CTD 6.25mg Tablet 15'S

Introduction About CTD 6.25MG TABLET

CTD 6.25mg Tablet is a diuretic (water pill) containing chlorthalidone. It is used to manage hypertension (high blood pressure) and edema (fluid retention) caused by conditions such as heart failure, liver disease, kidney disease and lung disease that works by increasing urine production, which helps eliminate excess water and salt from the body, thereby lowering blood pressure and reducing swelling.

CTD 6.25 Tablet helps your body get rid of excess water by increasing urine production and may be prescribed alone or with other medications. It should be taken during the day to reduce frequent urination at night. Always follow your doctor’s instructions regarding dose and duration, and do not stop the medication suddenly without consulting your doctor, as this could cause your blood pressure to rise again and increase your risk of heart disease and stroke. Most people with high blood pressure do not feel unwell, so regular use and monitoring are important to reduce complications.

Regular blood pressure monitoring is essential while taking this medication, as it forms just one part of an overall management plan. Alongside CTD 6.25 Tablet, managing high blood pressure should also include maintaining a healthy diet, engaging in regular physical activity, quitting smoking, limiting alcohol consumption, and achieving a healthy weight. You can continue your usual diet while on this medicine, but it is advisable to limit your salt intake.

Common side effects of CTD 6.25 Tablet include headache, dizziness, nausea, weakness, frequent urination, dry mouth, low blood pressure, and low potassium or electrolyte imbalance. If these effects are troublesome, consult your doctor. Before starting this medication, inform your doctor if you have any kidney or liver problems. Pregnant or breastfeeding women should seek medical advice before taking this medicine. Also, let your doctor know about all other medications you are taking before starting CTD 6.25 Tablet.

Uses Of CTD 6.25MG TABLET

• Hypertension (high blood pressure)
• Edema (fluid retention)

Benefits of CTD 6.25MG TABLET

1)Reduces high blood pressure (hypertension): CTD 6.25mg helps lower elevated blood pressure, which can reduce the risk of heart attack, stroke, and other cardiovascular complications.

2)Decreases excess fluid in the body (edema): This medicine promotes the removal of extra water and salt through urine, effectively treating swelling caused by heart failure, kidney, liver, or lung conditions.

3)Supports heart health: By controlling blood pressure and reducing fluid overload, CTD 6.25mg helps ease the workload on the heart and supports overall cardiovascular health.

4)Can be used alone or with other medications: CTD 6.25mg may be prescribed by your doctor as a single therapy or in combination with other antihypertensive medicines for better blood pressure control.

5)Part of a comprehensive treatment plan: For best results, CTD 6.25mg should be used alongside lifestyle changes such as a healthy diet, regular exercise, reducing salt intake, quitting smoking, moderating alcohol consumption, and maintaining a healthy weight. Regular blood pressure monitoring is also important.

How CTD 6.25MG TABLET Works

CTD 6.25mg Tablet contains chlorthalidone, a thiazide-like diuretic, which works primarily by increasing the excretion of sodium and water from the body through the kidneys.

Mechanism of Action of CTD 6.25mg Tablet

Chlorthalidone inhibits the Na?/Cl? symporter in the distal convoluted tubule of the kidney, reducing the reabsorption of sodium and chloride. This action leads to increased elimination of sodium, chloride, and water in urine, thereby decreasing the overall fluid volume in the body.

Role of Chlorthalidone in CTD 6.25mg Tablet

Chlorthalidone is the active ingredient in CTD 6.25mg Tablet. Its primary role is to treat high blood pressure and edema by promoting diuresis (increased urine production) and reducing fluid overload.

Understanding the Diuretic Effect

The diuretic effect of chlorthalidone means it helps the body remove excess water and salt, which lowers blood pressure and reduces swelling. This effect is particularly useful in managing conditions like hypertension, heart failure, and fluid retention due to kidney or liver disorders.

