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Introduction About DIABETROL 3D TABLET
DIABETROL 3D TABLET is a combination of Glibenclamide, Metformin, and Rosiglitazone, which belongs to the group of medicines called Antidiabetic agents. It is used in adults to manage type II diabetes mellitus along with diet and exercise.
Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused by inadequate production of a hormone called insulin (produced by the pancreas to metabolize glucose) in the body or if the body cannot utilize the secreted insulin properly.
Before and during management with DIABETROL 3D TABLET, your doctor may also take blood tests to monitor your blood cell levels, liver, and kidney function.
DIABETROL 3D TABLET is not recommended for use by pregnant women or breastfeeding women. Consult your doctor before taking it.
DIABETROL 3D TABLET is not recommended for use in patients with severe kidney problems, liver problems, acute heart failure, who have recently had a heart attack, have severe problems with their circulation (such as shock), or have breathing difficulties. Therefore, consult your doctor before taking it.
The most common side effects of taking DIABETROL 3D TABLET are nausea, vomiting, diarrhea, abdominal pain, loss of appetite, and change in taste. Consult your doctor if any of the side effects worsen.
Uses Of DIABETROL 3D TABLET
It is used in adults along with diet and exercise to:
- Manage type II diabetes mellitus
How DIABETROL 3D TABLET Works
DIABETROL 3D TABLET effectively controls blood sugar levels in patients with type II diabetes mellitus. Where Glibenclamide helps the pancreas secrete more insulin (a hormone that digests glucose in the body). It reduces blood glucose levels by increasing the amount of insulin secreted by the pancreas. Metformin blocks the amount of glucose produced by the liver. It also reduces the absorption of glucose in the intestines and allows the body to make better use of insulin. Rosiglitazone helps improve glycemic control by increasing insulin sensitivity.
How to use DIABETROL 3D TABLET
Take DIABETROL 3D TABLET before food or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition. Continue to take DIABETROL 3D TABLET for the stipulated duration instructed by your doctor without any interruption to achieve better results.
Side Effects Of DIABETROL 3D TABLET
Common
- nausea, vomiting, diarrhea, abdominal pain, and loss of appetite
- change in taste
- upper respiratory tract infections
- headache
Stop taking DIABETROL 3D TABLET and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reactions (such as skin rash, itching, hives, blisters, peeling of skin, increased sensitivity to the sun, swelling of the face, lips, mouth, tongue, or throat that may lead to difficulty breathing or swallowing, a fall in blood pressure, and sometimes progressing to shock)
- signs and symptoms of liver problems (such as nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin, or the whites of the eyes)
- severe hypoglycemia, including loss of consciousness, fits, or coma
- symptoms of lactic acidosis (such as vomiting, stomach pain, decreased heartbeat, difficulty breathing, muscle cramps, general weakness with severe tiredness, or reduced body temperature)
- signs and symptoms of heart failure include swelling or fluid retention, especially in the ankles or legs, shortness of breath or trouble breathing, especially when you lie down, an unusually fast increase in weight, and unusual tiredness
- symptoms of a heart attack such as chest discomfort in the center of your chest that lasts for more than a few minutes or that goes away or comes back, chest discomfort that feels like uncomfortable pressure, squeezing, fullness, or pain, pain or discomfort in your arms, back, neck, jaw, or stomach, shortness of breath with or without chest discomfort, breaking out in a cold sweat, nausea or vomiting, feeling lightheaded
- symptoms of macular edema, such as changes in vision
How To Manage Side Effects
Diarrhea
Drink lots of fluids, such as water or fruit juices, to keep yourself hydrated. Do not take any medicine on your own to manage diarrhea. Contact your doctor if your diarrhea does not improve.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids, such as water or electrolytes. Applying a pain-relieving balm to your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Loss Of Appetite
Eat when you are hungry. Eat smaller meals more often than usual. Snack only when you're hungry. Eat a nutritious snack that is rich in calories and protein, such as dried fruit and nuts.
