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Introduction About DIAKIT 4 KIT TABLET
DIAKIT 4 KIT TABLET is a combination of Atorvastatin, Glimepiride, Metformin and Ramipril which belongs to the group of medicines called Lipid-lowering drugs, Antidiabetic agents and Antihypertensive agents respectively. It is used in the management of hypertension, hyperlipidaemia and hyperglycaemia in adults when diet, exercise and management with single agents does not result in adequate results. It also protects the function of your heart and kidneys particularly in patients who have both hypertension and diabetes mellitus.
Take DIAKIT 4 KIT TABLET preferably after meals or as advised by your physician. Do not stop taking DIAKIT 4 KIT TABLET unless your doctor advice you to stop. While taking DIAKIT 4 KIT TABLET, avoid consumption of alcohol and grapefruit juice as it might worsen your existing condition. Do not take DIAKIT 4 KIT TABLET if you are pregnant or breastfeeding. Women of childbearing age must use a reliable contraceptive method to avoid pregnancy while undergoing therapy with DIAKIT 4 KIT TABLET.
Do not take DIAKIT 4 KIT TABLET if you are suffering from type I diabetes mellitus (insulin dependent diabetes), lactic acidosis or diabetic ketoacidosis.
Before taking DIAKIT 4 KIT TABLET, inform your doctor if you have any liver, kidney, heart or respiratory problems. You must also inform your doctor if you are recovering from any injury, operation, infections or from any form of stress, fasting or malnourished, perform extreme physical exercises without proper carbohydrate intake, have an unexplained muscle pain or muscle problems in the past, thyroid problems, personal or family history of muscle problems or stroke.
The most common side effects of taking DIAKIT 4 KIT TABLET are nausea, vomiting, indigestion, flatulence, changes in taste or metallic taste, low Vitamin B12 levels (signs include extreme tiredness, oral sores, pins and needles), inflammation of the nasal passages, throat pain, headache, joint pain, muscle pain and back pain, weight gain, neck pain and edema. Consult your doctor if any of these side effect trouble you.
Uses Of DIAKIT 4 KIT TABLET
- Management of hypertension, hyperlipidaemia and hyperglycaemia
- Protects the function of your heart and kidneys
How DIAKIT 4 KIT TABLET Works
DIAKIT 4 KIT TABLET contains four medicines namely, Atorvastatin, Glimepiride, Metformin and Ramipril. Atorvastatin is a lipid lowering medicine. It effectively reduces the levels of bad cholesterol (LDL) and triglycerides in the body by blocking the action of an enzyme called HMG-CoA reductase that synthesizes cholesterol within the body.
It also acts on the liver and improve the body’s ability to remove lipid particles from the blood. As a result, it reduces blood cholesterol levels and manage its associated risks.
Glimepiride stimulates the pancreas to secrete more insulin (a hormone involved in glucose metabolism). Metformin makes our body more sensitive to insulin which helps in digesting the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels. Additionally, it can also reduce the glucose produced by the liver and reduces its absoprtion in the body.
Ramipril is a vasodilator. It relaxes the blood vessels supplying the heart and other vital organs of the body. As a result, it improves blood flow and oxygen supply to the heart which reduces strain on the heart and improves heart functions. It can also improve blood supply to the kidneys which helps in delaying the worsening of kidney functions among diabetic patients.
How to use DIAKIT 4 KIT TABLET
Take DIAKIT 4 KIT TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Do not stop taking DIAKIT 4 KIT TABLET unless your doctor advice you to stop.
