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Introduction About DOFUSE 250MG INFUSION
DOFUSE 250MG INFUSION contains Dobutamine which belongs to the group of medicines called Cardiac Stimulants. It is used to improve heart functions. It restores heartbeat and blood pressure to normal levels among patients undergoing open heart surgery and in patients having heart failure or any other severe heart conditions that reduces heart rate (such as shock or cardiomyopathies (enlargement of heart muscles)).
It can also be used as an alternative to exercise during stress testing (a procedure used to detect heart problems). DOFUSE 250MG INFUSION is suitable for use both in adults and in children (including infants).
Before receiving DOFUSE 250MG INFUSION inform your doctor if you have asthma or any other respiratory disorders. You must also inform your doctor if you have any allergic conditions or low blood volume as a precaution.
DOFUSE 250MG INFUSION is not suitable for stress testing in patients having any heart or blood vessels disorders that hinder blood flow. It is also not recommended for use in pregnant and in breastfeeding women unless considered necessary by the physician.
The most common side effects of receiving DOFUSE 250MG INFUSION are fast heartbeat, headache, high or low blood pressure, shortness of breath, inflammation at the injection site, nausea and urge to pass urine. Consult your doctor if any of these side effects worsens.
Uses Of DOFUSE 250MG INFUSION
- Improves heart functions by restoring normal heartbeat and blood pressure
- Manage heart failure
- Manage shock (cardiogenic or septic shock)
- Manage any heart conditions that may result in poor circulation around the body (such as cardiomyopathies, open heart surgery)
- Used as an alternative to exercise during stress testing
How DOFUSE 250MG INFUSION Works
DOFUSE 250MG INFUSION is a cardiac stimulant. It stimulates the heart and improves heart functions. It helps your heart to work more effectively by strengthening the pumping action of the heart. It also improves blood circulation around the body by expanding the blood vessels present all over the body.
How to use DOFUSE 250MG INFUSION
DOFUSE 250MG INFUSION will be given only by a doctor or by a trained healthcare professional into the vein (intravenously).
Your doctor will decide the correct dose, duration of therapy and site of administration for you depending upon your age, body weight and health condition.
Side Effects Of DOFUSE 250MG INFUSION
Common
- increased heart rate
- chest pain
- abnormal heartbeat, palpitations
- high or low blood pressure
- narrowing of the blood vessels
- headache
- wheezing, shortness of breath
- increase in WBC count in blood
- increased bleeding tendency
- urge to pass urine
- nausea
- skin rash
- fever
- inflammation at the injection site
How To Manage Side Effects
Headache:
Try to take rest. Apply a pain-relieving balm on your forehead. If the symptom does not improve, consult with your doctor.
Nausea:
Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your symptom worsens.
Skin rash:
Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.
Inflammation at the site of injection:
Place an ice pack on the injected site. Do not move the affected area frequently. If the symptom worsens, consult your doctor.
Warning & Precautions
Pregnancy
DOFUSE 250MG INFUSION is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, inform your doctor before receiving this medicine if you are pregnant or think you may be pregnant or planning to have a baby.
Breastfeeding
DOFUSE 250MG INFUSION is not recommended for use in breastfeeding women. Therefore, inform your doctor before receiving this medicine if you are breastfeeding.
Driving and Using Machines
Do not drive or operate any machines if your ability is affected by DOFUSE 250MG INFUSION.
Allergy
Do not receive DOFUSE 250MG INFUSION if you are allergic to Dobutamine.
Lungs
DOFUSE 250MG INFUSION should be used with caution in patients with asthma or any allergic or respiratory conditions. Therefore, consult your doctor before receiving it.
Heart Disease
DOFUSE 250MG INFUSION is not recommended for use in patients who have narrowing of blood vessels supplying the heart (coronary artery stenosis) or other heart disorders. It should be used with caution in patients with other heart problems (such as coronary artery disease, or acute heart failure). Therefore, consult your doctor before receiving it.
Others
DOFUSE 250MG INFUSION is not recommended for use if you:
- have low blood volume (hypovolaemia)
- have any disorders in the blood vessels that hinders blood flow
Before receiving DOFUSE 250MG INFUSION, inform your physician if you:
- are allergic to sulfites
Use in pediatrics:
DOFUSE 250MG INFUSION should be used with caution in children and adolescents (aged between 0-18 years). Proper dose adjustments and careful monitoring are required in such patients.
Use in geriatrics:
DOFUSE 250MG INFUSION should be used with caution in elderly patients. Therefore, consult your doctor before receiving it.
