Combiflam Tablet 20'S

Introduction About COMBIFLAM TABLET

Combiflam Tablet is commonly chosen for short-term relief from everyday pain and fever. It is often used by people experiencing discomfort due to headache, body ache, toothache, muscle soreness, joint pain, or fever linked to routine conditions. Its dual-action formula combines ibuprofen and paracetamol, offering supportive relief when quick comfort is needed during busy routines or sudden aches.  

The tablet works by helping ease pain signals and lowering raised body temperature. It is ideally used by adults and older children who need convenient and fast relief from mild to moderate discomfort. It suits individuals looking for short-duration support without requiring stronger medicines. However, it should be taken only when needed and not for long-term or chronic pain unless advised by a healthcare professional.   

Combiflam is best taken after food or with a light snack to reduce the chances of acidity or stomach discomfort. Follow the recommended dose and maintain the advised gap between doses. Avoid combining it with other pain relievers or products that contain ibuprofen or paracetamol, as this may unintentionally increase the total dose. People with stomach ulcers, kidney or liver concerns, asthma, or heart-related issues should use it only after medical guidance. Inform your doctor if you are taking blood thinners, diuretics, or multiple medications. 

During pregnancy, especially in later stages, the tablet may not be suitable due to the ibuprofen component and should be used only after medical advice. Breastfeeding mothers should also consult a healthcare provider before taking it. Common side effects may include mild stomach discomfort, nausea, dizziness, headache, or skin reactions in sensitive individuals. If symptoms persist, worsen, or if you notice unusual reactions, seek prompt medical attention. 

Uses Of COMBIFLAM TABLET

• It is used to manage minor aches and pains such as headaches, toothaches, muscular aches, backaches and pain due to inflammation and for reduction of fever due to any of the above conditions

Benefits of COMBIFLAM TABLET

Combiflam Tablet for Pain

Combiflam Tablet helps provide relief from different types of day-to-day pain because it contains ibuprofen and paracetamol, which work together to ease discomfort. It is commonly used for headaches, muscle pain, joint pain, back pain, toothache, and period-related cramps. The combination helps reduce swelling and soothe pain more effectively than many single-ingredient medicines. It is suitable for short-term use when quick and reliable comfort is needed. Always follow the recommended dose and speak with a healthcare professional if the pain does not settle.

Combiflam Tablet for Fever

Combiflam Tablet helps lower fever and ease the tiredness, chills, and body aches that often accompany it. Paracetamol helps reduce body temperature, while ibuprofen supports relief from associated discomfort. It is commonly used during common colds, mild infections, or general feverishness for short-term relief. Taking it with a light meal or snack helps reduce stomach irritation. If fever lasts more than a couple of days or worsens, consult a healthcare provider for further guidance.

How COMBIFLAM TABLET Works

Mechanism of Action of Combiflam Tablet

Combiflam Tablet works through a dual-action formula containing Ibuprofen and Paracetamol, which complement each other to provide effective relief from pain and fever.

Ibuprofen is a non-steroidal anti-inflammatory agent (NSAID). It works by blocking the formation of prostaglandins, the natural chemicals in the body that cause pain, swelling, and inflammation. By reducing these chemicals, ibuprofen helps ease body aches, joint discomfort and headache.

Paracetamol, on the other hand, acts mainly in the brain. It helps reduce fever by acting on the body’s temperature-regulating centre and provides analgesic comfort by lowering the signals that carry pain sensations.

How to use COMBIFLAM TABLET

How to Take Combiflam Tablet

• Take the tablet after food or with a light snack to avoid stomach discomfort caused by ibuprofen.
• Swallow the tablet whole with a glass of water; do not crush or chew it.
• Use the tablet only when needed for pain or fever and avoid frequent or long-term use without advice.
• Follow the dose and interval recommended by your doctor or as written on the product label.
• Maintain a minimum gap of 6–8 hours between doses to avoid excess intake of ibuprofen or paracetamol.
• Avoid taking it along with other medicines containing paracetamol, ibuprofen, aspirin, or similar pain relievers.
• Do not exceed the maximum daily limit of paracetamol from all sources (including cold or flu medicines).
• If your pain or fever continues after recommended doses, seek medical guidance rather than increasing the dose.

