DIAMICRON XR MEX 60/500 Tablet 15's

Introduction About DIAMICRON XR MEX 60/500 TABLET

Diamicron XR MEX 60/500 Tablet is a combination of Gliclazide (60 mg) and Metformin (500 mg), formulated as an extended-release tablet to support balanced blood sugar control in adults with type 2 diabetes. This dual-action medicine works by stimulating the pancreas to release insulin and improving the body’s response to insulin, thereby reducing excess sugar production in the liver. Its extended-release design ensures a gradual release of medicine, helping maintain steady blood sugar levels throughout the day.

This tablet is generally considered for adults who require better glucose control when lifestyle changes such as diet and exercise alone are not sufficient. It may be especially useful for patients who experience fluctuations in blood sugar despite taking either Metformin or Gliclazide individually. The medicine is not recommended for children, pregnant women, or those with severe kidney, liver, or heart conditions. Elderly patients may use it with caution under close medical supervision.

 Diamicron XR MEX 60/500 should be taken once daily with a main meal, preferably in the morning. The tablet must be swallowed whole with water do not crush or chew, as this affects the extended-release property. Consistent daily use, combined with regular meals, helps reduce the chances of low blood sugar. Patients should monitor their blood sugar levels regularly and follow their doctor’s guidance for dose adjustments.

 This medicine should not be used by individuals with kidney disease, liver failure, chronic lung disease, or certain heart conditions. Alcohol should be avoided, as it increases the risk of side effects such as dizziness and hypoglycaemia. During pregnancy and breastfeeding, its use is not recommended unless clearly advised by a doctor. Common side effects may include nausea, stomach upset, dizziness, or episodes of low blood sugar. Patients should keep fast-acting sugar (like glucose tablets) handy in case of sudden hypoglycaemia. Regular follow-ups with a doctor are advised for safe and effective long-term use.

Uses Of DIAMICRON XR MEX 60/500 TABLET

• Used to manage type II diabetes mellitus

Benefits of DIAMICRON XR MEX 60/500 TABLET

Diamicron XR MEX 60/500 for Blood Sugar Control

Diamicron XR MEX 60/500 Tablet is formulated to support steady blood sugar levels in adults with type 2 diabetes. It combines Gliclazide, which stimulates the pancreas to release insulin. Metformin, helps the body use insulin more effectively and reduces excess sugar production in the liver. The extended-release (XR) formulation ensures that the medicine is released gradually, providing a more consistent effect throughout the day. This helps maintain stable blood sugar levels between meals and overnight. When used alongside a balanced diet, regular exercise, and healthy lifestyle habits, Diamicron XR MEX 60/500 can support better glucose balance, reduce fluctuations, and help people manage their daily energy levels more effectively.

How DIAMICRON XR MEX 60/500 TABLET Works

Diamicron XR MEX 60/500 Tablet works through a dual mechanism to help maintain steady blood sugar levels:

Gliclazide Action: Gliclazide stimulates the pancreas to release insulin, the hormone responsible for lowering blood sugar. This helps the body respond effectively to glucose after meals, supporting overall blood sugar stability.

Metformin Action: Metformin works by reducing sugar production in the liver and improving how the body uses insulin in muscles and other tissues. This decreases blood sugar spikes and supports better long-term glucose balance.

Extended-Release Advantage: The XR (extended-release) formulation ensures that the medicine is gradually released over time. This provides a consistent effect throughout the day, helping to maintain stable blood sugar levels between meals and overnight.

How to use DIAMICRON XR MEX 60/500 TABLET

• Follow Doctor’s Prescription: Always take the medicine exactly as prescribed by your doctor. Do not adjust the dose on your own.
• With Food: Take the tablet with your first main meal of the day to reduce the risk of stomach upset and low blood sugar.
• Swallow Whole: Do not crush, chew, or break the tablet, as it is an extended-release formulation. Swallow it whole with water.
• Once Daily: Usually taken once daily but follow your doctor’s instructions for timing and frequency.
• Missed Dose: If you miss a dose, take it as soon as you remember. Skip the missed dose if it’s almost time for the next one. Do not double the dose.
• Dose Adjustments: Your doctor may adjust the dosage based on your blood sugar readings, kidney function, or other health conditions.

