drowsiness without warning. Talk to your doctor if the symptoms worsen.

Dry mouth:

Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes that contain alcohol because they can be drying. Consult your doctor if symptoms don't improve.

Warning & Precautions

Pregnancy

DOXIN 10MG CAPSULE is not recommended for use in pregnancy or women planning to have a baby. Consult your doctor before taking DOXIN 10MG CAPSULE.

Breastfeeding

DOXIN 10MG CAPSULE is not recommended for use in breastfeeding women. Consult your doctor for advice before taking it.

Driving and Using Machines

Do not drive or operate any machines if you feel sleepy after taking this medicine. Consult your doctor before taking DOXIN 10MG CAPSULE.

Alcohol

Avoid consumption of alcohol while taking DOXIN 10MG CAPSULE as it may cause drowsiness.

Kidney

DOXIN 10MG CAPSULE should be taken with caution in patients with kidney problems. Dose will be adjusted by your doctor. Consult your doctor before taking it.

Liver

DOXIN 10MG CAPSULE is not recommended for use in patients with severe liver problems. Consult your doctor before taking it.

Allergy

DOXIN 10MG CAPSULE is not recommended for use if you are allergic to Doxepin or any other ingredients of this medicine.

Heart Disease

DOXIN 10MG CAPSULE should be taken with caution in patients who had a heart attack recently or have any other heart problems. Before taking DOXIN 10MG CAPSULE consult with your doctor.

Interactions

A. Drug - Drug interactions:

Before taking DOXIN 10MG CAPSULE, inform your doctor if you are taking any of the following medicines:

• monoamine oxidase inhibitors like isocarboxazid, phenelzine (medicines used to manage depression)
• barbiturates like phenobarbital, pentobarbital (medicines used to manage insomnia) or other sleeping medicines like triazolam, zolpidem
• medicines like telmisartan, losartan. captopril used to lower blood pressure
• sympathomimetics, such as nasal decongestants (Ex. oxymetazoline, phenylephrine, pseudoephedrine) and bronchodilators (Ex. salmeterol, albuterol) both are used for cold and hay fever
• medicines like fluticasone, beclomethasone used to manage asthma
• cimetidine (medicine used to manage ulcers and other stomach complaints)
• thyroid hormones like thyroxine (medicine used to manage thyroid disorders)
• chlorpromazine (medicine used to manage mental illness)
• sublingual nitrates like nitro-glycerine (used to manage angina and heart failure)
• buprenorphine/opioids (medicine used to manage opioid overdose)

Overdosage:

If you or anyone else accidentally takes too much of DOXIN 10MG CAPSULE, consult your doctor immediately or visit the nearby hospital. Signs and symptoms of overdose include drowsiness, stupor (nearly unconscious), blurred vision and excessive dryness of the mouth. Severe overdose may cause loss of consciousness, reduced breathing rate, convulsions (fits), low blood pressure, unusually fast heartbeat, or palpitations.

Synopsis

More Information

• Keep DOXIN 10MG CAPSULE out of reach of children
• Store at room temperature

FAQs About DOXIN 10MG CAPSULE

How does DOXIN 10MG CAPSULE work?

DOXIN 10MG CAPSULE works by increasing the concentration of the neurotransmitter called serotonin (a chemical that acts as a messenger between nerve cells of brain and throughout the body) and norepinephrine (a neurotransmitter that plays an important role in body’s fight-flight response) in the brain as these substances are found to be low in the depressed and anxiety patients.

What is DOXIN 10MG CAPSULE used for?

DOXIN 10MG CAPSULE is used to manage depression (mood disorder with the symptoms of sadness, loss of interest and suicidal thoughts) and difficulty in sleeping because of depression.

Does DOXIN 10MG CAPSULE cause drowsiness?

Yes, this medicine may cause drowsiness in some people. When you feel drowsy, lie, or sit down immediately. If you're experiencing a severe episode of vertigo, lie in a dark and quiet place with eyes closed. Talk to your doctor if the symptoms worsen.

Can DOXIN 10MG CAPSULE be taken with Zolpidem?

No, taking DOXIN 10MG CAPSULE along with Zolpidem may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Consult your doctor before taking this medicine.

Is DOXIN 10MG CAPSULE addictive?

No, DOXIN 10MG CAPSULE is one of the few medicines used to manage insomnia that doesn’t cause addiction or dependency. Consult your doctor for more information on safety measures.

References

1. KD. Tripathi. Antidepressants and Anti-Anxiety Drugs. Essentials of medical pharmacology. Eighth edition. 2019. Page –481-489.

2. Marie Rosa Mews, CandMed, Felicitas Rombold, MSc, and Arnim Quante, MD. Efficacy and Safety of Low-Dose Doxepin in Depressed Patients Suffering From Insomnia: A Retrospective, Naturalistic Case Series Analysis. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. January 2014. [Accessed 27th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048140/

3. Anasheh Almasi; Carlos E. Meza. Doxepin. NIH National Library of Medicine, National center for biotechnology information. Statpearls. January 2022. [Accessed 27th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK542306/

4. Recipharm Uppsala AB. Electronic Medicines Compendium (EMC). [Revised in August 2021]. [Accessed 27th May 2022] https://www.medicines.org.uk/emc/files/pil.13073.pdf

5. Morningside Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Revised in May 2021]. [Accessed 27th May 2022] https://www.medicines.org.uk/emc/files/pil.13350.pdf.

6. Mylan Pharmaceuticals Inc. U.S. Food & Drug Administration [Revised in May 2014] [Accessed 27th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/070791s027lbl.pdf

7. Dailymed. Doxepin (3mg). [Revised in January 2022] [Accessed 27th May 2022] DailyMed - DOXEPIN HYDROCHLORIDE tablet (nih.gov)

Author Details

Written By Dr. Shruthi M R - BDS

Reviewed For Accuracy By Dr. Aravindan Balachandran - MBBS, MD (Psychiatry)

Last updated on 12 Jan 2023 | 11:32 AM(IST)