DIPODEM 200mg Tablet 10's

Introduction About DIPODEM 200MG TABLET

DIPODEM 200MG TABLET contains Coumarin, chemically 5, 6 Benzo-alpha-pyrone, which is an Immunostimulant Anti-Inflammatory Drug. Dipodem tablet reduces swelling and promotes healing. Dipodem effectively reduces swelling through proteolysis and phagocytosis. Dipodem restores lymphatic function and accelerates wound healing. Dipopem offers better results as compared to proteolytic enzyme preparations. Dipodem is used for swelling related to lymphatic blockage, deep vein thrombosis, elephantiasis, cellulitis, diabetic foot or due to unknown origin.

It is highly prescribed in cases such as sprains, bruises, injuries, contusions, fractures, post-operative oedema, dental extractions, post-surgery, acute and sub-acute lymphangitis, and chronic venous sufficiency.

Studies have shown that Coumarin (5, 6 Benzo-alpha-pyrone) has been proven to reduce lymphedema and edema associated with elephantiasis (filariasis), and swelling due to unknown origin.

Take DIPODEM 200MG TABLET as advised by your physician. One tablet twice daily. Strictly follow the dosing schedule as suggested by your physician to achieve better results. Do not use this medicine for prolonged periods without medical supervision, as it could increase the risk of liver damage.

Before taking DIPODEM 200MG TABLET, inform your doctor if you have any liver or kidney problems. Do not take DIPODEM 200MG TABLET if you are allergic to Coumarin. Inform your doctor before taking DIPODEM 200MG TABLET if you are pregnant or breastfeeding as a precaution.

Uses Of DIPODEM 200MG TABLET

• Management of inflammation and oedema (such as lymphedema)
• Restores lymphatic function and controls infections (like sub-acute lymphangitis, elephantiasis)
• Improves microcirculation and signs of chronic venous sufficiency (lower extremity oedema with skin itchiness, discomfort, and varicose veins)
• Boosts immunity and accelerates wound healing
• Reduces pain and swelling associated with sprains, bruises, injuries, contusions, fractures, post-operative oedema, dental extractions

How DIPODEM 200MG TABLET Works

DIPODEM 200MG TABLET contains coumarin (5, 6 Benzo-alpha-pyrone) which is a powerful anti-inflammatory and immune-boosting medicine. It reduces oedema (swelling) caused by excess protein by increasing the number of macrophages (a type of immune cell (WBC) that is involved in engulfing and digesting foreign particles, debris, and pathogens in the body) and by causing the breakdown of excess proteins (proteolysis). Additionally, it also stops chronic inflammation, fibrosis, and bacterial growth caused by excess protein.

How to use DIPODEM 200MG TABLET

Take DIPODEM 200MG TABLET as advised by your physician. One tablet twice daily. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Do not exceed the recommended daily dosages. Your doctor will decide the correct dose and duration of therapy for you based on your age, body weight, and health condition.

Side Effects Of DIPODEM 200MG TABLET

There are limited studies regarding the safety of Coumarin (5, 6 Benzo-alpha-pyrone) in humans. Available studies suggest that it is safe and well tolerated with mild nausea and diarrhea during the initial days of the therapy, which typically disappears after the first month of therapy.

How To Manage Side Effects

Diarrhea

To manage diarrhea, it's crucial to stay hydrated by drinking plenty of clear fluids such as water, broth, or electrolyte solutions to replace lost fluids and electrolytes. Avoiding dairy products, caffeine, alcohol, and fatty or spicy foods can help reduce irritation to the digestive system. Eating small, bland meals such as bananas, rice, applesauce, and toast (BRAT diet) may also help firm up stools. Consult your doctor if your symptoms persist or did not improve.

Nausea And Vomiting

Eating small, bland meals throughout the day and staying hydrated can help alleviate symptoms. Ginger, either in tea form or as a supplement, may also provide relief. Avoiding lying down immediately after eating and practicing relaxation techniques such as deep breathing or meditation can help reduce nausea. Over-the-counter medications may be used if symptoms persist, but it's essential to consult a doctor before taking any medication, especially if nausea is severe or persistent.

Warning & Precautions

Pregnancy

Consult your doctor

There is no proper information regarding the use of DIPODEM 200MG TABLET in pregnant women. Therefore, inform your doctor before taking DIPODEM 200MG TABLET if you are pregnant or think you may be pregnant.

Breastfeeding

Consult your doctor

There is no proper information regarding the use of DIPODEM 200MG TABLET in breastfeeding women. Therefore, inform your doctor before taking DIPODEM 200MG TABLET if you are breastfeeding.

Kidney

Use with Caution

DIPODEM 200MG TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.

Liver

Consult your doctor

DIPODEM 200MG TABLET is metabolized via liver. Therefore, patients with liver problems must inform their doctor about the pre-existing liver conditions before taking this medicine. It is contraindicated for use in patients with hepatitis or any other severe forms of liver inflammation.

Allergy

Contraindicated

Do not take DIPODEM 200MG TABLET if you are allergic to Coumarin (5, 6 Benzo-alpha-pyrone).

Use In Pediatrics

Consult your doctor

There are no adequate studies regarding the use of DIPODEM 200MG TABLET in children and adolescents (aged below 18 years). Therefore, your doctor will decide whether Coumarin (5, 6 Benzo-alpha-pyrone) is suitable for your child or not after evaluating the risks and benefits.

Use In Geriatrics

Use with Caution

DIPODEM 200MG TABLET should be used with caution in elderly patients (aged 65 years or older). Therefore, consult your doctor before taking it.