Interactions
A. Drug-Drug interactions:
Before receiving DOFUSE 250MG INFUSION, inform your doctor if you are taking any of the following medicines such as:
- inhaled general anesthetics (used to cause loss of consciousness) such as halothane
- medicines used to control blood pressure, angina or other heart problems (such as atenolol, propranolol, phentolamine, bisoprolol, amlodipine, nitroglycerin, isosorbide mononitrate, captopril, enalapril, ramipril, lisinopril)
- alpha blockers (used to manage BPH) such as doxazosin, terazosin, prazosin
- dopamine (a medicine used to improve heart rate and blood pressure)
Overdosage:
DOFUSE 250MG INFUSION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, inform your doctor immediately if you experience any unusual symptoms such as nausea, vomiting, anxiety, racing heartbeat, headache, chest pain and shortness of breath.
Synopsis
| Drug | : | Dobutamine |
| Pharmacological Category | : | Ionotropic agent (selective beta-1 adrenergic agonist) |
| Therapeutic Indication | : | Heart conditions |
| Dosage Forms | : | Injection, Tablet |
More Information
- Keep DOFUSE 250MG INFUSION out of reach of children
- Store DOFUSE 250MG INFUSION at room temperature
- Protect DOFUSE 250MG INFUSION from direct sunlight
FAQs About DOFUSE 250MG INFUSION
Q: What is the use of DOFUSE 250MG INFUSION?
A: DOFUSE 250MG INFUSION is used to improve heart functions. It restores heartbeat and blood pressure to normal levels among patients undergoing open heart surgery and in patients having heart failure or any other severe heart conditions that reduces heart rate (such as shock or cardiomyopathies (enlargement of heart muscles)). It can also be used as an alternative to exercise during stress testing (a procedure used to detect heart problems).
Q: Is DOFUSE 250MG INFUSION safe?
A: DOFUSE 250MG INFUSION is safe when used under proper medical supervision and at the prescribed doses.
Q: What DOFUSE 250MG INFUSION does to my heart?
A: DOFUSE 250MG INFUSION is a cardiac stimulant. It stimulates the heart and improves heart functions. It helps your heart to work more effectively by strengthening the pumping action of the heart. It also improves blood circulation around the body by expanding the blood vessels present all over the body.
Q: What precautions do I need to follow before receiving DOFUSE 250MG INFUSION?
A: Before receiving DOFUSE 250MG INFUSION inform your doctor if you have asthma or any other respiratory disorders. You must also inform your doctor if you have any allergic conditions, low blood volume, any heart or blood vessels disorders that hinder blood flow as a precaution. Do not receive DOFUSE 250MG INFUSION without informing your doctor if you are pregnant or breastfeeding.
Q: How DOFUSE 250MG INFUSION is administered?
A: DOFUSE 250MG INFUSION will be given only by a doctor or by a trained healthcare professional into the vein (intravenously).
Q: Can DOFUSE 250MG INFUSION cause an increase in heart rate?
A: Yes. DOFUSE 250MG INFUSION is known to increase heart rate and is used to restore your heart rate during emergency conditions like cardiac failure.
Q: Can DOFUSE 250MG INFUSION cause high blood pressure?
A: Yes. DOFUSE 250MG INFUSION can be used to increase blood pressure in patients suffering from low blood pressure caused due to septic shock. For this reason, it should be used with caution in patients having hypertension. Therefore, inform your doctor before receiving it.
Q: Is DOFUSE 250MG INFUSION safe for use during pregnancy?
A: DOFUSE 250MG INFUSION is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, inform your doctor before receiving DOFUSE 250MG INFUSION if you are pregnant or think you may be pregnant or planning to have a baby.
Q: How long with it take for DOFUSE 250MG INFUSION to restore heart functions?
A: It may take around 1-2 minutes for this medicine to start working. The peak effect will be reached within 10 minutes of administration. However, this period may slightly vary between person-to-person based on their health condition.
References
1. KD. Tripathi. Adrenergic system and drugs. Essentials of medical pharmacology. 7th Edition. 2013. Page – 133, 134.
2. S. Shafia, Dobutamine use in Cardiac Patients. World Journal of Pharmaceutical and Medical Research. October 2016. [Accessed on 11th January 2023] https://www.researchgate.net/publication/309175269_DOBUTAMINE_USE_IN_CARDIAC_PATIENTS
3. hameln pharma ltd. Electronics Medicines Compendium (EMC). [Revised in February 2022]. [Accessed on 11th January 2023] https://www.medicines.org.uk/emc/files/pil.6270.pdf
4. Central Drugs Standard Control Organization. Dobutamine HCl injection. [Accessed on 11th January 2023] https://cdscoonline.gov.in/CDSCO/Drugs
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