Clofranil 25mg Tablet 10'S

Introduction About CLOFRANIL 25MG TABLET

CLOFRANIL 25MG TABLET contains Clomipramine which belongs to the group of medicines called Antidepressants. It is used to depression, obsessive compulsive disorder (OCD), phobias (fear) and collapse (cataplexy) associated with narcolepsy (a sleep disorder).

Before taking CLOFRANIL 25MG TABLET inform your doctor if you have any liver, kidney or heart problems, low blood pressure, problems in adrenal gland or thyroid gland, brain injury, history of fits, or any other mental illnesses apart from depression and OCD (such as mania, schizophrenia, anxiety etc).

CLOFRANIL 25MG TABLET is not recommended for use in pregnant or breastfeeding women unless considered necessary by the physician. Avoid drinking grapefruit juice or cranberry juice while taking CLOFRANIL 25MG TABLET as it may increase the risk of side effects.

Common side effects of taking CLOFRANIL 25MG TABLET are headache, dizziness, tiredness, nausea, vomiting, stomach upset, diarrhea, increased sweating. Consult your doctor if any of these side effect worsens.

You must also inform your doctor if you experience any unusual behaviours (such as anxiety, panic attacks, difficulty in sleeping, irritability, restlessness) or worsening of depression, suicidal thoughts or behaviour after taking CLOFRANIL 25MG TABLET.

Uses Of CLOFRANIL 25MG TABLET

Manages:

• Depression
• Obsessive Compulsive Disorder (OCD)
• Fear (phobias)
• Cataplexy (collapse associated with narcolepsy)

How CLOFRANIL 25MG TABLET Works

1. Helps Increase Key Brain Messengers

Clofranil supports the activity of two important neurotransmitters:

• Serotonin
• Norepinephrine

These chemical messengers help regulate mood, thought patterns, and emotional responses.

2. Slows Down the Reuptake Process

Normally, after these messengers send signals, the brain reabsorbs them quickly.
Clofranil slows this reabsorption process.
This helps maintain healthier levels of these neurotransmitters for longer.

3. Supports Better Communication Between Brain Cells

By keeping serotonin and norepinephrine available for longer:

• Signals between brain cells become more stable
• Thought processes become more regulated
• Mood-related pathways function more consistently

4. Gradual, Steady Effect

Clofranil works gradually. The brain adjusts over days to weeks as messenger levels stabilize.

How to use CLOFRANIL 25MG TABLET

Step-by-Step Guidance for Taking Clofranil Tablet

1. Take the tablet exactly as advised by your healthcare professional.
   Do not change the strength, frequency, or duration on your own.
2. Swallow the tablet whole with a full glass of water.
   Do not crush or chew it unless your doctor specifically recommends an alternate form.
3. Follow a consistent routine.
   Taking it at the same time daily helps maintain a steady level in the body.
4. If taking multiple medicines, keep a gap if suggested by your healthcare provider to avoid overlap concerns.
5. Continue taking it even if you feel better, unless your doctor advises dose adjustment or discontinuation.

Best Time to Take Clofranil 25mg

• Many individuals are advised to take it in the evening or at bedtime, especially during the early phase, as it may cause drowsiness in some people.
• If it does not make you drowsy, your doctor may advise daytime dosing instead.
• Always stick to one fixed time each day unless your doctor recommends a change.

Instructions for Taking Clofranil With or Without Food

• Clofranil can be taken with or without food.
• If you experience stomach discomfort, taking it after food or with a light snack may help.
• Avoid alcohol while on this medicine, as it may increase drowsiness or dizziness.

What if I forgot to take CLOFRANIL 25MG TABLET

• If you forget a dose, take it as soon as you remember.
• If it is almost time for your next dose:
  • Skip the missed dose
  • Take your next scheduled dose at the usual time
• Do not take two doses at the same time to make up for a missed one.
• If you miss doses frequently, inform your healthcare provider for guidance.

Overdose

If you or anyone else accidentally took more CLOFRANIL 25MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include drowsiness, stupor (unable to move but still conscious), uncoordinated muscle movement, restlessness, enhanced reflexes, muscle stiffness, irregular muscle contractions, writhing movements of the hands and feet, fits, high or low blood pressure, high fever, rapid or irregular heartbeat, sudden chest pain (angina), abnormally dilated pupil, shortness of breath, blue skin and a decrease or absence of urine production.

