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Introduction About CLISTIN SYRUP
CLISTIN SYRUP is a combination of Chlorpheniramine, Paracetamol and Phenylephrine which belongs to the group of medicines called Antihistamines, Analgesics and Nasal decongestants respectively. It is used to relieve the symptoms of allergic rhinitis (hay fever), common cold, other upper respiratory allergies, like headache, facial congestion and pressure, nasal congestion, runny nose, sneezing, minor aches and pains, itching of the nose, throat, or eyes, and watery eyes. It can also be used as an adjunct with antibiotics in sinusitis (inflammation of cavities around your nose), tonsillitis (inflammation of tonsils), and otitis media (inflammation inside the middle ear). Hay fever is a seasonal allergy that occurs in response to specific allergens like pollens, present at certain times of the year (spring or fall) and causes more short-term symptoms.
CLISTIN SYRUP is not recommended for use in children (aged less than 2 months). Consult your doctor for advice. Before taking CLISTIN SYRUP, inform your doctor if you have any kidney, liver, heart, thyroid, or lung problems, diabetes, or glaucoma. Consult your doctor for advice. CLISTIN SYRUP should be used with caution in pregnant and breastfeeding women, so consult your doctor before taking it.
The most common side effects of taking CLISTIN SYRUP are vomiting, nausea, allergic reaction, sleepiness, and headache. Contact your doctor if any of the above side effects worsen.
Uses Of CLISTIN SYRUP
It is used:
- to relieve the symptoms of allergic rhinitis, common cold, or other upper respiratory allergies
- as an adjunct with antibiotics in sinusitis, tonsillitis and otitis media
How CLISTIN SYRUP Works
CLISTIN SYRUP relieves upper respiratory symptoms where Chlorpheniramine binds to the histamine H1 receptor and blocks its action, resulting in temporary relief of the negative symptoms (runny nose, sneezing, watery and itchy eyes) brought on by histamine. Paracetamol relieves pain by elevation of the pain threshold and reduces fever by acting on the on the heat-regulating centre in your brain. Phenylephrine constricts blood vessels and reduces the blood flow to certain areas, thus decreasing swelling and allowing nasal and respiratory passages to open up.
How to use CLISTIN SYRUP
Take CLISTIN SYRUP as advised by your physician. Shake well before use. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of CLISTIN SYRUP
Common
- nausea
- sleepiness
- headache
Rare
Stop taking CLISTIN SYRUP and contact your doctor immediately if you experience any of the following side effects:
- allergic reactions (skin rash, itching, hives, swollen face, lips, or tongue)
- breathing problems
- vision changes
- cold, clammy skin
- dizziness
- increased heart rate, irregular heartbeat
- high blood pressure
- hallucinations, fits, shaking
- trouble urinating or change in the amount of urine
- extreme tiredness
- vomiting
- pain or cough gets worse
- fever worsening
- cough comes back or occurs with rash or headache that persists
- redness or swelling
How To Manage Side Effects
Dizziness Or Drowsiness
Lie down until dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes and alcohol.
Headache
Drink ample amount of water. Get adequate rest. Try to be relaxed and stress free. Ask your doctor before taking any medicine for headache.
Nausea And Vomiting
Take regular sips of a cold drink. Have ginger or peppermint tea. Stick to simple meals. Avoid eating oily or spicy foods. Get adequate rest. Drink lots of fluids, especially water. Do not take any medicine without asking your doctor.
Warning & Precautions
Pregnancy
Monitoring requiredCLISTIN SYRUP should be used in pregnant women only if considered clearly necessary by your doctor. Consult your doctor before taking it.
Breastfeeding
Monitoring requiredCLISTIN SYRUP should be used in breastfeeding women only if considered clearly necessary by your doctor. Consult your doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or use any machines during management with CLISTIN SYRUP. Consult your doctor for advice.
Alcohol
Consult your doctorAvoid consumption of alcohol with CLISTIN SYRUP. It should be used with caution in patients with alcohol dependence. Consult your doctor before taking CLISTIN SYRUP.
Kidney
Use with CautionCLISTIN SYRUP should be used with caution in patients having kidney dysfunction and urinary retention. Consult your doctor before taking it.
Liver
Consult your doctorCLISTIN SYRUP is not recommended for use in patients with liver insufficiency, failure or active liver disease. CLISTIN SYRUP should be used with caution in patients with liver dysfunction. Consult your doctor before taking it.
Allergy
ContraindicatedDo not take CLISTIN SYRUP if you are allergic to Chlorpheniramine, Paracetamol, Phenylephrine, or any other ingredients of this medicine.
Lungs
Use with CautionCLISTIN SYRUP should be used with caution in patients with chronic bronchitis, asthma, bronchiectasis, and cough that lasts long, or that occurs with too much phlegm. Consult your doctor before taking it.
Heart Disease
ContraindicatedCLISTIN SYRUP is not recommended in patients with severely high blood pressure or any other cardiovascular problems. Consult your doctor before taking it.
Use In Pediatrics
Consult your doctorCLISTIN SYRUP is not recommended for use in children (aged less than 2 years). Your doctor will prescribe the right dose depends on your child’s age, body weight and disease condition. Consult your doctor before taking it.
Use In Geriatrics
Use with CautionCLISTIN SYRUP should be used with caution in elderly patients as they may be at a greater risk of getting side effects. Consult your doctor before taking it.
