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Introduction About DAPAHENZ SM 1000 TABLET
DAPAHENZ SM 1000 TABLET is used in the management of type II diabetes mellitus when diet, exercise, and therapy with conventional medicines does not result in adequate response. It contains a combination of three medicines, namely, Dapagliflozin, Metformin, and Sitagliptin that works by making your pancreas secrete more insulin, an hormone responsible for digesting glucose molecules and enables your body cells absorb more sugar from blood circulation.
Take DAPAHENZ SM 1000 TABLET as directed by your physician. Taking this medicine after meals helps to avoid stomach upset. Do not stop using DAPAHENZ SM 1000 TABLET without talking to your doctor. Prior to the management, your doctor may want you to take several blood tests to understand your existing kidney condition.
DAPAHENZ SM 1000 TABLET is not recommended for use during pregnancy or in breastfeeding women. It is also not suitable for use if you have respiratory failure, severe kidney disease, liver disease, heart failure, or a recent myocardial infarction. Therefore, consult your doctor before taking it.
The most common side effects of taking DAPAHENZ SM 1000 TABLET are hypoglycemia (low blood glucose level), nausea, vomiting, headache, flatulence, genital infections, and increased or more frequent urination. Consult your doctor if any of the side effects worsen.
Uses Of DAPAHENZ SM 1000 TABLET
How DAPAHENZ SM 1000 TABLET Works
DAPAHENZ SM 1000 TABLET is a combination of dapagliflozin, metformin, and sitagliptin. Dapagliflozin works by inhibiting the reabsorption of glucose in the kidneys, increasing urinary glucose excretion, and reducing blood glucose levels. Metformin decreases the amount of glucose you absorb from your food and the amount of glucose made by the liver. It also increases the body's response to insulin, a natural substance that controls the amount of glucose in the blood. Sitagliptin helps control blood sugar levels by increasing substances (incretins) in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood.
How to use DAPAHENZ SM 1000 TABLET
- Take DAPAHENZ SM 1000 TABLET as advised by your physician.
- It can be taken with or without meals. However, taking this medicine with meals help reduce gastrointestinal discomfort
- Swallow this medicine whole with a glass of water, and do not crush or chew the medicine.
- Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.
- Do not stop taking this medicine without consulting your doctor. Otherwise, your blood sugar will rise again.
Side Effects Of DAPAHENZ SM 1000 TABLET
Common Side Effects of DAPAHENZ SM 1000 TABLET:
- Hypoglycemia (low blood glucose level)
- Nausea, vomiting
- Headache
- Flatulence
- Genital infections
- Increased or more frequent urination
- Drowsiness, dizziness
- Diarrhea, constipation
- Stomach pain
- Itching
- Dry mouth
- Decreased weight
- Thirst
Stop taking DAPAHENZ SM 1000 TABLET and consult your doctor immediately if you experience any of the following side effects:
- Symptoms of acute pancreatitis, such as severe and persistent abdominal pain that might reach through your back with or without nausea and vomiting
- Symptoms of allergic reactions such as rash, hives, blisters on the skin or peeling skin, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing
- Signs of bullous pemphigoid, such as blistering of the skin
- Symptoms of lactic acidosis include vomiting, abdominal pain, muscle cramps, a general feeling of not being well, severe tiredness, difficulty breathing, reduced body temperature, and a slow heartbeat
- The symptoms of diabetic ketoacidosis are nausea, vomiting, stomach pain, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to your breath, a sweet or metallic taste in your mouth, or a different odour to your urine or sweat, or rapid weight loss
- Signs of severe infections of the urinary tract include fever, chills, a burning sensation during urination, pain in your back or side, and blood in your urine
How To Manage Side Effects
Constipation
Include fiber-rich foods in your diet, such as fresh fruits, vegetables, and whole-grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Contact your doctor if constipation persists.
Diarrhea
Drink lots of fluids, such as water or fruit juices, to keep yourself hydrated. Do not take any medicine on your own to manage diarrhea. Contact your doctor if your diarrhea does not improve.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive amounts of alcohol. Consult your doctor if your dizziness worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids, such as water or electrolytes. Applying a pain-relieving balm to your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Warning & Precautions
Pregnancy
Consult your doctorThere are no well controlled human studies regarding the use of Dapagliflozin + Sitagliptin + Metformin in pregnant women. Animal studies have indicated few harmful side effects in their progeny. Therefore, DAPAHENZ SM 1000 TABLET should be taken by pregnant women only if your doctor considers it as clearly necessary.
