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Introduction About CLODREL 75MG TABLET
CLODREL 75MG TABLET is a prescription medication containing Clopidogrel, primarily used as a blood thinner (antiplatelet) to reduce blood clots. It helps in reducing the risk of stroke, heart attack, and other cardiovascular conditions.
This medication can be taken with or without food and should be taken at the same time every day. It is crucial to continue taking it, even if you feel fine. Stopping the medication could increase your risk of having a heart attack or stroke.
Common side effect of this medication includes dizziness, bleeding, bruising, stomach upset. Bleeding in the form of bruising, nose bleeds, blood in urine or stools (black-colored stools), or heavier periods than usual in women. If you cut or injure yourself, the bleeding may take longer than usual to stop. Typically, these bleeding episodes are mild and will resolve on their own. However, it is important to see a doctor immediately if the bleeding continues or if you are concerned.
This medication is not suitable for everyone. Avoid taking it if you are experiencing bleeding from any part of your body, such as a stomach ulcer or internal bleeding in the brain. Prior to using this medication, inform your doctor if you have a history of blood clotting issues or if you have recently undergone a major injury or surgery. You may need to temporarily stop taking this medicine before any planned surgeries or dental procedures.
Uses Of CLODREL 75MG TABLET
- By reducing blood clot formation, it helps in reducing the risk of stroke, heart attack, and other cardiovascular conditions.
Benefits of CLODREL 75MG TABLET
- Reduce blood clots that may lead to stroke and heart attack- Helps reduce the chances of blood clots, which can cause strokes or heart attacks.
- Reduces the risk of blood vessel blockages- Lowers the risk of blockages in blood vessels that can harm the heart
- Helps manage cardiovascular diseases such as coronary artery disease- Assists in managing heart conditions like coronary artery disease.
- Reduces the likelihood of complications following heart procedures, such as stent placement- Helps reduce the risk of complications after procedures like stent placements.
- Improves overall heart health by promoting better blood circulation- Enhances overall heart health by improving circulation in the body.
How CLODREL 75MG TABLET Works
CLODREL 75MG TABLET contains clopidogrel, an antiplatelet medication that works by inhibiting platelet aggregation. It does so by blocking the ADP (adenosine diphosphate) receptor on platelets, which is necessary for platelets to clump together and form blood clots. By preventing this process, CLODREL 75MG TABLET reduces the risk of blood clots, thereby lowering the chances of stroke, heart attack, or other cardiovascular events in individuals with conditions like atherosclerosis, or those who have undergone procedures like stent placement.
How to use CLODREL 75MG TABLET
Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage.
How to Take CLODREL 75MG TABLET?
- Take one tablet daily with or without food.
- Swallow the tablet whole with a glass of water. Do not crush or chew the medication.
- For best results, take the tablet at the same time each day.
Practical Tips for Users:
- Setting Reminders: Consider using a daily alarm or reminder on your phone to ensure you take your medication at the same time every day.
- Track Your Doses: Keeping a simple medication log can help you track when you have taken the medication, making it easier to avoid missed doses.
- Avoid Overdosing: Do not exceed the recommended dosage. If you accidentally take more than prescribed, contact your doctor immediately.
What if I forgot to take CLODREL 75MG TABLET
If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose. Do not take two doses at once to make up for a missed dose.
Side Effects Of CLODREL 75MG TABLET
Like all medicines, CLODREL 75MG TABLET may cause certain side effects in some individuals, although not everybody gets them.
The most common side effects of taking CLODREL 75MG TABLET are:
- Dizziness
- Bleeding
- Bruising
- Stomach upset
When to consult your doctor?
