Dolo 650 Tablet 15's

Introduction About DOLO 650MG TABLET

Dolo 650 Tablet is a widely trusted medicine containing Paracetamol (650 mg), known for its ability to provide effective relief from fever and mild to moderate pain. It works by blocking certain chemical messengers in the brain responsible for pain and temperature regulation. Commonly used under medical supervision, it helps manage discomfort from headache, body pain, back pain, muscle soreness, menstrual pain, toothache, and fever caused by common infections. Its gentle action on the stomach and predictable response make it one of the most recommended fever and pain relief tablets in India.

Dolo 650 Tablet is suitable for adults and children aged 12 years and above who require short-term relief from fever or body pain. It can be taken with or without food but taking it after a meal may help minimize stomach discomfort. Swallow the tablet whole with water do not crush or chew it. Maintain a minimum 4–6-hour gap between doses and avoid exceeding the recommended daily limit. Individuals with persistent pain or fever should consult a doctor before continuing use.

Patients with liver or kidney problems, alcohol consumption habits, or nutritional deficiencies should use Dolo 650 Tablet cautiously and only under medical supervision. Alcohol should be strictly avoided, as it increases the risk of liver injury. During pregnancy, the tablet should be used only if clearly advised by a doctor, particularly in the first trimester. It is generally considered safe during breastfeeding, as minimal amounts pass into breast milk, though consultation with a healthcare professional is recommended before use.

Dolo 650 Tablet is generally well-tolerated when used as directed. Some individuals may experience nausea, mild stomach discomfort, or allergic reactions such as rash or itching. Rarely, excessive or prolonged use may cause liver-related symptoms like yellowing of the skin or eyes, dark urine, or fatigue in such cases, medical attention is necessary. Always store the tablet in a cool, dry place and use only within the prescribed limits to ensure safety and effectiveness.

Uses Of DOLO 650MG TABLET

• Fever
• Headache & body pain
• Menstrual pains
• Signs of Flu, sore throat

Benefits of DOLO 650MG TABLET

Dolo 650 Tablet for Fever

Dolo 650 Tablet is widely used to help reduce fever and discomfort associated with infections, colds, or flu. It works by acting on the brain’s temperature-regulating centre to bring down raised body temperature effectively. The medicine helps you feel more comfortable while your body fights the underlying cause of the fever. It is gentle on the stomach and suitable for most individuals when used as directed.

Dolo 650 Tablet for Body Pain

Dolo 650 Tablet helps relieve mild to moderate body pain, including muscle aches, joint pain, back pain, or general fatigue. It works by blocking pain signals in the brain, providing effective comfort from pain and soreness. Its quick action helps reduce discomfort and allows you to continue your daily activities with ease. It is often preferred due to its reliable pain-relieving effect and good tolerance in most individuals.

How DOLO 650MG TABLET Works

Mechanism of action of Dolo 650 tablet:

Dolo 650 Tablet contains paracetamol (acetaminophen) as its active ingredient. It works by blocking chemical messengers called prostaglandins in the brain that are responsible for pain and fever. By acting on the temperature-regulating center in the hypothalamus, it helps reduce elevated body temperature. This medicine provides relief from mild to moderate pain, such as headache, muscle pain, or body ache. Unlike some other pain relievers, Dolo 650 Tablet is gentle on the stomach and does not interfere with blood clotting. Its effects usually begin within 30 to 60 minutes and last for about 4 to 6 hours.

How to use DOLO 650MG TABLET

How to take Dolo 650 tablet:

• Take Dolo 650 Tablet by mouth with a glass of water.
• It can be taken with or without food but taking it after meals may help reduce stomach discomfort.
• Swallow the tablet whole without crushing or chewing it.
• Maintain a proper time gap between doses as advised by your doctor.
• Do not take more than the recommended number of tablets in 24 hours.
• If your fever or discomfort continues, consult your doctor before continuing use.
• Always read the label or prescription instructions carefully before taking the medicine.

What if I forgot to take DOLO 650MG TABLET

• Take the missed dose of Dolo 650 Tablet as soon as you remember.
• If it’s almost time for your next scheduled dose, skip the missed one.
• Do not take a double dose to make up for the missed tablet.
• Taking more than the recommended dose can increase the risk of liver damage.
• Always follow your doctor’s advice and maintain the correct time gap between doses.
• Use the tablet only when needed for pain or fever relief.

