CORDARONE 100 Tablet 15's

Introduction About CORDARONE 100 TABLET

Cordarone 100 Tablet contains Amiodarone, which helps regulate irregular heartbeats by stabilizing the heart's electrical activity. This medication supports managing uneven heart rhythms such as atrial fibrillation, atrial flutter, and conditions like Wolff-Parkinson-White Syndrome when other options are limited.

Avoid consumption of alcohol and grapefruit juice during management with CORDARONE 100 TABLET. CORDARONE 100 TABLET is not recommended for use if you have signs of an allergic reaction including (a rash, swallowing or breathing difficulties, swelling of your lips, face, throat or tongue).

It is also not recommended to use if you have slower than usual heartbeat (called ‘sinus bradycardia’) or an illness called sino-atrial heart block, other problems with your heartbeat without a pacemaker fitted, are going to have a heart transplantation or have thyroid problems.

Before taking CORDARONE 100 TABLET, inform your doctor if you have heart failure, liver, lung problems or asthma, eyesight problems (optic neuritis), are about to have any surgery, have a pacemaker or implantable cardioverter defibrillator (ICD).

CORDARONE 100 TABLET is not recommended for pregnant or breastfeeding women and in children and adolescents below 18 years of age. CORDARONE 100 TABLET should be used with caution in elderly patients above 65 years of age. Common side effects of taking CORDARONE 100 TABLET are nausea, vomiting, change in taste, constipation, sleeping problems. Consult your doctor if any of the symptoms worsen.

Uses Of CORDARONE 100 TABLET

It manages:

• sudden, fast or uneven heartbeats (atrial flutter or atrial fibrillation) when other medicines either have not worked or cannot be used
• Wolff-Parkinson-White Syndrome

Benefits of CORDARONE 100 TABLET

• Helps stabilize the heart’s electrical activity by prolonging the cardiac action potential and refractory period, which reduces heart muscle excitability and abnormal rhythms.
• Has multiple electrophysiologic effects including blocking sodium, potassium, and calcium channels, and providing antisympathetic action to reduce rapid heart rates.
• Reduces cardiac workload by vasodilation, which may lower myocardial oxygen consumption.
• Useful in controlling ventricular rate and maintaining sinus rhythm in patients with arrhythmias.
• Effective in acute settings for managing fast heart rates, especially in patients with heart failure where other rate control agents pose risks.
• Can improve return of spontaneous circulation in cardiac arrest scenarios, although more research is ongoing about survival benefits.
• Offers a multi-class antiarrhythmic profile, integrating mechanisms from all four Vaughan Williams classes, providing broad rhythm control.

How CORDARONE 100 TABLET Works

The mechanism of action of Cordarone (Amiodarone 100mg) is complex and multifaceted, reflecting its classification primarily as a Class III antiarrhythmic agent with additional properties from other Vaughan Williams classes:

1. Amiodarone blocks potassium channels, which helps to slow down the electrical signals that make the heart beat too fast.
2. It also blocks sodium and calcium channels, which slows the heart’s electrical activity and helps maintain a steady rhythm.
3. Additionally, it reduces the effects of certain stress hormones on the heart by blocking adrenergic receptors.
4. Overall, these actions help the heart beat more regularly and control abnormal fast heart rhythms.

How to use CORDARONE 100 TABLET

Take Cordarone exactly as prescribed by your doctor. Swallow the tablet whole with a glass of water. It is important to follow the dosage schedule strictly and not to stop the medication abruptly without consulting your healthcare provider.

Dosage Guidelines for Cordarone 100mg

Management usually starts with higher doses (loading dose) to quickly achieve effective medicine levels, often 800 to 1600 mg daily divided into multiple doses for 1 to 3 weeks, followed by lowering to a maintenance dose generally between 100 to 400 mg daily based on response.

Recommended Dosage Schedule and Administration

The initial high dose (loading phase) is typically given for the first 1 to 3 weeks. Once controlled, the dosage is reduced to the lowest effective maintenance dose, which could be daily or alternate days, to minimize side effects. Always take doses consistently with regard to meals, especially if gastrointestinal discomfort occurs.

Instructions for Safe Use of Cordarone Tablet

Ensure regular monitoring of thyroid, liver, and lung functions as recommended by your healthcare professional. Inform your doctor about any other medicines you use to avoid interactions. Avoid sudden discontinuation and do not adjust dosage without medical advice.

Taking Cordarone 100mg With or Without Food

Cordarone can be taken with or without food; however, taking it with meals may help reduce stomach upset.

Important Precautions During Cordarone Use

Avoid prolonged exposure to sunlight as the medicine can cause skin sensitivity. Follow all monitoring advice given by your healthcare provider, including regular blood tests and scans. Report any unusual symptoms like breathing difficulties, vision changes, or swelling to your doctor immediately.

What if I forgot to take CORDARONE 100 TABLET

If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double up to make up for a missed dose. Contact your healthcare provider if you are unsure.