What if I forgot to take COMBIFLAM TABLET

• If you miss a dose, take it when you remember only if you still need it for pain or fever.
• If your next dose is due soon, skip the missed dose and continue your usual schedule.
• Do not take two tablets together to make up for the missed dose.
• Avoid taking doses too close to each other to prevent stomach discomfort or side effects.
• Follow the recommended time gap between doses.
• If your symptoms continue or get worse, speak with a healthcare professional.

Overdose

If you or someone else has taken more Combiflam Tablet than recommended, contact a doctor or visit a medical facility right away. Signs of taking too much may include nausea, stomach upset, vomiting, irritation in the stomach, dizziness, drowsiness, feeling unusually restless, seizures, or blood in the urine.

Side Effects Of COMBIFLAM TABLET

Common side effects of Combiflam Tablet

• dizziness
• drowsiness
• indigestion
• heartburn
• changes in kidney function
• higher levels of liver enzymes
• excessive sweating
• stomach pain
• nausea, vomiting
• diarrhoea

When to Seek Medical Attention?

Stop taking this medicine and inform your doctor immediately if you experience any of the following side effects:

• Severe stomach pain, vomiting, or black stools.
• Breathing difficulty, swelling of the face, rash, or signs of allergy.
• Strong dizziness, unusual tiredness, or confusion.
• Persistent fever or pain that does not improve after a few days.
• Yellowing of the skin/eyes or very dark urine.
• Reduced urine output or signs of dehydration.

How To Manage Side Effects

Warning & Precautions

Other Warnings for COMBIFLAM TABLET

Before taking Combiflam Tablet inform your doctor if you:

• have systemic lupus erythematosus (SLE) (condition of the immune system affecting connective tissue resulting in joint pain, skin changes and disorder of other organs)
• have a blood clotting disorder
• have a gastrointestinal disorder, ulceration, bleeding in the stomach or duodenum

Safety Advice

• Use only for short-term relief and avoid frequent or long-term use without medical guidance.
• Do not combine with other painkillers or medicines containing ibuprofen, paracetamol, or aspirin.
• Avoid taking it on an empty stomach to prevent acidity or stomach discomfort.
• Check labels of other medicines to avoid extra or hidden paracetamol intake.
• Avoid use if dehydrated from vomiting, diarrhoea, or heavy sweating until hydration improves.
• Monitor stomach symptoms, and stop use if you notice severe pain, black stools, or repeated vomiting.
• Inform your doctor before procedures, as ibuprofen may affect bleeding.
• Be cautious in hot weather and ensure proper meals and fluids.
• Keep the medicine away from children to prevent accidental intake.

Diet and Lifestyle Advice

• Take with food: Have the tablet with a light meal or snack to avoid acidity and stomach discomfort.
• Avoid spicy or oily foods: These may worsen indigestion or heartburn while using the tablet.
• Stay hydrated: Drink plenty of water to support digestion and reduce stomach irritation.
• Limit caffeine and alcohol: Coffee, energy drinks, and alcohol may increase acidity or liver/kidney strain.
• Avoid long-term use: Use Combiflam only for short-term relief and avoid frequent, repeated doses.
• Rest well: Adequate rest helps your body manage pain or fever more effectively.
• Do not combine with other painkillers: Avoid taking other ibuprofen or paracetamol-containing medicines.
• Monitor your symptoms: If pain or fever continues or worsens, seek medical guidance.
• Protect your stomach: Avoid taking the tablet on an empty stomach or during dehydration.