Overdose

Taking an excessive amount of paracetamol may lead to serious liver damage, which can be potentially life-threatening. If an overdose is suspected, it is important to seek medical help right away, even if there are no immediate symptoms. Signs of overdose may include nausea, vomiting, loss of appetite, confusion, or yellowing of the skin and eyes.

Side Effects Of DOLO 650MG TABLET

Common side effects of Dolo 650 tablet:

• Nausea or vomiting
• Stomach discomfort
• Drowsiness or tiredness
• Skin reactions
• Loss of appetite

When to Seek Medical Attention?

Stop taking Dolo 650 tablet and contact your doctor immediately if you experience any of the following side effects:

• Possible signs of liver strain such as nausea, vomiting, yellowing of the skin or eyes, dark urine, itching, or severe abdominal pain.
• Persistent fever that does not reduce after taking the tablet.

How To Manage Side Effects

Warning & Precautions

Other Warnings for DOLO 650MG TABLET

Before taking Dolo 650 tablet, inform your doctor if you:

• have sepsis (blood infection)

Safety Advice

• Dosage Limit: Do not take more than the recommended number of tablets in 24 hours. Overuse can cause serious liver damage.
• Other Medicines: Avoid taking Dolo 650 Tablet along with other products containing paracetamol to prevent accidental overdose.
• Medical Conditions: Inform your doctor if you have anemia, dehydration, malnutrition, or chronic alcohol use before taking this medicine.
• Duration of Use: Do not use Dolo 650 Tablet for an extended period without medical guidance. If discomfort continues, seek professional advice.
• Missed Dose: If you forget a dose, take it as soon as you remember. If it’s almost time for the next dose, skip the missed one do not double the dose.

Diet and Lifestyle Advice

• Stay Hydrated: Drink plenty of water or clear fluids throughout the day to help your body recover and stay hydrated, especially during fever or discomfort.
• Eat Light and Balanced Meals: Choose easy-to-digest foods like soups, fruits, rice, and vegetables. Avoid oily, spicy, or processed foods that may upset the stomach.
• Avoid Alcohol: Refrain from consuming alcohol while taking Dolo 650 Tablet, as it can increase the risk of liver strain.
• Limit Caffeine: High caffeine intake may irritate the stomach; opt for herbal teas or water instead.
• Get Enough Rest: Adequate sleep and rest help your body regain strength and support faster recovery from fever or body discomfort.
• Maintain a Cool Environment: If taking the tablet for fever, stay in a cool, comfortable space to help regulate body temperature.
• Avoid Skipping Meals: Eat small, frequent meals to maintain energy levels and reduce nausea or weakness.
• Consult Before Using Other Medicines: Always inform your doctor about any other prescription, herbal, or over-the-counter medicines you take to avoid interactions.

1. Dolo 650 Tablet vs Crocin 650 Tablet

Parameter	Dolo 650 Tablet	Crocin 650 Tablet
Active Ingredient	Paracetamol 650 mg	Paracetamol 650 mg
Pharmacological Category	Analgesic and Antipyretic	Analgesic and Antipyretic
Primary Use	Helps reduce fever and provides relief from mild to moderate pain (like headache, muscle pain, and body ache)	Used to relieve fever and mild pain such as cold-related fever, toothache, or headache
Manufacturer	Micro Labs Ltd.	GlaxoSmithKline (GSK)
Onset of Action	Usually starts working within 30–60 minutes	Usually starts working within 30–60 minutes
Form	Oral tablet	Oral tablet
Other Ingredients	Standard excipients for stability and absorption	May vary slightly based on formulation
Prescription Requirement	Generally available as an over-the-counter medicine	Generally available as an over-the-counter medicine
Safety Profile	Gentle on the stomach when used as directed; avoid alcohol use	Gentle on the stomach when used as directed; avoid alcohol use

2. Dolo 650 Tablet vs Calpol 650 Tablet

Feature	Dolo 650 Tablet	Calpol 650 Tablet
Active Ingredient	Paracetamol 650 mg	Paracetamol 650 mg
Primary Use for Fever	Helps in lowering body temperature and easing fever-related discomfort.	Used for reducing fever and relieving discomfort from elevated body temperature.
Brand / Manufacturer	Brand: Dolo (Micro Labs Ltd)	Brand: Calpol (GlaxoSmithKline)
Onset & Duration	Starts action within about 30-60 minutes; effect lasts around 4-6 hours.	Similar onset and duration about 30-60 minutes for onset; duration around 4-6 hours.
Key Considerations	Same active ingredient, so therapeutic effect for fever is expected to be similar.	Same active ingredient choice may depend on availability, brand preference, or cost.