Overdose

If you or anyone else accidentally takes too much CORDARONE 100 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms include feeling dizzy, faint or tired, confusion, slow heartbeat, damage to the liver or nausea.

Side Effects Of CORDARONE 100 TABLET

Common

• nausea, vomiting, constipation, change in taste
• tanning more easily in the sun
• slightly slower heartbeat
• nightmares, sleep problems
• scaly and itchy rash
• reduced sex drive

When to consult a doctor?

• allergic reaction (rash, swollen eyelids, face, lips, throat or tongue)
• Stevens-Johnson syndrome (blistering or peeling of the skin around the lips, eyes, mouth, nose and genitals, flu-like symptoms and fever)
• toxic epidermal necrolysis (severe blistering rash in which layers of the skin may peel off, feeling generally unwell, fever, chills and muscle pain)
• bullous dermatitis (fluid filled blisters on the skin)
• flu like symptoms and a rash on the face followed by an extended rash with a high temperature, enlarged lymph nodes (DRESS)
• yellowing of the skin or eyes (jaundice), feeling tired or sick, loss of appetite, stomach pain or high temperature. (signs of liver problems or damage)
• shortness of breath or difficulty breathing, tightness in the chest, coughing which will not go away, wheezing, weight loss and fever (inflammation of your lungs)

How To Manage Side Effects

Constipation

• Stay Hydrated: Drink plenty of water daily to help soften stools and support bowel movements.
• Increase Fiber Intake: Include more high-fiber foods such as fruits, vegetables, and whole grains in your diet to promote regularity.
• Exercise Regularly: Physical activity encourages intestinal motility and can reduce constipation.
• Use Laxatives if Needed: If constipation persists, talk to your healthcare provider about safe over-the-counter laxatives or stool softeners.
• Do Not Ignore the Urge: Responding promptly to bowel urges helps to control constipation buildup.
• Consult Your Doctor: Persistent or severe constipation should be reported to your doctor, as dosage adjustment or additional interventions may be necessary.

Nausea And Vomiting

• Take with Food: Taking Cordarone tablets with meals can help reduce stomach upset and nausea.
• Stay Hydrated: Drink plenty of water throughout the day to stay hydrated, which can ease nausea.
• Eat Small, Frequent Meals: Instead of large meals, opt for smaller, more frequent meals to reduce nausea and maintain energy.
• Avoid Strong Odors and Greasy Foods: These can trigger or worsen nausea and should be limited.
• Rest and Relax: Resting in a comfortable position and avoiding sudden movements may help reduce nausea symptoms.
• Consult Your Doctor: If nausea is persistent, severe, or accompanied by other symptoms like vomiting or abdominal pain, inform your healthcare provider promptly. They might adjust your dose or suggest anti-nausea medications.

Warning & Precautions

Pregnancy

Contraindicated

CORDARONE 100 TABLET is generally not recommended for use in pregnant women or women planning to have a baby. Consult with your doctor before taking it.

Breastfeeding

Contraindicated

CORDARONE 100 TABLET is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Consult with your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel like your eyesight is blurry after taking CORDARONE 100 TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol during management with CORDARONE 100 TABLET, as it may increase the chances of liver problems.

Liver

Use with Caution

CORDARONE 100 TABLET should be taken with caution in patients with liver disease. Consult with your doctor before taking it.

Allergy

Contraindicated

Do not take CORDARONE 100 TABLET if you are allergic to Amiodarone, iodine or any other ingredients of this medicine.

Lungs

Use with Caution

CORDARONE 100 TABLET should be taken with caution in patients with asthma or other lung disease. Consult with your doctor before taking it.

Heart Disease

Consult your doctor

CORDARONE 100 TABLET is not recommended for use if you have slower than usual heartbeat (called ‘sinus bradycardia’) or an illness called sino-atrial heart block, other problems with your heartbeat without a pacemaker fitted or are going to have a heart transplantation.

CORDARONE 100 TABLET should be taken with caution in patients with heart failure or if you have a pacemaker or implantable cardioverter defibrillator (ICD). Consult with your doctor before taking it.

Use In Pediatrics

Contraindicated

CORDARONE 100 TABLET is generally not recommended for use in children and adolescents below 18 years of age. Consult your doctor before taking it.

Use In Geriatrics

Use with Caution

CORDARONE 100 TABLET should be used with caution in elderly patients above 65 years of age. Dose will be adjusted by your doctor.  Consult with your doctor before taking it.