Breastfeeding
Consult your doctorIt is not known whether the medicines, Dapagliflozin + Sitagliptin + Metformin gets excreted in breast milk. Animal studies have reported the excretion of medicine in milk as well as pharmacologically mediated effects in nursing offspring. A risk to the infant cannot be excluded. Therefore, breastfeeding women should not take DAPAHENZ SM 1000 TABLET unless considered necessary by the physician.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you have dizziness and drowsiness after taking DAPAHENZ SM 1000 TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking DAPAHENZ SM 1000 TABLET, as it may increase the risk of lactic acidosis.
Kidney
Consult your doctorDAPAHENZ SM 1000 TABLET is not recommended for use in patients with severe kidney disease. It should be used with caution in patients with mild to moderate kidney disease. Consult your doctor before taking it.
Liver
ContraindicatedDAPAHENZ SM 1000 TABLET is not recommended for use if you have liver disease. Consult your doctor before taking it.
Allergy
ContraindicatedDAPAHENZ SM 1000 TABLET is not recommended for use if you are allergic to dapagliflozin, metformin, sitagliptin, or any of the other ingredients of this medicine.
Lungs
ContraindicatedDAPAHENZ SM 1000 TABLET is not recommended for use if you have respiratory failure. Consult your doctor before taking it.
Heart Disease
ContraindicatedDAPAHENZ SM 1000 TABLET is not recommended for use if you have heart failure or a recent myocardial infarction. Consult your doctor before taking it.
Use In Pediatrics
ContraindicatedDAPAHENZ SM 1000 TABLET is not recommended for use in children and adolescents below 18 years of age as safety and efficacy are not clinically established. Contact your doctor before taking.
Use In Geriatrics
Use with CautionDAPAHENZ SM 1000 TABLET should be used with caution in elderly patients (aged 65 years or older). Contact your doctor before taking.
Others
DAPAHENZ SM 1000 TABLET is not recommended for use if you:
- Have Type 1 diabetes mellitus
- Have acute metabolic acidosis (such as lactic acidosis or diabetic ketoacidosis)
- Have diabetic pre-coma
- Have dehydration
- Have a severe infection
- Have shock
- Are scheduled for a lab test
- Are planned for surgery
Before taking DAPAHENZ SM 1000 TABLET, inform your doctor if you:
- Have a history of pancreatitis
- Have or have had gallstones
- Have very high levels of triglycerides (a form of fat) in your blood
Interactions
A. Drug-Drug interactions:
Before taking DAPAHENZ SM 1000 TABLET, inform your doctor if you are taking prescription, non-prescription, or herbal supplements.
- Sulphonylureas or with insulin (other medicines used to manage diabetes mellitus) Ex. glimepiride
- Ketoconazole and itraconazole (medicines used to manage fungal infections)
- Ritonavir (a medicine used to manage viral infections)
- Clarithromycin (a medicine used to manage bacterial infections)
- Corticosteroids (medicines used to manage pain and inflammatory conditions) like asthma and arthritis Ex. dexamethasone
- Medicines that increase urine production (diuretics) Ex. furosemide
- Medicines used to manage pain and inflammation (NSAIDs and COX-2-inhibitors, such as ibuprofen and celecoxib)
- Medicines for the management of high blood pressure (ACE inhibitors and angiotensin II receptor antagonists) Ex. enalapril, losartan
- Sympathomimetics (medicines used in the management of asthma) Ex. salbutamol
- Iodinated contrast agents or alcohol-containing medicines
- Medicines used to manage stomach problems, such as cimetidine
- Ranolazine, a medicine used to manage angina
- Dolutegravir, a medicine used to manage HIV infection
- Vandetanib, a medicine used to manage a specific type of thyroid cancer
- Digoxin (to manage irregular heartbeats and other heart problems)
Overdosage:
If you or anyone else accidentally took too much of this medicine, consult your doctor immediately. The symptoms of an overdose include hypoglycemia. Overdosage may cause lactic acidosis, and symptoms include feeling cold or uncomfortable, severe nausea or vomiting, stomach pain, unexplained weight loss, muscular cramps, or rapid breathing.