Drug - Drug interaction

1. Interaction with Blood Thinners (e.g., Warfarin)

• Interaction: Long-term or frequent use of paracetamol may enhance the effect of blood thinners, increasing the risk of bleeding.
• Management: If you are on warfarin or similar medicines, your doctor may monitor your blood clotting parameters more closely. Avoid using Dolo 650 Tablet regularly without medical supervision.

2. Interaction with Anti-Seizure Medicines (e.g., Phenytoin, Carbamazepine)

• Interaction: These medicines may increase the breakdown of paracetamol in the liver, reducing its effect and increasing the risk of liver damage.
• Management: Use Dolo 650 Tablet cautiously and avoid high or prolonged doses. Your doctor may adjust the dosage or suggest an alternative.

3. Interaction with Rifampicin (used for Tuberculosis)

• Interaction: Rifampicin may increase the metabolism of paracetamol, reducing its effectiveness and increasing the chance of liver toxicity.
• Management: Inform your doctor if you are taking rifampicin. Regular liver function monitoring may be needed.

4. Interaction with Chloramphenicol (Antibiotic)

• Interaction: Taking Dolo 650 Tablet with chloramphenicol may increase the risk of toxicity from the antibiotic.
• Management: Your doctor may adjust the dose or monitor for signs of side effects.

5. Interaction with Antifungal Medicines (e.g., Fluconazole)

• Interaction: Certain antifungal drugs may increase paracetamol levels in the body, leading to possible liver strain
• Management: Use under medical supervision and avoid exceeding the recommended dose.

6. Interaction with Other Paracetamol-Containing Products

• Interaction: Taking multiple products that contain paracetamol can lead to accidental overdose and liver injury.
• Management: Check all medication labels carefully and avoid combining them without a doctor’s advice.

Drug - Food interaction

1. Interaction with Caffeine-Rich Beverages (Tea, Coffee, Energy Drinks)

• Interaction: Excessive caffeine intake may increase restlessness or stomach discomfort and can add stress on the liver when combined with paracetamol.
• Management: Limit caffeine-containing drinks while using Dolo 650 Tablet to prevent overstimulation and support liver health.

2. Interaction with Fatty or Fried Foods

• Interaction: Heavy, fatty, or oily meals can delay the absorption of paracetamol, making it take longer for the medicine to show effect.
• Management: Prefer light and easily digestible meals. If needed, take the tablet after food to avoid stomach upset.

3. Interaction with Herbal or Dietary Supplements

• Interaction: Certain herbal products like St. John’s Wort or Kava may affect liver enzymes and increase the risk of liver strain when taken with paracetamol.
• Management: Inform your doctor about any herbal or dietary supplements you use before starting Dolo 650 Tablet.

4. Interaction with Dehydrating Foods or Low Fluid Intake

• Interaction: Insufficient hydration may slow down drug metabolism and put additional pressure on the liver and kidneys.
• Management: Drink plenty of water and stay hydrated throughout the day while taking the tablet.

Synopsis

Drug	Paracetamol
Pharmacological Category	Analgesic and Antipyretic (Paracetamol-based medicine)
Therapeutic Indication	Provides relief from fever and mild to moderate pain such as headache, muscle pain, body ache, toothache, and menstrual discomfort under medical supervision
Dosage Forms	Oral tablet

More Information

FAQs About DOLO 650MG TABLET

Q: What is Dolo 650 Tablet used for?

A: Dolo 650 Tablet helps reduce fever and relieve mild to moderate pain such as headache, muscle ache, back pain, or toothache. It contains paracetamol, which works by lowering the body’s temperature and easing discomfort. It is suitable for adults and children above 12 years of age, as advised by a doctor.

Q: Can I take Dolo 650 Tablet on an empty stomach?