Side Effects Of DIAKIT 4 KIT TABLET
Common
- nausea, vomiting
- diarrhea, stomach pain, loss of appetite, flatulence
- changes in taste, metallic taste
- low Vitamin B12 levels (signs include extreme tiredness, oral sores, pins and needles)
- inflammation of the nasal passages
- throat pain, nose bleeds
- allergic reactions
- increase in blood sugar levels
- increase in blood creatine kinase
- headache, dizziness
- joint pain, muscle pain and back pain
- liver problems
- fainting while standing up (postural hypotension)
Uncommon
- weight gain
- having nightmares, insomnia
- tingling sensation
- decreased sensation to pain or touch
- changes in sense of taste
- loss of memory
- blurring of vision
- ringing in the ears followed by vomiting
- neck pain, muscle fatigue
- fatigue, feeling unwell, weakness, chest pain
- swelling especially in the ankles (oedema)
- raised temperature
- passing more urine, increased sweating
Rare
- visual disturbance
- unexpected bleeding or bruising
- cholestasis (yellowish discoloration of the skin and whites of the eyes)
- tendon injury
Stop taking DIAKIT 4 KIT TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of lactic acidosis (cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)
- serious allergic reaction (such as hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
- signs of liver problems (such as nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin or the whites of the eyes)
- severe skin rashes and photo sensitivity
- severe hypoglycemia and loss of consiousness
- severe allergic reactions (such as skin rash, blisters in the skin, severe peeling, blistering of the skin and swelling of the skin, mouth, eyes, face, lips, tongue and/or throat with difficulty in breathing or swallowing)
- unexplained muscle pain or weakness, especially if accompanied by fever, weakness, or reddish-brown urine (rhabdomyolysis)
- unexpected bleeding or bruising
- severe skin rash with joint disorders and changes in blood counts (Lupus-like disease syndrome)
- chest pain, forceful heartbeat
How To Manage Side Effects
Bloating
To manage flatulence, consider dietary adjustments and lifestyle changes. Identify and limit gas-producing foods such as beans, cabbage, and carbonated drinks. Chew food thoroughly to aid digestion and reduce the likelihood of swallowing air. Introduce probiotics through yogurt or supplements to promote a healthy gut flora. Regular physical activity can also aid digestion. If persistent, consult a healthcare professional to rule out underlying issues and discuss potential solutions, such as medications or further dietary modifications.
Dizziness Or Drowsiness
Managing dizziness involves addressing potential underlying causes and making lifestyle adjustments. If you experience sudden or severe dizziness, it's important to sit or lie down to manage the risk of falling. Ensure proper hydration and maintain a balanced diet to regulate blood sugar levels. Avoid sudden movements and try to rise slowly from a seated or lying position. If dizziness persists, it's advisable to consult with a healthcare professional to rule out any serious medical conditions.
Headache
Stay well-hydrated, as dehydration can contribute to headaches. Get adequate rest and maintain a regular sleep schedule. Practice stress-management techniques, such as deep breathing or meditation, to alleviate tension. Over-the-counter pain relievers like acetaminophen or ibuprofen can provide relief, but it's essential to follow recommended dosages. Applying a cold or warm compress to the forehead may also ease discomfort. If headaches persist or worsen, seek medical advice to rule out underlying issues and receive appropriate> management.
Nausea And Vomiting
To manage nausea and vomiting, it is essential to focus on hydration, rest, and dietary adjustments. Stay well-hydrated by sipping on clear fluids like water or ginger tea. Opt for small, frequent meals to ease the digestive process, avoiding strong-smelling or heavy foods. Ginger, known for its anti-nausea properties, can be consumed through tea or candies. Adequate rest is crucial for recovery, allowing your body to heal. If symptoms persist, consult a healthcare professional who may recommend medications or other interventions tailored to the underlying cause of nausea and vomiting.
Warning & Precautions
Pregnancy
ContraindicatedDIAKIT 4 KIT TABLET is not recommended for use in pregnant women. Therefore, consult your doctor before taking it. Women of childbearing age must use a reliable contraceptive method to avoid pregnancy while undergoing therapy with DIAKIT 4 KIT TABLET. However, if you accidentally become pregnant while taking DIAKIT 4 KIT TABLET, stop taking it and consult your doctor immediately.
Breastfeeding
ContraindicatedDIAKIT 4 KIT TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if your ability is affected by DIAKIT 4 KIT TABLET.
Alcohol
Use with CautionDIAKIT 4 KIT TABLET should be used with caution in patients who consume large amounts of alcohol. Therefore, it is advisable to avoid alcohol consumption while taking DIAKIT 4 KIT TABLET to achieve maximum benefits.
