Diplene AF Cream 20gm
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Introduction About DIPLENE AF CREAM
DIPLENE AF CREAM contains Clobetasol, which belongs to the group of medicines called Topical corticosteroids. It is used in adults and adolescents (aged 12 years or above) to manage inflammatory skin conditions such as psoriasis, eczema and dermatitis that have not responded to milder steroid creams or ointments.
Psoriasis is an immune-mediated skin disease that speeds up the growth cycle of skin cells, causing patches of thick red skin and silvery scales, typically on the elbows, knees, scalp, lower back, face, palms, and soles, but can affect other places also. Eczema (also called dermatitis) includes several different types of skin swelling, causing dry, itchy skin and rashes on the face, inside the elbows, behind the knees, and on the hands and feet. Scratching the skin can make it turn red, swell and itch even more.
DIPLENE AF CREAM is not recommended for use in patients with other bacterial, fungal, or viral infections (such as herpes simplex, chicken pox and tuberculosis). Before using DIPLENE AF CREAM, inform your doctor if you have a skin infection, diabetes, adrenal gland problem, scheduled surgery, acne, plaques around your mouth, underarms, anus, or genitals and liver diseases.
DIPLENE AF CREAM should be used during pregnancy only if recommended by your doctor. DIPLENE AF CREAM should be used with caution by breastfeeding women. DIPLENE AF CREAM is not recommended for use by children under 12 years of age. The most common side effects of using DIPLENE AF CREAM are thinning of the skin, widening of small veins in the skin, skin discomfort and dryness. Contact your doctor if any of your symptoms get worse or persist.
Uses Of DIPLENE AF CREAM
- Manage inflammatory condition of the skin such as psoriasis, eczema, dermatitis, etc
How DIPLENE AF CREAM Works
DIPLENE AF CREAM is a topical corticosteroid with anti-itching, anti-inflammatory and vasoconstrictive properties. It acts by blocking the release of certain chemical mediators (prostaglandins, leukotrienes) in the body that causes pain, inflammation and swelling. As a result, it effectively reduces the skin redness, itchiness, inflammation, swelling, and irritation associated with certain skin problems.
How to use DIPLENE AF CREAM
Always apply DIPLENE AF CREAM as directed by your physician. It is for external use only. Wash your hands before and after application. Apply a thin layer of DIPLENE AF CREAM on the affected area. Do not cover the affected site after applying DIPLENE AF CREAM.
Avoid contact of DIPLENE AF CREAM with your eyes (including eyelids), ears, nose, armpits or with other mucous membranes (such as the vagina). Do not apply DIPLENE AF CREAM to the damaged skin.
Side Effects Of DIPLENE AF CREAM
Common
- irritation and burning at the infected site
- thinning of the skin
- widened small veins in the skin
- skin discomfort, dryness
Uncommon
- wounds that take time to heal
Rare
Stop using DIPLENE AF CREAM and contact your doctor immediately if you experience any of the following:
- reduced adrenal function (tiredness, nausea, vomiting, lack of energy, low blood pressure, weakness, heart attack)
- Cushing’s syndrome (weight gain, thin arms, legs, belly fat)
- hyperglycaemia (high blood sugar)
- vision problems like cataract (cloudy lens) and glaucoma (high pressure in the eye)
- skin reactions at the infected area
- growth impairment in children
- dizziness
- worsening of psoriasis (red, scaly, thick patches on the skin)
How To Manage Side Effects
Irritation and burning:
Avoid sharing vessels, personal items, or cosmetics with others. Use disinfects on objects you use in public spaces, such as gym equipment. Drink enough water and consume a nutritious diet. Do not use irritants or harsh chemicals. Sleep seven to eight hours every night. Use sunscreens to manage sunburn and other sun damage. Wash hands regularly with soap and water.
Warning & Precautions
Pregnancy
DIPLENE AF CREAM should be used during pregnancy only if recommended by your doctor. Consult your doctor before using DIPLENE AF CREAM.
Breastfeeding
DIPLENE AF CREAM should be used with caution by breastfeeding women. Consult your doctor before using DIPLENE AF CREAM.
Driving and Using Machines
DIPLENE AF CREAM is not expected to have any effects on your ability to drive and use machines.
Liver
DIPLENE AF CREAM should be used with caution in patients with liver disease. Consult your doctor before using DIPLENE AF CREAM.
Allergy
Do not use DIPLENE AF CREAM if you are allergic to Clobetasol or any of the other ingredients in this medicine.
Lungs
DIPLENE AF CREAM should not be used in patients with unmanageed tuberculosis. Consult your doctor before using DIPLENE AF CREAM.
Others
DIPLENE AF CREAM is not recommended for use if you:
- have other bacterial, or viral infections (Ex. herpes simplex, chicken pox, cold sores)
- have fungal infections (Ex. ringworm, athletes’ foot or thrush)
- have a weak immune response
- have acne rosacea or acne vulgaris
- are about to have any surgery
- have plaques around your mouth, underarms, back passage, or genitals
Before using DIPLENE AF CREAM inform your doctor if you:
- have a skin infection
- have diabetes
- have adrenal gland problems
- have acne
- have a history of irritation or other skin reactions to a steroid medicine
Use in pediatrics:
DIPLENE AF CREAM is not recommended for use in children (under 12 years of age). Consult your child’s doctor for advice.
