Netmeds First Membership
Quick Links
Introduction About COLIZOLE DS 800/160MG TABLET
COLIZOLE DS 800/160MG TABLET is a combination of Sulphamethoxazole and Trimethoprim which belongs to the group of medicines called Antibiotics. It is used to manage lung infections (pneumonia or Pneumocystis jiroveci pneumonia) caused by a bacteria called Pneumocystis jirovecii and toxoplasmosis (infection with the Toxoplasma gondii parasite).
It can also be used to manage urinary tract infections, respiratory tract infections (such as bronchitis), ear infections (such as otitis media) and an infection called nocardiosis which can affect the lungs, skin and brain. COLIZOLE DS 800/160MG TABLET is suitable for use both in adults and in adolescents (aged 12 years or above).
Take COLIZOLE DS 800/160MG TABLET for the stipulated duration as instructed by your doctor even if you feel better during the midway of the therapy to achieve better results. Failing to complete the full course of the therapy or skipping doses in between the therapy may not result in adequate infection control.
Before taking COLIZOLE DS 800/160MG TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have asthma, any allergic conditions, genetic disorders, blood-related disorders, folic acid deficiency, high blood potassium levels or if you are malnourished as a precaution.
Consult your doctor before taking this medicine if you are pregnant or breastfeeding. The most common side effects of taking COLIZOLE DS 800/160MG TABLET are headache, nausea, diarrhea, high blood potassium levels, fungal infections of the mouth or vagina and skin rashes. Consult your doctor if any of these side effects troubles you.
Uses Of COLIZOLE DS 800/160MG TABLET
It is used in adults and in adolescents (aged 12 years or above) to manage the following bacterial infections:
- Lung infections (Ex. Pneumonia or Pneumocystis jiroveci pneumonia) caused by a bacteria called Pneumocystis jirovecii
- Toxoplasmosis (an infection with the Toxoplasma gondii parasite)
- Urinary tract infections
- Respiratory tract infections (Ex. bronchitis)
- Ear infections (Ex. otitis media)
- Nocardiosis (a bacterial infection that affects the lungs, skin and brain)
How COLIZOLE DS 800/160MG TABLET Works
COLIZOLE DS 800/160MG TABLET is a powerful antibiotic. It kills the susceptible bacteria by blocking the production of certain essential vitamins (folate) that are necessary for the bacteria to grow, multiply and survive. Therefore, it destroys the susceptible bacteria and manages their further growth and multiplication within the body which helps in reducing the severity of the infection.
How to use COLIZOLE DS 800/160MG TABLET
Take COLIZOLE DS 800/160MG TABLET as advised by your physician. Swallow COLIZOLE DS 800/160MG TABLET with a glass of water. Do not crush or chew the medicine. COLIZOLE DS 800/160MG TABLET can be taken with or without food.
Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight and severity of the infection.
Do not stop taking COLIZOLE DS 800/160MG TABLET once your symptom subsides. It is important to take COLIZOLE DS 800/160MG TABLET for the stipulated duration as recommended by your doctor to achieve better results.
Side Effects Of COLIZOLE DS 800/160MG TABLET
Common
- high potassium levels in blood causing abnormal heartbeats
- fungal infection (thrush or candidiasis) of mouth or vagina
- headache, nausea, diarrhoea
- skin rashes
Uncommon
- vomiting
Rare
Stop taking COLIZOLE DS 800/160MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reactions (such as skin rashes, itching, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing, chest pain and fainting)
- severe skin reactions (such as generalised skin redness with pustules accompanied by fever, ulcers in the mouth, throat, nose, genitals, red, swollen eyes, severe skin rash with blistering and peeling of skin, red pinpoint targets under the skin)
- signs of abnormal WBC count (such as fever, swollen glands, weakness, light-headedness, shortness of breath, bruising with or without skin rash)
- unexpected worsening of cough and shortness of breath
How To Manage Side Effects
Diarrhea
Drink plenty of fluids, such as water or fruit juice to keep yourself hydrated. Consuming ORS can also be beneficial. Do not consume any medicine on your own without consulting your doctor. If your diarrhea worsens, contact your doctor immediately.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Nausea And Vomiting
Take COLIZOLE DS 800/160MG TABLET with, or just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods. Please consult your doctor immediately if you experience severe nausea and vomiting.
Warning & Precautions
Pregnancy
Use with CautionCOLIZOLE DS 800/160MG TABLET should be used with caution in pregnant women. Therefore, consult your doctor for advice before taking it.
