DEPRID 25 Tablet 10's
Netmeds First Membership
Quick Links
Introduction About DEPRID 25 TABLET
DEPRID 25 TABLET contains Imipramine which belongs to the group of medicines called Anti-depressants. It is used for the management of symptoms of depressive illness. It also provides relief of nocturnal enuresis (bed wetting) in children. Nocturnal enuresis is the involuntary urination in children while sleeping at the age beyond which bedwetting is not expected.
During management with DEPRID 25 TABLET, your doctor may regularly monitor the blood cell count and liver function test. As DEPRID 25 TABLET causes teeth related problems, you are advised to have dental check-ups frequently.
DEPRID 25 TABLET is not recommended for use in patients having severe liver disease and heart disease such as heart block or have recently had a heart attack, irregular heartbeats. DEPRID 25 TABLET should be taken with caution in patients having severe kidney disease, history of epilepsy (fits) or brain damage. Consult your doctor for advice.
DEPRID 25 TABLET is not recommended for use in pregnant and breastfeeding women. DEPRID 25 TABLET is generally not recommended for use in children aged under 6 years and it should be used with caution in elderly patients.
Some serious effects of DEPRID 25 TABLET includes suicidal thoughts or attempts, thoughts of killing or harming yourself and worsening of depression or anxiety. Contact your doctor or go to the hospital immediately if you feel such symptoms.
The most common side effects of taking DEPRID 25 TABLET are nervousness, dizziness, headache, dry mouth, vision changes and constipation. Consult your doctor if any of the side effects worsen.
Uses Of DEPRID 25 TABLET
- Manage symptoms of depressive illness
- Provides relief of nocturnal enuresis (bed wetting) in children
How DEPRID 25 TABLET Works
DEPRID 25 TABLET effectively reduces the symptoms of depression where imipramine works by increasing the concentration of the neurotransmitter called norepinephrine and serotonin as this substance is found to be low in patients with depression. Through its anticholinergic effect (blocking acetylcholine), imipramine controls the involuntary muscle movements, thereby it provides relief from nocturnal enuresis or bedwetting in children.
How to use DEPRID 25 TABLET
Take DEPRID 25 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of DEPRID 25 TABLET
Common
- fatigue (general weakness), restlessness, drowsiness, disorientation, delirium (mental disturbances causing confused thinking), confusion, hallucinations (seeing or hearing things that wasn’t there), anxiety or agitation, sleep disturbances, swings from depression to hypomania or mania (extreme mood changes)
- tremor (involuntary shaking movements of hands and legs commonly)
- tingling or prickling sensation, numbness, headache, dizziness
- heart problems like sinus tachycardia and ECG changes in patients with normal heart status and postural hypotension (low blood pressure when standing up from sitting position), irregular heartbeat, conduction disorders, palpitations (fast or fluttering heartbeat)
- dry mouth, sweating, visual disturbances, blurred vision, hot flushes
- disturbances in urination, constipation
- nausea, vomiting, anorexia (eating disorder causing people to fear of weight gain)
- allergic reactions like urticaria, skin rash
- weight gain
- disturbances in libido (sexual drive) and potency
Rare
- psychotic symptoms activation
- fits or seizures
- signs of impaired liver function like yellowing of skin, and eyes, abdominal pain, loss of appetite
Stop taking DEPRID 25 TABLET and contact your doctor immediately if you experience any of the following side effects:
- allergic reaction like pneumonitis (symptoms include fever, cough, chills, breathing difficulties, nausea, unusual weight loss) and skin rash, which may cause itchiness, sensitivity to the sun light or sun lamps, puffy or swollen face or tongue, which may become severe resulting in shortness of breath, shock and collapse
- suicidal thoughts or attempts, killing or harming yourself and worsening of depression or anxiety
How To Manage Side Effects
Vomiting:
Take this medicine with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Consult your doctor if your symptom worsens.
Headache:
Drink ample amount of water. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.
Dizziness
Lie or sit down immediately when you feel dizzy. If you're feeling severe episode of spinning (vertigo), lie in a dark and quite place with eyes closed. Try to avoid vehicle driving. Discuss with your doctor if the symptom worsens.