- Severe allergic reactions symptoms such as swelling of the face, lips, tongue, or throat, difficulty breathing, skin rash or hives
- Bleeding symptoms such as unusual or prolonged bleeding (e.g., nosebleeds, gum bleeding), blood in urine or stools, vomiting blood or material that looks like coffee grounds, severe or unexplained bruising, coughing up blood
- Stroke-like symptoms such as sudden numbness or weakness, especially on one side of the body, difficulty speaking or understanding speech, sudden vision changes, sudden severe headache
- Severe stomach or abdominal pain
- Liver problems symptoms such as yellowing of the skin or eyes (jaundice)
How To Manage Side Effects
Dizziness Or Drowsiness
- Sit or Lie Down: If you feel dizzy, sit down or lie down immediately to prevent falling. Keep your head still and close your eyes if needed.
- Hydrate: Dehydration can cause dizziness, so drink water or electrolyte-replenishing drinks like sports drinks.
- Avoid Sudden Movements: When standing or sitting, do so slowly to avoid triggering dizziness. Take your time when getting up.
- Eat Small, Regular Meals: Low blood sugar can cause dizziness, so eat small meals throughout the day and avoid skipping meals.
- Fresh Air: Sometimes dizziness can be alleviated by taking slow, deep breaths in a well-ventilated area.
Warning & Precautions
Pregnancy
ContraindicatedCLODREL 75MG TABLET is not recommended for use in pregnant women. It is important to consult your doctor before taking this medication.
Breastfeeding
ContraindicatedCLODREL 75MG TABLET is not recommended for use in breast-feeding women. It is important to consult your doctor before taking this medication.
Driving and Using Machines
Consult your doctorCLODREL 75MG TABLET is unlikely to affect your ability to drive or to use machines. It is important to consult your doctor before taking this medication.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking CLODREL 75MG TABLET as it may cause increase the risk of bleeding.
Kidney
Use with CautionCLODREL 75MG TABLET should be used with caution in patients with kidney disease. Consult your doctor before taking it.
Liver
Consult your doctorCLODREL 75MG TABLET is not recommended for use in patients with severe liver disease and should be used with caution in patients with liver disease. Consult your doctor before taking it.
Allergy
ContraindicatedDo not take this medication if you are allergic to clopidogrel or to any other ingredients of this medicine.
Use In Pediatrics
ContraindicatedCLODREL 75MG TABLET is not recommended for use in children and adolescents. Consult your pediatrician before giving it.
Use In Geriatrics
Use with CautionCLODREL 75MG TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking it.
Other Warnings for CLODREL 75MG TABLET
Before taking CLODREL 75MG TABLET, inform your doctor if you:
- have a risk of bleeding such as internal bleeding (Ex. stomach ulcer, bleeding inside any tissues organs or joints of your body)
- had recent serious injury, surgery (including dental)
- have a planned surgery (including dental) in the next seven days
- have or had a clot in an artery of your brain (ischemic stroke) which occurred within the last seven days
- had a past medical history of non-traumatic brain hemorrhage (condition marked by bleeding inside brain in the absence of trauma or surgery)
Who should not take [GBNKEYWORD
CLODREL 75MG TABLET is not recommended for use if you:
- have a medical condition (such as a stomach ulcer or bleeding within the brain)
Safety Advice
- Follow your doctor's instructions regarding the exact dosage.
- Do not exceed the recommended daily dosage.
- Take one tablet daily with or without food.
- Swallow the tablet whole with a glass of water. Do not crush or chew the medication.
- For best results, take the tablet at the same time each day.
- CLODREL 75MG TABLET may raise your risk of bleeding, so exercise caution when shaving, using sharp objects, or trimming your fingernails or toenails.
- Do not stop taking this medication without consulting your doctor, as discontinuing it could increase the risk of another heart attack or stroke.
- If you are planning to have surgery or dental management, your doctor may advise you to temporarily stop taking CLODREL 75MG TABLET.
- Limit alcohol intake, as it can raise the risk of bleeding and may affect the effectiveness of the medication.
- Let your doctor know if you have kidney problems or liver problems
- Let your doctor know If you are pregnant or planning to become pregnant or breastfeeding women.
- CLODREL 75MG TABLET should be included in a comprehensive management plan that may also involve lifestyle modifications such as diet and exercise.
