CONIMAB 100mg Infusion 10ml
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Introduction About CONIMAB 100MG INFUSION
CONIMAB 100MG INFUSION contains Rituximab which belongs to the group of medicines called Anticancer drugs. It is used to manage blood cancer (leukaemia) and lymph cancer (lymphoma). It can also be used to manage various auto-immune disease conditions such as rheumatoid arthritis, granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels) and pemphigus vulgaris (severe skin blistering and peeling especially on the mouth, nose, throat, eyes and genitals).
It is mostly used in combination with other cytotoxic anticancer agents to achieve better results. It is suitable for use both in adults and in children (aged 6 months or older). CONIMAB 100MG INFUSION will be administered to you only by an oncologist or a trained professional into your vein (as intravenous infusion).
Before receiving CONIMAB 100MG INFUSION inform your doctor if you have any heart problems (such as chest pain, heart attack, heart failure or abnormal heartbeat). You must also inform your doctor if you currently have or previously had hepatitis B infection or any other mild infections (including minor cough and cold) as a precaution.
CONIMAB 100MG INFUSION is not recommended for use in pregnant or breastfeeding women. Both men and women receiving CONIMAB 100MG INFUSION must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with CONIMAB 100MG INFUSION.
The most common side effects of receiving this medicine are fever, chills, skin rashes with itching, shortness of breath and low blood pressure. Consult your doctor if any of these side effect worsens.
Uses Of CONIMAB 100MG INFUSION
It is used to manage:
- Blood cancer (Chronic lymphocytic leukaemia)
- Lymph cancer (Non-Hodgkin’s Lymphoma)
- Rheumatoid arthritis (joint pain and inflammation)
- Granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels)
- Pemphigus vulgaris (severe skin blistering and peeling especially on the mouth, nose, throat, eyes and genitals)
How CONIMAB 100MG INFUSION Works
CONIMAB 100MG INFUSION is a monoclonal antibody. It destroys the immune cells (B-cells) that triggers cancer formation. It also reduces the production of certain chemicals within the body (such as rheumatoid factor, T-cells, cytokines) that causes inflammation, pain and swelling which helps in managing various autoimmune diseases.
How to use CONIMAB 100MG INFUSION
CONIMAB 100MG INFUSION will be given to you only by a doctor or a nurse into the vein (intravenously).
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Side Effects Of CONIMAB 100MG INFUSION
Common
- increased infections (bacterial, viral or fungal)
- low RBC, WBC and platelet counts in blood
- nausea, vomiting, diarrhea, stomach pain, constipation, indigestion
- mouth ulcers
- hair loss
- fever, chills, pneumonia, shingles, cold, sinusitis
- thrush, urinary tract infection
- headache, dizziness, tiredness, weakness
- hepatitis B infection
- high blood sugar and cholesterol levels
- weight loss, lack of appetite
- numbness, tingling, pricking, burning sensation on the skin
- restlessness, problems in falling asleep, anxiety, depression
- flushing (skin redness)
- eye inflammation or watery eyes
- ringing sound in the ears, ear pain
- uneven or fast heart rate, high or low blood pressure
- shortness of breath, runny nose, nasal itching and repeated sneezing
- increased sweating, night sweats
- muscle pain, joint pain, back pain, neck pain
- pain while passing urine
- fungal foot infection (athlete’s foot)
- tremors (shakiness)
- swelling of the hands or ankles
Uncommon
- blood clotting problems
- changes in taste
- slow heart rate
- chest tightness and lung problems
Rare
Contact your doctor immediately if you experience any of the following side effects:
- fever, chills, shivering, nausea, vomiting, skin rashes with blisters and itching, flushing, pain at the infusion site, headache, tiredness, wheezing, high blood pressure, palpitations, swelling of throat or tongue, runny or itchy nose and chest pain
- fever, cough, sore throat, burning pain while passing urine, feeling weak or generally unwell
- signs of brain problem (such as memory loss, trouble thinking, difficulty in walking or vision problems)
- signs of severe skin reactions (such as severe skin blistering and redness that may appear on the on the mucous membranes, such as inside the mouth, the genital areas or the eyelids, with fever)
How To Manage Side Effects
Constipation
Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate managements for constipation.
Diarrhea
Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to manage diarrhoea and consult your doctor if the symptom gets worse.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Consult your doctor if your dizziness worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Consult your doctor if your headache worsens.