Nausea And Vomiting
Take DIABETROL 3D TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Skin rash Or Itching
Avoid hot baths because hot water can irritate your skin further. Do not scratch the affected area. Use sunscreen and wear protective clothing while going outside. Use unscented moisturizers to soothe and hydrate the affected area. Contact your doctor if your rashes worsen.
Stomach Pain
Try to have smaller meals but take them frequently. Keep a heat pad on your stomach. Do not self-manage and contact your doctor if the stomach pain does not improve.
Warning & Precautions
Pregnancy
ContraindicatedDIABETROL 3D TABLET is generally not recommended for use by pregnant women due to a lack of safety data. However, consult your doctor for advice.
Breastfeeding
ContraindicatedDIABETROL 3D TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. However, consult your doctor for advice.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if you have symptoms of low blood sugar, such as weakness, dizziness, increased sweating, a fast heartbeat, vision disorders, or difficulty in concentration after taking DIABETROL 3D TABLET.
Alcohol
Consult your doctorAvoid consuming alcohol while taking DIABETROL 3D TABLET, as it may increase the risk of unwanted effects.
Kidney
ContraindicatedDIABETROL 3D TABLET is not recommended for use in patients with severe kidney disease. Therefore, consult your doctor for advice.
Liver
ContraindicatedDIABETROL 3D TABLET is not recommended for use in patients with liver problems. Therefore, consult your doctor for advice.
Allergy
ContraindicatedDo not take DIABETROL 3D TABLET if you are allergic to glibenclamide, metformin, rosiglitazone, or any of the other ingredients of this medicine.
Heart Disease
ContraindicatedDIABETROL 3D TABLET is not recommended for use in patients with acute heart failure or who have recently had a heart attack, have severe problems with their circulation (such as shock), or have breathing difficulties. Therefore, consult your doctor for advice.
Use In Pediatrics
ContraindicatedDIABETROL 3D TABLET is generally not recommended for use in children and adolescents (aged below 18 years) due to a lack of safety data. Therefore, consult your doctor for advice.
Use In Geriatrics
Use with CautionDIABETROL 3D TABLET should be used with caution in elderly patients (aged 65 years or older). Therefore, consult your doctor for advice.
Others
DIABETROL 3D TABLET is not recommended for use if you:
- have uncontrollable diabetes
- have type I diabetes mellitus (insulin-dependent diabetes)
- have lactic acidosis (the buildup of lactic acid in the body)
- have diabetic ketoacidosis (a diabetic complication causing episodes of fatigue, nausea, frequent urination, and muscular stiffness)
- are in a diabetic coma
- are severely dehydrated (due to excessive vomiting, diarrhea, sweating, increased physical activity, or if you drink less fluids)
- have severe infections affecting your lungs or kidneys
- are scheduled for any upcoming surgeries
Before taking DIABETROL 3D TABLET, inform your doctor if you:
- are recovering from an injury, operation, infection with fever, or any other form of stress
- undernourishment, irregular meal time, missed or delayed meal, or period of fasting
- are scheduled for any X-rays
- have hormonal imbalances (Ex. thyroid problems)
- have problems in the adrenal cortex or pituitary gland (Ex. hyperaldosteronism, Cushing’s syndrome)
- have G6PD deficiency (a genetic disorder that affects red blood cells in the body)
- have a type of diabetic eye disease called macular edema (swelling of the back of the eye)
Interactions
A. Drug-Drug interactions:
Before taking DIABETROL 3D TABLET, inform your doctor if you are taking any of the following medicines, such as:
- other medicines used to manage diabetes mellitus (such as insulin or metformin)
- medicines used to manage pain and inflammation (Ex. aspirin, ibuprofen, celecoxib, phenylbutazone, azapropazone, and oxyphenbutazone)
- medicines used to manage urinary infections (sulfamethoxazole)