Kidney
Consult your doctorDIAKIT 4 KIT TABLET is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.
Liver
Consult your doctorDIAKIT 4 KIT TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take DIAKIT 4 KIT TABLET if you are allergic to Atorvastatin, Glimepiride, Metformin, or Ramipril or to any other sulfonylureas (Ex. glyburide, gliclazide) or sulphonamides (Ex. sulfasalazine).
Lungs
Use with CautionDIAKIT 4 KIT TABLET should be used with caution in patients with lung diseases (such as severe respiratory failure). Therefore, consult your doctor before taking it.
Heart Disease
Consult your doctorDIAKIT 4 KIT TABLET is not recommended for use in patients with severe heart problems (such as heart failure). It should be used with caution in patients with other heart problems. Therefore, consult your doctor before taking it.
Use In Pediatrics
ContraindicatedDIAKIT 4 KIT TABLET is not recommended for use in children and in adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Use In Geriatrics
Use with CautionDIAKIT 4 KIT TABLET should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before taking it.
Others
DIAKIT 4 KIT TABLET is not recommended for use if you:
- have type I diabetes mellitus (insulin dependent diabetes)
- have lactic acidosis (build-up of lactic acid in the body)
- have diabetic ketoacidosis (a diabetic complication causing episodes of fatigue, nausea, frequent urination and muscular stiffness)
- have severe uncontrollable decrease in blood pressure
Before taking DIAKIT 4 KIT TABLET, inform your doctor if you:
- are recovering from any injury, operation, infections or from any form of stress
- have G6PD deficiency
- are on fasting or malnourished, starved, on an irregular diet, or feeling weak
- perform extreme physical exercises without proper carbohydrate intake
- are an alcoholic
- have edema (swelling of body parts)
- have an unexplained muscle pain
- had any muscle problems in the past
- have improper functioning of thyroid gland
- have personal or family history of muscle problems
- are alcoholic
- are overweight
- have a previous history of stroke with bleeding the brain
- have small holes or pockets in the brain due to previous stroke
- are severely dehydrated due to any recent sickness such as vomiting or diarrhea
- have any autoimmune disease that affects the skin or collagen (Ex. lupus erythematosus, rheumatoid arthritis, or scleroderma)
- are scheduled for any upcoming surgery
- have any desensitization management (used to reduce the effect of an allergy to bee or wasp stings)
- have high blood potassium levels
Interactions
A.Drug-Drug Interactions:
Before taking DIAKIT 4 KIT TABLET, inform your doctor if you are taking any of the following medicines:
- antidiabetics (such as teneligliptin, rosiglitazone, insulin, gliclazide)
- pain killers (Ex. aspirin, ibuprofen, celecoxib, phenylbutazone, azopropazone, oxyphenbutazone, phenazone)
- antibiotics (amikacin, nitrofurantoin, sulfamethoxazole, tetracyclines, chloramphenicol, ciprofloxacin, clarithromycin, fusidic acid, erythromycin, clarithromycin, telithromycin)
- Antifungal agents (Ex. fluconazole, miconazole, isuvaconazole)
- medicines used to manage blood clotting (Ex. warfarin)
- medicines used for male sex hormone replacement therapy (Ex. testosterone)
- Antidepressants (such as moclobemide, isocarboxazid, phenelzine, tranylcypromine, fluoxetine, St John’s wort)
- Heart medicines (Ex. enalapril, lisinopril, ramipril, atenolol, propranolol, telmisartan, olmesartan, clonidine, guanethidine and reserpine, disopyramide, prazosin, doxazosin, ranolazine, amlodipine, diltiazem, digoxin, verapamil, amiodaron, valsartan, aliskiren, sacubitril/valsartan)
- gout medicines (Ex. allopurinol, probenecid, sulfinpyrazone)
- Anticancer agents (Ex. cyclophosphamide, ifosfamide, trofosfamide, vandetanib, crizotinib and olaparib)
- fenfluramine (a medicine used for obesity and fits)
- pentoxifylline (a medicine which can improve blood flow in the body)
- anti-allergic medicines (Ex. tritoqualine)
- alpha blockers (medicines used to manage high blood pressure or prostate problems) Ex.