Mouth Ulcers
Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on the affected areas of the mouth if required. Consult your doctor if the symptom did not improve.
Nausea And Vomiting
Stick to simple meals. Avoid eating oil rich or spicy foods. If your nausea worsens, consult your doctor for advice.
Skin rash Or Itching
Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.
Warning & Precautions
Pregnancy
ContraindicatedCONIMAB 100MG INFUSION is generally not recommended for use in pregnant women. However, consult your doctor before receiving it. Women of childbearing potential must use a suitable contraceptive to avoid pregnancy while undergoing therapy with CONIMAB 100MG INFUSION and until 12 months after stopping the therapy. If you accidentally became pregnant while receiving CONIMAB 100MG INFUSION, inform your doctor immediately.
Breastfeeding
ContraindicatedCONIMAB 100MG INFUSION is not recommended for use in breastfeeding women. Therefore, consult your doctor before receiving it.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if your ability is affected by CONIMAB 100MG INFUSION.
Alcohol
Consult your doctorAvoid consumption of alcohol while receiving CONIMAB 100MG INFUSION as it may make you feel drowsier.
Allergy
ContraindicatedTalk to your doctor before receiving CONIMAB 100MG INFUSION if you are allergic to rituximab.
Heart Disease
Consult your doctorCONIMAB 100MG INFUSION is not recommended for use in patients with severe heart failure or uncontrollable heart problems. It should be used with caution in patients with other heart problems (such as angina, fast heart rate or heart failure). Therefore, consult your doctor before receiving it.
Others
CONIMAB 100MG INFUSION is not recommended for use if you:
- have any serious infection that affects the whole body
- have a weak immune system
Before receiving CONIMAB 100MG INFUSION, inform your doctor if you:
- currently have or previously had hepatitis B infection
- are yet to receive any vaccinations
- have any infection (including mild cough and cold)
- have a previous history of severe infections
Use in pediatrics:
CONIMAB 100MG INFUSION should be used in children and adolescents (aged below 18 years) only if prescribed by the physician. Therefore, consult your doctor for advice before receiving it.
Use in geriatrics:
CONIMAB 100MG INFUSION should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before receiving it.
Interactions
A. Drug-Drug interactions:
Before receiving CONIMAB 100MG INFUSION, inform your doctor if you are taking any of the following medicines such as:
- medicines used to manage high blood pressure (such as atenolol, propranolol, amlodipine, enalapril, olmesartan, losartan)
- medicines that can suppress immune functions (such as ciclosporin, tacrolimus)
- other anticancer medicines (such as Trastuzumab, Bevacizumab, Alemtuzumab, Cetuximab)
Overdosage:
CONIMAB 100MG INFUSION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unusual symptoms.
Synopsis
| Drug | : | Rituximab |
| Pharmacological Category | : | Unarmed Monoclonal Antibody |
| Therapeutic Indication | : | Autoimmune diseases |
| Dosage Forms | : | Injection, Infusion |
More Information
- Keep CONIMAB 100MG INFUSION out of reach of children
- Store CONIMAB 100MG INFUSION in a refrigerator (between 2-8°C)
FAQs About CONIMAB 100MG INFUSION
Q: What CONIMAB 100MG INFUSION is used for?
A: CONIMAB 100MG INFUSION is used to manage blood cancer (leukaemia) and lymph cancer (lymphoma). It can also be used to manage various auto-immune disease conditions such as rheumatoid arthritis, granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels) and pemphigus vulgaris (severe skin blistering and peeling especially on the mouth, nose, throat, eyes and genitals).
Q: How CONIMAB 100MG INFUSION works on my body?
A: CONIMAB 100MG INFUSION is a monoclonal antibody. It destroys the immune cells (B-cells) that triggers cancer formation. It also reduces the production of certain chemicals within the body (such as rheumatoid factor, T-cells, cytokines) that causes inflammation, pain and swelling which helps in managing various autoimmune diseases.
Q: Can CONIMAB 100MG INFUSION manage cancer?
A: The manage rate of cancer depends upon the severity of the disease. However, CONIMAB 100MG INFUSION acts by managing the abnormal growth and multiplication of cancer cells in the body, which may help in managing cancer completely.
Q: Can the use of CONIMAB 100MG INFUSION cause hair loss?
