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Introduction About CLAVILIP 10/75MG CAPSULE
CLAVILIP 10/75MG CAPSULE is used to reduce elevated cholesterol and triglyceride levels in patients when a low-fat diet and lifestyle changes alone have failed. It is a combination of Atorvastatin and Clopidogrel which belongs to the group of medicines called HMG-CoA reductase inhibitors and Antiplatelet medicines respectively. It can also be used to reduce the risk of heart problems such as myocardial infarction, angina (chest pain), heart failure including stroke or revascularization procedures in adult patients with or without a clinically evident chronic heart disease.
Along with management with CLAVILIP 10/75MG CAPSULE, patient should follow an appropriate lipid-lowering diet as advised by their doctor to enhance recovery. Before using the medicine, inform your doctor if you have any liver or kidney disease. Patients with active liver disease should discontinue the use of CLAVILIP 10/75MG CAPSULE as it may cause serious side effects in them.
It is not recommended for use in pregnant or breastfeeding women and in patients with bleeding disorders. It is not suitable for use in children and adolescents (aged below 18 years). Avoid consumption of grapefruit juice or alcohol while taking CLAVILIP 10/75MG CAPSULE as it may lead to unwanted interactions. The most common side effects are muscle pain, joint pain, diarrhoea, nausea, headache or stomach pain. Consult your doctor if any of the side effects worsen.
Uses Of CLAVILIP 10/75MG CAPSULE
It is used to reduce:
- elevated cholesterol and triglyceride levels in patients when a low-fat diet and lifestyle changes alone have failed
- the risk of heart problems such as myocardial infarction (MI), angina, heart failure including stroke or revascularization procedures in adult patients with or without clinically evident of chronic heart disease
How CLAVILIP 10/75MG CAPSULE Works
CLAVILIP 10/75MG CAPSULE reduces elevated cholesterol and risk of heart disease, where Atorvastatin acts by inhibiting the action of an enzyme called HMG-CoA reductase, which is required to catalyze the formation of cholesterol and Clopidogrel acts by inhibiting platelet aggregation, which is believed to be an important factor resulting in heart problems.
How to use CLAVILIP 10/75MG CAPSULE
- Take CLAVILIP 10/75MG CAPSULE as advised by your physician
- Swallow the medicine with a glass of water. Do not crush or chew the medicine
- Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition
Side Effects Of CLAVILIP 10/75MG CAPSULE
Common side effects of CLAVILIP 10/75MG CAPSULE:
- diarrhoea
- stomach pain
- indigestion or heartburn
- constipation, flatulence, indigestion
- joint pain, muscle and back pain
Stop taking CLAVILIP 10/75MG CAPSULE and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reactions (such as swelling of the face, lips, tongue, and/or throat which can lead to difficulty in breathing or swallowing)
- unexpected or unusual bleeding or bruising, hematoma
- signs of liver problems such as yellowing of the skin and/or the eyes (jaundice), whether associated with bleeding which appears under the skin as red pinpoint dots
- signs of infection or extreme tiredness (due to decrease of some blood cells)
Warning & Precautions
Pregnancy
ContraindicatedCLAVILIP 10/75MG CAPSULE is not recommended for use in pregnant women.
Breastfeeding
ContraindicatedCLAVILIP 10/75MG CAPSULE is not recommended for use in breast-feeding women.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if your ability is affected after taking CLAVILIP 10/75MG CAPSULE.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking CLAVILIP 10/75MG CAPSULE.
Kidney
Use with CautionCLAVILIP 10/75MG CAPSULE should be used with caution in patients with kidney disease.
Liver
ContraindicatedCLAVILIP 10/75MG CAPSULE is not recommended for use in patients with active liver disease, including unexplained persistent elevations in hepatic transaminase levels.
Allergy
ContraindicatedDo not take CLAVILIP 10/75MG CAPSULE if you are allergic to Atorvastatin or Clopidogrel.
Lungs
Use with CautionCLAVILIP 10/75MG CAPSULE should be used with caution in patients with severe respiratory failure.
Use In Pediatrics
ContraindicatedCLAVILIP 10/75MG CAPSULE is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety and effectiveness.
Use In Geriatrics
Use with CautionCLAVILIP 10/75MG CAPSULE should be used with caution in elderly patients (65 years of age or above). During prolonged management with the medicine, your doctor will monitor you regularly.