- hormonal replacement therapy (used to manage menstrual disorders in women) Ex. estradiol
- thiazide diuretics (Ex. hydrochlorothiazide)
- levothyroxine (a medicine used for thyroid problems)
- Antipsychotics (such as chlorpromazine, prochlorperazine, lithium)
- corticosteroids (used to manage pain and inflammation) Ex. prednisolone, betamethasone
- Antiasthmatics (Ex. salbutamol, terbutaline)
- adrenaline (a medicine used to manage emergency conditions)
- medicines used to manage constipation (Ex. lactulose, liquid paraffin)
- glucagon, diazoxide (medicines used to manage signs of low blood sugar levels)
- cimetidine (a medicine used to manage stomach ulcers)
- rifampicin (a medicine used for tuberculosis)
- dolutegravir (a medicine used to manage HIV infection)
- racecadotril (a medicine used to manage diarrhea)
- medicines that supplement potassium to the body (Ex. spironolactone, triamterene or amiloride)
- medicines used to manage organ transplant rejection (Ex. ciclosporin, temsirolimus, sirolimus, everolimusmedicines used to manage bacterial infection (such as)
- medicines used to manage fungal infection (such as ketoconazole, itraconazole, voriconazole, fluconazole, posaconazole)
- rifampin (a medicine used to manage tuberculosis infection)
- other lipid lowering agents (such as gemfibrozil, fenofibrate, colestipol or ezetimibe)
- Antiviral agents (Ex. letermovir, ritonavir, lopinavir, atazanavir, indinavir, darunavir, the combination of tipranavir/ritonavir, telaprevir, boceprevir and the combination of elbasvir/grazoprevir, ledipasvir/sofosbuvir)
- oral contraceptives (Ex. levonorgestrel)
- medicines used to relieve pain (Ex. morphine, aspirin, ibuprofen, celecoxib, valdecoxib)
B. Drug-Food Interaction:
Avoid consumption of grapefruit while taking DIAKIT 4 KIT TABLET as it may reduce its effectiveness.
Overdosage:
If you or anyone else accidentally took more DIAKIT 4 KIT TABLET, you may experience the signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, fast heartbeat and confusion). To manage this, consume any sugary food immediately. If the symptom did not improve or worsens contact your doctor immediately. Other symptoms of overdosage might include vomiting, stomach pain with muscle cramps, feeling generally unwell with severe tiredness and difficulty in breathing.
Synopsis
| Drug | : | Atorvastatin, Glimepiride, Metformin, Ramipril |
| Pharmacological Category | : | HMG-CoA reductase inhibitors, Sulfonylureas, Biguanides, ACE Inhibitors |
| Therapeutic Indication | : | Controls blood pressure, blood sugar and blood cholesterol |
| Dosage Forms | : | Tablet |
More Information
- Keep DIAKIT 4 KIT TABLET out of reach of children
- Store DIAKIT 4 KIT TABLET at room temperature
FAQs About DIAKIT 4 KIT TABLET
Q: What is DIAKIT 4 KIT TABLET used for?
A: DIAKIT 4 KIT TABLET is used in the management of hypertension, hyperlipidaemia and hyperglycaemia in adults when diet, exercise and management with single agents does not result in adequate results. It also protects the function of your heart and kidneys particularly in patients who have both hypertension and diabetes mellitus.
Q: How and when to take DIAKIT 4 KIT TABLET?
A: Take DIAKIT 4 KIT TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Q: How long should I take DIAKIT 4 KIT TABLET?
A: You need to take DIAKIT 4 KIT TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Q: What is the best time to take DIAKIT 4 KIT TABLET?
A: DIAKIT 4 KIT TABLET must be taken with meals to avoid gastrointestinal side effects.
Q: What to do if I forgot to take a dose of DIAKIT 4 KIT TABLET?