What if I forgot to take DIAMICRON XR MEX 60/500 TABLET

• If you miss a dose of Diamicron XR MEX 60/500 Tablet, take it as soon as you remember.
• If it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule.
• Do not take two doses at the same time to make up for the missed dose, as this may increase the chance of unwanted effects like dizziness, low blood sugar, or weakness.
• Try to take the medicine at the same time each day to maintain steady blood sugar control.
• If you frequently forget doses, consider setting a reminder or alarm to help you stay consistent.
• For repeated missed doses, consult your doctor for personalized advice.

Overdose

If you or anyone else accidentally took more of Diamicron XR MEX 60/500 tablet, consult your doctor immediately or visit the nearby hospital. Overdosage may cause low blood sugar (hypoglycaemia), and symptoms include dizziness, light-headedness, hunger, nervousness, shaky feelings, drowsiness, confusion, perspiration, and palpitations.

Side Effects Of DIAMICRON XR MEX 60/500 TABLET

Common side effects of Diamicron XR MEX 60/500 tablet:

• nausea
• diarrhoea
• gastric pain
• constipation
• vomiting
• metallic taste in the mouth

When to Seek Medical Attention?

Stop taking Diamicron XR MEX 60/500 tablet and consult your doctor immediately if you experience any of the following side effects:

• Signs of very low blood sugar such as shakiness, sweating, rapid heartbeat, blurred vision, dizziness, or sudden weakness
• Unusual tiredness or shortness of breath that does not improve with rest.
• Severe stomach pain, nausea, or vomiting that persists.
• Allergic reactions like skin rash, itching, swelling of face/lips/tongue, or difficulty in breathing.
• Sudden chest pain, irregular heartbeat, or fainting spells.
• Unexplained weight loss or persistent loss of appetite.
• Dark urine or yellowing of the skin/eyes, which could indicate liver concerns.

How To Manage Side Effects

Nausea And Vomiting

• Ginger: Sip ginger tea or chew a small piece of fresh ginger to help settle the stomach and reduce nausea.
• Lemon Water: Drinking warm water with a few drops of fresh lemon juice can provide quick relief from vomiting sensations.
• Peppermint: Peppermint tea or simply inhaling peppermint oil aroma may calm the stomach muscles and reduce the urge to vomit.
• Clove (Laung): Chewing a clove or drinking clove tea may help reduce nausea and soothe the digestive system.
• Hydration: Take small sips of clear fluids such as coconut water, oral rehydration solution, or plain water to prevent dehydration.
• Banana or Rice Water: Eating a ripe banana or sipping rice water (the liquid left after boiling rice) may calm the stomach and restore energy.
• Rest: Sit in a comfortable upright position and avoid lying down immediately after vomiting to prevent reflux.
• Light Foods: Once you feel better, start with bland foods like toast, rice, or applesauce before returning to regular meals.

Stomach Pain

• Warm Water: Sip a glass of warm water slowly to help relieve trapped gas and improve digestion.
• Ginger Tea: Fresh ginger or ginger tea may soothe the stomach and reduce bloating.
• Fennel Seeds: Chewing fennel seeds or drinking fennel tea can ease gas and indigestion.
• Peppermint: Peppermint tea or oil capsules (if suitable for you) may relax digestive muscles and reduce stomach discomfort.
• Carom Seeds (Ajwain): A traditional remedy chewing ajwain seeds with a pinch of salt may help reduce acidity and gastric pain.
• Warm Compress: Applying a warm water bag to your stomach can relax abdominal muscles and ease discomfort.
• Small, Frequent Meals: Instead of heavy meals, eat smaller portions more often to reduce stomach strain.
• Avoid Triggers: Limit spicy, oily, or carbonated foods that may worsen gastric issues.

Warning & Precautions

Pregnancy

Contraindicated

The use of Diamicron XR MEX 60/500 tablet is not advised during pregnancy. Always seek guidance from your healthcare professional before considering its use. 

Breastfeeding

Consult your doctor

It is not known whether or its by-products pass into breast Diamicron XR MEX 60/500 tablet milk. Please consult your healthcare professional before use if you are breastfeeding.

Driving and Using Machines

Use with Caution

Avoid driving or operating heavy machinery if you experience symptoms such as dizziness, blurred vision, weakness, rapid heartbeat, sweating, or difficulty concentrating after taking Diamicron XR MEX 60/500 tablet

Alcohol

Contraindicated

Avoid alcohol while using Diamicron XR MEX 60/500 tablet, as it may increase the likelihood of unwanted side effects.

