Direc 2mg Solution 25ml

Introduction About DIREC 2MG SOLUTION

DIREC 2MG SOLUTION contains Diazepam which belongs to the group of medicines called Benzodiazepines. DIREC 2MG SOLUTION is used in adults for short term (14 days) management of severe anxiety occurring with or without insomnia (sleeping difficulty) or other mental disorder, muscle spasms, cerebral palsy (condition causing muscle rigidity), epilepsy, to relieve the symptoms of acute alcohol withdrawal, to control muscle spasm due to tetanus.

DIREC 2MG SOLUTION is used in children above 6 months of age for management of night terrors or sleep walking, muscle spasms due to tetanus (nervous system disease caused by bacteria toxin), for management of tension and irritability caused due to cerebral palsy. It is also used in both adults and children before surgery helps patient to relax and sleep.

Avoid alcohol, grapefruit juice, caffeinated drinks while taking DIREC 2MG SOLUTION as it may lead to unwanted effects.

DIREC 2MG SOLUTION is not recommended for use in patients suffering from severe breathing problems, severe liver disease, phobia, chronic psychosis, hyperkinesis (excessive restlessness), myasthenia gravis, severe liver disease, sleep apnoea, unmanageed depression with or without anxiety. Consult your doctor before taking.

DIREC 2MG SOLUTION should be used with caution in patients suffering from alcoholism and drug abuse, kidney problems, personality disorder, epilepsy, self-harming thoughts and arteriosclerosis. Consult your doctor before taking.

DIREC 2MG SOLUTION is not recommended for use in pregnant women or planning a pregnancy. DIREC 2MG SOLUTION is not recommended for use in breast feeding women as it may pass through breast milk. Consult your doctor before taking.

DIREC 2MG SOLUTION is not recommended for use in children below 6 months of age as its safety is not established. Consult your doctor before giving DIREC 2MG SOLUTION to your child.

DIREC 2MG SOLUTION should be used with caution in elderly patients as it may cause sedation, drowsiness, confusion and have effects on muscles causing falls and injuries. Consult your doctor before taking.

The most common side effects of taking DIREC 2MG SOLUTION are drowsiness, confusion, ataxia (uncoordinated muscle movements) tremor, fatigue, withdrawal symptoms. Consult your doctor in case any of side effects worsens.

Uses Of DIREC 2MG SOLUTION

It is used for the following conditions:

• short term management for severe anxiety occurring with or without insomnia or other mental disorder
• muscle spasms, cerebral palsy
• epilepsy   
• symptoms of acute alcohol withdrawal symptoms
• muscle spasm due to tetanus (in adults and children)
• night terrors, sleep walking, manages tension and irritability caused due to cerebral palsy (in children)

DIREC 2MG SOLUTION is also used in both adults and children before surgery help patient to relax and sleep.

How DIREC 2MG SOLUTION Works

DIREC 2MG SOLUTION belongs benzodiazepine which works by binding to specific receptors in brain and enhancing the activity of an inhibitory neurotransmitter (a chemical in brain) GABA which in result suppress the abnormal and excessive activity of neurons in brain.

How to use DIREC 2MG SOLUTION

Take DIREC 2MG SOLUTION as advised by your physician. Shake DIREC 2MG SOLUTION well before use. Your doctor will decide the exact dose and duration of management for you depending upon your age, body weight and disease condition.

Side Effects Of DIREC 2MG SOLUTION

How To Manage Side Effects

Nausea or Vomiting:

Take the medicine, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if nausea and vomiting worsen.

Itchy skin:

Avoid hot showers because hot water can irritate the skin and do not scratch the affected area. Use sunscreen and protective clothing when going outdoors or use unscented moisturizers to soothe and hydrate the skin. Contact your doctor if itching persists.

Constipation:

Eat plenty of fibre rich foods such as fresh fruits, vegetables and cereals. Drink plenty of water and exercise regularly. Contact your doctor in case constipation persists.