CTD 6.25mg Tablet and Electrolyte Balance

By increasing sodium excretion, chlorthalidone also causes the body to lose potassium and, to a lesser extent, magnesium and chloride, potentially leading to electrolyte imbalances such as low potassium (hypokalemia) and low sodium (hyponatremia). Regular monitoring of electrolyte levels is recommended during management.

Impact on Blood Pressure and Fluid Levels

Initially, CTD 6.25mg Tablet lowers blood pressure by reducing plasma and extracellular fluid volume, which decreases cardiac output. Over time, the main effect is a sustained reduction in peripheral vascular resistance, helping to maintain lower blood pressure even after fluid levels stabilize. By reducing fluid overload, it also eases symptoms of edema and supports cardiovascular health.

How to use CTD 6.25MG TABLET

Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage.

Recommended Dosage:

The typical starting dose for hypertension is 12.5 mg to 25 mg once daily, adjusted based on your doctor’s advice and your response to management. For edema, the dose may range from 25 mg to 50 mg daily.

Administration Guidelines:

Swallow the tablet whole with a glass of water; do not crush or chew it. Take it at the same time each day for best results. CTD 6.25mg can be taken with or without food, but consistency is important.

Best Time to Take CTD 6.25mg Tablet:

Take the tablet during the daytime, preferably in the morning, to avoid frequent urination at night. Avoid taking it within four hours of bedtime.

What if I forgot to take CTD 6.25MG TABLET

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed one, do not double up to make up for it.

Side Effects Of CTD 6.25MG TABLET

Like all medicines, CTD 6.25mg Tablet may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking CTD 6.25mg Tablet are:

• Headache
• Dizziness
• Nausea
• Weakness
• Frequent urination
• Dry mouth
• Low blood pressure
• Low potassium
• Electrolyte imbalance

When to consult your doctor?

• Severe allergic reactions symptoms such as swelling of the face, lips, tongue, or throat, difficulty breathing, severe skin rash or itching
• Irregular or fast heartbeat symptoms such as palpitations or abnormal heart rhythms
• Severe muscle cramps or weakness
• Extreme dizziness or fainting, Sudden drop in blood pressure, feeling lightheaded, or loss of consciousness
• Severe low sodium (hyponatremia) symptoms such as confusion, tiredness, or seizures

How To Manage Side Effects

Warning & Precautions

Other Warnings for CTD 6.25MG TABLET

Before taking CTD 6.25mg Tablet, inform your doctor if you have:

• Diabetes or issues with blood sugar control
• High cholesterol levels
• experience trouble in vision or eye pain

Who should not take [GBNKEYWORD

CTD 6.25mg Tablet is not recommended for use if you have:

• Very low urine output (less than 100 ml in 24 hours)
• Very low blood pressure (hypotension)
• Gout (high uric acid levels)
• Are on a low-sodium (salt) diet or severe electrolyte imbalance (such as low sodium, potassium, or magnesium levels)
• Addison’s disease (a condition where your adrenal gland does not work properly)

Diet and Lifestyle Advice

What diet, exercise, and lifestyle changes can help enhance the effectiveness of the CTD 6.25 mg tablet?