Dry mouth:
Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes that contain alcohol because they can be drying. Consult your doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
DEPRID 25 TABLET is not recommended for use during pregnancy. If it is taken during last three months of pregnancy DEPRID 25 TABLET may cause breathing difficulties, colic, lethargy, irritability, blood pressure changes, tremors, spasm when the baby is born. Consult with your doctor before taking DEPRID 25 TABLET.
Breastfeeding
DEPRID 25 TABLET is not recommended for use in breastfeeding woman. Consult with your doctor before taking DEPRID 25 TABLET.
Driving and Using Machines
Do not drive or operate any machinery while taking DEPRID 25 TABLET as it may cause drowsiness, blurred vision or impair alertness.
Alcohol
Avoid consumption of alcohol while taking DEPRID 25 TABLET.
Kidney
DEPRID 25 TABLET is not recommended for use in patients who are unable to urinate. It should be used with caution in patients having severe kidney disease. Consult with your doctor before taking DEPRID 25 TABLET.
Liver
DEPRID 25 TABLET is not recommended for use in patients having severe liver disease. Consult with your doctor before taking DEPRID 25 TABLET.
Allergy
Do not take DEPRID 25 TABLET if you are allergic to Imipramine or other tricyclic antidepressants such as amitriptyline or any other ingredients of this medicine.
Heart Disease
DEPRID 25 TABLET is not recommended for use in patients having heart disease such as heart block or have recently had a heart attack, irregular heartbeats. Consult with your doctor before taking DEPRID 25 TABLET.
Others
DEPRID 25 TABLET is not recommended for use if you:
- have mania (increased and exaggerated behaviour)
- have porphyria (red blood cell disorder causing skin blisters, abdominal pain and brain/ nervous system disorders)
- have increased eye pressure (glaucoma)
Before taking DEPRID 25 TABLET, inform your doctor if you:
- have psychiatric disorder (Ex. schizophrenia or manic depression)
- are withdrawing alcohol
- have glaucoma
- have an enlarged prostate gland
- have an overactive thyroid gland
- have a history of epilepsy (fits) or brain damage
- have low blood pressure or poor circulation
- have adrenal gland tumour (Ex. phaeochromocytoma or neuroblastoma)
- are suffering from panic attacks and long-term constipation
- are wearing contact lenses
- are being given electroconvulsive therapy (ECT)
- are scheduled to have any surgery, including dental surgeries, which involves an anaesthetic
Use in pediatrics:
DEPRID 25 TABLET is not recommended for use in children below 6 years of age. Consult your child’s doctor for advice.
Use in geriatrics:
DEPRID 25 TABLET should be used with caution in elderly patients. Consult your doctor for advice before taking it.
Interactions
A. Drug - Drug interactions:
Before taking DEPRID 25 TABLET, inform your doctor if you are taking any of the following medicines:
- medicines used to manage epilepsy (Ex. carbamazepine, phenytoin phenobarbital)
- benzodiazepines like nitrazepam, diazepam, alprazolam, oxazepam (used to manage insomnia and anxiety)
- selective serotonin reuptake inhibitors (SSRIs) like fluoxetine, fluvoxamine (used for depression)
- disulfiram (used to manage alcohol addiction)
- nicotine replacement therapy (used to stop smoking)
- methylphenidate (medicine used to manage attention deficit/hyperactivity disorder (ADHD))
- medicines used to manage blood clots (Ex. warfarin)
- antihistamines like chlorpheniramine (used to manage allergies)
- altretamine (medicine to manage some types of cancer)
- apraclonidine and brimonidine (used to manage glaucoma)
- baclofen (used as muscle relaxant)
- painkillers like nefopam, codeine, tramadol, dihydrocodeine (used to manage pain)
- medicines to manage some heart conditions (Ex. diltiazem, verapamil, labetalol, quinidine, propranolol)
- glyceryl trinitrate and isosorbide dinitrate (used to manage angina)
- medicines used to manage high blood pressure (Ex. guanethidine, bethanidine methyldopa, debrisoquine, reserpine, clonidine or diuretics like furosemide)
- thioridazine, chlorpromazine (used to manage some mental illnesses)
- cimetidine (a medicine used to manage stomach ulcers)
- entacapone or selegiline (used to manage Parkinson’s disease)
- oral contraceptives or hormone replacement therapy (HRT) (used to manage pregnancy)
- appetite suppressants (Ex. diethylpropion, liraglutide)
- sympathomimetic medicines (which may be present in many cough and cold remedies or local anaesthetics) like adrenaline (epinephrine), isoprenaline, ephedrine, noradrenaline (norepinephrine), phenylpropanolamine and phenylephrine
- ritonavir (used to manage HIV)
- buprenorphine or opioids medicines (used to manage pain)
- thyroid medicine like carbimazole and propylthiouracil (used to manage hyperthyroidism)
Overdosage:
If you or anyone else accidentally take too much of DEPRID 25 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose include irregular or fast heartbeat, drowsiness, agitation, low blood pressure, fits, coma, muscle spasm or rigidity, vomiting or fever.