Side Effects Of CLOFRANIL 25MG TABLET

Common

• headache, dizziness, tiredness, sleepiness
• nausea, vomiting, stomach upset
• increased hunger, weight gain
• dry mouth, constipation, diarrhea
• increased sweating, fast heart rate
• feeling lightheaded while standing up
• feeling shaky, restless or anxious
• low sex drive, inability to maintain an erection
• muscle twitching
• numbness or tingling in the arms and legs
• ringing in the ears (tinnitus)

When to consult a doctor?

• signs of serotonin syndrome (feeling agitated, hallucinations, confusion, loss of consciousness, fast heartbeat, feeling dizzy, increased sweating, flushing, tremors, stiff muscles, or muscle twitching, loss of coordination, nausea, vomiting, diarrhea or seizures)
• worsening of depression, suicidal thoughts or behavior
• behavioural changes (such as feeling excited anxiety, panic attacks, difficulty in sleeping, irritability, hallucinations, restlessness)
• difficulty in passing urine
• signs of allergic reactions (such as skin rash, swelling of the hands, face, tongue, neck or throat, increased fluid in tissues, fast heart rate, difficulty in breathing)
• signs of Neuroleptic malignant syndrome (such as high fever, rigid muscles, mood swings, fast or irregular heartbeat, changes in blood pressure, increased sweating)
• increased infections, fever, chills, sore throat, mouth ulcers
• signs of liver problems (such as nausea, vomiting, generally feel unwell, loss of appetite, fever, yellowing of the skin or whites of the eyes, light coloured stools and dark-coloured urine)
• sever muscle pain and damage

Warning & Precautions

Pregnancy

Contraindicated

CLOFRANIL 25MG TABLET is not recommended for use in pregnant women, unless considered necessary by the physician. Therefore, inform your doctor before taking CLOFRANIL 25MG TABLET if you are pregnant or planning to become pregnant.

Breastfeeding

Contraindicated

CLOFRANIL 25MG TABLET is not recommended for use in breast feeding women as it may pass through the breast milk. Therefore, consult your doctor before taking it.

Driving and Using Machines

Use with Caution

CLOFRANIL 25MG TABLET may impair your ability to drive or handle heavy tools. Therefore, avoid driving or handling any heavy tools or machines as a precaution.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking CLOFRANIL 25MG TABLET as it may increase the risk of side effects.

Kidney

Use with Caution

CLOFRANIL 25MG TABLET should be used with caution in patients with kidney diseases. Therefore, consult your doctor before taking it.

Liver

Consult your doctor

CLOFRANIL 25MG TABLET is not recommended for use in patients with severe liver diseases. It should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.

Allergy

Contraindicated

Do not take CLOFRANIL 25MG TABLET if you are allergic to Clomipramine or to any other tricyclic antidepressants (such as imipramine, amitriptyline).

Heart Disease

Consult your doctor

CLOFRANIL 25MG TABLET is not recommended for use in patients with heart problems (including a recent heart attack). It should be used with caution in patients with irregular heartbeat. Therefore, consult your doctor before taking it.

Use In Pediatrics

Contraindicated

CLOFRANIL 25MG TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice before taking it.

Use In Geriatrics

Use with Caution

CLOFRANIL 25MG TABLET should be used with caution in elderly patients. Therefore, consult your doctor before taking it. Proper dose adjustments and careful monitoring are required in such patients.