Use in geriatrics:
DIPLENE AF CREAM should be used with caution in elderly patients (aged above 65 years). Consult your doctor before using DIPLENE AF CREAM.
Interactions
A. Drug-Drug interactions:
Before using DIPLENE AF CREAM, inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, non-prescription or any herbal medicine.
Overdosage:
If you or anyone else accidentally used more of DIPLENE AF CREAM, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include features of hypercortisolism (easy bruising, wide purple stretch marks, mainly on the stomach, breasts, hips, and under the arms, weak muscles).
Synopsis
| Drug | : |
Clobetasol |
| Pharmacological Category | : |
Topical corticosteroid |
| Therapeutic Indication | : |
Inflammatory condition of the skin like psoriasis, eczema, dermatitis, etc |
| Dosage Forms | : |
Ointment, Lotion, Cream, Gel, Foam, Topical solution, Shampoo |
More Information
- Keep DIPLENE AF CREAM out of reach from children
- Store at room temperature
FAQs About DIPLENE AF CREAM
What is DIPLENE AF CREAM used for?
DIPLENE AF CREAM is used in adults and adolescents (aged 12 years or above) to manage inflammatory skin conditions such as psoriasis, eczema and dermatitis that have not responded to milder steroid creams or ointments.
Can I use DIPLENE AF CREAM for wounds?
DIPLENE AF CREAM is not intended for use on wounds. Do not use it for any indication other than prescribed. Consult your doctor for advice.
Can we use DIPLENE AF CREAM for kids?
DIPLENE AF CREAM is not recommended for use in children (younger than 12 years of age). Consult your child’s doctor for advice. The doctor will decide on an appropriate dose or select a suitable alternative management for your child.
Can DIPLENE AF CREAM be used for vitiligo?
DIPLENE AF CREAM can be used for the management of limited areas of vitiligo. Do not use it for any indication other than prescribed. Consult your doctor for advice.
Can I use DIPLENE AF CREAM on my face for face brightening?
DIPLENE AF CREAM is not intended for beauty purposes. Do not use it for any indication other than prescribed. Consult your doctor for advice.
Will over-usage of DIPLENE AF CREAM cause any harmful side effects?
Long term usage of DIPLENE AF CREAM can cause some systemic effects such as suppression of pituitary-adrenal function, resulting in secondary adrenal insufficiency. Consult your doctor for advice.
Can I use DIPLENE AF CREAM along with my regular medications if I already have a skin infection?
No. Do not use DIPLENE AF CREAM without consulting your doctor if you already have a skin infection. Avoid using DIPLENE AF CREAM for other infections as it may cause other serious effects.
How should I use DIPLENE AF CREAM?
Always apply DIPLENE AF CREAM as directed by your physician. It is for external use only. Wash your hands before and after application. Apply a thin layer of DIPLENE AF CREAM on the affected area. Do not cover the affected site after applying DIPLENE AF CREAM. Avoid contact of DIPLENE AF CREAM with your eyes (including eyelids), ears, nose, armpits or with other mucous membranes (such as the vagina). Do not apply DIPLENE AF CREAM on the damaged skin. Contact your doctor immediately if you cannot see any improvement in your condition even after using DIPLENE AF CREAM for the stipulated duration.
Can DIPLENE AF CREAM be used on the face?
No. DIPLENE AF CREAM should not be used on the face, groin, or armpits. Consult your doctor for advice.
References
1. Tilo Grosser, Emer Smyth and Garret A. FitzGerald. Dermatological Pharmacology. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1682.
2. KD Tripathi. Drugs Acting on Skin and Mucous Membranes. Essentials of Pharmacology. Seventh edition. 2013. Page no: 895.
3. J Clin Aesthet Dermatol. Topical Corticosteroid Therapy for Psoriasis—A Review of Clobetasol Propionate 0.025% Cream and the Clinical Relevance of Penetration Modification. NCBI. PMC US National Library of Medicine. National Institute of Health February 2020. [Accessed on 14th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158910/
4. Stiefel, a GSK Company. Study to Evaluate Safety, Efficacy and Tolerability of Clobetasol Propionate for Chronic Hand Dermatitis. NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in October 2012] [Accessed on 27th August 2022] https://clinicaltrials.gov/ct2/show/NCT00828464?term=clobetasol&cond=Skin+Diseases&draw=2&rank=1
5. Lupin limited. U.S. Food and Drug Administration. [Revised in May 2020] [Accessed on 14th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213691s000lbl.pdf
6. Sandoz Canada Inc health Canada. Sandoz Clobetasol (Clobetasol Propionate Solution). [Revised in December 2017] [Accessed on 14th June 2022] https://pdf.hres.ca/dpd_pm/00054412.PDF
7. Torrent Pharmaceuticals Ltd. Cortaz Foam (Clobetasol propionate Topical Foam 0.05% w/w). [Revised in July 2021] [Accessed on 27th August 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2893.pdf
8. Dailymed. Clobetasol propionate. [Revised in September 2020] [Accessed on 27th August 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=2d4fa3a3-dc1c-4d3c-9959-4751e09d25be&type=display
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