Kidney

Contraindicated

This medicine is generally not suitable for individuals with kidney disorders. Speak with your healthcare professional for appropriate alternatives.

Liver

Contraindicated

Diamicron XR MEX 60/500 tablet is usually avoided in people with liver failure. Seek medical advice for safer options.

Allergy

Contraindicated

Do not take Diamicron XR MEX 60/500 tablet if you are allergic to Gliclazide, Metformin, or any of the inactive ingredients listed on the packaging.

Lungs

Contraindicated

Individuals with chronic lung conditions, such as chronic obstructive pulmonary disease (COPD), are generally advised not to use this medicine.

Heart Disease

Contraindicated

This medicine is usually avoided in people with heart conditions such as coronary artery disease, heart failure, or poor circulation in the limbs.

Use In Pediatrics

Contraindicated

The safety and effectiveness of Diamicron XR MEX 60/500 tablet in children have not been established, so its use is not advised in paediatric patients.

Use In Geriatrics

Use with Caution

In elderly patients with normal kidney function, this medicine may be prescribed with caution under medical supervision.

Who should not take [GBNKEYWORD

Diamicron XR MEX 60/500tablet is not recommended for use if you:

• have type 1 diabetes mellitus
• have severe ketosis and acidosis
• planned for surgery
• have severe trauma
• have severe infections

Safety Advice

• Regular Monitoring: Check blood sugar levels regularly to ensure the medicine is working effectively and safely.
• Medical Checkups: Periodic kidney and liver function tests are recommended during long-term use.
• Illness or Infection: Blood sugar may fluctuate during illness, fever, or infection. Inform your doctor if you notice unusual readings.
• Surgery or Procedures: Notify your healthcare provider if you are scheduled for surgery or diagnostic tests, as temporary adjustments may be needed.
• Medication Changes: Always inform your doctor if you start new medicines, supplements, or herbal products. They may interact with this tablet.
• Travel Precautions: Carry your medicine and blood sugar monitoring tools during travel. Plan meals and medicine timing carefully.
• Symptoms Awareness: Be alert for unusual fatigue, excessive thirst, or frequent urination, and report these to your doctor.
• Storage Safety: Keep the medicine away from heat, moisture, and light to maintain potency.
• Emergency Preparedness: Keep fast-acting sugar sources (like glucose tablets) handy in case of sudden low blood sugar.

Diet and Lifestyle Advice

• Balanced Meals: Include vegetables, whole grains, lean proteins, and healthy fats in your diet to support stable blood sugar levels.
• Controlled Carbohydrates: Monitor carbohydrate intake at each meal. Avoid large portions of sugary or refined foods.
• Regular Meal Timing: Take the tablet with meals and try to eat at consistent times daily to prevent low blood sugar episodes.
• Hydration: Drink enough water throughout the day to support kidney function and overall health.
• Physical Activity: Engage in moderate exercise like walking, cycling, or swimming, as recommended by your doctor. Regular activity helps improve blood sugar balance.
• Weight Management: Maintain a healthy weight to support effective functioning of the medicine and overall metabolic health.
• Avoid Smoking: Smoking may worsen cardiovascular risk. Quitting supports overall health and medicine effectiveness.
• Monitor Symptoms: Keep track of any unusual fatigue, dizziness, or blood sugar fluctuations, and report to your doctor.
• Consistency: Combine medication with healthy lifestyle habits for better blood sugar control and overall wellbeing.

1. Diamicron XR MEX 60/500 Tablet and Diamicron MR 60 Tablet

2.Diamicron XR MEX 60/500 and Janumet 50/500, focused on long-term use suitability.

Drug - Drug interaction

1. Other Antidiabetic Medicines

• Interaction: Using Diamicron XR MEX 60/500 together with insulin, sulfonylureas, or other oral antidiabetics may cause a greater risk of hypoglycaemia (low blood sugar).
• Management: Regularly monitor blood glucose levels. Your prescriber may need to adjust doses or provide guidance on recognizing hypoglycaemia symptoms.

2. Antibiotics (e.g., Ciprofloxacin, Clarithromycin)

• Interaction: Some antibiotics can increase or decrease the blood levels of Gliclazide and Metformin, raising the risk of side effects or altering glucose control.
• Management: Inform your prescriber before starting antibiotics. Temporary adjustment of your diabetes medicine may be required.