- medicines used to manage bacterial and fungal infections (such as tetracyclines, neomycin, chloramphenicol, trimethoprim, ciprofloxacin, clarithromycin, fluconazole, miconazole, and isavuconazole)
- medicines used to manage blood clotting (Ex. warfarin)
- medicines used for muscle buildup (Ex. nandrolone, oxymetholone)
- medicines used for male sex hormone replacement therapy (Ex. testosterone)
- medicines used to manage depression (such as moclobemide, isocarboxazid, phenelzine, tranylcypromine, and fluoxetine)
- medicines used to manage high blood cholesterol levels (Ex. fenofibrate, nicotinic acid, gemfibrozil, and colesevelam)
- medicines used to manage high blood pressure and heart conditions (Ex. enalapril, lisinopril, ramipril, verapamil, ranolazine, atenolol, propranolol, telmisartan, olmesartan, clonidine, guanethidine, hydrochlorothiazide, bendroflumethiazide, bosentan, and reserpine)
- medicines used to manage gout (Ex. probenecid, sulfinpyrazone)
- medicines used to manage cancer (Ex. cyclophosphamide, ifosfamide, trofosfamide, vandetanib, crizotinib, and olaparib)
- fenfluramine (a medicine used to manage obesity)
- pentoxifylline (a medicine that can improve blood flow in the body)
- medicines used to manage allergic rhinitis (Ex. tritoqualine)
- sympatholytics (medicines used to manage high blood pressure, heart failure, or prostate problems) (Ex. prazosin, doxazosin, clonidine)
- medicines containing female sex hormones (Ex. estradiol, progesterone)
- levothyroxine (a medicine used to manage thyroid problems)
- medicines to manage mental illness (such as chlorpromazine and prochlorperazine)
- corticosteroids (used to manage pain and inflammatory conditions) (Ex. prednisolone, betamethasone, and hydrocortisone)
- beta-2 agonists such as salbutamol or terbutaline (used to manage asthma)
- medicines used to raise heartbeat, to manage asthma or nasal congestion, coughs and colds, to reduce weight, or in life-threatening emergencies (adrenaline and sympathomimetics)
- medicines used to manage constipation (Ex. lactulose, liquid paraffin)
- medicines used to manage epilepsy (Ex. phenytoin)
- medicines to manage nervousness and sleep problems (barbiturates) (Ex. phenobarbital)
- medicines used to reduce increased pressure in the eye (Ex. acetazolamide)
- glucagon, diazoxide (medicines used to manage signs of low blood sugar levels)
- rifampicin (a medicine used to manage tuberculosis)
- medicines to manage stomach ulcers (H2 antagonists) (Ex. cimetidine)
- dolutegravir (a medicine used to manage HIV infection)
Overdosage:
If you or anyone else accidentally takes too much of DIABETROL 3D TABLET, consult your doctor immediately or go to a hospital right away. Symptoms of an overdose may cause low blood sugar levels and lactic acidosis. Symptoms include vomiting, abdominal pain, muscle cramps, a general feeling of not being well with severe tiredness, and difficulty breathing. Further symptoms include a reduced body temperature and heartbeat.
Synopsis
| Drug | : | Glibenclamide, Metformin, Rosiglitazone |
| Pharmacological Category | : | Sulfonylureas, biguanides, and thiazolidinediones |
| Therapeutic Indication | : | Type II diabetes mellitus |
| Dosage Forms | : | Tablet |
More Information
- Keep DIABETROL 3D TABLET out of reach of children
- Store DIABETROL 3D TABLET at room temperature
FAQs About DIABETROL 3D TABLET
Q: Does DIABETROL 3D TABLET cause weight gain?
A: Yes. DIABETROL 3D TABLET may cause weight gain in some individuals. To avoid this, follow a healthy diet and engage in regular physical activity, as advised by your physician. However, if it bothers you, consult your doctor.
Q: How do I take DIABETROL 3D TABLET?
A: Take DIABETROL 3D TABLET before food or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.
Q: Can DIABETROL 3D TABLET be taken with insulin?
A: Consult your doctor before taking DIABETROL 3D TABLET along with insulin, as it may increase the chances of hypoglycemia (decreased blood sugar levels).
