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Introduction About CZ L CAPSULE
CZ L CAPSULE is a combination of Levocetirizine and Pseudoephedrine which belongs to the group of medicines called Antihistamines and Nasal Decongestants respectively. It is used to get relief from symptoms of hay fever or other respiratory allergies. The symptoms are runny nose, sneezing, itchy and watery eyes, itching of the nose and nasal congestion.
CZ L CAPSULE is not recommended for use in patients having severe kidney disease. It should be taken with caution in patients who have heart or liver disease, epilepsy, thyroid, high blood pressure, diabetes and difficulty in urination.
In pregnant women, CZ L CAPSULE should be used with caution and it is contraindicated in breast-feeding mothers unless advised by the doctor. CZ L CAPSULE is not recommended for use in children below 12 years of age.
The most common side effects of taking CZ L CAPSULE are dry mouth, headache, tiredness and downiness. Talk to your doctor if any of these worsen or doesn’t improve.
Uses Of CZ L CAPSULE
- Reduces the symptoms of hay fever or other respiratory allergies
How CZ L CAPSULE Works
CZ L CAPSULE helps to reduce the symptoms of hay fever or other respiratory allergies, where levocetirizine is a H1 receptor antagonist which stops the action of histamine by acting on histamine receptors which results in muscle relaxation, decrease in flare responses and non- activation of cough receptors. Pseudoephedrine is an alpha-adrenergic agonist which effectively relaxes the bronchial muscles and blood vessels.
How to use CZ L CAPSULE
Take CZ L CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of CZ L CAPSULE for you depending upon your age, body weight and disease condition.
Side Effects Of CZ L CAPSULE
Common
- dry mouth
- headache
- tiredness
- downiness
- diarrhoea
- constipation
- difficulty in sleeping
Uncommon
- exhaustion
- abdominal pain
Rare
Stop taking CZ L CAPSULE and consult your doctor immediately if you experience any of the following side effects:
- nervousness, sleepiness, or dizziness
- allergic reactions (signs include swelling of the mouth, face and/or throat or swallowing difficulties together with hives (angioedema), breathing difficulties or a sudden fall in blood pressure leading to collapse or shock)
- seizures
- thoughts of harming yourself
How To Manage Side Effects
Dry mouth:
Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.
Constipation:
Take fiber rich foods in your diet such as fresh fruits, vegetables, whole grain cereals and drink plenty of fluids. Exercise more regularly and stay active. Consult your doctor if the symptom does not improve.
Headache:
Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Inform your doctor if the symptom does not improve.
Diarrhoea:
Drink lot of fluids such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Inform your doctor if the symptom gets worse.
Stomach pain:
Try to rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, inform your doctor.
Warning & Precautions
Pregnancy
CZ L CAPSULE should be used with caution in pregnant women only if considered clearly necessary. Consult your doctor before taking it.
Breastfeeding
CZ L CAPSULE is not recommended for use in breastfeeding women unless advised by the doctor as it may pass through breast milk. Consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any machines if you feel sleepy, tired and exhausted after taking CZ L CAPSULE.
Alcohol
Avoid the use of alcohol while taking CZ L CAPSULE as it may reduce alertness and affect the performance.
Kidney
CZ L CAPSULE is not recommended for use in patients with severe kidney failure and should be used with caution in patients with mild to moderate kidney diseases. Consult your doctor before taking it.
Liver
CZ L CAPSULE should be used with caution in patients with liver disease. Consult your doctor before taking it.
Allergy
Do not take CZ L CAPSULE if you are allergic to Levocetirizine, Pseudoephedrine or other antihistamines such as cetirizine.
Heart Disease
CZ L CAPSULE should be used with caution in patients with heart disease. Consult your doctor before taking it.