Interactions

A. Drug-drug interactions:

• Calcium channel blockers (nitrendipine)
• Statins (simvastatin)

B. Drug-Food interactions:

Avoid consumption of grapefruit juice while taking DIPODEM 200MG TABLET, as it could lead to adverse effects.

Overdosage:

If you or anyone else accidentally took more of this medicine, consult your doctor immediately.

Synopsis

More Information

FAQs About DIPODEM 200MG TABLET

Q: What is 5, 6 Benzo-alpha-pyrone?

A: 5, 6 Benzo-alpha-pyrone (Coumarin) is an Immunostimulant Anti-Inflammatory Drug. It is used in the management of inflammation and oedema.

Q: What is DIPODEM 200MG TABLET used for?

A: DIPODEM 200MG TABLET is used in the management of inflammation and oedema, improves microcirculation, accelerates wound healing, reduces pain and swelling associated with sprains, bruises, injuries, contusions, fractures, post-operative oedema, dental extractions, acute and sub-acute lymphangitis, and chronic venous sufficiency.

Q: How DIPODEM 200MG TABLET works?

A: DIPODEM 200MG TABLET works by reducing inflammation, fibrosis, and bacterial growth caused by the excess protein. It reduces oedema by making your body have more immune cells that can engulf and digest the toxins (proteins) accumulated in the body or by breaking down them into fragments.

Q: Are Benzopyrone and 5, 6 Benzo-alpha-pyrone the same?

A: Yes. Benzopyrone and 5, 6 Benzo-alpha-pyrone both the same. They are two different synonyms representing Coumarin (alpha-benzopyrones).

Q: How does Benzopyrone manage lymphedema?

A: DIPODEM 200MG TABLET reduces oedema by making your body a greater number of immune cells that can engulf and digest the toxins (proteins) accumulated in the body or by breaking down them into fragments.

Q: Is DIPODEM 200MG TABLET an anticoagulant?

A: DIPODEM 200MG TABLET contains Coumarin, chemically 5, 6 Benzo-alpha-pyrone, which is an Immunostimulant Anti-Inflammatory Drug, not an anticoagulant (blood thinning agents). They are slightly different in their chemical structures compared to the bis-4-hydroxycoumarins (anticoagulants) with different therapeutic uses.

Q: What are the side effects of taking DIPODEM 200MG TABLET?

A: There are limited studies regarding the safety of Coumarin (5, 6 Benzo-alpha-pyrone) in humans. Available studies suggest that it is safe and well tolerated with mild nausea and diarrhea during the initial days of the therapy, which typically disappears after the first month of therapy.

Q: Can DIPODEM 200MG TABLET be used in children?

A: There are no adequate studies regarding the use of DIPODEM 200MG TABLET in children and adolescents (aged below 18 years). Therefore, your doctor will decide whether Coumarin (5, 6 Benzo-alpha-pyrone) is suitable for your child or not after evaluating the risks and benefits.

Q: Can DIPODEM 200MG TABLET be used during pregnancy?

A: There is no proper information regarding the use of DIPODEM 200MG TABLET in pregnant women. Therefore, inform your doctor before taking DIPODEM 200MG TABLET if you are pregnant or think you may be pregnant.

References

1. Pharm Products. DIPODEM 200MG TABLETs. [Accessed on 24th April 2024]. https://www.pharmproducts.com/lympedium-tablet/

2. Caroline M A Badger, Nancy J Preston, Kate Seers, Peter S Mortimer. Benzo-pyrones for reducing and controlling lymphoedema of the limbs. September 2003. [Accessed on 21st August 2024]. https://core.ac.uk/download/pdf/68425.pdf

3. J R Casley-Smith, J R Casley-Smith. Modern treatment of lymphoedema. II. The benzopyrones. NIH. National Library of Medicine. National Center for Biotechnology Information. PubMed. 1992. [Accessed on 21st August 2024]. https://pubmed.ncbi.nlm.nih.gov/1294055/

4. Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms. NIH. National Library of Medicine. National Center for Biotechnology Information. PubMed. 2021 August. [Accessed on 21st August 2024]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440074/

5. J R Casley-Smith, C T Wang, J R Casley-Smith, C Zi-hai. Treatment of filarial lymphoedema and elephantiasis with 5,6-benzo-alpha-pyrone (coumarin). NIH. National Library of Medicine. National Center for Biotechnology Information. PubMed. 1993, October. [Accessed on 21st August 2024]. https://pubmed.ncbi.nlm.nih.gov/8251778/

6. Albert-Adrien Ramelet. α-Benzopyrones. Venoactive Drugs. ScienceDirect.com. [Accessed on 21st August 2024]. https://www.sciencedirect.com/topics/neuroscience/coumarin

7. Frontiers in Pharmacology. Safety Profile of Nutraceuticals Rich in Coumarins: An Update. 24th January 2024. [Accessed on 21st August 2024]. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.803338/full

Useful Diagnostic Tests

• Complete Blood Count (CBC)/ Hemogram
• Peripheral Smear Examination By Pathologist
• Serum Electrolytes/ Electrolytes Profile
• Anti Nuclear Antibodies (Ana)
• Absolute Neutrophil Count, Blood
• Full Body Health Checkup Advanced
• Full Body Checkup - Comprehensive
• Healthy Midlife Checkup
• Men Health Checkup - Advanced
• Complete Women Checkup

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Thamada Manikanta Praveen - MBBS, MD (General Medicine)

Last updated on 12 Nov 2024 | 10:47 AM(IST)