A: Hair loss is one of the common side effects of receiving CONIMAB 100MG INFUSION. If it bothers you, consult your doctor for advice.
Q: Can the use of CONIMAB 100MG INFUSION cause mouth ulcers?
A: Mouth ulcers are one of the common side effects of receiving CONIMAB 100MG INFUSION. Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on the affected areas of the mouth if required. Consult your doctor if the symptom did not improve.
Q: Can CONIMAB 100MG INFUSION be used in children?
A: CONIMAB 100MG INFUSION should be used in children and adolescents (aged below 18 years) only if prescribed by the physician. Therefore, consult your doctor for advice before receiving it.
Q: What precautions must be followed while receiving CONIMAB 100MG INFUSION?
A: Before receiving CONIMAB 100MG INFUSION inform your doctor if you have any heart problems (such as chest pain, heart attack, heart failure or abnormal heartbeat). You must also inform your doctor if you currently have or previously had hepatitis B infection or any other mild infections (including minor cough and cold) as a precaution. CONIMAB 100MG INFUSION is not recommended for use in pregnant or breastfeeding women. Both men and women receiving CONIMAB 100MG INFUSION must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with CONIMAB 100MG INFUSION.
Q: What happens if I stop receiving CONIMAB 100MG INFUSION?
A: No. Do not stop receiving CONIMAB 100MG INFUSION without consulting your doctor as it may make your symptoms reappear. Therefore, take CONIMAB 100MG INFUSION as advised by your doctor for the stipulated duration.
Q: Can CONIMAB 100MG INFUSION be used during pregnancy?
A: CONIMAB 100MG INFUSION is generally not recommended for use in pregnant women. If you accidentally became pregnant while receiving CONIMAB 100MG INFUSION, inform your doctor immediately.
Q: Can the use of CONIMAB 100MG INFUSION make me feel tired?
A: Yes. CONIMAB 100MG INFUSION may make you feel tired easily. This is because, it reduces the levels of red blood cells in your blood and may make you anaemic. Consult your doctor if you experience tiredness after receiving CONIMAB 100MG INFUSION. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while taking this medicine.
Q: Can I drive a car after receiving CONIMAB 100MG INFUSION?
A: CONIMAB 100MG INFUSION may make you feel tired or dizzy. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by CONIMAB 100MG INFUSION.
Q: How CONIMAB 100MG INFUSION is administered?
A: CONIMAB 100MG INFUSION will be given to you only by a doctor or a nurse into a vein (as an intravenous infusion).
Q: How to control nausea caused due to CONIMAB 100MG INFUSION?
A: Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with CONIMAB 100MG INFUSION. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-manage nausea.
Q: What are the side effects of receiving CONIMAB 100MG INFUSION?
A: The most common side effects of receiving this medicine are fever, chills, skin rashes with itching, shortness of breath and low blood pressure. Consult your doctor if any of these side effect worsens.
References
1. KD. Tripathi. Chemotherapy of Neoplastic Diseases. Essentials of Medical Pharmacology. 7th Edition. Page – 872.
2. Nazma Hanif, Faiz Anwer. Rituximab. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed central. September 2022. [Accessed on 28th January 2023] https://www.ncbi.nlm.nih.gov/books/NBK564374/
3. Roche Products Ltd. MabThera 100 mg and 500 mg concentrate solution for infusion. Rituximab. Electronics Medicines Compendium. [Revised in January 2022]. [Accessed on 28th January 2023] https://www.medicines.org.uk/emc/files/pil.3801.pdf
4. Biogen and Genentech USA, Inc. RITUXAN® (rituximab) injection, for intravenous use. U.S. Food and Drug Administration. [Revised in December 2021]. [Accessed on 28th January 2023] https://www.gene.com/download/pdf/rituxan_prescribing.pdf
5. Biogen and Genentech USA, Inc. Rituxan. Rituximab. [Accessed on 28th January 2023] https://www.rituxan.com/
6. Central Drugs Standard Control Organization. Rituximab (finished formulation import). July 2000. [Accessed on 28th January 2023] https://cdscoonline.gov.in/CDSCO/Drugs
Useful Diagnostic Tests
- Complete Blood Count
- Peripheral Smear Examination
- Rheumatoid Factor-Agglutination
- Rheumatoid Factor-Turbidometry
- Rheumatoid Factor IgG Antibody
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