Category	Recommendations	Rationale/Benefit
Diet	- Moderate sodium restriction (e.g., follow DASH diet) - Increase potassium-rich foods (bananas, oranges, spinach, potatoes) - Limit processed foods and added salt - Avoid grapefruit and grapefruit juice	- Enhances blood pressure control and reduces potassium loss. - Potassium helps offset diuretic-induced loss. - Grapefruit may increase drug effects.
Exercise	- Aim for at least 30 minutes of moderate activity (e.g., brisk walking, cycling) most days - Include strength training 2x/week	- Regular exercise lowers blood pressure and improves heart health
Weight	- Maintain a healthy body weight - Aim for gradual weight loss if overweight	- Weight loss can significantly reduce blood pressure
Hydration	- Stay hydrated, but do not overdrink - Monitor for signs of dehydration (dry mouth, dizziness)	- Chlorthalidone increases urination; balance is important
Alcohol	- Limit alcohol intake	- Excess alcohol can raise blood pressure and cause dehydration
Sun Exposure	- Use sunscreen and protective clothing	- Chlorthalidone can make skin more sensitive to sunlight.
Medication Timing	- Take in the morning with food	- Reduces risk of nighttime urination and stomach upset.
Routine Monitoring	- Regularly check blood pressure and potassium levels - Report muscle weakness, cramps, or palpitations to your doctor	- Early detection of side effects or electrolyte imbalance.
Smoking	- Avoid smoking	- Smoking raises blood pressure and cardiovascular risk

 

Conclusion:

• DASH diet is especially recommended for those with high blood pressure, focusing on vegetables, fruits, whole grains, and low-fat dairy, and limiting sodium and saturated fat.
• Potassium-rich foods are important because chlorthalidone can lower potassium levels.
• Moderate sodium restriction enhances the blood pressure-lowering effect and reduces potassium loss.
• Avoid grapefruit as it can interact with chlorthalidone and increase its effects.

Consult your doctor before making any significant changes, especially regarding diet and exercise, to ensure they are appropriate for your health conditions and medications.

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking CTD 6.25mg Tablet:

1)Lithium (used for certain mental health conditions):

• Interaction: CTD 6.25mg Tablet can increase lithium levels in the blood.
• Effects: Higher risk of lithium toxicity, which may cause tremors, confusion, nausea, and irregular heartbeat.
• Management: Your doctor may avoid this combination or monitor lithium and electrolyte levels closely if both medicines are necessary.

2)Anti-diabetic medicines (e.g., insulin, metformin):

• Interaction: CTD 6.25mg Tablet may reduce the effectiveness of anti-diabetic drugs.
• Effects: Possible increase in blood sugar levels, making diabetes harder to control.
• Management: Blood sugar should be monitored regularly, and your doctor may adjust the dose of your anti-diabetic medication if needed.

3)Digoxin (used for heart failure and irregular heartbeat):

• Interaction: CTD 6.25mg Tablet may lower potassium and magnesium levels, increasing the risk of digoxin toxicity.
• Effects: Symptoms may include nausea, vomiting, vision changes, and abnormal heart rhythms.
• Management: Your doctor may monitor your electrolyte levels and adjust your digoxin dose as necessary.

4)Nonsteroidal Anti-Inflammatory Drugs (NSAIDs, e.g., ibuprofen, naproxen):

• Interaction: NSAIDs can reduce the blood pressure-lowering effect of CTD 6.25mg Tablet and increase the risk of kidney problems.
• Effects: Reduced effectiveness in lowering blood pressure and possible worsening of kidney function.
• Management: Use NSAIDs with caution and under medical supervision; regular monitoring of blood pressure and kidney function may be required.

5)Corticosteroids (e.g., prednisone):

• Interaction: Corticosteroids may increase the risk of electrolyte imbalance (especially low potassium) when used with CTD 6.25mg Tablet.
• Effects: Increased risk of muscle weakness, irregular heartbeat, or cramps.
• Management: Your doctor may monitor your electrolyte levels more closely and adjust doses as needed.

Drug - Food interaction

1)Alcohol

• Interaction: Alcohol can increase the blood pressure-lowering effect of CTD 6.25mg Tablet.
• Effects: Higher risk of dizziness, fainting, or a sudden drop in blood pressure.
• Management: Avoid or limit alcohol consumption while taking this medicine.

2)High-Sodium Foods (Salty Foods)

• Interaction: Consuming foods high in salt may reduce the effectiveness of CTD 6.25mg Tablet.
• Effects: May counteract the blood pressure-lowering and fluid-reducing effects of the medicine.
• Management: Limit your intake of salty foods and follow your doctor’s advice on dietary salt.