Diarrhoea:

Drink plenty of water or fruit juices to keep you hydrated. Do not take any medicine on your own for managing diarrhoea and contact your doctor if diarrhoea worsen.

Headache:

Rest and relax. Drink plenty of water and electrolytes. Apply a pain-relieving balm on the head if needed. Do not consume alcohol and contact your doctor if your headache did not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operate machinery if you feel dizziness. Avoid alcohol consumption as it aggravates dizziness and contact your doctor if dizziness worsens.

Warning & Precautions

Pregnancy

DIREC 2MG SOLUTION is not recommended for use in pregnant women or planning a pregnancy. Consult your doctor before taking.

Breastfeeding

DIREC 2MG SOLUTION is not recommended for use in breast feeding women as DIREC 2MG SOLUTION may pass through breast milk. Consult your doctor before taking.

Driving and Using Machines

DIREC 2MG SOLUTION causes sleepiness, forgetfulness, poor coordination, dizziness which can affect your driving ability. Do not drive or operate machines after taking DIREC 2MG SOLUTION.

Alcohol

Do not consume alcohol while taking DIREC 2MG SOLUTION as it increases the sedative effect of DIREC 2MG SOLUTION and makes you very sleepy.

Kidney

DIREC 2MG SOLUTION should be used with caution in patients suffering from kidney problems. Consult your doctor before taking.

Liver

DIREC 2MG SOLUTION is not recommended for use in patients suffering from severe liver disease. Consult your doctor before taking.

Allergy

Do not take DIREC 2MG SOLUTION if you are allergic to Diazepam, other benzodiazepines or other ingredients of this medicine.

Lungs

DIREC 2MG SOLUTION is not recommended for use in patients with severe breathing problems, including slow and/or shallow breathing. Consult your doctor before taking

Interactions

A. Drug-Drug interactions:

Before taking DIREC 2MG SOLUTION, inform your doctor if you are taking any of the following medicine:

• sodium oxybate, modafinil (used for management of narcolepsy)
• fluvoxamine, fluoxetine, isocarboxazid, amitriptyline (medicines used for management of depression)
• clozapine, olanzapine, fluphenazine, zuclopenthixol, haloperidol, methotrimeprazine (medicine used for management of mental disorders)
• cetirizine, chlorpheniramine (medicine used for management of allergies)
• halothane, isoflurane (medicines used during surgeries)
• alprazolam, chlordiazepoxide (medicine used for management of anxiety)
• zolpidem, zopiclone (medicine used for management of sleep disorders)
• erythromycin, clarithromycin (medicines used for management of bacterial infections)
• suxamethonium, tubocurarine (medicine used for muscle relaxation)
• morphine, methadone and buprenorphine (medicine used as strong painkillers)
• phenobarbital (medicine used for management of epilepsy and mental disorders)
• furosemide, chlorothiazide, diltiazem, verapamil (medicines used for management of high blood pressure)
• isosorbide mononitrate (medicines used in heart patients)
• magnesium carbonate, magnesium hydroxide (medicines used for management of acidity)
• disulfiram (medicine used to manage alcohol addiction)
• phenytoin, carbamazepine, sodium valproate (medicines used in management of epilepsy)
• theophylline (medicine used to manage asthma and other breathing disorders)
• cimetidine, omeprazole or esomeprazole (medicines used for management of acidity)
• rifampicin, isoniazid (medicine used for management of tuberculosis)
• St John’s wort (herbal medicine used for management of mental illness)
• amprenavir, atazanavir, ritonavir, delavirdine, efavirenz, indinavir, nelfinavir, zidovudine or saquinavir (medicines used for management of viral infections)
• fluconazole, itraconazole, ketoconazole or voriconazole (medicines used for management of fungal infections)
• oral contraceptives (medicines used to manage pregnancy)
• cisapride (medicine used for management of stomach problems)
• betamethasone, dexamethasone (medicines used to manage inflammation)
• levodopa (medicine used to manage Parkinson’s disease)
• ketamine (medicine used during surgeries)
• nabilone (medicine used to manage nausea and vomiting)
• doxazosin and beta blockers such as propranolol, metoprolol (medicine used to manage high blood pressure) and moxonidine (medicine used to manage mild to moderate high blood pressure)
• valproic acid (medicine used to manage fits and mental disorders)
• idelalisib (used to manage cancer)