Synopsis
| Drug | : | Dapagliflozin, Metformin, and Sitagliptin |
| Pharmacological Category | : | Antidiabetics |
| Therapeutic Indication | : | Type 2 diabetes mellitus |
| Dosage Forms | : | Tablet |
More Information
Storage
- Keep DAPAHENZ SM 1000 TABLET out of reach of children
- Store at room temperature
FAQs About DAPAHENZ SM 1000 TABLET
Q: What is DAPAHENZ SM 1000 TABLET used for?
A: It is used to manage type 2 diabetes mellitus along with diet and exercise when diabetes cannot be controlled with other medicines.
Q: Who should not take DAPAHENZ SM 1000 TABLET?
A: DAPAHENZ SM 1000 TABLET is not recommended for use if you have respiratory failure, severe kidney disease, liver disease, heart failure, recent myocardial infarction, Type 1 diabetes mellitus, acute metabolic acidosis (such as lactic acidosis and diabetic ketoacidosis), diabetic pre-coma, dehydration, severe infection, or shock. Consult your doctor before taking it.
Q: Can I take alcohol while using DAPAHENZ SM 1000 TABLET?
A: No. Avoid consumption of alcohol while taking DAPAHENZ SM 1000 TABLET, as it may increase the risk of lactic acidosis.
Q: Is DAPAHENZ SM 1000 TABLET safe for kidneys?
A: DAPAHENZ SM 1000 TABLET is not recommended for use in patients with severe kidney disease. It should be used with caution in patients with mild to moderate kidney disease. Consult your doctor before taking it.
Q: How does DAPAHENZ SM 1000 TABLET work?
A: DAPAHENZ SM 1000 TABLET is a combination of dapagliflozin, metformin, and sitagliptin. Dapagliflozin increases urinary glucose excretion and reduces blood glucose levels. Metformin decreases the amount of glucose you absorb from your food and the amount of glucose made by the liver. It also increases the body's response to insulin, a natural substance that controls the amount of glucose in the blood. Sitagliptin helps control blood sugar levels by increasing substances (incretins) in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood.
Q: Can I use DAPAHENZ SM 1000 TABLET with other diabetic medications?
A: Your doctor may advise DAPAHENZ SM 1000 TABLET with or without other medications to control your blood sugar levels. However, it is advised to maintain a proper diet and exercise to achieve controlled blood sugar levels while using this medicine with or without other antidiabetic medications.
Q: Can DAPAHENZ SM 1000 TABLET be used during pregnancy?
A: DAPAHENZ SM 1000 TABLET is not recommended for use during pregnancy. Consult your doctor before taking it.
Q: Does DAPAHENZ SM 1000 TABLET cause low blood sugar?
A: Yes. DAPAHENZ SM 1000 TABLET may cause low blood sugar. Stop taking DAPAHENZ SM 1000 TABLET and contact your doctor if you experience any unusual symptoms like weakness, shaking, sweating, drowsiness, dizziness, feeling very anxious, fast heartbeat, hunger, headache, change in vision, change in mood or confusion, and irritability.
Q: Is DAPAHENZ SM 1000 TABLET safe for kids?
A: DAPAHENZ SM 1000 TABLET is not recommended for use in children and adolescents below 18 years of age as safety and efficacy are not clinically established. Contact your doctor before taking.
Q: What are the side effects of DAPAHENZ SM 1000 TABLET?
A: The most common side effects of taking DAPAHENZ SM 1000 TABLET are hypoglycemia (low blood glucose level), nausea, vomiting, headache, flatulence, genital infections, and increased or more frequent urination. Consult your doctor if any of the side effects worsen.
References
1. K.D. Tripathi. Insulin, oral hypoglycaemic drugs and glucagon. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page - 278, 275.
2. Clifford J Bailey, Jorge L Gross, Delphine Hennicken, Nayyar Iqbal, Traci A Mansfield, and James F List. Uses of metformin and dapagliflozin. Biomed Central (BMC). February 2013. [Accessed on 12th July 2024] click here
3. La Renon Healthcare. Dapagliflozin+Metformin+Sitagliptin. [Accessed on 12th July 2024] click here
4. TORRENT PHARMACEUTICALS LTD. Dapagliflozin and Sitagliptin. [Accessed on 12th July 2024] click here
5. TORRENT PHARMACEUTICALS LTD. Sitagliptin and Metformin. [Accessed on 12th July 2024] click here
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