1. Combiflam Tablet vs Ibuprofen Tablet

Point of Comparison	Combiflam Tablet	Ibuprofen Tablet
Composition	Contains Ibuprofen + Paracetamol (dual ingredient).	Contains only Ibuprofen (single ingredient).
How it works	Offers combined action one reduces inflammation; the other reduces discomfort and fever-like symptoms.	Mainly reduces inflammation and discomfort through anti-inflammatory action.
Best suited for	Useful when both pain and mild fever-like symptoms are present together.	Useful mainly when inflammation is the major cause of discomfort.
Onset & Relief	Dual action may offer broader relief for mixed types of pain.	Works well for pain linked to swelling or inflammation.
Stomach tolerance	Paracetamol makes it gentler for some users compared to ibuprofen alone.	May cause more stomach irritation in sensitive individuals.
Use in fever-like symptoms	Often preferred due to paracetamol component.	Not usually used alone for fever-like symptoms.
Flexibility of dosing	Dose depends on combination limits of both ingredients.	More flexible dosing since only ibuprofen is present.
Suitability for repeated use	Not preferred for frequent or long-term use without supervision.	Repeated use may increase stomach, kidney, or heart-related risks.
When it may be chosen	When wider relief is needed for body aches, flu-like discomfort, or headaches.	When inflammation is the main issue, such as joint swelling or muscle injury.
Important caution	Must avoid other paracetamol-containing medicines.	Must avoid using with other NSAIDs to prevent stomach irritation.

2. Combiflam vs Meftal Spas - Cramps

Point of Comparison	Combiflam Tablet	Meftal Spas Tablet
Composition	Contains Ibuprofen + Paracetamol.	Contains Dicyclomine + Mefenamic Acid.
Primary action	Works mainly on pain and inflammation.	Works on muscle spasms + pain, especially in abdominal cramps.
Best for	Suitable for general body aches, headaches, muscle pain, or mild discomfort.	Commonly preferred for menstrual cramps, stomach cramps, and spasm-related pain.
Effect on cramps	Helps with discomfort but may not directly relax muscle spasms.	Specifically designed to relax spasms, making it more suitable for cramp-related pain.
Stomach tolerance	Can cause acidity in some users. Best taken after food.	May also cause acidity; caution advised for sensitive stomachs.
When to choose	When you have mixed pain or need broader relief from body aches.	When cramps (especially menstrual or abdominal) are the main cause of discomfort.
Important caution	Avoid combining with other paracetamol-containing medicines.	Not suitable for those sensitive to antispasmodics or NSAIDs; use only as advised.

Drug - Drug interaction

1. Blood Thinners (e.g., Warfarin)

• Interaction: Ibuprofen may increase the risk of bleeding when taken with blood thinners.   
• Management: Your doctor may adjust the dose or switch to a safer alternative. Avoid taking multiple doses without supervision. Watch for signs of unusual bleeding and report immediately.   

2. Other NSAIDs (e.g., Diclofenac, Naproxen, Aspirin)

• Interaction: Combining multiple NSAIDs increases the risk of stomach irritation, acidity, and kidney strain.
• Management: Avoid taking Combiflam with other NSAIDs unless your doctor approves. Stick to the recommended single pain reliever. Take the medicine after food to reduce irritation.

3. Other Paracetamol-Containing Medicines

• Interaction: Using more than one paracetamol product increases the risk of liver damage.
• Management: Read labels carefully and avoid duplicate paracetamol doses. Use Combiflam as the only paracetamol-containing medicine. Seek advice if you are unsure about ingredients.

4. Blood Pressure Medicines (e.g., ACE inhibitors, ARBs, Diuretics)

• Interaction: Ibuprofen may reduce the effect of BP medicines and increase kidney strain.
• Management: Monitor your blood pressure more closely. Drink enough water and avoid long-term use. Doctors may adjust the BP medicine or suggest a safer pain-relief option. 

5. Lithium (used for mood conditions)

• Interaction: Ibuprofen may increase lithium levels in the blood, raising toxicity risk.
• Management: Only use Combiflam if your doctor approves. Regular blood monitoring may be suggested. Report symptoms like tremors, confusion, or dizziness.

6. Methotrexate

• Interaction: Ibuprofen can increase the effects and side effects of methotrexate.
• Management: Avoid combining unless strictly advised. Doctors may adjust methotrexate timing or dose. Watch for signs of toxicity such as mouth sores or tiredness.