Synopsis
| Drug | : | Imipramine |
| Pharmacological Category | : | Tricyclic Antidepressants |
| Therapeutic Indication | : | Depression, Nocturnal enuresis (in children) |
| Dosage Forms | : | Tablet, Capsule |
More Information
- Keep DEPRID 25 TABLET out of reach of children
- Store at room temperature
FAQs About DEPRID 25 TABLET
What is DEPRID 25 TABLET and why it is given?
DEPRID 25 TABLET contains Imipramine which belongs to the group of medicines called Tricyclic Anti-depressants. It is used for the management of symptoms of depressive illness. It also provides relief of nocturnal enuresis (bed wetting) in children.
Can pregnant woman take DEPRID 25 TABLET?
DEPRID 25 TABLET is not recommended for use during pregnancy. If it is taken during last three months of pregnancy DEPRID 25 TABLET may cause breathing difficulties, colic, lethargy, irritability, blood pressure changes, tremors, spasm when the baby is born. Consult with your doctor before taking it.
Does DEPRID 25 TABLET cause suicidal thoughts?
In some patients, DEPRID 25 TABLET causes suicidal thoughts or attempts, killing or harming yourself and worsening of depression or anxiety at the starting of the management with antidepressants. Contact your doctor or go to the hospital immediately if you feel such symptoms.
Does DEPRID 25 TABLET cause dry mouth?
One of the common side effects of DEPRID 25 TABLET is dry or sore mouth and throat. It can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes that contain alcohol because they can be drying.
Do I need to take any test while taking DEPRID 25 TABLET?
During management with DEPRID 25 TABLET, your doctor may regularly monitor the blood cell count and liver function test. As DEPRID 25 TABLET causes teeth related problems, you are advised to have dental check-ups frequently.
How long should I need to take DEPRID 25 TABLET?
Take DEPRID 25 TABLET as long as advised by your physician. Do not stop taking it early without taking to your doctor as it may cause withdrawal symptoms like nausea or vomiting, diarrhoea, stomach pain, difficulty in sleeping, anxiety, nervousness, headache and irritability.
References
1. KD. Tripathi. Antidepressants and Anti-Anxiety Drugs. Essentials of medical pharmacology. Eighth edition. 2019. Page –485.
2. Imipramine. NIH National Library of Medicine, National Centre for biotechnology information. PubChem. September 2022. [Accessed on 7th September 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Imipramine
3. Rola Fayez; Vikas Gupta. Imipramine. National Library of Medicine, National center for biotechnology information. Stat pearls. Revised in July 2022. [Accessed on 7th September 2022] https://www.ncbi.nlm.nih.gov/books/NBK557656/#:~:text=The%20anticholinergic%20properties%20of%20imipramine,%2C%20and%20narrow%2Dangle%20glaucoma.
4. Torrent Pharmaceuticals Ltd. Antidep (Imipramine Hydrochloride 25mg and 75mg Tablet). [Revised in January 2022] [Accessed on 7th September 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1940.pdf
Author Details