3. Corticosteroids (e.g., Prednisolone, Dexamethasone)

• Interaction: These medicines may raise blood sugar levels, reducing the effect of Diamicron XR MEX 60/500.
• Management: Blood glucose monitoring is recommended. Dose changes or additional advice from your prescriber may be necessary.

4. Diuretics (Water Tablets such as Furosemide, Hydrochlorothiazide)

• Interaction: Can reduce the kidney’s ability to clear Metformin, increasing the risk of lactic acidosis (a rare but serious complication).
• Management: Kidney function should be monitored regularly. Avoid dehydration and report any unusual fatigue, muscle pain, or breathing issues.

5. Heart Medicines (e.g., Beta-blockers like Atenolol, ACE inhibitors like Ramipril)

• Interaction: ACE inhibitors may enhance the blood sugar–lowering effect. Beta-blockers can mask symptoms of low blood sugar such as rapid heartbeat.
• Management: Monitor blood sugar closely. Learn to recognize other hypoglycaemia symptoms such as sweating, hunger, or dizziness.

6. Thyroid Medicines (Levothyroxine)

• Interaction: May reduce the effectiveness of Diamicron XR MEX 60/500 in controlling glucose.
• Management: Blood sugar checks and dose adjustments may be required under medical supervision.

Drug - Food interaction

1. High-Sugar Foods and Beverages

• Interaction: Consuming foods or drinks high in sugar (cakes, candies, sweetened drinks) can raise blood glucose and reduce the effectiveness of the medicine.
• Management: Follow a balanced, diabetes-friendly diet as advised by your healthcare professional. Keep sugar intake under control to support the medicine’s action.

2. High-Fat or Heavy Meals

• Interaction: Large fatty meals may slow down the absorption of the extended-release tablet, possibly affecting its action.
• Management: Maintain a balanced diet with controlled portions. Spread your carbohydrate intake throughout the day instead of relying on heavy meals.

3. Caffeine (Coffee, Energy Drinks)

• Interaction: Excessive caffeine can sometimes interfere with blood sugar stability and may mask symptoms of low blood sugar such as palpitations.
• Management: Moderate your caffeine intake and stay alert for other signs of hypoglycaemia such as sweating, dizziness, or hunger.

4. Grapefruit and Certain Citrus Juices

• Interaction: While evidence is limited, grapefruit juice may interfere with the metabolism of some diabetes medicines, potentially altering drug levels.
• Management: Best to avoid excessive grapefruit intake or consult your healthcare provider before including it in your diet.

Synopsis

More Information

FAQs About DIAMICRON XR MEX 60/500 TABLET

Q: What is Diamicron XR MEX 60/500 Tablet used for?

A: Diamicron XR MEX 60/500 Tablet is commonly prescribed for people with type 2 diabetes to help manage blood sugar levels. It combines two medicines, Gliclazide and Metformin, which work together to support better control of glucose. Doctors recommend it when lifestyle measures like diet and exercise are not enough. It is usually taken once daily but always follow your doctor’s advice.

Q: Can Diamicron XR MEX 60/500 Tablet be taken on an empty stomach?

A: No, it is not recommended to take this tablet on an empty stomach. Since it can lower blood sugar, taking it without food may cause weakness, dizziness, or sweating. Always swallow the tablet with a meal to ensure safe and effective use.

Q: What should I do if I forget a dose of Diamicron XR MEX 60/500?

A: If you forget to take your tablet, take it as soon as you remember. But if it is almost time for your next scheduled dose, skip the missed one and continue normally. Do not double the dose to make up for the missed one. Missing doses frequently may affect blood sugar control, so try to take it regularly.

Q: Can I stop taking Diamicron XR MEX 60/500 Tablet suddenly?

A: Do not stop this medicine suddenly without talking to your doctor. Stopping on your own may cause your blood sugar levels to rise quickly. Your doctor may adjust the dose or suggest an alternative if needed. Always follow medical guidance for safe discontinuation.

Q: Is Diamicron XR MEX 60/500 Tablet safe for children?

A: No, this medicine is not recommended for children. Its safety and effectiveness in people below 18 years of age have not been studied well. Doctors usually prescribe it only for adults with type 2 diabetes.