3)Low-Sodium Diet

• Interaction: Strict low-sodium diets, when combined with CTD 6.25mg Tablet, may increase the risk of low sodium levels in the blood.
• Effects: Symptoms such as confusion, weakness, or seizures due to hyponatremia (low sodium).
• Management: Do not start a low-sodium diet without consulting your doctor while on this medication.

Synopsis

Drug	:	Chlorthalidone
Pharmacological Category	:	Thiazide diuretic
Therapeutic Indication	:	Hypertension (high blood pressure), Edema (fluid retention)
Dosage Forms	:	Tablet

More Information

1.How does CTD 6.25mg compare to other similar medications, and in what situations might it be preferred over alternative options?

Medicine (Generic)	Typical Dose Range	Main Uses	Key Benefits	Common Side Effects	When Preferred/Chosen Over Others
Chlorthalidone (CTD 6.25 mg)	6.25–25 mg once daily	Hypertension, Edema	Longer half-life; effective BP control; reduces stroke/heart failure risk	Dizziness, low potassium, headache, frequent urination	Preferred for sustained BP control due to longer action; may be chosen if once-daily dosing is needed or if patient has not responded to other thiazides
Hydrochlorothiazide	12.5–50 mg once daily	Hypertension, Edema	Widely used, short-acting, well-tolerated	Dizziness, low potassium, headache	Often first-line for mild hypertension; may be chosen for shorter duration of action or cost
Indapamide	1.25–2.5 mg once daily	Hypertension, Edema	Thiazide-like; less effect on glucose/lipids	Dizziness, hypokalemia	Preferred in patients with diabetes or metabolic syndrome
Metolazone	2.5–10 mg once daily	Edema (esp. in heart failure, kidney disease)	Potent diuresis, effective in renal impairment	Dizziness, electrolyte imbalance	Used when stronger diuresis is needed or in renal impairment2

 

Notes on Choosing CTD 6.25 mg:

• Longer duration of action than hydrochlorothiazide, providing more consistent blood pressure control over 24 hours.
• May be preferred in patients with uncontrolled blood pressure on other thiazides or who need once-daily dosing for adherence.
• Chosen when edema is present alongside hypertension, or when there is a need to reduce the risk of stroke/heart failure.
• May be avoided or used with caution in patients with kidney, liver, or heart disease, or those at risk for low potassium.

Conclusion:
CTD 6.25 mg (chlorthalidone) is often chosen over other thiazide diuretics for its longer action and proven cardiovascular benefits, especially when sustained blood pressure control is needed or other thiazides are insufficient. It is important to tailor the choice to the patient's overall health profile and risk factors.

FAQs About CTD 6.25MG TABLET

References

1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Heart Failure. Hypertension. Pharmacotherapy Handbook. Ninth edition. Page-75, 87.

2. Connor C. Kerndt; Jayesh B. Patel. Chlorthalidone. NIH. National Library of Medicine. National Center of Biotechnology Information. PMC PubMed Central. [Revised in May 2022]. [Accessed on 9th July 2025] 

3. Stela Dineva, Katya Uzunova, Velichka Pavlova, Elena Filipova, Krassimir Kalinov, and Toni Vekov. Comparative efficacy and safety of chlorthalidone and hydrochlorothiazide—meta-analysis. NIH. National Library of Medicine. National Center of Biotechnology Information. PMC PubMed Central. October 2018. [Accessed on 9th July 2025] 

4. Atlantic Pharma, S.A. Electronic Medicines Compendium (EMC). [Revised in September 2020] [Accessed on 9th July 2025] 

5. Johnlee Pharmaceutical Pvt Ltd. Thalidon 6.25 mg. [Accessed on 9th July 2025] 

6. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 9th July 2025] 

Useful Diagnostic Tests

• Complete Blood Count (CBC)
• ECG

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