Other Warnings for CORDARONE 100 TABLET

Before taking CORDARONE 100 TABLET, inform your doctor if you:

• have any issues with your eyesight (optic neuritis)
• are about to have any surgery
• have Stevens-Johnson syndrome (blistering or peeling of the skin around the lips, eyes, mouth, nose and genitals, flu-like symptoms and fever)
• have toxic epidermal necrolysis (severe blistering rash in which layers of the skin may peel off, feeling generally unwell, fever, chills and muscle pain)
• intolerance to certain sugars

Who should not take CORDARONE 100 TABLET

CORDARONE 100 TABLET is not recommended for use if you:

• have signs of an allergic reaction include (a rash, swallowing or breathing difficulties, swelling of your lips, face, throat or tongue)
• history of thyroid problems

Diet and Lifestyle Advice

• Maintain a Heart-Healthy Diet: Focus on fresh fruits, vegetables, whole grains, lean proteins, and healthy fats. Limit saturated fats, trans fats, and processed foods to support overall heart health.
• Stay Hydrated: Drink plenty of water throughout the day to helps to control dehydration and support kidney and liver function during management.
• Manage Sun Exposure: Since amiodarone can make your skin sensitive to sunlight, wear protective clothing, use broad-spectrum sunscreen, and avoid prolonged sun exposure.
• Avoid Alcohol and Smoking: Alcohol can increase the risk of liver damage, and smoking may worsen heart or lung side effects. Quitting smoking and limiting alcohol can improve overall health.
• Regular Exercise: Engage in moderate physical activity like walking or yoga, as tolerated and approved by your doctor, to improve cardiovascular health and reduce stress.
• Monitor for Side Effects: Be alert for signs of thyroid or lung issues, skin reactions, or vision changes. Seek prompt medical advice if symptoms occur.
• Follow Medication and Monitoring Schedules: Take medications exactly as prescribed and attend all scheduled tests to monitor your heart, liver, and thyroid health.
• Limit Caffeine: Excess caffeine may cause palpitations or anxiety—moderate intake is advisable.
• Stress Management: Practice relaxation techniques such as deep breathing, meditation, or hobbies to reduce stress, which can impact heart health.

Drug - Drug interaction

• Digoxin and Beta Blockers: Increases risk of slow heart rate, heart block; monitor heart rate and adjust doses.
• Warfarin: Increases anticoagulant effect, raising bleeding risk; reduce warfarin dose and monitor prothrombin time closely.
• Phenytoin: Raises phenytoin blood levels; monitor for toxicity and adjust dose as needed.
• Certain Antiarrhythmics (quinidine, procainamide): Amiodarone raises their levels; dose adjustment and close monitoring required.
• Macrolide and Fluoroquinolone Antibiotics, Azole Antifungals: These inhibit amiodarone metabolism and can increase amiodarone levels; avoid or use with caution.
• Statins (simvastatin, lovastatin): Increased risk of muscle toxicity; limit statin dose when used with amiodarone.
• CYP450 Inhibitors (like grapefruit juice): Increase amiodarone exposure; avoid concurrent use.
• CYP450 Inducers (like St. John’s Wort): Reduce amiodarone effectiveness.
• Other QT-Prolonging Drugs: Increased risk of dangerous heart rhythms; avoid combination.

Drug - Food interaction

• Grapefruit and Grapefruit Juice: Avoid grapefruit products as they inhibit the enzyme (CYP3A4) that helps break down amiodarone in the intestine, leading to increased drug levels and higher risk of side effects.
• Food and Absorption: Taking Cordarone with food increases absorption, leading to higher and faster peak blood levels, especially with high-fat meals. It is generally safe to take with or without food, but taking it with meals may help reduce stomach upset.
• Alcohol and Tobacco: Use caution with alcohol and tobacco as they may interact with amiodarone or worsen side effects.
• Other Dietary Considerations: No specific vitamin or mineral restrictions are generally necessary, but always inform your healthcare provider about supplements or dietary habits.

Synopsis

More Information

Which Antiarrhythmic Medication Is Best Cordarone (Amiodarone), Dronedarone (Multaq), Sotalol (Betapace), Flecainide, or Propafenone Based on Effectiveness, Side Effects, and Use Cases?

FAQs About CORDARONE 100 TABLET

References

1. KD. Tripathi. Antiarrhythmic Drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 533.

2. Ruben ML Colunga Biancatelli, Viviana Congedo, Leonardo Calvosa, Marco Ciacciarelli, Alessandro Polidoro and Luigi Iuliano. Adverse reactions of Amiodarone. National library of medicine, National center for biotechnology information. Pubmed Central. 2019. [Accessed on 4th November 2025] 

3. Hugo Van Herendael and Paul Dorian. Amiodarone for the treatment and prevention of ventricular fibrillation and ventricular tachycardiaNational library of medicine, National center for biotechnology information. Pubmed Central. 2010. [Accessed on 4th November 2025] 

4. S.C. Zentiva S.A. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 4th November 2025] 

Useful Diagnostic Tests

• ECG at Home
• ECG + BP Check at Home
• Full Body Checkup with ECG & BP at Home
• Comprehensive Cardiac Risk Screening with 12 Lead ECG and BP
• Cardiac Risk Profile
• Kidney package Basic

Author Details

Written By Dr. Shruthi M R - BDS

Reviewed For Accuracy By Dr. Thamada Manikanta Praveen - MBBS, MD (General Medicine)

Last updated on 12 Jan 2023 | 09:57 AM(IST)