Other Warnings for CLOFRANIL 25MG TABLET

Before taking CLOFRANIL 25MG TABLET inform your doctor if you:

• suffer from epilepsy (fits)
• have brain injury or any damage in the brain
• have hypokalaemia (low potassium levels in the blood)
• have any blood disorders
• have low blood pressure
• want to undergo electric shock therapy (ECT)
• suffer from schizophrenia or other mental illnesses (such as anxiety)
• have an overactive thyroid gland
• have severe constipation for a long time
• have phaeochromocytoma or neuroblastoma (tumour of the adrenal gland)
• wear contact lenses
• previously had suicidal thoughts
• are going to have any surgery (including dental procedures)

Who should not take CLOFRANIL 25MG TABLET

CLOFRANIL 25MG TABLET is not recommended for use if you:

• suffer from mania (mood disorder that causes high levels of excitement)
• have narrow-angle glaucoma (increased eye pressure)
• have difficulty in passing urine

Safety Advice

• Do not stop taking the medicine suddenly without medical guidance, as this may lead to withdrawal-related discomfort. 
• Inform the doctor if you have ever experienced seizures or are taking medicines that affect seizure threshold.
• If you notice sudden mood shifts, unusual thoughts, or behavioural changes, inform your doctor immediately. 
• This medicine may reduce the body’s ability to tolerate heat. Stay hydrated and avoid overheating.
• Some people may experience increased skin sensitivity in sunlight. Using protective clothing or sunscreen may be helpful. 
• Children are highly sensitive to such medicines; accidental intake requires urgent medical attention.

Diet and Lifestyle Advice

Diet tips

1. Follow a Balanced, Nutritious Diet

• Include fruits, vegetables, whole grains, and lean proteins to support overall well-being.
• Eating at regular intervals may help maintain energy levels.

2. Stay Hydrated

• Drink enough water through the day, especially if you experience dry mouth.
• Limit high-sugar or caffeinated beverages if they increase restlessness or sleep disturbance.

3. Prefer Light, Easily Digestible Meals

• Some people may experience digestive discomfort.
• Opt for smaller, more frequent meals if heavy meals cause uneasiness.

4. Limit Excess Caffeine

• High caffeine intake may increase restlessness or interfere with sleep patterns.
• Prefer moderate to low caffeine consumption.

5. Avoid Alcohol

• Alcohol may increase drowsiness and reduce alertness.
• It's safer to avoid alcohol completely while using the tablet.

Lifestyle Tips

1. Maintain a Regular Sleep Routine

• Try to sleep and wake up at the same time daily.
• Create a calm bedtime environment free from screens or heavy meals.

2. Manage Stress Mindfully

• Gentle relaxation techniques such as:
  • Deep breathing
  • Light stretching
  • Meditation
  • Journaling
• These may help support emotional balance.

3. Incorporate Light to Moderate Physical Activity

• Walking, yoga, or simple exercises can help support overall wellness.
• Avoid strenuous workouts if you feel dizzy or less alert.

4. Avoid Driving Until You Know How You Feel

• Clofranil may cause drowsiness in some individuals.
• Perform activities requiring alertness only once you understand its effects on your body.

5. Keep a Consistent Daily Routine

• Maintaining structure in daily tasks may support a sense of stability and comfort.

6. Stay Connected

• Regular communication with friends, family, or support groups may help maintain emotional well-being.

7. Avoid Overheating

• Staying in very hot environments for long periods may cause discomfort.
• Keep cool, stay hydrated, and avoid prolonged heat exposure.

Drug - Drug interaction

a) Medicines That May Increase Drowsiness

Caution is advised if taken with:

• Sleeping pills
• Anti-allergy medicines (sedating types)
• Certain pain relievers that cause drowsiness
• Calming or mood-acting medicines

These combinations may increase sleepiness and reduce alertness.

b) Medicines Affecting Heart Rhythm

Inform your doctor if you use:

• Certain antibiotics
• Some antifungal medicines
• Heart-related rhythm-regulating medicines

These combinations may require monitoring of heartbeat pattern.

c) Blood Pressure–Related Medicines

Some blood pressure medicines may increase dizziness or affect blood pressure control when used together.
Doctors may adjust the dose or monitor regularly.

d) Medicines That Lower Seizure Threshold

Certain medicines used for:

• Mood conditions
• Pain
• Infections
  may increase susceptibility to seizures when used together.

e) Other Mood-Acting or Serotonin-Influencing Medicines

Combining multiple mood-acting medicines may need careful monitoring to avoid excessive effects on the nervous system.

f) Medicines Affecting Liver Enzymes

Some medicines may alter how Clofranil is processed in the body (e.g., enzyme-inhibiting or inducing medicines).