Breastfeeding
Use with CautionCOLIZOLE DS 800/160MG TABLET should be used with caution in breastfeeding women. Therefore, consult your doctor for advice before taking it.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if your ability is affected by COLIZOLE DS 800/160MG TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking COLIZOLE DS 800/160MG TABLET.
Kidney
Consult your doctorCOLIZOLE DS 800/160MG TABLET is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.
Liver
ContraindicatedCOLIZOLE DS 800/160MG TABLET is not recommended for use in patients with severe liver problems. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take COLIZOLE DS 800/160MG TABLET if you are allergic to Sulphamethoxazole, trimethoprim, sulphonamide medicines (such as gliclazide, glibenclamide) or to thiazide diuretics (such as Bendroflumethiazide).
Lungs
Use with CautionCOLIZOLE DS 800/160MG TABLET should be used with caution in patients with asthma. Therefore, consult your doctor before taking it.
Use In Pediatrics
ContraindicatedCOLIZOLE DS 800/160MG TABLET is not recommended for use in children and adolescents (aged below 12 years). However, consult your doctor for advice before taking it.
Use In Geriatrics
Use with CautionCOLIZOLE DS 800/160MG TABLET should be used with caution in elderly patients. Therefore, consult your doctor for advice before taking it.
Others
COLIZOLE DS 800/160MG TABLET is not recommended for use if you:
- ever had bleeding problems (such as thrombocytopenia)
- have porphyria (a rare blood disorder)
Before taking COLIZOLE DS 800/160MG TABLET, consult your doctor if you:
- have any allergic conditions (such as watery eyes, itchy nose, repeated sneezing)
- have anemia or vitamin B9 (folic acid) deficiency
- have G6PD deficiency (a genetic disorder that affect metabolism)
- have phenylketonuria (build-up of an amino acid called phenylalanine in the body)
- are underweight or malnourished
- have high blood potassium levels
- have very low RBC, WBC and platelet counts in blood
Interactions
A. Drug-Drug Interactions:
Before taking COLIZOLE DS 800/160MG TABLET, inform your doctor if you are taking any of the following medicines such as:
- diuretics (medicines used to remove excess water from the body) such as furosemide, hydrochlorothiazide
- pyrimethamine (a medicine used to manage malaria)
- medicines used for blood thinning (such as warfarin)
- phenytoin (a medicine used to manage epilepsy)
- medicines used to manage diabetes (such as glibenclamide, glipizide, tolbutamide or repaglinide)
- rifampicin (an antibiotic used to manage tuberculosis)
- medicines used to manage heart problems (such as digoxin or procainamide)
- amantadine (a medicine used to manage Parkinson’s disease)
- medicines used to manage HIV infections (such as zidovudine or lamivudine)
- medicines that can increase the amount of potassium in blood, such as potassium-sparging diuretics (Ex. spironolactone, acetazolamide), certain steroids (like prednisolone) or ACE inhibitors (Ex. captopril, enalapril, lisinopril)
- medicines used to suppress immune function and to manage graft rejection (such as ciclosporin, azathioprine)
- methotrexate (a medicine used to manage certain cancers or joint pain)
- folinic acid (a type of vitamin B9 supplement)
- contraceptive medicines (birth control pills) Ex. ethinylestradiol, dydrogesterone
B. Drug-Food Interaction:
COLIZOLE DS 800/160MG TABLET is preferably taken with meals to avoid unwanted stomach problems. However, it can also be taken on an empty stomach. Avoid consuming foods rich in potassium while taking this medicine.
Overdosage:
If you or anyone else accidentally took more COLIZOLE DS 800/160MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include nausea, vomiting, dizziness and confusion.
Synopsis
| Drug | : | Sulphamethoxazole, Trimethoprim |
| Pharmacological Category | : | Sulphonamides, Diaminopyrimidine |
| Therapeutic Indication | : | Bacterial Infections |
| Dosage Forms | : | Tablet, Syrup, Suspension, Injection, Infusion, Eye drops |
More Information
- Keep COLIZOLE DS 800/160MG TABLET out of reach of children
- Store COLIZOLE DS 800/160MG TABLET at room temperature
FAQs About COLIZOLE DS 800/160MG TABLET
Q: What is the use of COLIZOLE DS 800/160MG TABLET?
A: COLIZOLE DS 800/160MG TABLET is used to manage severe bacterial infections including lung infections, toxoplasmosis (infection with the Toxoplasma gondii parasite), urinary tract infections, respiratory tract infections (such as bronchitis), ear infections (such as otitis media) and an infection called nocardiosis which can affect the lungs, skin and brain.
Q: How COLIZOLE DS 800/160MG TABLET works in my body?