B. Drug food interaction:

Avoid consuming grapefruit juice as it may increase DIREC 2MG SOLUTION levels in blood. Do not consuming caffeinated drinks while taking DIREC 2MG SOLUTION as it may reduce the effect of DIREC 2MG SOLUTION.

Overdosage:

In case you or anybody else accidentally takes too much of DIREC 2MG SOLUTION consult the doctor immediately or visit the nearby hospital. Symptoms of overdosage of DIREC 2MG SOLUTION are ataxia, drowsiness, clumsiness and loss of coordination, feeling sleepy or deep sleep, speech problems, low blood pressure, irregular or slow heartbeat, uncontrolled eye movement, muscle weakness or paradoxical excitation.

Synopsis

More Information

• Keep DIREC 2MG SOLUTION out of reach of children
• Store DIREC 2MG SOLUTION below 25°C

FAQs About DIREC 2MG SOLUTION

What are uses of DIREC 2MG SOLUTION?

DIREC 2MG SOLUTION is used in adults for short term (14 days) management of severe anxiety occurring with or without insomnia (sleeping difficulty) or other mental disorder, muscle spasms, cerebral palsy (condition causing muscle rigidity), epilepsy, to relieve the symptoms of acute alcohol withdrawal, to control muscle spasm due to tetanus.

Is DIREC 2MG SOLUTION safe for children?

DIREC 2MG SOLUTION is not recommended for use in children below 6 months of age as its safety is not yet established. Consult your doctor before taking.

Does DIREC 2MG SOLUTION make you sleepy?

Yes, DIREC 2MG SOLUTION make you feel sleepy. Avoid alcohol consumption while taking this medicine as it makes you very sleepy and do not drive or operate any machines.

Does DIREC 2MG SOLUTION calm you down?

DIREC 2MG SOLUTION improves the effect of a chemical in the brain called gamma-aminobutyric acid (GABA), a chemical whose transmission across nerves in the brain is known to produce a calming effect.

What are the side effects of taking DIREC 2MG SOLUTION?

The most common side effects of taking DIREC 2MG SOLUTION are drowsiness, confusion, ataxia (loss of coordination of muscle movements), tremor, fatigue, withdrawal symptoms. Consult your doctor in case any of side effects worsens.

Who should not take DIREC 2MG SOLUTION?

DIREC 2MG SOLUTION is not recommended for use in patients suffering from severe breathing problems, severe liver disease, phobia, chronic psychosis, hyperkinesis (excessive restlessness), myasthenia gravis (muscle weakness), severe liver disease, sleep apnoea (severe breathing difficulty during sleep), unmanageed depression with or without anxiety, allergic history to diazepam, other benzodiazepines. Consult your doctor before taking.

References

1. KD Tripathi. Drugs Acting on Central Nervous System. Essentials of Medical Pharmacology. 7th edition.2013. Page-418.

2. Jaberpreet S. Dhaliwal, Alan Rosani, Abdolreza Saadabadi. Diazepam. National Centre for Biotechnology. NLM. National Institute of Health. Statpearls. May 2022. [Accessed on 10th September 2022] https://www.ncbi.nlm.nih.gov/books/NBK537022/#article-20488.s6

3. Accord. Electronic Medicines Compendium. [Revised in April 2021] [Accessed on 10th September 2022] https://www.medicines.org.uk/emc/product/5783/smpc

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. Aravindan Balachandran - MBBS, MD (Psychiatry)

Last updated on 11 Nov 2022 | 04:26 PM(IST)