Distinon 60mg Tablet 10'S

Introduction About DISTINON 60MG TABLET

Distinon 60mg Tablet contains Pyridostigmine Bromide, often included in care routines that support neuromuscular function. It may be advised by healthcare experts for individuals managing certain muscle-related conditions like myasthenia gravis, paralytic ileus (paralysis of digestive tract muscles) and urinary retention after surgery. It is commonly used as part of a broader care approach under medical supervision.

Pyridostigmine works by stopping the breakdown of a chemical called acetylcholine, which is required to stimulate muscle movement by improving the communication between nerves and muscles.

Do not take DISTINON 60MG if your digestive or urinary tract is obstructed. Inform your doctor if you have kidney, heart, or thyroid problems, stomach ulcer, fits, or parkinson’s disease. DISTINON 60MG should be used in pregnant women only if considered necessary by your doctor. It should be used with caution among breastfeeding women.

Common side effects of taking DISTINON 60MG are nausea, vomiting, diarrhea, stomach cramps or pains, low blood pressure, muscle cramps and twitching. Contact your doctor if any of the symptoms worsen.

Uses Of DISTINON 60MG TABLET

Manages:

• myasthenia gravis
• paralytic ileus
• urinary retention after surgery

Benefits of DISTINON 60MG TABLET

• Supports neuromuscular transmission
• Often included in care plans involving muscle fatigue and strength-related concerns
• May help in daily function and mobility when used as advised

How DISTINON 60MG TABLET Works

• Blocks Acetylcholinesterase Activity
  Pyridostigmine temporarily blocks the enzyme called acetylcholinesterase, which normally breaks down acetylcholine (a neurotransmitter).
• Increases Acetylcholine Levels at Neuromuscular Junctions
  By preventing this breakdown, the amount of acetylcholine in the neuromuscular junction increases. This leads to improved signaling between nerves and muscles.
• Enhances Muscle Contraction
  The boost in acetylcholine helps the muscles receive stronger signals, improving muscle contraction and strength, especially useful in conditions where this communication is weak.

How to use DISTINON 60MG TABLET

How Should You Take Distinon 60mg Tablet?

Distinon 60mg is typically taken orally with a glass of water. It is important to follow the dosage schedule recommended by your healthcare provider. The dosage may vary depending on your age, muscle strength, and how your body responds to the medicine.

Can Distinon Be Taken With or Without Food?

Distinon can be taken with or without food, although some individuals may find it easier on the stomach when taken after a light meal or snack. If it causes stomach discomfort or nausea, taking it with food may help minimize these effects.

When Is the Best Time to Take Distinon 60mg?

The ideal time to take Distinon depends on your daily routine and symptom pattern.

• Many individuals take their first dose in the morning, especially if symptoms like muscle weakness appear early in the day.
• Spacing doses evenly through the day helps maintain steady levels in the body.

Always follow the interval and frequency recommended by your doctor.

Dosage Frequency and Duration: What to Know

• The usual frequency ranges from 2 to 5 times daily, depending on individual needs.
• Dosage intervals may be customized (e.g., every 4 to 6 hours) to match symptom timing.
• Avoid sudden stopping; always consult your doctor before making any changes.

The total duration of use is based on clinical evaluation and progress tracking.

How to Take Distinon 60mg Safely at Home

Here are a few tips for safe use at home:

• Store at room temperature, away from heat or moisture.
• Keep track of your muscle strength or energy levels to discuss at your next follow-up.
• Maintain a medicine log or diary if taking multiple medications.
• Keep the tablet in its original packaging to avoid confusion.

What if I forgot to take DISTINON 60MG TABLET

• If you miss a dose, take it as soon as you remember.
• If it is almost time for your next scheduled dose, skip the missed dose—do not double up.
• Setting a daily reminder can help maintain consistency.

Overdose

Consult your doctor immediately or visit the nearby hospital in case of overdosage. Symptoms of overdose are muscle or stomach cramps, diarrhea, nausea, vomiting, increased saliva, pin-point pupils of the eyes, sweating, muscle twitching, weakness and slow heartbeat.

Side Effects Of DISTINON 60MG TABLET

COMMON

• nausea, vomiting
• diarrhea, stomach cramps or pains
• increased saliva
• chest tightness, low blood pressure
• muscle cramps and twitching

Rare but Notable Effects: What You Should Know

• skin rash
• Breathing difficulty
• Slow heartbeat
• Unusual tiredness

When to Seek Immediate Medical Attention:

• allergic reaction (sudden wheeziness, trouble breathing, swelling of the eyelids, face or lips, rash or itching affecting your whole body)
• cholinergic crisis (visual disturbance, more than normal tear or phlegm production, irregular heartbeat, rash, too much sweating, shaking, sudden urgency to urinate)

What to Expect with Distinon 60mg

• Some individuals may notice improved muscle control or reduced fatigue over time. However, response varies, and continuous follow-up with a healthcare provider is essential for safe and optimal usage.

Warning & Precautions

Pregnancy

Consult your doctor

Pyridostigmine has been classified by the U.S. FDA as Pregnancy Category C, meaning animal studies have shown adverse effects, and there are no well-controlled studies in humans but potential benefits may outweigh risks in certain cases. Animal reproduction studies report mild to moderate effects on fetal weight or development, but typically only at very high doses.

Breastfeeding

Use with Caution

DISTINON 60MG should be used with caution in breastfeeding women as a small amount is passed in the breast milk. Lactating individuals may be able to use pyridostigmine under medical supervision, monitoring the infant for signs of increased secretions, restlessness, or feeding difficulties is advisable.

