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Introduction About DORIKEM 500MG INJECTION
DORIKEM 500MG INJECTION contains Doripenem which belong to the group of medicines called Antibiotics. It is used in adults to manage serious bacterial infections of the respiratory tract (Ex. pneumonia), urinary tract (Ex. pyelonephritis), stomach and blood (Ex. sepsis).
DORIKEM 500MG INJECTION should be used under careful medical supervision. It will be given to you only by a doctor or a nurse into the vein. Make sure to receive therapy with DORIKEM 500MG INJECTION for the stipulated duration instructed by your doctor. Stopping therapy or skipping doses in between therapy may not control infection effectively.
Before receiving DORIKEM 500MG INJECTION inform your doctor if you have any kidney problems. You must also inform your doctor if you previously experienced diarrhea after taking any antibiotics or have a previous history of stroke or fits as a precaution.
Inform your doctor before receiving DORIKEM 500MG INJECTION if you are pregnant, think you may be pregnant or planning to have a baby or breastfeeding. The most common side effects of receiving DORIKEM 500MG INJECTION are stomach pain, nausea, vomiting, diarrhoea, headache, skin rash and pain or inflammation at the site of injection. Consult your doctor if any of these side effect worsens.
Uses Of DORIKEM 500MG INJECTION
It is used in adults to manage the following serious bacterial infections:
- Pneumonia that is acquired in the hospital setting
- Complicated Urinary tract infections (Ex. kidney infections (pyelonephritis))
- Complicated intra-abdominal infections (infections of areas around the stomach)
- Blood infections (Ex. sepsis)
How DORIKEM 500MG INJECTION Works
DORIKEM 500MG INJECTION is a powerful antibiotic. It kills the susceptible bacteria by interfering with the bacterial cell wall synthesis. It is effective against a wide range of bacteria (including both gram-positive and gram-negative bacteria). As a result, it destroys the susceptible bacteria, manages their further growth and multiplication and reduces the severity of the infection.
How to use DORIKEM 500MG INJECTION
DORIKEM 500MG INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously).
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and severity of infection. Do not stop therapy or skip doses in between the therapy to achieve better control over infection.
Side Effects Of DORIKEM 500MG INJECTION
Common
- nausea, vomiting
- diarrhoea
- headache
- skin rash, itchy skin
- injection site reactions (pain and inflammation)
- fungal infections of mouth or vagina
- increased liver enzymes
Uncommon
- increased numbers of WBC and platelets
- fits
Rare
Contact your doctor immediately if you experience any of the following side effects:
- signs of severe allergic reactions (such as skin rash, itching, swelling of the face, lips, throat or tongue causing difficulty in breathing or swallowing)
- severe skin reactions (such as widespread skin rash, blistering, peeling or bleeding on any part of the skin with fever, chills, enlarged lymph nodes and malaise or pink or reddish skin lesions on palms or soles)
- severe bloody diarrhea
How To Manage Side Effects
Diarrhea
Drink plenty of fluids, such as water or fruit juice to keep yourself hydrated. Consuming ORS can also be beneficial. Do not consume any medicine on your own without consulting your doctor. If your diarrhea worsens, contact your doctor immediately.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Injection Site Reactions
Place an ice pack at the site of injection. Do not move the affected area. Consult your doctor if the symptom worsens.
Nausea And Vomiting
Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if nausea worsens.
Skin rash Or Itching
Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.
Warning & Precautions
Pregnancy
Use with CautionDORIKEM 500MG INJECTION should be used in pregnant women only if considered necessary by the physician. Therefore, consult your doctor before receiving it.
Breastfeeding
Monitoring requiredDORIKEM 500MG INJECTION may pass through the breast milk. Therefore, it should be used in breastfeeding women only if considered necessary by the physician.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if your ability is affected by DORIKEM 500MG INJECTION.
Kidney
Use with CautionDORIKEM 500MG INJECTION should be used with caution in patients with kidney problems. Therefore, consult your doctor before receiving it.
Allergy
ContraindicatedTalk to doctor before receiving DORIKEM 500MG INJECTION if you are allergic to Doripenem or to any other antibiotics (such as cephalosporins, penicillin antibiotics etc).
Use In Pediatrics
ContraindicatedDORIKEM 500MG INJECTION is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor before receiving it.
Use In Geriatrics
Consult your doctorThere is no evidence of effects of DORIKEM 500MG INJECTION on geriatric patients over the age of 65 years. Therefore, contact your doctor before receiving.
Others
Before receiving DORIKEM 500MG INJECTION inform your doctor if you:
- previously experienced diarrhea after taking an antibiotic
- have ulcerative colitis (inflammation of gut)
- have a previous history of stroke
- have a previous history of fits
Interactions
A. Drug-Drug Interactions:
Before receiving DORIKEM 500MG INJECTION, inform your doctor if you are taking any of the following medicine:
- Probenecid (medicine used to manage gout)
- Valproic acid, sodium valproate, valpromide (medicines used to manage epilepsy)
Overdosage:
DORIKEM 500MG INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, contact your doctor if you experience any unusual side effects.