Others
CLAVILIP 10/75MG CAPSULE is not recommended for use if you have:
- bleeding disorders
Before taking CLAVILIP 10/75MG CAPSULE, inform your physician if you have:
- hypothyroidism, diabetes
- repeated or unexplained muscle aches or pains
- personal history or family history of muscle problems
- previous muscular problems during management with other lipid-lowering medicines
- blood disorder that makes you prone to internal bleeding (bleeding inside any tissues, organs or joints of your body)
- recent serious injury
- recent surgery (including dental surgery)
- any planned surgeries
Interactions
A. Drug-Drug interactions:
Before taking CLAVILIP 10/75MG CAPSULE inform your doctor, if you are taking any of these medicines:
- Anti-lipidemic agents (Ex. cholestyramine, colestipol, gemfibrozil, ezetimibe)
- Thienopyridine (Ex. ticlopidine)
- Anti-depressants (Ex. fluoxetine, fluvoxamine, citalopram, sertraline, venlafaxine, duloxetine, desvenlafaxine)
- Vitamins (Ex. niacin)
- Immunosuppressants (Ex. cyclosporin)
- Antibiotics (Ex. telithromycin, clarithromycin, fusidic acid)
- HIV protease inhibitors (ritonavir or lopinavir)
- Anti-fungal (Ex. itraconazole)
- proton pump inhibitors (Ex. omeprazole and esomeprazole)
- Ant-diabetic agents (Ex. repaglinide)
- Antimicrotubule agents (Ex. Paclitaxel)
- Anti-TB agents (Ex. rifampin)
- Cardiac glycosides (Ex. digoxin)
- Oral contraceptives (Ex. norethindrone, ethinyl estradiol)
- Anti-gout agents (Ex. colchicine)
- non-steroidal anti-inflammatory agents (Ex. aspirin)
- Anti-coagulants (Ex. heparin and warfarin)
- St. john’s wort
B. Drug-Food interaction:
While taking CLAVILIP 10/75MG CAPSULE, avoid taking large quantities (not more than one or two small glasses) of grapefruit juice as it can alter the effects of this medicine resulting in undesired therapeutic outcomes.
Overdosage:
If you or anyone else accidentally takes too much of CLAVILIP 10/75MG CAPSULE, contact your doctor immediately or go to a hospital straight away because of increased risk of bleeding.
Synopsis
| Drug | : | Atorvastatin, Clopidogrel |
| Pharmacological Category | : | HMG-CoA reductase inhibitors, Anti-platelet medication |
| Therapeutic Indication | : | Controls blood cholesterol levels, Reduces the risk of heart diseases |
| Dosage Forms | : | Tablet, Capsule |
More Information
Disease description:
Hyperlipidaemia:
Hyperlipidaemia is a condition in which cholesterol (hypercholesterolaemia) or triglycerides (hypertriglyceridaemia) or both (mixed hyperlipidaemia) are abnormally elevated in the serum.
Heart attack:
Heart attack occurs when the flow of blood to the heart is severely reduced or blocked. The blockage is usually due to a buildup of fat, cholesterol and other substances in the heart (coronary) arteries. The fatty, cholesterol-containing deposits are called plaques.
FAQs About CLAVILIP 10/75MG CAPSULE
Q: What foods should I avoid while taking CLAVILIP 10/75MG CAPSULE?
A: While taking the medicine, avoid eating foods high in fat or cholesterol such as fried or processed foods, grapefruit juice, dairy products and red meat which can lead to poor therapeutic outcomes to manage disease.
Q: Can I drink alcohol while taking CLAVILIP 10/75MG CAPSULE?
A: No, avoid drinking alcohol while taking CLAVILIP 10/75MG CAPSULE as it may increase the risk of bleeding in the stomach or delay bleeding time. Drinking alcohol also worsens the condition of the patient resulting in an increased risk of heart attack or stroke.
Q: Can I try to get pregnant while taking CLAVILIP 10/75MG CAPSULE?
A: No. It should be discontinued from use if you are trying to get pregnant because it may cause severe abnormalities to the growing fetus. Also, it is advised that women of childbearing potential should use a suitable contraceptive method to avoid pregnancy while taking the medicine.
Q: Can I continue to take CLAVILIP 10/75MG CAPSULE before any planned surgeries?
A: No, avoid taking CLAVILIP 10/75MG CAPSULE if you are going to undergo any surgery (including dental surgery) because this medicine can make you bleed more than usual. Your doctor might either ask you to discontinue the management with CLAVILIP 10/75MG CAPSULE for some time or may suggest an alternative therapy to improve your disease condition.
Q: Can CLAVILIP 10/75MG CAPSULE be taken during periods?
A: CLAVILIP 10/75MG CAPSULE generally may increase your tendency to bleed and if taken during periods, it may cause heavy menstrual bleeding.
References
1. KD. Tripathi. Hypolipidemic Drugs and Plasma Expanders & Drugs Affecting Coagulation, Bleeding and Thrombosis. Essentials of medical pharmacology. Seventh edition. 2013. Page – 636 & 630.
2. Thomas P. Bersot. Drug therapy for hypercholesterolemia and dyslipidemia. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 894-898.
3. Gerald G. Briggs and Roger K. Freeman. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 321-2775.
4. Ospedale Misericordia e Dolce. Atorvastatin and Clopidogrel High Dose in Stable Patients with Residual High Platelet Activity (ACHIDO). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in January 2012] [Accessed on 29th October 2022] click here
5. Goeng Bae Kim, Jeong Kyung Kim, Sul Park, Jae Jin Jeong, Hyung Sik Yoon, Sang Hun Ko, Jae Ee Ko, Soo Jin Park, Seon Woo Nam, Jae Hwan Lee, and Min Soo Hyon. Effect of Atorvastatin and Clopidogrel Co-Administration After Coronary Stenting in Korean Patients with Stable Angina. NCBI; PMC US National Library of Medicine, National Institute of Health. January 2011. [Accessed on 29th October 2022] click here
6. Cipla Ltd. Atorlip CV Capsules (Atorvastatin calcium + Clopidogrel). Ciplamed. [Revised in October 2016]. [Accessed on 29th October 2022] click here
7. CP Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Revised in March 2020] [Accessed on 29th October 2022] click here
8. APL Swift Services (Malta) Limited or Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 29th October 2022] click here
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