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Introduction About COENAC 400 INJECTION
COENAC 400 INJECTION contain N-Acetylcysteine which belongs to a group of medicine called Mucolytic agents. It is used to manage paracetamol overdose (where you may have taken too much paracetamol). It helps to protect the liver from damage by the high levels of paracetamol.
COENAC 400 INJECTION is very effective when given during the first 8 hour following paracetamol overdose. The effectiveness is reduced as the time interval increase, but it can still help when given up to 24 hours after the overdose. It works by increasing the level of glutathione, an antioxidant that neutralises the toxic products of paracetamol.
This medicine will be administered by a doctor or nurse. Do not drive or operate machinery while receiving this medicine, since it may cause feeling unwell. Before receiving this medicine tell your doctor if you have ever had kidney disease, heart disease or liver problems. Pregnant and breastfeeding women should consult their doctor before receiving this medicine.
Uses Of COENAC 400 INJECTION
- Used to manage Paracetamol overdose
How COENAC 400 INJECTION Works
COENAC 400 INJECTION work by increasing the level of glutathione, an antioxidant that neutralises the toxic products of paracetamol.
How to use COENAC 400 INJECTION
COENAC 400 INJECTION given as an intravenous infusion (a drip into a vein) by a doctor or nurse.
Side Effects Of COENAC 400 INJECTION
Rare
- coughing, noisy breathing
- respiratory arrest (stop breathing)
- chest tightness or pain
- puffy eye, blurred vision, pain in the face or eye
- sweating, feeling unwell
- raised temperature, hot, red face, and skin
- liver problems
- fainting, collapsing, fits
- reduction in blood platelets, which increases the risk of bleeding or bruising
- acidosis which may cause weariness, vomiting, thirst or restlessness
- anxiety
- joint pain or disease
- bluish skin from low oxygen level in the blood
Stop taking COENAC 400 INJECTION and contact your doctor immediately if you experience this side effect:
- swelling of the face, lips, or tongue, wheezing, difficulty in breathing
- nausea, vomiting
- irritation at the injection site
- skin rash, itching
- flushing (red face or feeling hot)
- low blood pressure resulting in dizziness
- rapid heartbeat or increased blood pressure
How To Manage Side Effects
Cough And Cold
Drink fluids which help thin the mucus in your throat. Suck on cough drops or hard candies.
Dizziness Or Drowsiness
Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.
Nausea And Vomiting
Try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
Skin rash Or Itching
Apply a cold, wet cloth, or ice pack on the skin. Moisturize your skin. Apply cooling agents, such as menthol or calamine.
Warning & Precautions
Pregnancy
Use with CautionCOENAC 400 INJECTION should be used with caution in pregnant women. Consult your doctor before receiving medicine.
Breastfeeding
Use with CautionCOENAC 400 INJECTION should be used with caution in breast feeding women. Consult your doctor before receiving the medicine.
Driving and Using Machines
Use with CautionDo not drive or operate machinery while receiving this medicine, since it may cause feeling unwell.
Alcohol
ContraindicatedConsumption of alcohol is not recommended during management with COENAC 400 INJECTION.
Kidney
Use with CautionCOENAC 400 INJECTION should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
Liver
Use with CautionCOENAC 400 INJECTION should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
Allergy
ContraindicatedDo not receive COENAC 400 INJECTION if you are allergic (hypersensitive) to N-Acetylcysteine or any other ingredients of this medicine.
Lungs
Use with CautionCOENAC 400 INJECTION should be used with caution in patients suffering from active lung diseases (asthma or breathing difficulties). Consult your doctor for advice.
Interactions
Tell your doctor about all the medicine you take, including prescription and non-prescription medicine, vitamins, and herbal supplements.
Synopsis
| Drug | : | N-Acetylcysteine |
| Pharmacological Category | : | Antidote, Mucolytic Agent |
| Therapeutic Indication | : | Paracetamol overdose |
| Dosage Forms | : | Effervescent Tablet, Tablet, Capsule, Powder, Injection, Syrup |
More Information
Storage
- Store below 20-25°C
- Keep out of reach of children
FAQs About COENAC 400 INJECTION
Q: How does COENAC 400 INJECTION work?
A: It works by increasing the level of glutathione, an antioxidant that neutralises the toxic products of paracetamol.
Q: Can COENAC 400 INJECTION cause skin itching?
A: Yes, this medicine may cause skin itching in some individuals. Apply a cold, wet cloth, or ice pack on the skin. Moisturize your skin. Apply cooling agents, such as menthol or calamine.
Q: How do you take COENAC 400 INJECTION?
A: This medicine given as an intravenous infusion (a drip into a vein) by a doctor or nurse.
References
1. KD Tripathi. Drugs for Cough and Bronchial Asthma. Essentials of Medical Pharmacology. seventh edition.2013. Page-219.
2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page-65-68.
3. Kennon J. Heard, M.D. N-Acetylcysteine for Acetaminophen Poisoning.US National Library of Medicines, National Institutes of Health. 17 Jul 2008. [Accessed 07 Nov 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637612/
4. Panpharma GmbH; Electronic Medicines Compendium (EMC); [Revised on Dec 2019] [Accessed 07 Nov 2020] https://www.medicines.org.uk/emc/files/pil.3447.pdf
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