Q: What should I do if I experience low blood sugar after taking DIABETROL 3D TABLET?
A: Low blood sugar is a common side effect of taking DIABETROL 3D TABLET. Try to have sugar-rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey, or sugary candy. If you cannot see any improvement in your condition or if your condition worsens, contact your doctor.
Q: What are the side effects of DIABETROL 3D TABLET?
A: The most common side effects of taking DIABETROL 3D TABLET are nausea, vomiting, diarrhea, abdominal pain, loss of appetite, and change in taste. Consult your doctor if any of the side effects worsen.
Q: What precautions do I need to follow while taking DIABETROL 3D TABLET?
A: Before taking DIABETROL 3D TABLET, inform your doctor if you are recovering from an injury, operation, infection with fever, or any other form of stress or have undernourishment, irregular meal time, missed or delayed meal or period of fasting, scheduled for any X-rays, or have hormonal imbalances (Ex. thyroid problems), problems in the adrenal cortex or pituitary gland (Ex. hyperaldosteronism, Cushing’s syndrome), or have G6PD deficiency (a genetic disorder that affects red blood cells in the body) or macular edema (swelling of the back of the eye).
Q: What are the lifestyle changes to be followed while taking DIABETROL 3D TABLET?
A: During therapy with DIABETROL 3D TABLET, follow the diet and lifestyle changes instructed by your doctor. Always carry a sugary snack (such as biscuits, glucose drinks, or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia.
References
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270 & 275.
2. Alan J Garber, Daniel S Donovan Jr, Paresh Dandona, Simon Bruce, Jong-Soon Park. Efficacy of glyburide/metformin tablets compared with initial monotherapy in type 2 diabetes. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. August 2003. [Accessed on 29th January 2024] https://pubmed.ncbi.nlm.nih.gov/12915642/
3. Virendra Rambiritch, Breminand Maharaj, and Poobalan Naidoo. Glibenclamide in patients with poorly controlled type 2 diabetes: a 12-week, prospective, single-center, open-label, dose-escalation study. NIH. National Library of Medicine. National Center of Biotechnology Information. PMC. PubMed Central. April 2014. [Accessed on 29th January 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983009/
4. Chanelle Medical. Health Product Regulatory Authority. (HPRA). [Revised in May 2016] [Accessed on 29th January 2024] https://www.hpra.ie/img/uploaded/swedocuments/2179143.PA0688_040_002.752e1eeb-1045-476a-97ac-9f7549199666.000001Product%20Leaflet%20Approved%205mg.160725.pdf
5. Bristol-Myers Squibb Company; U.S. Food & Drug Administration; [Revised in December 2018] [Accessed on 29th January 2024] https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021178s018lbl.pdf
6. Central Drugs Standard Control Organization. Glibenclamide+Metformin. [Accessed on 17th January 2024] https://cdscoonline.gov.in/CDSCO/Drugs
7. GlaxoSmithKline. U.S. Food & Drug Administration. [Accessed on 29th January 2024] https://www.accessdata.fda.gov/drugsatfda_docs/label/2004/21071slr009,21410slr005,006_avandamet_lbl.pdf
8. Brown & Burk UK Ltd. Electronic Medicines Compendium (EMC) [Revised in May 2022] [Accessed on 29th January 2024] https://www.medicines.org.uk/emc/files/pil.10760.pdf
9. GlaxoSmithKline. Rosiglitazone. [Revised in November2020] [Accessed on 29th January 2024] https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Avandia/pdf/AVANDIA-PI-MG.PDF
Useful Diagnostic Tests
- HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
- Blood Glucose Fasting (FBS)
- Random Blood Sugar (RBS)
- Post Prandial Blood Sugar (PPBS)
- Insulin-Fasting
- Insulin Postprandial (PP)
- Vital Diabetes Care
- Extended Diabetes Care
- Advance Diabetes Care
- Comprehensive Diabetes Care
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