Others
CLISTIN SYRUP is not recommended for use if you have:
- diabetes
- overactive thyroid
- a condition in which there is increased pressure inside your eye
- seizures
- an enlarged prostate gland
- phaeochromocytoma (a tumor in adrenal gland)
- a blood clot that obstructs a vein
Before taking CLISTIN SYRUP, inform your doctor if you:
- have intestinal obstruction
- smoke or consume tobacco
Interactions
A. Drug - Drug interactions:
Before taking CLISTIN SYRUP, inform your doctor if you are taking any of the following medicine:
- medicines used to manage depression (Ex. isocarboxazid, phenelzine, tranylcypromine)
- cholestyramine (used to lower blood cholesterol levels)
- medicines used to manage nausea and vomiting (Ex. metoclopramide, domperidone)
- medicines used to induce sleep or manage anxiety (Ex. zolpidem, diazepam, alprazolam)
- warfarin (used for blood clot)
- medicines used in high blood pressure (reserpine, veratrum alkaloids, methyldopa, mecamylamines)
- medicines used to relax muscles (Ex. salbutamol, terbutaline)
Overdosage:
If you or anyone else accidentally took too much of CLISTIN SYRUP, contact your doctor immediately or visit nearby hospital.
Synopsis
| Drug | : | Chlorpheniramine, Paracetamol, Phenylephrine |
| Pharmacological Category | : | Antihistamine, Antipyretic-Analgesic, Nasal decongestant |
| Therapeutic Indication | : | Symptoms of upper respiratory allergies, Common Cold |
| Dosage Forms | : | Tablet, Syrup, Suspension, Liquid, Drops, Oral Suspension |
More Information
- Keep CLISTIN SYRUP out of reach of children
- Store below 30°C
FAQs About CLISTIN SYRUP
Q: Can CLISTIN SYRUP be used on infants?
A: CLISTIN SYRUP is not recommended for use in children (aged less than 2 years). Your doctor will prescribe the right dose depends on your child’s age, body weight and disease condition. Consult your doctor before taking it.
Q: What if I forget to take a dose of CLISTIN SYRUP?
A: If you forget to take a dose of CLISTIN SYRUP, take it as soon as you remember. However, omit the missed dose if it is almost time for the next dose. Do not take the medicine twice to make up for a forgotten dose.
Q: Can I stop taking CLISTIN SYRUP?
A: Do not stop taking CLISTIN SYRUP without consulting your doctor. You can do it if you experience any serious side effects with your doctor’s consultation. If you have any more doubts regarding the use of CLISTIN SYRUP, ask your doctor.
Q: Can CLISTIN SYRUP cause dizziness?
A: Dizziness is a common side effect of CLISTIN SYRUP. In such case, lie down until dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol and tell your doctor if your dizziness does not improve.
Q: What precautions do I need to follow while taking CLISTIN SYRUP?
A: Patients taking CLISTIN SYRUP must inform their doctor about their pre-existing disease conditions like kidney, liver, heart, thyroid, or lung problems, diabetes, or glaucoma.
Q: Can CLISTIN SYRUP be taken during pregnancy?
A: CLISTIN SYRUP should be used in pregnancy only if considered clearly necessary by your doctor. If you are pregnant, think you may be pregnant or are planning to get pregnant, consult your doctor before taking this medicine.
References
1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Allergic Rhinitis. Pharmacotherapy Handbook. Ninth edition. Page- 813.
2. Kiran, M., Vakharia, M., Pawaskar, L., & Sheikh, S. Efficacy and safety of a fixed dose combination of paracetamol, chlorpheniramine maleate and phenylephrine in management of common cold: a phase IV, open-labelled, multi-centric study. International Journal of Basic & Clinical Pharmacology. 2018. [Accessed on 21st June 2022] https://www.ijbcp.com/index.php/ijbcp/article/view/3076
3. PubChem Compound Summary for CID 2725, Chlorpheniramine. National Center for Biotechnology Information. June 2022. [Accessed on 21st June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Chlorpheniramine#section=Mechanism-of-Action
4. Centaur Pharma. Chlorpheniramine + Paracetamol + Phenylephrine. [Accessed on 22nd June 2022] https://www.centaurpharma.com/downloads/Sinarest-Oral-Drops2018.pdf
5. Pharmasynth Formulation Ltd. Chlorpheniramine + Paracetamol + Phenylephrine. [Accessed on 22nd June 2022] https://pharmasynth.in/product/sedoril-kid/
6. Zuventus Healthcare Ltd. Chlorpheniramine + Paracetamol + Phenylephrine. [Accessed on 22nd June 2022] http://www.zuventus.co.in/patient_wise_products_selected.aspx?Medi_Id=219
7. Ticoma Pharmacia. Chlorpheniramine + Paracetamol + Phenylephrine. [Accessed on 22nd June 2022] https://www.jabsbiotech.com/product/paracetamol-phenylephrine-hydrochloride-chlorpheniramine-maleate-syrup#tab-additional_information
8. Wellona Pharma. Chlorpheniramine + Paracetamol + Phenylephrine. [Accessed on 22nd June 2022] https://wellonapharma.com/product/finished/paracetamol-phenyephrine-chlorpheniramine-suspension
9. Comed Chemicals. Chlorpheniramine + Paracetamol + Phenylephrine. [Accessed on 22nd June 2022] https://comedchemicals.com/product?id=22
10. Franco Indian Pharmaceuticals Pvt. Ltd. Chlorpheniramine + Paracetamol + Phenylephrine. [Accessed on 22nd June 2022] http://www.francoindian.com/products/grilinctus-paediatric-syrup.htm
11. Kepler healthcare Pvt. Ltd. Chlorpheniramine + Paracetamol + Phenylephrine. [Accessed on 22nd June 2022] https://keplerhealthcare.com/product/nosier-syrup/
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