Driving and Using Machines

Consult your doctor

Consult your doctor if you have any side effect that may stop you from driving or using machines.

Kidney

Consult your doctor

DISTINON 60MG is not considered for use in patients who cannot pass urine because of an obstruction. DISTINON 60MG should be taken cautiously in patients with kidney disease or impairment. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take DISTINON 60MG if you are allergic to Pyridostigmine or any of the other ingredients of this medicine.

Lungs

Use with Caution

DISTINON 60MG should be used cautiously in patients with obstructive respiratory diseases like bronchial asthma or chronic obstructive pulmonary disease (COPD).

Heart Disease

Use with Caution

DISTINON 60MG should be taken cautiously in patients with slow heart rate, a recent blockage in a blood vessel to the heart, low blood pressure, or irregular heartbeat.

Use In Pediatrics

Consult your doctor

Your doctor will prescribe the correct dose of DISTINON 60MG for your child, depending on age, body weight and health condition.

Use In Geriatrics

Use with Caution

DISTINON 60MG should be used cautiously in elderly patients (aged above 65 years) with irregular heartbeat or other heart condition.

Other Warnings for DISTINON 60MG TABLET

Before taking DISTINON 60MG, inform your doctor if you:

• have fits
• have stomach ulcer
• have parkinson’s disease
• have vagotonia (a disruption of the vagus nerve causing constipation, sweating and muscle cramps)
• have an overactive thyroid
• had a surgery to remove your thymus gland
• intolerance to some sugars

Who should not take [GBNKEYWORD

DISTINON 60MG is not recommended for use, if you:

• have twisted or obstructed digestive tract

Diet and Lifestyle Advice

1. Stay Hydrated Throughout the Day

Pyridostigmine may increase sweating or cause mild stomach discomfort. Drinking enough water can help maintain electrolyte balance and reduce fatigue.

2. Eat Small, Balanced Meals

Large meals may worsen muscle fatigue in some individuals. Consider eating smaller, more frequent meals that are rich in proteins, complex carbohydrates, and fiber.

Foods that support muscle activity:

• Lean protein (tofu, fish, eggs)
• Whole grains (brown rice, oats)
• Leafy greens and fresh fruits

Avoid heavy, greasy meals if experiencing digestive upset.

3. Be Mindful of High-Fiber or Gassy Foods

Some users may experience mild bloating or cramping. Limit intake of cabbage, beans, carbonated beverages, and excessive raw vegetables if you notice such issues.

4. Maintain a Consistent Daily Routine

Try to take your tablet at the same time daily as advised by your healthcare provider. This supports stable blood levels and reduces symptom fluctuations.

5. Gentle Exercise and Rest Balance

Low-impact activities such as walking, stretching, and yoga can help support muscle flexibility and general well-being. Avoid overexertion and balance activity with rest periods.

6. Support Emotional Wellbeing

Living with a condition that affects muscle strength can affect mood. Consider stress-reducing habits like:

• Breathing exercises
• Journaling
• Joining patient support groups (online or offline)

7. Keep a Symptom and Food Journal

Track how you feel after eating specific foods or adjusting your routine. This helps you and your provider identify patterns and optimize your plan.

Drug - Drug interaction

Synopsis

More Information

Comparison of Distinon 60mg Tablet with Similar Medicines

Did you know

• Pyridostigmine bromide was first introduced in the 1950s as a derivative of neostigmine, designed to have fewer gastrointestinal side effects and a longer duration of action. It is now used globally in supporting conditions involving nerve-to-muscle transmission.
• Pyridostigmine was issued as a nerve agent pretreatment in military settings (e.g., during the Gulf War) to help preserve enzyme function in case of exposure to certain chemical agents. This highlights its unique pharmacological properties and global significance.
• Distinon does not act on muscles directly. Instead, it enhances the communication between nerves and muscles, helping improve voluntary movement in conditions where this transmission is disrupted.
• Taking Distinon with food may delay how quickly it starts working, but it may reduce stomach-related side effects like cramping or nausea. That is why dosing schedules are often customized.
• Distinon is frequently included in international clinical guidelines for supporting individuals with autoimmune or genetic neuromuscular transmission disorders—conditions that often require lifelong management and support.

FAQs About DISTINON 60MG TABLET

References

1. Tilo Grosser, Emer Smyth and Garret A. FitzGerald. Anticholinergic Agents. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 213.

2. Maggi, L., & Mantegazza, R. Management of myasthenia gravis. SpringerLink. August 2012. [Accessed on 1st August 2025] 

3. University of Aarhus. Effect of Pyridostigmine (Mestonin) on Muscle Strength in myasthenia Gravis. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in April 2018] [Accessed on 1st August 2025] 

4. Labiana Pharmaceuticals S.L.U. Health Products Regulatory Authority (HPRA). [Revised in December 2019] [Accessed on 1st August 2025] 

5. Actavis Group PTC ehf. Pyridostigmine. [Revised in March 2022] [Accessed on 1st August 2025] 

6. Bausch Health Companies Inc. Pyridostigmine. [Revised in December 2020] [Accessed on 1st August 2025] 

7. iNova Pharmaceuticals (Australia) Pty Limited. Pyridostigmine. [Revised in March 2021] [Accessed on 1st August 2025] 

Useful Diagnostic Tests

• Edrophonium test
• Electromyography (EMG)
• CT-scan
• MRI Scan
• Serum cholinesterase levels
• Thymus imaging

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Srikar Modepu - MBBS, MD (Diabetology)

Last updated on 07 Aug 2025 | 12:19 PM(IST)