A: It is generally safe to take Dolo 650 Tablet on an empty stomach but taking it after food is recommended. Having it with or after meals helps reduce the chance of stomach irritation. Always follow your doctor’s advice for best results.

Q: How often can I take Dolo 650 Tablet?

A: You can take Dolo 650 Tablet every 4-6 hours if needed, but not more than 4 tablets (2600 mg) in 24 hours unless advised by a doctor. Taking more than the recommended dose can harm your liver. Always follow the prescribed schedule.

Q: Can I take Dolo 650 Tablet for cold and flu?

A: Yes, Dolo 650 Tablet may help relieve fever, body pain, and headache caused by cold or flu. However, it does not treat the infection itself. If symptoms persist for more than a few days, consult your doctor for further evaluation.

Q: Can Dolo 650 Tablet be taken with other medicines?

A: Inform your doctor about all medicines you are taking before using Dolo 650 Tablet. Combining it with other paracetamol-containing medicines can increase the risk of liver damage. Avoid alcohol and herbal supplements without medical advice.

Q: What are the common side effects of Dolo 650 Tablet?

A: Dolo 650 Tablet is generally well-tolerated, but some people may experience mild side effects such as nausea, stomach discomfort, or allergic skin rashes. If you notice yellowing of the skin, eyes, or dark urine, seek medical help immediately.

Q: What happens if I take too much Dolo 650 Tablet?

A: Taking too much Dolo 650 can cause serious liver damage. Symptoms may include nausea, vomiting, confusion, or yellowing of the skin or eyes. Seek immediate medical help even if you feel fine after an overdose.

Q: Can children take Dolo 650 Tablet?

A: Dolo 650 Tablet is suitable for children aged 12 years and above. For younger children, paracetamol syrup or lower-strength tablets are preferred. Always consult a paediatrician before giving any medicine to a child.

Q: Can I take Dolo 650 Tablet for a headache?

A: Yes, Dolo 650 Tablet is effective in relieving mild to moderate headaches. It helps reduce the pain and discomfort quickly. However, if headaches are frequent or severe, speak to a healthcare professional.

Q: How long does Dolo 650 Tablet take to work?

A: Dolo 650 Tablet usually starts working within 30 to 60 minutes of taking it. The effect may last for 4-6 hours. Always follow the prescribed timing for continued relief from fever or pain.

Q: Can I take Dolo 650 Tablet with milk or juice?

A: Yes, Dolo 650 Tablet can be taken with water, milk, or juice if preferred. However, water is the best choice for proper absorption. Avoid taking it with alcohol or caffeinated beverages.

Q: Can Dolo 650 Tablet cause allergic reactions?

A: Swelling or breathing difficulty. Stop using the tablet and consult a doctor immediately if these symptoms occur.

Q: What should I avoid while taking Dolo 650 Tablet?

A: Avoid drinking alcohol or taking other paracetamol-containing medicines while using Dolo 650. Also, do not exceed the prescribed dose or take it continuously for long periods without consulting a doctor.

Q: Is Dolo 650 Tablet habit-forming?

A: No, Dolo 650 Tablet is not habit-forming. It is a safe pain and fever reducer when used responsibly under medical advice. However, prolonged or excessive use should be avoided.

Q: Can Dolo 650 Tablet be used for menstrual pain?

A: Yes, Dolo 650 Tablet can help relieve mild to moderate menstrual cramps by reducing pain and discomfort. For severe or recurring pain, seek medical advice for additional treatment options.

Q: Can I take Dolo 650 Tablet daily?

A: Dolo 650 Tablet should not be taken daily unless advised by a doctor. It is meant for temporary relief from pain or fever. Long-term or frequent use may affect liver health.

Q: When should I consult a doctor while taking Dolo 650 Tablet?

A: Consult your doctor if your fever lasts more than 3 days or pain continues for over 5 days. Also, seek medical advice if you experience yellowing of the skin, severe nausea, or unusual tiredness.

References

1. KD. Tripathi. NSAIDs and Antipyretic-Analgesics. Essentials of Medical Pharmacology. Seventh edition. 2013. Page-206.
2. Ulderico Freo, Chiara Ruocco, Alessandra Valerio, Irene Scagnol and Enzo Nisoli. Paracetamol: A Review of Guideline Recommendations. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. August 2021. [Accessed on 28th October 2025] 
3. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 28th October 2025]  

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