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Introduction About DISMOL P 500/50MG INJECTION
DISMOL P 500/50MG INJECTION is a combination of Paracetamol and Tramadol which belongs to the group of medicines called Analgesics and Opioid Analgesics respectively. DISMOL P 500/50MG INJECTION is used in the management of moderate to severe pain.
Pain is a complex and unpleasant sensation consisting of a physiological and a psychological response to a noxious stimulus. Pain is a warning mechanism that protects us by influencing it to withdraw from harmful stimuli, which is primarily associated with injury.
Before receiving DISMOL P 500/50MG INJECTION, inform your doctor if you have respiratory disorders, gastrointestinal obstruction, including paralytic ileus, fits or seizures, have recently suffered from a head injury, depression, kidney or liver problems.
DISMOL P 500/50MG INJECTION is not recommended for use in pregnant women and during breast-feeding more than once as it may pass through breast milk.
DISMOL P 500/50MG INJECTION is not recommended for use in children (under 12 years of age) and should be used with caution in elderly patients (aged 65 years and above).
The common side effects of receiving DISMOL P 500/50MG INJECTION are nausea, dizziness, drowsiness, vomiting, gastrointestinal problems (such as constipation, flatulence, diarrhoea), stomach pain and dry mouth. Inform your physician if any of the side effects worsen.
Uses Of DISMOL P 500/50MG INJECTION
- Manage moderate to severe pain
How DISMOL P 500/50MG INJECTION Works
DISMOL P 500/50MG INJECTION contains Tramadol and Paracetamol. Tramadol acts on pain receptors present in the central nervous system. It blocks the nerve signals responsible for pain. Paracetamol acts as an analgesic by inhibiting the release of certain chemical mediators that produce pain. Tramadol and paracetamol, in combination, have a faster action and provide quick relief from pain.
How to use DISMOL P 500/50MG INJECTION
DISMOL P 500/50MG INJECTION is given to you by your physician or nurse. DISMOL P 500/50MG INJECTION is given into the vein (intravenously). Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of DISMOL P 500/50MG INJECTION
Common
- nausea
- dizziness, drowsiness
- vomiting
- digestion problems (constipation, flatulence, diarrhoea)
- stomach pain
- dry mouth
- itching, sweating
- headache, shaking
- confusion, sleep disorders, mood changes (anxiety, nervousness, feeling of high spirits)
Uncommon
- increase in pulse or blood pressure increase in pulse or blood pressure, heart rate or heart rhythm disorders
- difficulty or pain on passing water/protein in the urine
- skin reactions (such as rashes, hives)
- tingling or numbness sensation in hands or feet, ringing in the ears, involuntary muscle twitching
- depression, nightmares, memory lapses
- difficulty swallowing, blood in the stools
- shivering, hot flushes, pain in the chest
Rare
- uncoordinated movements
- addiction
- blurred vision
Stop receiving DISMOL P 500/50MG INJECTION and contact your doctor immediately if you experience any of the following side effects:
- allergic rection (signs include skin rashes, sudden swelling of the face and neck, difficulties breathing or drop of blood pressure and fainting)
- hallucinations (hearing, seeing or sensing things that are not really there)
- breathing difficulty
- fits
- transient loss of consciousness (syncope)
How To Manage Side Effects
Nausea or vomiting:
Stick to simple meals. Avoid eating oil rich, fried or spicy foods. Inform your doctor if the symptom does not improve.
Diarrhoea:
Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Inform your doctor if the symptom does not improve.
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Inform your doctor if the symptom does not improve.
Constipation:
Take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Inform your doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
DISMOL P 500/50MG INJECTION is generally not recommended for use in pregnant women. Consult your doctor before receiving it.
Breastfeeding
DISMOL P 500/50MG INJECTION is not recommended for use in breast-feeding women. Consult your doctor before receiving it.
Driving and Using Machines
Do not drive or operate any machines if you feel drowsy after receiving DISMOL P 500/50MG INJECTION.
Alcohol
Avoid consumption of alcohol while receiving DISMOL P 500/50MG INJECTION because it might make you feel drowsy and it is not recommended for use in patients with acute alcohol poisoning.
Kidney
DISMOL P 500/50MG INJECTION should be used with caution in patients with kidney problems. Consult your doctor before receiving DISMOL P 500/50MG INJECTION.
Liver
DISMOL P 500/50MG INJECTION is not recommended for use in patients with severe liver disorder and should be used with caution in patients with liver problems or jaundice. Consult your doctor before receiving DISMOL P 500/50MG INJECTION.
Allergy
Do not receive DISMOL P 500/50MG INJECTION if you are allergic to Paracetamol, Tramadol or any other ingredients of this medicine.
Lungs
DISMOL P 500/50MG INJECTION should be used with caution in patients who have severe difficulties in breathing like asthma or severe lung problems. Consult your doctor before receiving DISMOL P 500/50MG INJECTION.
Others
DISMOL P 500/50MG INJECTION is not recommended for use if you:
- have epilepsy (which is not adequately controlled by your current medicine)
- known or suspected gastrointestinal obstruction including paralytic ileus
Before receiving DISMOL P 500/50MG INJECTION, inform your doctor if you:
- have epilepsy or already experienced fits or seizures
- have recently suffered from a head injury, shock or severe headaches associated with vomiting
- have depression
Use in paediatrics:
DISMOL P 500/50MG INJECTION is not recommended for use in children (under 12 years of age). Consult your child’s doctor for advice.