Drug - Food interaction

a) Alcohol

• Alcohol may increase drowsiness, dizziness, and affect coordination.
• It is generally advisable to avoid alcohol while using this tablet.

b) Caffeine-Rich Foods or Drinks

Large amounts of:

• Coffee
• Energy drinks
• Strong tea
  may interfere with sleep quality or increase restlessness in some individuals.

c) Heavy, Fat-Rich Meals

Such meals may slow down how the medicine is absorbed in some individuals, although this differs from person to person.

d) Grapefruit or Grapefruit Juice (If Applicable)

Grapefruit may affect the way certain medicines are metabolized.
Users should discuss their intake with a healthcare professional.

e) Nutritional Supplements

Inform your doctor if you regularly take:

• Herbal supplements
• Ayurvedic products
• High-dose vitamins or minerals
  as some may interact with mood-acting medicines.

Synopsis

More Information

Comparison with similar medicines

1. Clofranil vs. Newer Serotonin-Acting Medicines

Newer medicines commonly used for similar clinical purposes often:

• Are simpler to dose for many users.
• May have a lower chance of causing drowsiness, dry mouth, or constipation.
• Usually require less heart monitoring, but still need medical supervision.
• Can have their own unique considerations such as digestion-related discomfort or sleep changes.

Clofranil, compared to these:

• May require slower dose adjustment.
• May need extra caution in adults above a certain age due to dizziness or blood-pressure changes.
• Might be preferred in cases where a more comprehensive effect across multiple pathways is sought (doctor-decided).

2. Clofranil vs. Medicines With Primarily Sedating Action

Some medicines are mainly sedating in nature and are used when sleep-supportive calming is specifically required.

Compared with those, Clofranil:

• Offers broader mood-modulating action, not just sedation.
• May cause drowsiness but not typically intended solely for sleep support.
• May require more medical monitoring than simple sedative-class options.

3. Clofranil vs. Medicines With Primarily Serotonin-Selective Action

These options often:

• Have fewer anticholinergic effects.
• Are usually favored when a lighter side-effect profile is desired.
• May, however, cause digestive changes, sleep disruption, or headache in some people.

Clofranil, in comparison:

• May have stronger dry-mouth or constipation-related effects.
• Might be preferred when a multi-pathway mechanism is considered helpful.
• Needs careful dose guidance due to its broader activity.

4. Clofranil vs. Medicines With Primarily Norepinephrine-Focused Action

This category may be chosen when alertness-supportive effects are preferred.

Compared to those medicines:

• Clofranil may cause more drowsiness.
• May require more heart monitoring at higher strengths.
• Is less activating and may feel more calming for some individuals.

Doctors may check the following before planning this medicine:

• Your past medical history
  (any long-term conditions or previous sensitivity to similar medicines)
• Heart health
  (heartbeat, blood pressure, any heart-related issues)
• Kidney and liver function
  (to plan the right dose)
• Any history of seizures
• Medicines you are currently taking
  (including OTC and herbal products)
• Sleep pattern and alertness levels
• Eye health
  (especially if there is a history of high eye pressure)
• Urinary or prostate-related issues
• Weight and appetite changes
• Pregnancy or breastfeeding status
• Alcohol or substance use
• Age-related factors
  (extra caution in older adults)

FAQs About CLOFRANIL 25MG TABLET

References

1. KD. Tripathi. Antidepressant and Antianxiety Drugs. Essentials of Medical Pharmacology. 7th Edition. 2013. Page 455, 458.

2. Marcia Wilson, Jayson Tripp. Clomipramine. Stat pearls. NIH. National Library of Medicine. National Center for Biotechnology Information. May 2022. [Accessed on 18th February 2026] 

3. Clomipramine in the treatment of patients with obsessive-compulsive disorder. The Clomipramine Collaborative Study Group. NIH. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. August 1991. [Accessed on 18th February 2026] 

4. Generics UK. Limited. Electronic Medicines Compendium. [Revised in November 2020] [Accessed on 18th February 2026] 

5. Teva Pharmaceuticals. Hungary. Clomipramine. [Revised in October 2021] [Accessed on 18th February 2026] 

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Aravindan Balachandran - MBBS, MD (Psychiatry)

Last updated on 19 Nov 2022 | 03:09 PM(IST)