Others
Before taking CZ L CAPSULE tell your doctor if you:
- have epilepsy or at risk of convulsions
- have high blood pressure
- have thyroid disease
- have diabetes
- are unable to empty your bladder (due to spinal cord injury or enlarged prostate)
- have schedule for allergy testing
Use in paediatrics:
CZ L CAPSULE is not recommended for use in children below 12 years of age. Consult your child’s doctor for advice.
Use in geriatrics:
CZ L CAPSULE should be used with caution in elderly patients. Consult your doctor before taking it.
Interactions
A. Drug - Drug interactions:
Before taking CZ L CAPSULE, inform your doctor if you are taking any of the following medicines:
- monoamine oxidase inhibitors such as isocarboxazid, phenelzine (used to manage depression)
Overdosage:
If you or anyone else accidentally takes too much of CZ L CAPSULE, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of CZ L CAPSULE includes sleepiness/drowsiness in adults and in children it may cause excitation and restlessness followed by sleepiness/drowsiness.
Synopsis
| Drug | : | Levocetirizine, Pseudoephedrine |
| Pharmacological Category | : | Antihistamines, Nasal Decongestants |
| Therapeutic Indication | : | Relief from symptoms of hay fever or other respiratory allergies, sinus congestion and pressure, reduces swelling of the nasal passages |
| Dosage Forms | : | Tablet, Capsule |
More Information
- Keep CZ L CAPSULE out of reach of children
- Keep at a temperature of 20°C-25°C
FAQs About CZ L CAPSULE
Q: Is CZ L CAPSULE safe to use in pregnant and breast-feeding women?
A: CZ L CAPSULE should be used with caution in pregnant and breast-feeding women only if clearly advised by the doctor. Consult your doctor for advice before taking it.
Q: Can CZ L CAPSULE cause drowsiness?
A: Yes, drowsiness is a common side-effect of CZ L CAPSULE. Therefore, it is not recommended to drive or use machineries if you feel drowsy after taking CZ L CAPSULE. Consult your doctor before taking it.
Q: How does CZ L CAPSULE work?
A: CZ L CAPSULE helps to reduce the symptoms of hay fever or other respiratory allergies, where levocetirizine is a H1 receptor antagonist which stops the action of histamine by acting on histamine receptors which results in muscle relaxation, decrease in flare responses and non- activation of cough receptors. Pseudoephedrine is an alpha-adrenergic agonist which effectively relaxes the bronchial muscles and blood vessels.
Q: Can CZ L CAPSULE be used in patients with kidney problems?
A: CZ L CAPSULE is not recommended for use in patients with severe kidney failure and should be used with caution in patients with mild to moderate kidney diseases. Consult your doctor before taking it.
Q: What should I know before taking CZ L CAPSULE?
A: CZ L CAPSULE is not recommended for use in patients having severe kidney disease. It should be taken with caution in patients who have heart or liver disease, epilepsy, thyroid, high blood pressure, diabetes and those are unable to empty the bladder. Talk to your doctor before taking it.
References
1. KD. Tripathi. Histamines and Antihistamines & Drugs Acting on ANS. Essentials of medical pharmacology. Seventh edition. 2013. Page – 167 & 138
2. Levocetirizine. NIH National Library of Medicine, National center for biotechnology information. Pubchem. [Accessed on 30th May 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Levocetirizine
3. Pseudoephedrine. NIH National Library of Medicine, National center for biotechnology information. Pubchem. [Accessed on 30th May 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Pseudoephedrine#section=Mechanism-of-Action
4. Synthon BV. Electronic Medicines Compendium (EMC). [Revised in November 2021]. [Accessed on 30th May 2022] https://www.medicines.org.uk/emc/files/pil.8568.pdf
5. Padagis Israel Pharmaceuticals Ltd. NIH National Library of Medicine. Dailymed. [Revised in November 2021]. [Accessed on 30th May 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4a4da1e6-2ad1-47f7-a9b3-7d845962ef3b
Useful Diagnostic Tests
- Complete Blood Count (CBC)
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