7. Certain Antibiotics (e.g., Ciprofloxacin, Levofloxacin)

• Interaction: Combining NSAIDs with some antibiotics may increase nervous system-related side effects in rare cases.
• Management: Use together only if prescribed. Inform your doctor if you feel restless, anxious, or dizzy. Avoid self-medication during antibiotic use.

8. Antidepressants (SSRIs, SNRIs)

• Interaction: Using SSRIs/SNRIs with ibuprofen may increase stomach bleeding risk.
• Management: Doctor may add a stomach-protective medicine. Take after meals and avoid alcohol. Report stomach pain, black stools, or vomiting.

9. Anti-Seizure Medicines (e.g., Phenytoin, Carbamazepine)

• Interaction: Paracetamol may interact with metabolism of some anti-seizure medicines.
• Management: Your doctor may adjust doses or monitor levels. Avoid repeated Combiflam use without permission. Report unusual tiredness or difficulty balancing.  

10. Cholesterol-Lowering Medicines (e.g., Statins)

• Interaction: Paracetamol is generally safe, but frequent use may increase liver strain when combined with statins.
• Management: Limit long-term use of Combiflam. Inform the doctor if you feel muscle weakness or fatigue. Have liver tests if recommended.

11. Corticosteroids (e.g., Prednisolone)

• Interaction: NSAIDs combined with steroids may raise the chance of stomach ulcers.
• Management: Doctors may prescribe a gastric-protective medicine. Avoid alcohol and spicy foods. Take the tablet strictly after meals.

12. Anti-TB Medicines (e.g., Isoniazid, Rifampicin)

• Interaction: These medicines may increase liver strain when mixed with paracetamol.
• Management: Use Combiflam only with doctor approval. Limit frequent use. Watch for signs like yellow skin, dark urine, or loss of appetite.

Drug - Food interaction

1. Spicy or Oily Foods

• Interaction: Spicy, oily, or deep-fried foods may irritate the stomach lining and increase the chance of acidity or stomach discomfort, especially when taking ibuprofen-containing medicines.
• Management: Take the tablet with a light meal or a snack instead of spicy or oily food. Choose bland foods like rice, roti, or toast to keep your stomach comfortable.

2. Caffeine-Rich Foods (Coffee, Tea, Energy Drinks)

• Interaction: Caffeine can increase the chances of stomach upset or acidity when combined with ibuprofen. 
• Management: Try to limit coffee or energy drinks close to your dose. Opt for water or herbal tea around the time you take the tablet.

3. Grapefruit or Grapefruit Juice

• Interaction: Grapefruit may slow down how some medicines break down in the body. Though not a major interaction, it may slightly increase stomach irritation for sensitive users.
• Management: If you already have gastric sensitivity, avoid grapefruit close to your dose. Otherwise, occasional intake is usually acceptable.

4. Heavy Meals

• Interaction: Taking the tablet after a very heavy or large meal may delay its absorption and reduce how quickly you feel relief.
• Management: Take it after a normal, light meal or small snack to help the medicine work effectively without irritating the stomach.

5. Low-Carb or Fasting States

• Interaction: Taking the tablet on an empty stomach or during fasting can increase the risk of acidity, nausea, or stomach discomfort due to ibuprofen.
• Management: Always take the tablet with at least a small snack like biscuits, banana, or milk, even if you are fasting.

Synopsis

Drug	Paracetamol and Ibuprofen
Pharmacological Category	Analgesic, Antipyretic, and Non-steroidal Anti-inflammatory Drug (NSAID)
Therapeutic Indication	Fever, headache, body aches, muscle pain, joint discomfort and toothache
Dosage Forms	Tablet

More Information

• Keep out of reach of children
• Store at room temperature

FAQs About COMBIFLAM TABLET

Q: What is Combiflam Tablet used for?

A: Combiflam Tablet is commonly taken to ease discomfort, body aches, and inflammation. People use it for headaches, muscle pain, joint pain, or fever-like symptoms. It combines two ingredients that support relief. It is meant for short-term use only. Follow the dose your doctor recommends.

Q: Can I take Combiflam on an empty stomach?

A: It is better to take it after food. Empty stomach use may cause acidity or irritation. Eating something light can protect your stomach. People with gastric issues should be extra careful. Follow your doctor’s advice.

