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INTRODUCTION ABOUT DOMSTOP SUSPENSION

DOMSTOP SUSPENSION contains Domperidone which belongs to the group of medicines called Dopamine antagonists. It is used to manage nausea (feeling sick) and vomiting (being sick).

Nausea and vomiting are not a disease but symptoms of different conditions such as infections, food poisoning, motion sickness, overeating, blocked intestine, migraine, indigestion and many more.

DOMSTOP SUSPENSION is not recommended for use in patients having heart or moderate to severe liver diseases, bleeding in the stomach or intestines, blockage or tear in your intestines, and tumors in the pituitary gland (prolactinoma). DOMSTOP SUSPENSION should be used with caution in patients having kidney diseases.

DOMSTOP SUSPENSION should be used with caution in pregnant women and should be used in breastfeeding women only if considered clearly necessary by the doctor. Ask for your doctor’s advice before taking. DOMSTOP SUSPENSION should be used with caution in elderly patients (above 60 years of age).

DOMSTOP SUSPENSION should not be used in children below 12 years or weighing less than 35kgs. Consult with your child’s doctor. The common side effect of taking DOMSTOP SUSPENSION includes dry mouth. Consult with your doctor if this worsens or doesn’t improve.

USES OF DOMSTOP SUSPENSION

manages nausea and vomiting

HOW DOMSTOP SUSPENSION WORKS

DOMSTOP SUSPENSION has an anti-emetic property which acts by blocking a chemical messenger in the brain called dopamine, that transfers information through nerve endings. DOMSTOP SUSPENSION functions by inhibiting the muscle contraction that occurs naturally in the digestive system and enhances the peristaltic movement in the food pipe which helps in facilitating the digestion time faster, this causes calming down effect, thereby relieving nausea or vomiting sensation.

DIRECTIONS FOR USE

Take DOMSTOP SUSPENSION as advised by your physician. Shake well before use. Your doctor will decide the appropriate dose and duration of DOMSTOP SUSPENSION for you depending on your age, body weight and disease condition.

SIDE EFFECTS OF DOMSTOP SUSPENSION

COMMON

dry mouth

UNCOMMON

feeling anxious
feeling drowsy
headache
diarrhoea
itchy skin, rash
unusual production of breast milk in men and women
painful or tender breasts
lowering of sexual desire in men

RARE

Stop taking DOMSTOP SUSPENSION and consult your doctor immediately if you experience any of the following side effects

severe reaction having symptoms such as swelling of the hands, feet, ankle, face, lips and throat which may cause difficulty in swallowing or breathing
itchy lumpy rash (hives), nettle rash (urticaria)
uncontrolled movements, which include irregular movements of eyes, an unusual movement of the tongue, abnormal posture (Ex. twisted neck)
have a fast unusual heartbeat
seizures (fits)

HOW TO MANAGE SIDE EFFECTS

Dry mouth:

Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes that contain alcohol because they can be drying. Consult your physician for advice.

Diarrhoea:

Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. Ask for your doctor’s advice if diarrhoea doesn’t improve.

Headache:

Try to take rest and don’t involve yourself in exertive activities. Rest in a quiet and dark room. Apply a pain-relieving balm on your forehead. Ask for your doctor’s advice if the headache doesn’t improve

Drowsiness:

Take adequate sleep. Do not involve in rigorous activities. Do not interfere with your sleep cycle. Talk to your doctor if the drowsiness doesn’t improve.

Itchy skin:

Hot water makes your skin irritated, so avoid taking hot showers. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. To soothe and hydrate the irritated skin, apply moisturizers. Contact your doctor if itching worsens.

WARNING & PRECAUTIONS

PREGNANCY

DOMSTOP SUSPENSION should be used with caution in pregnant women. Consult your doctor before taking it.

BREASTFEEDING

DOMSTOP SUSPENSION is not recommended for use in breastfeeding women as it may pass through breast milk. DOMSTOP SUSPENSION may cause unwanted side effects affecting the heart in a breastfed baby. It should only be used only if considered clearly necessary by the doctor. Consult your doctor before taking DOMSTOP SUSPENSION.

DRIVING AND USING MACHINES

DOMSTOP SUSPENSION does not affect the ability to drive or use machines.

KIDNEY

DOMSTOP SUSPENSION should be taken with caution in patients with kidney problems such as kidney impairment or kidney failure. Your doctor might consider adjusting your dose. Consult your doctor before taking it.

LIVER

DOMSTOP SUSPENSION is not recommended for use in patients having moderate to severe liver diseases such as liver function impairment or liver failure. Consult your doctor before taking it.

ALLERGY

Do not take DOMSTOP SUSPENSION if you are allergic to Domperidone or any other ingredients present in it.

HEART DISEASE

DOMSTOP SUSPENSION is not recommended in patients suffering from heart problems such as prolonged QT corrected interval (reading in eco cardiogram (ECG) machine) or heart failure (heart cannot pump blood properly). Kindly consult a doctor before taking DOMSTOP SUSPENSION.

OTHERS

DOMSTOP SUSPENSION is not recommended for use if you:

tumor in the pituitary gland (prolactinoma)
history of blockage or tear in the intestine
hypokalemia (low level of potassium)
hyperkalemia (increased levels of potassium in the blood)
hypomagnesemia (decreased levels of magnesium in the blood)
signs and symptoms of bleeding in the stomach or intestine (black tarry bowel motions or blood in your bowel motions)

Use in pediatrics:

DOMSTOP SUSPENSION is not recommended for use in children below 12 years of age or weighing less than 35 kgs. Consult with your child’s doctor before giving DOMSTOP SUSPENSION to your child.