- It is essential to have regular follow-up appointments with your doctor to track your progress and assess how well CLODREL 75MG TABLET is working.
Diet and Lifestyle Advice
1.What are some diet and exercise recommendations that can support cardiovascular health and complement the use of CLODREL 75MG TABLET?
|
Category |
Recommendation |
Rationale |
|
Heart-Healthy Diet |
1. Increase Omega-3 Fatty Acids |
Include fatty fish (e.g., salmon, mackerel), chia seeds, and walnuts. Omega-3s help reduce inflammation and lower the risk of clotting. |
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2. Limit Saturated and Trans Fats |
Avoid processed foods, fried items, and fatty cuts of meat. This helps lower LDL cholesterol and reduces the strain on the heart. |
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3. Eat More Fruits and Vegetables |
Aim for at least 5 servings per day. Rich in antioxidants, vitamins, and fiber, they promote overall cardiovascular health. |
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4. Whole Grains over Refined Carbs |
Choose whole wheat, brown rice, quinoa, oats, etc. These help manage blood sugar and maintain heart health. |
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5. Moderate Sodium Intake |
Limit salt consumption to 2,300 mg/day (or less). Excessive salt can elevate blood pressure and strain the heart. |
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6. Incorporate Plant-Based Proteins |
Beans, lentils, and tofu offer alternatives to meat, which can help lower cholesterol levels and promote heart health. |
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7. Hydration |
Drink plenty of water to help maintain proper circulation and support the body in processing medications. |
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8. Limit Processed Sugars and Sweets |
Reducing sugar helps maintain healthy weight and supports better blood sugar control, which is key for heart health. |
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Exercise Recommendations |
1. Aerobic Exercise (e.g., Walking, Cycling, Swimming) |
Engage in moderate-intensity exercise for at least 150 minutes per week. This helps improve circulation and reduce blood pressure. |
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2. Strength Training |
Incorporate 2-3 days per week to build muscle mass, which improves metabolism and heart health. |
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3. Flexibility Exercises (e.g., Yoga, Stretching) |
Enhances circulation, reduces stress, and improves overall flexibility, which is important for cardiovascular health. |
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4. Low-Impact Exercises (e.g., Elliptical, Stationary Bike) |
If joint problems exist, low-impact exercises provide cardiovascular benefits without excessive strain. |
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5. High-Intensity Interval Training (HIIT) (for advanced fitness levels) |
Short bursts of intense activity followed by rest. HIIT can improve cardiovascular fitness but should be used cautiously for those on CLODREL 75MG TABLET due to increased clotting risks. |
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Lifestyle Modifications |
1. Stress Management Techniques |
Practice mindfulness, meditation, or breathing exercises to lower stress, as high stress can negatively affect heart health. |
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2. Maintain a Healthy Weight |
Weight loss, if necessary, can help reduce blood pressure, improve cholesterol levels, and lower the risk of heart disease. |
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3. Smoking Cessation |
Smoking increases clot formation and damages blood vessels. Quitting smoking is crucial for heart health. |
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4. Limit Alcohol Intake |
Limit to moderate levels (up to 1 drink per day for women and 2 for men). Excessive alcohol can lead to high blood pressure and heart issues. |
Drug - Drug interaction
Inform your physician if you are taking any of the following medicine before taking CLODREL 75MG TABLET:
- Other Antihypertensive Medications
• Interactions: Combining CLODREL 75MG TABLET with other antihypertensive medications, such as ACE inhibitors (e.g., enalapril), diuretics (e.g., furosemide), or beta-blockers (e.g., atenolol), may lead to an excessive decrease in blood pressure (hypotension).
• Effects: Potential outcomes include severe hypotension, dizziness, lightheadedness, and fainting.