Q: How long does it take for Diamicron XR MEX 60/500 Tablet to work?

A: The medicine usually starts working within a few hours after the first dose. However, it may take a few days to weeks for blood sugar levels to stabilize. The extended-release form provides steady action throughout the day, helping maintain balance.

Q: Can Diamicron XR MEX 60/500 Tablet cause low blood sugar?

A: Yes, it can sometimes cause low blood sugar (hypoglycaemia), especially if you skip meals, delay eating, or take alcohol. Symptoms include sweating, trembling, headache, and blurred vision. Carrying a small snack or sugar source can help in such cases.

Q: What are the common side effects of Diamicron XR MEX 60/500?

A: Some people may experience nausea, stomach upset, diarrhoea, or dizziness. Others may notice low blood sugar symptoms like weakness or sweating. These effects are usually mild and temporary. If they persist or become bothersome, consult your doctor

Q: Can Diamicron XR MEX 60/500 Tablet be taken with other medicines?

A: Yes, but it may interact with some medicines like steroids, blood pressure tablets, or other diabetes medicines. Always inform your doctor about all the medicines you are taking. Your doctor may adjust the dose or monitor you closely to avoid side effects.

Q: What foods should I avoid while taking Diamicron XR MEX 60/500 Tablet?

A: There are no strict food restrictions, but it is wise to limit sugary drinks, fried foods, and high-calorie snacks. Eating balanced meals with controlled carbs helps the tablet work better. Avoid skipping meals, as it increases the risk of low blood sugar.

Q: Can Diamicron XR MEX 60/500 Tablet be crushed or chewed?

A: No, this tablet should be swallowed whole with water. Crushing or chewing may affect the extended-release property, causing the medicine to release too quickly. Always follow the instructions on the pack or as directed by your doctor.

Q: What should I do if I take too much Diamicron XR MEX 60/500 Tablet?

A: Taking more than the prescribed dose can cause very low blood sugar or stomach upset. Symptoms may include sweating, confusion, and dizziness. Seek immediate medical help if you suspect an overdose.

Q: Is Diamicron XR MEX 60/500 Tablet habit-forming?

A: No, this medicine is not habit-forming. It is prescribed only for controlling blood sugar and must be taken as directed by your doctor. However, stopping it suddenly without advice can be harmful.

Q: Can I take Diamicron XR MEX 60/500 Tablet with insulin?

A: Sometimes doctors may prescribe it along with insulin if extra support is needed for blood sugar control. This combination requires close monitoring as the risk of low sugar increases. Always follow your doctor’s advice when using both.

Q: Is Diamicron XR MEX 60/500 the same as Diamicron MR 60?

A: No, they are different. Diamicron XR MEX 60/500 contains two medicines (Gliclazide + Metformin), while Diamicron MR 60 contains only Gliclazide. The XR MEX version provides dual action and extended release, while the MR version has single action.

Q: Can Diamicron XR MEX 60/500 Tablet be taken long term?

A: Yes, it is often prescribed for long-term use in managing type 2 diabetes. However, regular blood sugar checks and medical follow-ups are important. Your doctor will decide the duration depending on your health and response to the medicine.

Q: Who should not take Diamicron XR MEX 60/500 Tablet?

A: This tablet is not suitable for people with severe kidney disease, liver failure, heart failure, or lung disease. It should also be avoided by those who are allergic to Gliclazide or Metformin. Pregnant and breastfeeding women should consult their doctor before use.

References

1. KD. Tripathi. Insulin, Oral Antidiabetic Drugs and Glucagon. Essentials of medical pharmacology. Eight edition. 2019. Page –295.

2. Corcoran C, Jacobs TF. Metformin. NIH National Library of Medicine, National centre for biotechnology information. Stat Pearls. [Revised in 17th August 2023]. [Accessed on 9th September 2025] 

3. Panacea Biotec Limited. Gliclazide and metformin. [Revised in 9th September 2014] [Accessed on 9th September 2025] 

4. Drug bank. Gliclazide. [Revised in 6th September 2025] [Accessed on 9th September 2025] 

5. Drug bank. Metformin. [Accessed on 9th September 2025] 

User Feedback

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, also known as Glycated Haemoglobin, Glycosylated Haemoglobin

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 10 Sep 2025 | 03:36 PM(IST)