A: If you forgot to take a dose of DIAKIT 4 KIT TABLET, take it as soon as you remember. However, if it is time for the next dose of DIAKIT 4 KIT TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of DIAKIT 4 KIT TABLET to compensate the missed ones.
Q: Can I stop taking DIAKIT 4 KIT TABLET without consulting your doctor?
A: No. You should not stop taking DIAKIT 4 KIT TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using DIAKIT 4 KIT TABLET, consult your doctor for advice.
Q: Will taking a higher dose of DIAKIT 4 KIT TABLET be more effective?
A: No, taking a higher dose of DIAKIT 4 KIT TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: Can I take medication for high blood pressure along with DIAKIT 4 KIT TABLET?
A: It is not advisable to take medicines to control blood pressure while taking DIAKIT 4 KIT TABLET without consulting your doctor, as they have known interactions with DIAKIT 4 KIT TABLET.
Q: How to manage the side effects of DIAKIT 4 KIT TABLET?
A: Low blood sugar is a common side effect of taking DIAKIT 4 KIT TABLET. Try to have sugar rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey or sugary candy. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack, or drink, and check the blood sugar levels once again. If your condition did not improve, consult your doctor immediately.
Q: Can DIAKIT 4 KIT TABLET be taken with insulin?
A: Co-administration of DIAKIT 4 KIT TABLET with insulin is considered risky as they can increase the chances of hypoglycemia (low blood sugar levels). Therefore, consult your doctor before taking it.
Q: Can DIAKIT 4 KIT TABLET be used in pregnant women?
A: DIAKIT 4 KIT TABLET is not recommended for use in pregnant women. Therefore, consult your doctor for advice before taking it.
Q: Does DIAKIT 4 KIT TABLET cause weight gain?
A: Yes. DIAKIT 4 KIT TABLET may cause weight gain in some individuals. To avoid this, follow a healthy diet and regular physical activity as advised by your physician. However, if you experience any weight gain due to swelling of body parts (such as in face, legs, or hands), consult your doctor immediately.
Q: What are the side effects of taking DIAKIT 4 KIT TABLET?
A: The most common side effects of taking DIAKIT 4 KIT TABLET are nausea, vomiting, indigestion, flatulence, changes in taste or metallic taste, low Vitamin B12 levels (signs include extreme tiredness, oral sores, pins and needles), inflammation of the nasal passages, throat pain, headache, joint pain, muscle pain and back pain, weight gain, neck pain and edema. Consult your doctor if any of these side effect trouble you.
References
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page-270, 275 & 277.
2. KD. Tripathi. Insulin, Hypolipidemic Drugs and Plasma Expanders. Essentials of medical pharmacology. Seventh edition. 2013. Page-637.
3. Brown & Burk UK Limited. Glimepiride 1 mg/2 mg/3 mg/4 mg Tablets Glimepiride. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 27th January 2024] https://www.medicines.org.uk/emc/files/pil.10742.pdf
4. Rx Farma Limited. Metformin 500, 850 and 1000mg. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 27th January 2024] https://www.medicines.org.uk/emc/files/pil.11951.pdf
5. Sun Pharmaceutical Industries. Atorvastatin 10, 20, 40 and 80mg. Electronic Medicines Compendium (EMC). [Revised in September 2023] [Accessed on 27th January 2024] https://www.medicines.org.uk/emc/files/pil.4339.pdf
6. Zentiva Pharma UK Limited. Atorvastatin 30 and 60mg. Electronic Medicines Compendium (EMC). [Revised in May 2023] [Accessed on 27th January 2024] https://www.medicines.org.uk/emc/files/pil.11753.pdf
7. Sanofi RAMIPRIL 1.25MG, 2.5MG, 5MG AND 10MG TABLETS. Electronic Medicines Compendium (EMC). [Revised in November 2020] [Accessed on 27th January 2024].
Useful Diagnostic Tests
- HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
- Blood Glucose Fasting (FBS)
- Post Prandial Blood Sugar (PPBS)
- Netmeds Diabetic Checkup
- Advance Diabetes Monitoring (Senior Female)
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