• Management: Close monitoring of blood pressure is crucial. Dose adjustments of CLODREL 75MG TABLET or the concomitant antihypertensive medication may be needed. Gradual dose titration and frequent blood pressure checks should be performed to avoid abrupt drops in pressure. - Antiplatelet and Anticoagulant Medications
• Interactions: Co-administration of CLODREL 75MG TABLET with other antiplatelet agents (e.g., aspirin, ticagrelor) or anticoagulants (e.g., warfarin) may increase the risk of bleeding.
• Effects: Increased bleeding risk, including gastrointestinal bleeding or hematomas.
• Management: Routine monitoring of clotting parameters (e.g., INR levels) is advised. Patients should be educated about signs of bleeding, and the dosage of CLODREL 75MG TABLET or anticoagulants may need to be adjusted. - Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
• Interactions: Using CLODREL 75MG TABLET in conjunction with NSAIDs (e.g., ibuprofen, naproxen) may reduce the antiplatelet effects of CLODREL 75MG TABLET , impairing its ability to prevent clot formation.
• Effects: Potential increased risk of thrombotic events (e.g., heart attack or stroke) and gastrointestinal issues like ulcers or bleeding.
• Management: If NSAIDs are necessary, consider using the lowest effective dose for the shortest period possible. Close monitoring for any signs of cardiovascular events or GI bleeding is recommended. - Proton Pump Inhibitors (PPIs)
• Interactions: Proton pump inhibitors (e.g., omeprazole) may reduce the effectiveness of CLODREL 75MG TABLET by interfering with its absorption in the stomach.
• Effects: Reduced platelet inhibition, which may lead to increased thrombotic events.
• Management: If a PPI is required, select alternatives like H2 blockers (e.g., ranitidine) or adjust CLODREL 75MG TABLET dosage accordingly. Close monitoring for cardiovascular events is advised. - Antidiabetic Medications
• Interactions: When CLODREL 75MG TABLET is used with antidiabetic medications, especially insulin or sulfonylureas (e.g., glibenclamide), there may be an increased risk of hypoglycemia.
• Effects: Symptoms of hypoglycemia, such as sweating, dizziness, confusion, or fainting, may occur.
• Management: Regular blood glucose monitoring is essential. Dose adjustments of antidiabetic medications may be needed to prevent hypoglycemia. - CYP2C19 Inhibitors
• Interactions: Medications that inhibit CYP2C19 (e.g., fluconazole, cimetidine) can reduce the metabolism of CLODREL 75MG TABLET, potentially increasing its concentration and antiplatelet effect.
• Effects: Increased risk of bleeding, particularly in high-risk patients.
• Management: Dose adjustments of CLODREL 75MG TABLET may be necessary. Frequent monitoring for signs of bleeding is important. - Selective Serotonin Reuptake Inhibitors (SSRIs) (e.g., Fluoxetine, Sertraline, Paroxetine, Citalopram)
- Interactions: Combining CLODREL 75MG TABLET with SSRIs may increase the risk of bleeding due to the additive effect on platelet function. SSRIs may inhibit serotonin reuptake, and CLODREL 75MG TABLET antiplatelet action could further heighten bleeding risk.
- Effects: Increased risk of bleeding, including gastrointestinal bleeding, bruising, and prolonged bleeding after injury.
- Management: Close monitoring for signs of bleeding, including bruising or unusual bleeding. Dose adjustments may be required for either CLODREL 75MG TABLET or the SSRI, or an alternative antidepressant with a lower bleeding risk may be considered. Educate patients about bleeding symptoms and encourage them to report any unusual bruising or bleeding promptly.