A: COLIZOLE DS 800/160MG TABLET is a powerful antibiotic. It kills the susceptible bacteria by blocking the production of certain essential vitamins (folate) that is necessary for the bacteria to grow, multiply and survive. Therefore, it destroys the susceptible bacteria and manages their further growth and multiplication within the body which helps in reducing the severity of the infection.
Q: How should I take COLIZOLE DS 800/160MG TABLET?
A: Take COLIZOLE DS 800/160MG TABLET as advised by your physician. It can be taken with or without food. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Q: For how long should I take COLIZOLE DS 800/160MG TABLET?
A: Take COLIZOLE DS 800/160MG TABLET for the stipulated duration as prescribed by your doctor. Do not skip the medicine or stop taking it on your own as it can cause the infection to reappear.
Q: Can COLIZOLE DS 800/160MG TABLET be given to pregnant women?
A: COLIZOLE DS 800/160MG TABLET should be used with caution in pregnant women. Therefore, consult your doctor for advice before taking it.
Q: What precautions should I follow while taking COLIZOLE DS 800/160MG TABLET?
A: Before taking COLIZOLE DS 800/160MG TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have asthma, any allergic conditions, genetic disorders, blood-related disorders or if you are malnourished as a precaution. Consult your doctor before taking this medicine if you are pregnant or breastfeeding. Regularly visit your doctor for check-up and perform all medical tests recommended by your doctor without fail. Take COLIZOLE DS 800/160MG TABLET for the stipulated duration recommended by your doctor to achieve better results. Failing to do so may cause the symptom to re-occur.
Q: What are the common side effects of taking COLIZOLE DS 800/160MG TABLET?
A: The most common side effects of taking COLIZOLE DS 800/160MG TABLET are headache, nausea, diarrhea, high blood potassium levels, fungal infections of mouth or vagina and skin rashes. Consult your doctor if any of these side effects troubles you.
Q: Can I stop taking COLIZOLE DS 800/160MG TABLET once my symptoms subside?
A: Do not stop taking this medicine once your symptom subsides. It is important to take the full course of COLIZOLE DS 800/160MG TABLET to achieve better results. Failing to complete the full course of the therapy or skipping doses in between the therapy may not result in adequate infection control. It may also cause your symptoms to reappear.
Q: Can the use of COLIZOLE DS 800/160MG TABLET cause diarrhea?
A: COLIZOLE DS 800/160MG TABLET may cause diarrhea in some individuals. If you experience diarrhea, drink plenty of fluids, such as water or fruit juice to keep yourself hydrated. Consuming ORS can also be beneficial. Do not consume any medicine on your own without consulting your doctor. If your diarrhea worsens contact your doctor immediately.
Q: What should I do if I forgot to take a dose of COLIZOLE DS 800/160MG TABLET?
A: If you forgot to take a dose of COLIZOLE DS 800/160MG TABLET, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose to compensate the forgotten dose.
References
1. KD. Tripathi. Antimicrobial Drugs. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 689, 705 & 706.
2. Tyler R. Kemnic, Meghan Coleman. Trimethoprim Sulfamethoxazole. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2022. [Accessed on 16th February 2023]. https://www.ncbi.nlm.nih.gov/books/NBK513232/#:~:text=Trimethoprim%2Fsulfamethoxazole%2C%20also%20known%20as,for%20many%20types%20of%20illnesses.
3. Erwin L. van der Veen, Anne G. M. Schilder, Tim K. Timmers, Maroeska M. Rovers, Ad C. Fluit, Marc J. Bonten, Maurine A. Leverstein-van Hall. Effect of long-term trimethoprim/sulfamethoxazole treatment on resistance and integron prevalence in the intestinal flora: a randomized, double-blind, placebo-controlled trial in children. Journal of Antimicrobial Chemotherapy. Oxford Academic. May 2009. [Accessed on 16th February 2023]. https://academic.oup.com/jac/article/63/5/1011/713419
4. Aspen Pharma Trading Limited. Co-Trimoxazole 160 mg/800 mg Forte Tablets. Electronic Medicines Compendium. [Revised in September 2022]. [Accessed on 16th February 2023]. https://www.medicines.org.uk/emc/files/pil.6997.pdf
5. Aspen Pharma Trading Limited. Co-Trimoxazole 80 mg/400 mg Tablets. Electronic Medicines Compendium. [Revised in July 2021]. [Accessed on 16th February 2023]. https://www.medicines.org.uk/emc/files/pil.6999.pdf
Useful Diagnostic Tests
- Complete blood count
Author Details