Synopsis
| Drug | : | Doripenem |
| Pharmacological Category | : | Carbapenems |
| Therapeutic Indication | : | Serious Bacterial Infection |
| Dosage Forms | : | Injection |
More Information
- Keep DORIKEM 500MG INJECTION out of the sight and reach of children
- Store DORIKEM 500MG INJECTION at room temperature or in a refrigerator (2-8°C) based on the instructions given in the product label
FAQs About DORIKEM 500MG INJECTION
Q: What is the use of DORIKEM 500MG INJECTION?
A: DORIKEM 500MG INJECTION is used to manage pneumonia acquired in the hospital setting, complicated stomach and urinary tract infections and blood infections.
Q: How DORIKEM 500MG INJECTION works in my body?
A: DORIKEM 500MG INJECTION kills the susceptible bacteria by interfering with the bacterial cell wall synthesis. It is effective against a wide range of bacteria (including both gram-positive and gram-negative bacteria).
Q: Can [GBNKEYWORD] be used in patients with kidney problems?
A: DORIKEM 500MG INJECTION should be used with caution in patients with kidney problems. Therefore, consult your doctor before receiving it.
Q: How DORIKEM 500MG INJECTION is administered?
A: DORIKEM 500MG INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously).
Q: For how long should I take DORIKEM 500MG INJECTION?
A: Take DORIKEM 500MG INJECTION for the stipulated duration as prescribed by your doctor. Do not skip the medicine or stop receiving it on your own as it may cause the infection to become severe.
Q: Can DORIKEM 500MG INJECTION be given to pregnant women?
A: DORIKEM 500MG INJECTION should be used in pregnant women only if considered necessary by the physician. Therefore, consult your doctor before receiving it.
Q: What precautions should I follow while receiving DORIKEM 500MG INJECTION?
A: Before receiving DORIKEM 500MG INJECTION inform your doctor if you have any kidney problems. You must also inform your doctor if you previously experienced diarrhea after taking any antibiotics or have a previous history of stroke or fits or if you are pregnant or breastfeeding as a precaution.
Q: What are the common side effects of receiving DORIKEM 500MG INJECTION?
A: The most common side effects of receiving DORIKEM 500MG INJECTION are stomach pain, nausea, vomiting, diarrhoea, headache, skin rash and pain or inflammation at the site of injection. Consult your doctor if any of these side effect worsens.
Q: Can I stop receiving DORIKEM 500MG INJECTION once my symptoms subside?
A: Do not stop receiving DORIKEM 500MG INJECTION once your symptoms subside. It is important to take the full course of DORIKEM 500MG INJECTION to achieve better results. Failing to complete the full course of the therapy or skipping doses in between the therapy may not result in adequate infection control. It may also cause your symptoms to reappear.
Q: Can the use of DORIKEM 500MG INJECTION cause diarrhea?
A: DORIKEM 500MG INJECTION may cause diarrhea in some individuals. If you experience diarrhea, drink plenty of fluids, such as water or fruit juice to keep yourself hydrated. Consuming ORS can also be beneficial. Do not consume any medicine on your own without consulting your doctor. If your diarrhea worsens contact your doctor immediately.
Q: What kind of infections that DORIKEM 500MG INJECTION can manage?
A: DORIKEM 500MG INJECTION is an antibiotic. It is used to manage infections caused by bacteria. It kills harmful bacteria by binding to the bacterial cell and interfering with cell wall synthesis. It can manage bacterial infections of the respiratory tract, urinary tract, stomach and blood.
Q: Is DORIKEM 500MG INJECTION a steroid?
A: No. DORIKEM 500MG INJECTION is an antibiotic and not a steroid medicine.
Q: Can DORIKEM 500MG INJECTION manage viral infections?
A: No. DORIKEM 500MG INJECTION cannot manage viral infections. It manages only bacterial infections. It acts by killing the susceptible bacteria which are responsible for causing infections, and therefore not effective against any viral infections.
References
1. KD. Tripathi. Beta-lactam Antibiotics. Essentials of Medical Pharmacology. 7th Edition. 2013. Page –731.
2. Olga Hilas, PharmD, BCPS, CGP, Danielle C. Ezzo, PharmD, BCPS, and Tomasz Z. Jodlowski, PharmD, BCPS. Doripenem (Doribax), a New Carbapenem Antibacterial Agent. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. March 2008. [Accessed on 10th January 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730083/
3. Cipla Ltd. Doricrit I.V. Injection (Doripenem). Ciplamed.com. [Revised in September 2013]. [Accessed on 10th January 2023] https://ciplamed-library.com/content/doricrit-iv-injection
4. Janssen Pharmaceutica NV. Doribax 500 mg powder for solution for infusion Doripenem. European Medical Agency. [Revised in April 2009]. [Accessed on 10th January 2023] https://www.ema.europa.eu/en/documents/product-information/doribax-epar-product-information_en.pdf
5. Shionogi & Co. Ltd. DORIBAX (doripenem) Powder, For Solution for Intravenous use. U.S. Food and Drug Administration. [Revised in April 2009]. [Accessed on 10th January 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022106s002s005lbl.pdf
6. Central Drugs Standard Control Organization. Doripenem 500 mg powder for injection (Additional Indication). August 2010. Doripenem (as monohydrate) Injection 250mg/500mg. February 2009. [Accessed on 10th January 2023] https://cdscoonline.gov.in/CDSCO/Drugs
Useful Diagnostic Tests
- Complete Blood Count (CBC)
- Renal Function Tests (RFT)
- Liver Function Tests (LFT)
Author Details