Synopsis
| Drug | : | Clopidogrel |
| Pharmacological Category | : | Antiplatelets |
| Therapeutic Indication | : | By reducing blood clot formation, it helps in reducing the risk of stroke, heart attack, and other cardiovascular conditions |
| Dosage Forms | : | Tablet |
More Information
01. Product Comparison
a) CLODREL 75MG TABLET Vs Ecosprin
|
Aspect |
CLODREL 75MG TABLET(Clopidogrel) |
Ecosprin (Aspirin) |
|
Drug Class |
Antiplatelet (P2Y12 receptor inhibitor) |
Antiplatelet (COX inhibitor) |
|
Mechanism of Action |
Inhibits ADP binding to P2Y12 receptors on platelets, preventing activation and aggregation. |
Inhibits cyclooxygenase (COX-1 and COX-2), reducing thromboxane A2, which prevents platelet aggregation. |
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Primary Use |
Prevents blood clots in conditions like atherosclerosis, heart attack, stroke, and peripheral artery disease. |
Prevents blood clots in cardiovascular conditions, such as heart attack, stroke, and in the prevention of clot formation in people with cardiovascular disease. |
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Indications |
- Acute coronary syndrome (ACS) |
- Primary and secondary prevention of heart attack and stroke |
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- Stroke prevention |
- Angina, myocardial infarction (MI) prevention |
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- Myocardial infarction (MI) prevention |
- Prevention of thrombotic events in high-risk patients |
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Onset of Action |
2-4 hours |
30 minutes to 1 hour |
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Duration of Action |
24-48 hours (after a single dose) |
4-6 hours |
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Side Effects |
- Bleeding risk |
- Gastrointestinal irritation (e.g., ulcers, bleeding) |
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- Gastrointestinal issues (less common than aspirin) |
- Allergic reactions, asthma exacerbation |
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- Rarely, thrombotic thrombocytopenic purpura (TTP) |
- Gastrointestinal bleeding (rare but serious) |
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Contraindications |
- Active bleeding |
- Active gastrointestinal bleeding |
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- Severe liver impairment |
- Asthma (in some cases), history of GI ulcers |
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- Hypersensitivity to clopidogrel |
- Hypersensitivity to aspirin |
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Risk of Bleeding |
Higher bleeding risk (due to inhibition of platelet aggregation) |
Higher risk of gastrointestinal bleeding, less platelet effect compared to Clopidogrel |
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Usage in Patients with GI Conditions |
Preferred for patients with a history of GI issues (less GI irritation than aspirin) |
May not be ideal for patients with active gastrointestinal ulcers or issues |
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Use in Patients with Asthma |
Preferred (lower risk of asthma exacerbation) |
Not preferred for patients with asthma (can exacerbate symptoms) |
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Clopidogrel vs Aspirin |
Clopidogrel is often preferred for long-term antiplatelet therapy in patients with a high risk of bleeding or GI issues. |
Aspirin is more commonly used for prevention in lower-risk patients due to its cost-effectiveness and availability. |
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Co-Administration with Other Medications |
Often co-administered with aspirin in dual antiplatelet therapy, especially post-stent placement. |
Can be taken alone or with other cardiovascular medications. |
Why CLODREL 75MG TABLET Might Be Preferred in Certain Cases:
- Gastrointestinal Safety: CLODREL 75MG TABLETtends to cause less gastrointestinal irritation compared to Ecosprin, making it a better choice for individuals with a history of gastric ulcers, gastritis, or other GI concerns.
- Bleeding Risk Management: CLODREL 75MG TABLEThas a more targeted mechanism of action (via the P2Y12 receptor), and its bleeding risk is often more manageable compared to aspirin's broader impact on COX enzymes, which can also increase the risk of gastrointestinal bleeding.
- Asthma or Respiratory Concerns: CLODREL 75MG TABLETis preferred in patients with asthma, as aspirin can exacerbate respiratory symptoms in individuals with asthma or other allergic conditions.
