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Introduction About DONANCE 10 TABLET
DONANCE 10 TABLET contains Donepezil which belongs to the group of medicines called Cholinesterase inhibitors. It is indicated for the management of mild to moderately severe Alzheimer’s dementia.
Alzheimer's disease is a brain disorder that causes dementia (a group of symptoms that affect the memory, thinking and social abilities of a person) by destroying the memory and other important mental functions in the brain which is characterized by memory loss, confusion, and behavioral changes.
Before taking DONANCE 10 TABLET, inform your doctor if you are allergic to Donepezil, have asthma, heart, kidney, or liver disease.
DONANCE 10 TABLET is not recommended for use if you have severe liver disease. Consult your doctor before taking medicine.
DONANCE 10 TABLET is generally not recommended for use in pregnant and breastfeeding women unless it is considered clearly necessary. Consult your doctor before taking DONANCE 10 TABLET.
The safety and effectiveness of DONANCE 10 TABLET in pediatric patients have not been established.
The most common side effects of taking DONANCE 10 TABLET are diarrhoea, feeling sick, tiredness, difficulty in sleeping, common cold, loss of appetite, hallucinations, and aggressive behaviour. Consult your doctor if any of these above side effects get worse.
Uses Of DONANCE 10 TABLET
- Used to manage mild to moderately severe Alzheimer’s dementia
How DONANCE 10 TABLET Works
DONANCE 10 TABLET belongs to cholinesterase inhibitor which works by increasing the levels of a chemical messenger (acetylcholine) involved in transmission of nerve signals. This improves memory and thinking. Memory loss in Alzheimer’s disease occurs due to disturbances of signal transmission in the brain.
How to use DONANCE 10 TABLET
Take DONANCE 10 TABLET as advised by your physician. Swallow DONANCE 10 TABLET with a glass of water and do not chew or crush the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of DONANCE 10 TABLET
Common
- diarrhea
- nausea
- headache
- muscle cramp
- tiredness
- difficulty in sleeping (insomnia)
- common cold
- loss of appetite
- hallucinations
- unusual dreams including nightmares
- agitation
- aggressive behaviour
- fainting, dizziness
- indigestion
- vomiting
- rash, itching
- passing urine uncontrollably
- pain
Uncommon
- slow heartbeat
Rare
- uncontrollable or shaky movements with stiffness on the face and tongue which may also involve limbs
- irregular heartbeats
Stop taking DONANCE 10 TABLET and contact your doctor if you experience any of the following side effects:
- signs of stomach or duodenal ulcers such as stomach pain and indigestion
- signs of bleeding in the stomach or intestines such as passing black tar like stools or visible blood from the rectum
- seizures (fits) or convulsions
- signs of hepatitis (liver damage) such as feeling or being sick, loss of appetite, feeling unwell, fever, itching, yellowing of the skin and eyes, and dark coloured urine
- signs of a neuroleptic malignant syndrome (serious brain disorder) such as fever with muscle stiffness, sweating or a lowered level of consciousness
- signs of rhabdomyolysis such as muscle weakness, tenderness or pain, particularly, if at the same time, you feel unwell, have a high temperature or have dark urine
How To Manage Side Effects
Diarrhea
Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to manage diarrhea and consult your doctor if the symptom gets worse.
Dizziness Or Drowsiness
Try to rest and relax and get enough sleep. Try to avoid driving or operating any tools or machines while you are feeling dizzy. Limit your consumption of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom does not improve.
Indigestion
Try to reduce your consumption of tea, coffee, cola or alcohol and lose weight if you are obese. Avoid smoking and do not eat three to four hours before going to bed. Consult your doctor if the symptom does not improve.
Nausea And Vomiting
Try to take DONANCE 10 TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.
Tiredness
Make sure you take rest and drink plenty of fluids. Avoid or limit the consumption of alcohol. Try to take DONANCE 10 TABLET at a time when you can sit down (or lie down) when the symptoms are at their worst. Try not to drive or use tools or machinery until you feel well.
Warning & Precautions
Pregnancy
Monitoring requiredDONANCE 10 TABLET is generally not recommended for use during pregnancy unless it is considered clearly necessary. Consult your doctor before taking DONANCE 10 TABLET.
Breastfeeding
ContraindicatedDONANCE 10 TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking DONANCE 10 TABLET.
Driving and Using Machines
Use with CautionDONANCE 10 TABLET may cause tiredness, dizziness and muscle cramp which could affect your ability to drive or operate machines. If you experience these side effects, do not drive or operate machines. Consult your doctor before taking DONANCE 10 TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking DONANCE 10 TABLET because it may alter the effect of this medicine.
Kidney
Use with CautionDONANCE 10 TABLET should be used with caution in patients with mild kidney disease. Consult your doctor before taking DONANCE 10 TABLET.
Liver
Consult your doctorDONANCE 10 TABLET is not recommended for use in patients with severe liver disease. It should be used with caution in patients with liver problems or hepatitis. Consult your doctor before taking DONANCE 10 TABLET.
Allergy
ContraindicatedDo not take DONANCE 10 TABLET if you are allergic to Donepezil or piperidine derivatives such as haloperidol, thioridazine, or any of the other ingredients of this medicine.
Lungs
Use with CautionDONANCE 10 TABLET should be used with caution in patients with asthma or long-term lung disease. Consult your doctor before taking DONANCE 10 TABLET.
Heart Disease
Use with CautionDONANCE 10 TABLET should be used with caution in patients with heart diseases such as irregular or very slow heartbeat, fast heartbeat, abnormal heart rhythms, family history of prolonged QT interval (fast and chaotic heartbeats), had heart failure, or heart attack. Consult your doctor before taking DONANCE 10 TABLET.