Use in geriatrics:
DISMOL P 500/50MG INJECTION should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before receiving it.
Interactions
A. Drug-Drug interactions:
Before receiving DISMOL P 500/50MG INJECTION, inform your doctor if you are taking any of the following medicines:
- medicines used to manage nausea and vomiting (Ex. metoclopramide, domperidone or ondansetron)
- medicines used against infections (Ex. ketoconazole, flucloxacillin, erythromycin)
- medicine used to reduce cholesterol in the blood (Ex. cholestyramine)
- medicine used in the management of depression or Parkinson’s disease (Ex. monoamine oxidase inhibitors such as phenelzine, isocarboxazid)
- amitriptyline (used to manage depression)
- medicine used to help stop smoking (Ex. bupropion)
- baclofen (used as muscle relaxant)
- warfarin, phenprocoumon (used to manage or manage blood clots)
- medicine used to manage epilepsy (Ex. carbamazepine)
- morphine, buprenorphine, nalbuphine or pentazocine (used to manage severe pain)
Overdosage:
DISMOL P 500/50MG INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. Consult your doctor immediately if you feel any unusual symptoms.
Synopsis
| Drug | : | Paracetamol, Tramadol |
| Pharmacological Category | : | Analgesics, Opioid analgesics |
| Therapeutic Indication | : | Moderate to severe pain |
| Dosage Forms | : | Tablet, Injection |
More Information
- Store at room temperature
FAQs About DISMOL P 500/50MG INJECTION
What is DISMOL P 500/50MG INJECTION used for?
DISMOL P 500/50MG INJECTION is used in the management of moderate to severe pain. Tramadol and paracetamol, in combination, have a faster action and provide quick relief from pain. Your doctor may recommend this combination only when it is needed.
What are the common side effects of DISMOL P 500/50MG INJECTION?
The common side effects of receiving DISMOL P 500/50MG INJECTION are nausea, dizziness, drowsiness, vomiting, digestion problems (such as constipation, flatulence, diarrhoea), stomach pain, dry mouth, itching, headache, confusion, sleep disorders and mood changes. Consult your physician if any of the side effects worsen.
Is DISMOL P 500/50MG INJECTION safe to use in breastfeeding women?
DISMOL P 500/50MG INJECTION is not recommended for use during breast-feeding more than once as it may pass through breast milk. Consult your doctor for advice before receiving this medicine.
Can DISMOL P 500/50MG INJECTION be used in patients with liver problems?
DISMOL P 500/50MG INJECTION is not recommended for use in patients with severe liver disorder and should be used with caution in patients with liver problems or jaundice. Consult your doctor before receiving it.
Does DISMOL P 500/50MG INJECTION cause constipation?
DISMOL P 500/50MG INJECTION may cause constipation in some individuals. To manage this effect, take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Inform your doctor if the symptom does not improve.
References
1. KD. Tripathi. Opioid Analgesics and Antagonists. Essentials of medical pharmacology. seventh edition. 2017. Page – 469.
2. Moron Merchante I, Pergolizzi JV Jr, van de Laar M, Mellinghoff HU, Nalamachu S, O'Brien J, Perrot S, Raffa RB. Tramadol/Paracetamol fixed-dose combination for chronic pain management in family practice: a clinical review. NIH, National Library of Medicine, National center for biotechnology information. April 2013 [Accessed on 18th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041254/
3. Joseph V Pergolizzi, Jr, Mart van de Laar, Richard Langford, Hans-Ulrich Mellinghoff, Ignacio Moron Merchante, Srinivas Nalamachu, Joanne O’Brien, Serge Perrot, and Robert B Raffa. Tramadol/paracetamol fixed-dose combination in the management of moderate to severe pain. NIH, National Library of Medicine, National center for biotechnology information. August 2012. [Accessed on 18th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442743/
4. Janssen Pharmaceutica (Pty) Ltd. Tramacet Tablets (Paracetamol Plus Tramadol). [Revised in February 2016] [Accessed on 18th November 2022] https://www.sahpra.org.za/wpcontent/uploads/2020/06/TRAMACET_PI_Janssen-Pharmaceutica_MCC-Format15-February-2016.pdf
5. Ronak Exim Private Limited. Food and Drugs Authority (Ghana FDA) Paracetamol Plus Tramadol. [Revised in December 2019] [Accessed on 18th November 2022] https://fdaghana.gov.gh/img/pils/Tdrona%20Plus%20Tablets%20(Paracetamol%20and%20Tramadol%20Hydrochloride).pdf
6. Accord Healthcare Limited. Health Products Regulatory Authority (HPRA). [Revised in April 2022] [Accessed on 18th November 2022] https://www.hpra.ie/img/uploaded/swedocuments/69c7503f-69b6-4157-bb80-4c4fdbeff3ba.pdf
7. Janssen Ortho LLC. U.S. Food & Drug Administration. [Revised in August 2017] [Accessed on 18th November 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021123s014lbl.pdf
8. Grunenthal Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 18th November 2022] https://www.medicines.org.uk/emc/files/pil.455.pdf
Useful Diagnostic Tests
- Liver function test
- Kidney function test
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