- Long-Term Therapy: For patients needing long-term antiplatelet therapy, CLODREL 75MG TABLET might be preferred over aspirin due to its more specific action on platelets, leading to a lower risk of side effects like gastrointestinal bleeding.
b) CLODREL 75MG TABLETVs Coumadin
|
Feature |
CLODREL 75MG TABLET(Clopidogrel) |
Coumadin (Warfarin) |
|
Drug Class |
Antiplatelet (thienopyridine) |
Anticoagulant (Vitamin K antagonist) |
|
Mechanism of Action |
Inhibits platelet aggregation by blocking ADP receptor |
Inhibits synthesis of clotting factors (II, VII, IX, X) by interfering with Vitamin K |
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Primary Use |
Prevents thrombosis (in patients with cardiovascular diseases like atherosclerosis, stents, etc.) |
Prevents blood clot formation (for atrial fibrillation, deep vein thrombosis, pulmonary embolism, etc.) |
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Indications |
- Acute coronary syndrome (ACS) |
- Atrial fibrillation |
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- Post-stent placement |
- Deep vein thrombosis (DVT) |
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- Stroke prevention (in patients with atherosclerosis) |
- Pulmonary embolism (PE) |
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Monitoring Required |
No routine blood tests needed |
Regular monitoring of INR (International Normalized Ratio) to adjust dose |
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Onset of Action |
2-6 hours |
24-72 hours, but full effect takes 5-7 days |
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Duration of Action |
5-7 days (platelet effect) |
2-5 days (depends on INR levels) |
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Reversal Agent |
None specifically; platelet transfusion if needed |
Vitamin K (oral or IV), Fresh Frozen Plasma (FFP), Prothrombin Complex Concentrate (PCC) |
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Dietary Restrictions |
None (does not interact with food) |
Avoid Vitamin K-rich foods (e.g., leafy greens) |
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Risk of Bleeding |
Moderate (as an antiplatelet) |
High (due to anticoagulant effects) |
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Side Effects |
- Bleeding |
- Bleeding |
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- Gastrointestinal disturbances (e.g., diarrhea) |
- Skin necrosis (rare) |
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- Rash |
- Hair loss |
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Pregnancy Category |
Category B (safer, but consult doctor) |
Category X (contraindicated in pregnancy) |
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Half-life |
6-8 hours |
20-60 hours (variable depending on individual factors) |
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Preferred In |
- Acute coronary syndrome or after stent placement |
- Long-term anticoagulation (e.g., atrial fibrillation, DVT) |
|
Why CLODREL 75MG TABLET Might Be Preferred |
- No need for regular INR monitoring |
- More convenient for long-term use in patients with high risk of embolism |
Why CLODREL 75MG TABLET Might Be Preferred:
- No Need for Regular Monitoring: CLODREL 75MG TABLET does not require frequent blood tests, which is a significant advantage for patients who are unable to frequently visit healthcare providers for INR testing.
- Fewer Dietary Restrictions: Unlike Coumadin, which requires careful monitoring of Vitamin K intake (present in many foods like leafy greens), CLODREL 75MG TABLET does not have these restrictions, making it easier for patients to maintain a normal diet.
- Faster Onset: CLODREL 75MG TABLET acts more quickly than Coumadin, which is important for certain acute conditions like after coronary interventions.
- Safety in Pregnancy: CLODREL 75MG TABLET is considered safer during pregnancy compared to Coumadin, which is contraindicated.
FAQs About CLODREL 75MG TABLET
Q: What is CLODREL 75MG TABLET used for?
A: CLODREL 75MG TABLET is a prescription medication containing Clopidogrel, primarily used as a blood thinner (antiplatelet) to reduce blood clots. It helps in reducing the risk of stroke, heart attack, and other cardiovascular conditions.
Q: How does CLODREL 75MG TABLET work?
A: CLODREL 75MG TABLET contains Clopidogrel, an anti-platelet medication that helps to reduce blood clot formation by inhibiting platelet aggregation. This reduces the risk of blockages in the blood vessels and minimizes the chances of heart attacks or strokes.
Q: What are the common side effects of CLODREL 75MG TABLET?
A:Common side effects of CLODREL 75MG TABLET may includes bleeding (nosebleeds, gum bleeding, or bruising), headache, dizziness, abdominal pain, nausea, and diarrhea. If you experience any severe side effects such as excessive bleeding, dizziness, or unusual weakness, consult your doctor immediately.