Use In Pediatrics
Consult your doctorThe safety and effectiveness of DONANCE 10 TABLET in pediatric patients have not been established. Consult your doctor before taking DONANCE 10 TABLET.
Use In Geriatrics
Use with CautionDONANCE 10 TABLET should be used with caution in elderly patients (aged 65 years above). Consult your doctor before taking DONANCE 10 TABLET.
Others
Before taking DONANCE 10 TABLET, inform your doctor if you:
- have low levels of magnesium or potassium in your blood
- have difficulty passing urine
- have stomach or duodenal ulcers
- have seizures (fits) or convulsions
Interactions
A. Drug-Drug Interactions:
Before taking DONANCE 10 TABLET, inform your doctor, if you are taking any of the following medicine:
- Anti-arrhythmics (Ex. amiodarone, sotalol)
- Antidepressants (Ex. citalopram, escitalopram, amitriptyline, fluoxetine)
- Antipsychotics (Ex. pimozide, sertindole, ziprasidone)
- Antibiotics (Ex. clarithromycin, erythromycin, levofloxacin, moxifloxacin, rifampicin)
- Anti-fungal agents (Ex. ketoconazole)
- other medicines used to manage Alzheimer’s disease (Ex. galantamine)
- medicines used for arthritis (Ex. aspirin, non-steroidal anti-inflammatory (NSAID) drugs such as ibuprofen, or diclofenac sodium)
- anticholinergics medicines (Ex. tolterodine)
- anticonvulsants (Ex. phenytoin, carbamazepine)
- Cardiac drugs (Ex. quinidine, beta-blockers such as propanolol and atenolol)
- muscle relaxants (Ex. diazepam, succinylcholine)
- general anesthetics (Ex. propofol, ketamine, thiopental)
- medicines obtained without a prescription (Ex. herbal remedies)
Overdosage:
If you or anyone else accidentally takes too much of DONANCE 10 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are feeling and being sick, drooling, sweating, slow heart rate, low blood pressure (lightheadedness or dizziness when standing), breathing problems, losing consciousness and seizures (fits) or convulsions.
Synopsis
| Drug | : | Donepezil |
| Pharmacological Category | : | Acetyl cholinesterase Inhibitor |
| Therapeutic Indication | : | Alzheimer disease |
| Dosage Forms | : | Tablet, Syrup, Orally disintegrating strips |
More Information
Storage
- Keep the medicine out of reach in children
- Store DONANCE 10 TABLET at room temperature
FAQs About DONANCE 10 TABLET
Q: Can DONANCE 10 TABLET cure Alzheimer's disease?
A: No, DONANCE 10 TABLET does not cure Alzheimer's disease. It helps to manage symptoms and may improve cognitive function in some patients.
Q: Can I stop taking DONANCE 10 TABLET suddenly?
A: You should not stop taking DONANCE 10 TABLET suddenly without consulting your doctor. Abruptly stopping the medication may cause a worsening of symptoms.
Q: What should I do if I miss a dose?
A: If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not take two doses at the same time to make up for a missed dose.
Q: Can DONANCE 10 TABLET interact with other medications?
A: Yes, DONANCE 10 TABLET can interact with other medications. It's important to inform your doctor about all the medications you are taking, including over-the-counter drugs, vitamins, and herbal supplements.
Q: Is there a need for regular monitoring while on DONANCE 10 TABLET?
A: Yes, your doctor may monitor your progress regularly to ensure the medication is working effectively and to check for any adverse effects.
Q: What DONANCE 10 TABLET is used for?
A: DONANCE 10 TABLET is indicated for the management of mild to moderately severe Alzheimer’s dementia.
Q: For how long should I take DONANCE 10 TABLET?
A: Your doctor might advise you on how long you should continue to take DONANCE 10 TABLET. You will need to consult your doctor from time to time to review your management and assess your symptoms.
Q: What happens if you take more DONANCE 10 TABLET than your required dose?
A: If you or anyone else accidentally takes too much of DONANCE 10 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are feeling and being sick, drooling, sweating, slow heart rate, low blood pressure (lightheadedness or dizziness when standing), breathing problems, losing consciousness and seizures (fits) or convulsions.
Q: What side effects are seen with DONANCE 10 TABLET?
A: The most common side effects of taking DONANCE 10 TABLET are diarrhoea, feeling sick, tiredness, difficulty in sleeping, common cold, loss of appetite, hallucinations, and aggressive behavior. Consult your doctor if any of these symptoms gets worse. Consult your doctor if any of these symptoms gets worse.
Q: Is it safe to drive after taking DONANCE 10 TABLET?
A: DONANCE 10 TABLET may cause tiredness, dizziness and muscle cramp which could affect your ability to drive or operate machines. If you experience these side effects, do not drive or operate machines. Consult your doctor before taking DONANCE 10 TABLET.
References
1. KD. Tripathi. Central Nervous System Stimulants and Cognition Enhancers. Essentials of medical pharmacology. Seventh edition. 2013. Page-490.
2. Eisai Inc. The Effectiveness and Safety of Donepezil Hydrochloride (E2020) In Subjects with Mild to Severe Alzheimer's Disease Residing in An Assisted Living Facility. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in September 2018] [Accessed on 5th August 2024] https://clinicaltrials.gov/ct2/show/NCT00571064
3. Ben Seltzer. Donepezil: a review. NIH National Library of Medicine, National center for biotechnology information. October 2005. [Accessed on 5th May 2024] https://pubmed.ncbi.nlm.nih.gov/16863459/
4. Eisai Inc. U.S. Food & Drug Administration. [Revised in February 2012] [Accessed on 5th May 2024] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020690s035,021720s008,022568s005lbl.pdf
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