Q: What are the common side effects?

A: You may experience stomach discomfort, acidity, or nausea. Some people may feel dizziness or mild allergy-like symptoms. Most side effects are short-lived. Taking it with food reduces stomach issues. Stop use and seek help if symptoms become severe.

Q: Can Combiflam cause allergies?

A: Yes, some people may get rashes, itching, or swelling. Stop the medicine if you notice unusual symptoms. Severe allergy signs need quick medical help. People allergic to NSAIDs should avoid it. Inform your doctor about past drug allergies.

Q: What happens if I take too many tablets?

A: Overdose can harm your liver or stomach. You may feel nausea, stomach pain, or dizziness. Do not wait seek medical help immediately. Keep the medicine away from children. Never exceed the recommended dose.

Q: Can Combiflam make me sleepy?

A: It usually does not cause much drowsiness. However, some people may feel dizzy or tired. Avoid driving if you feel unsteady. Take it with food to reduce discomfort. Inform your doctor if sleepiness continues.

Q: Can I use Combiflam for headaches?

A: Many people take it for headaches or body aches. Its two ingredients help reduce discomfort. Use it after meals for better tolerance. If headaches are frequent, seek medical help. Do not use it daily without advice.

Q: Can I take Combiflam with antibiotics?

A: In many cases, both can be taken together. But some combinations may increase stomach irritation. Always inform your doctor about all medicines. Your doctor will guide you on safe use. Report any unusual symptoms.

Q: Does Combiflam affect the stomach?

A: Yes, it may cause acidity or irritation in some people. Take it with food to reduce discomfort. Avoid spicy foods and alcohol during use. People with ulcers should be cautious. Stop use if stomach pain becomes severe.

Q: Who should avoid Combiflam?

A: People with severe liver, kidney, or stomach issues should avoid it. Those allergic to NSAIDs should not use it. Pregnant women should avoid it unless advised. Regular alcohol drinkers should be cautious. Always check warnings on the label.

Q: Can Combiflam increase blood pressure?

A: Ibuprofen may cause a small rise in BP in some people. Those with high BP should use it cautiously. Avoid long-term or frequent use. Monitor symptoms if you feel uneasy. Speak to your doctor if you have BP issues.

Q: Is Combiflam safe for diabetic patients?

A: Diabetic patients should take it only if a doctor approves. Ibuprofen may sometimes affect kidney function. Monitor your blood sugar if you feel unwell. Do not take it regularly without guidance. Share your medical history with your doctor.

Q: Can Combiflam cause acidity?

A: Yes, acidity is a common side effect. Taking it with meals helps reduce irritation. Avoid spicy and oily foods while using it. Drink enough water for better digestion. Seek medical help if acidity becomes severe.

Q: Can I take Combiflam if I have asthma?

A: People with asthma should be cautious. Some may experience breathing issues with NSAIDs. Inform your doctor before using it. Use it only if your doctor says it is safe. Stop use if breathing becomes difficult.

Q: What should I do if my pain doesn’t improve?

A: If pain continues after taking the tablet, avoid taking extra doses. Persistent symptoms may need medical evaluation. Your doctor can check for underlying causes. Do not rely on Combiflam for long-term relief. Use only as advised and seek help if symptoms last.

References

1. Joseph. T. Dipiro. Pharmacotherapy. A Pathophysiologic Approach. Eighth edition. Page No: 1067-1068.

2. Derry, Christopher J et al. Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. [Revised in 24th Jun 2013] . [Accessed on 24th November 2025] 

3. Reckitt Benckiser Healthcare. Electronic Medicines Compendium (EMC). [Accessed on 24th November 2025] 

4. Alpha pharm Ptd. Limited. [Accessed on 24th November 2025] 

5. European Medicines Agency. [Revised in  7th August 2017] [Accessed on 24th November 2025] 

6. Motrin. U.S. Food and Drug Administration. [Revised in 20th January 2007] [Accessed on 24th November 2025] 

Useful Diagnostic Tests

• Renal function test
• Liver function test
• Fever Package

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