Q: Can CLODREL 75MG TABLET be taken with other medications?
A: CLODREL 75MG TABLET may interact with certain medications such as anticoagulants, NSAIDs, and some antidepressants. It is important to inform your doctor about all the medications you are currently taking to avoid potential drug interactions.
Q: What should I do if I miss a dose of CLODREL 75MG TABLET?
A: If you miss a dose of CLODREL 75MG TABLET take it as soon as you remember, unless it’s almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once to make up for a missed dose.
Q: Is CLODREL 75MG TABLET safe for pregnant or breastfeeding women?
A: CLODREL 75MG TABLET is generally not recommended for use in pregnant women and breastfeeding mothers, as the drug can pass into breast milk and potentially affect the baby. Always consult your doctor before taking this medication.
Q: Can I drink alcohol while taking CLODREL 75MG TABLET?
A: Alcohol may increase the risk of bleeding while you are taking CLODREL 75MG TABLET. It is advisable to limit alcohol consumption or avoid it altogether while taking this medication.
Q: How long should I take CLODREL 75MG TABLET?
A: The duration for taking CLODREL 75MG TABLET depends on the condition being managed. For long-term reduction of heart attack or stroke, your doctor will guide you on how long to take it. Do not stop taking the medication abruptly without consulting your doctor.
Q: What should I do if I experience excessive bleeding while taking CLODREL 75MG TABLET?
A: If you notice excessive bleeding, such as prolonged or uncontrollable nosebleeds, unusual bruising, or coughing up blood, seek medical attention immediately. CLODREL 75MG TABLET increases the risk of bleeding, and prompt medical care is necessary.
Q: Can CLODREL 75MG TABLET be used for children?
A: CLODREL 75MG TABLET is generally not recommended for use in children. It is primarily prescribed for adults at risk of cardiovascular events. Consult a doctor for the appropriate management for children.
References
1. KD. Tripathi. Drugs Affecting Coagulation, Bleeding and Thrombosis. Seventh edition. 2013. Page – 630.
2. Mylan Pharmaceuticals. Food Study of Clopidogrel Bisulfate Tablets 75 mg to Plavix Tablets 75 mg. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in April 2008] [Accessed on 24th July 2025] 
3. Craig J. Beavers; Imama A. Naqvi. Clopidogrel. NIH National Library of Medicine, National center for biotechnology information. May 2022 [Accessed on 24th July 2025] 
4. Peng-Xin Ge , Li-Ping Jiang , Ting Tai , Ting Zhu , Jin-Zi Ji , Yi-Fei Li , Qiong-Yu Mi , Hong-Guang Xie. Short-term standard alcohol consumption enhances platelet response to clopidogrel through inhibition of the Nrf2/Ces1 pathway and induction of Cyp2c in mice. NIH National Library of Medicine, National center for biotechnology information. PubMed.gov. August 2021 [Accessed on 24th July 2025]
5. Matthew T Roe , Shaun G Goodman, E Magnus Ohman, Susanna R Stevens, Judith S Hochman, Shmuel Gottlieb, Felipe Martinez, Anthony J Dalby, William E Boden, Harvey D White, Dorairaj Prabhakaran, Kenneth J Winters, Philip E Aylward, Jean-Pierre Bassand, Darren K McGuire, Diego Ardissino, Keith A A Fox, Paul W Armstrong. Elderly patients with acute coronary syndromes managed without revascularization: insights into the safety of long-term dual antiplatelet therapy with reduced-dose prasugrel versus standard-dose clopidogrel NIH National Library of Medicine, National center for biotechnology information. PubMed.gov. August 2013 [Accessed on 24th July 2025]
6. APL Swift Services (Malta) Limited. Electronic medicines compendium (EMC). [Revised in March 2021] [Accessed on 24th July 2025]
7. Sanofi Winthrop Industrie. Electronic medicines compendium (EMC). [Revised in September 2021] [Accessed on 24th July 2025]
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