Use in geriatrics:

DOMSTOP SUSPENSION should be used with caution for use over 60 years of age, as DOMSTOP SUSPENSION be associated with an increased risk of heart rhythm disorder and cardiac arrest. Consult your doctor before taking it.

INTERACTIONS

A. Drug-Drug interactions:

Before taking DOMSTOP SUSPENSION, inform your doctor if you are taking any of the following medicines:

medicines to manage fungal infections (Ex. ketoconazole, fluconazole, and voriconazole)
medicines to manage bacterial infections (Ex. erythromycin, clarithromycin, telithromycin, moxifloxacin, pentamidine)
medicine to manage heart problems or high blood pressure (Ex. amiodarone, dronedarone, quinidine, disopyramide, bepridil, dofetilide, sotalol, diltiazem, verapamil)
medicines to manage psychoses (Ex. haloperidol, pimozide, sertindole), medicine to manage depression (Ex. citalopram, escitalopram)
medicines to manage gastrointestinal disorders (such as cisapride, diphemanil, dolasetron, prucalopride)
medicines to manage allergies (Ex. mequitazine, mizolastine)
medicine to manage malaria (specifically halofantrine)
medicines to manage AIDS/HIV (Ex. ritonavir, atazanavir)
medicine to manage cancer (Ex. toremifene, vandetanib, vincamine)
medicine used to manage drug addiction (Ex. methadone)

Overdosage:

If you or anyone else accidentally took too much of this medicine, consult your doctor immediately. The symptoms might include feeling sleepy, confused, uncontrolled movements of the eye and tongue and abnormal posture (like a twisted neck).

SYNOPSIS

Drug	:	Domperidone
Pharmacological Category	:	Dopamine antagonists
Therapeutic Indication	:	Nausea and Vomiting
Dosage Forms	:	Tablets, Capsules, Dispersible tablets, Rapitab, Suspension, Oral Suspension, Syrup, Oral Drops, Drops

MORE INFORMATION

Keep DOMSTOP SUSPENSION out of reach of children
Store DOMSTOP SUSPENSION at room temperature below 30°C

FAQs ABOUT DOMSTOP SUSPENSION

What is DOMSTOP SUSPENSION and why is it prescribed?

DOMSTOP SUSPENSION contains Domperidone which belongs to the group of medicines called Dopamine antagonists. It is used in managing nausea and vomiting.

How long can I take DOMSTOP SUSPENSION?

It is recommended that DOMSTOP SUSPENSION be taken for the shortest period and at the lowest dose. This is because DOMSTOP SUSPENSION can cause an irregular heartbeat when taken for a longer period or at a high dose. Ask for your doctor’s advice.

Can I take DOMSTOP SUSPENSION with antibiotics?

Use of DOMSTOP SUSPENSION with antibiotics like erythromycin, levofloxacin, and some antifungals is not recommended as this can cause interaction. Please consult your doctor for advice before using any antibiotics with DOMSTOP SUSPENSION.

Does DOMSTOP SUSPENSION increase milk secretion?

Yes, DOMSTOP SUSPENSION can increase milk secretion also known as galactorrhoea. This is an uncommon side effect of using DOMSTOP SUSPENSION. Talk to your doctor if you are experiencing this side effect while taking this medicine.

Does DOMSTOP SUSPENSION cause heart problems?

DOMSTOP SUSPENSION may be associated with an increased risk of heart problems (like an irregular heartbeat) and heart attacks. The risk also increases when DOMSTOP SUSPENSION is given together with other medicines. Inform the doctor of your medication history when taking DOMSTOP SUSPENSION.

Does DOMSTOP SUSPENSION cause dry mouth?

Yes, DOMSTOP SUSPENSION can cause dry mouth. Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes that contain alcohol because they can be drying. Consult your physician for advice.

What is the best time to take DOMSTOP SUSPENSION?

It is recommended to take DOMSTOP SUSPENSION before meals. If taken after meals, absorption of the medicine is somewhat delayed. Patients should try to take each dose of DOMSTOP SUSPENSION at a scheduled time to avoid missing a dose.

REFERENCES

1. KD Tripathi. Antiemetics. Essentials of Medical Pharmacology. Eighth edition. 2019. Page - 414.

2. Rhew K, Han N, Oh JM. Impact of Safety Warning on Domperidone Prescribing for Geriatric Patients in South Korea: Analysis of National Insurance Claim Data. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubmed Central. August 2019. [Accessed on 3rd November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719182/

3. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubchem. Domperidone. [Accessed on 3rd November 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Domperidone

4. Savio C Reddymasu, Irfan Soykan, Richard W McCallum. Domperidone: review of pharmacology and clinical applications in gastroenterology. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubmed.gov. September 2007. [Accessed on 3rd November 2022] https://pubmed.ncbi.nlm.nih.gov/17488253/

5. Sofarimex - Industria Quimica e Farmacêutica Lda. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 03rd November 2022] https://www.medicines.org.uk/emc/files/pil.3188.pdf

6. Torrent Pharmaceuticals Ltd. Domstal Baby (Domperidone). [Revised in February 2022] [Accessed on 3rd November 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2518.pdf

7. Medley Pharmaceuticals Ltd. Motinorm drops (Domperidone). [Accessed on 3rd November 2022] https://www.medleylab.com/product/suprakare/anti-emetic.html

8. Torque Pharmaceuticals Pvt. Ltd. Peridon Drops (Domperidone). [Accessed on 3rd November 2022] https://www.torquepharma.com/peridon-drops/

9. Aristo Pharma Ltd. Apuldon (Domperidone). [Accessed on 3rd November 2022]. https://aristopharma.com/upload/product_pdf/1649581141.pdf

AUTHOR DETAILS

Written By Dr. Priyanka Goel - BDS

Last updated on 11 Nov 2022 | 05:10 PM(IST)

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