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Introduction About CIPLASTIM INJECTION
CIPLASTIM INJECTION contains Filgrastim which belongs to the group of medicines called Cytokines. CIPLASTIM INJECTION is used to increase the number of white blood cells to manage infections after chemotherapy management and bone marrow transplant. CIPLASTIM INJECTION is also used before high-dose chemotherapy to make the bone marrow produce more stem cells after management. It is also used to manage infections in patients suffering from severe chronic neutropenia (rare blood disorder marked by abnormal white blood cell levels). The medicine is also indicated for use to reduce the risk of infections in patients with advanced HIV infection.
CIPLASTIM INJECTION is not recommended for use in patients allergic to Filgrastim. It is also not recommended for use in patients suffering from hereditary fructose intolerance (rare genetic disorder marked by inability of the body to break down fructose). Before receiving CIPLASTIM INJECTION, inform your doctor if you suffer from sickle cell anemia (inherited blood disorder), osteoporosis (condition marked by weak and gentle bones), and/or have kidney/liver problems.
CIPLASTIM INJECTION is generally not recommended for use in pregnant and breastfeeding women. It should be used with caution in children and adolescents (aged below 18 years) and in elderly patients (aged 65 years and above) after consulting the doctor. The most common side effects of receiving CIPLASTIM INJECTION are anemia, headache, decreased appetite, nausea, vomiting, constipation, diarrhea, and/or unusual hair loss. Consult your doctor if any of these symptoms worsens.
Uses Of CIPLASTIM INJECTION
- Increases white blood cell count after chemotherapy management and bone marrow transplant to manage infections in affected individuals
- Mange infections in patients suffering from severe chronic neutropenia
- Helps to reduce risk of infections in patients with advanced HIV infection
How CIPLASTIM INJECTION Works
CIPLASTIM INJECTION works by stimulating the bone marrow to produce more neutrophils (type of white blood cell) which helps in fighting the microorganisms and manage the occurrence of infection after chemotherapy/bone marrow transplant in affected individuals.
How to use CIPLASTIM INJECTION
CIPLASTIM INJECTION will be given to you only by a doctor or a nurse into the skin as a subcutaneous injection or into the vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of CIPLASTIM INJECTION
Common
- Thrombocytopenia (reduced ability of blood to clot)
- Anemia
- Headache
- Decreased appetite, nausea, vomiting, constipation, diarrhea
- Unusual hair loss/thinning
- Pain, general weakness/feeling unwell, tiredness, fever, muscle spasm
- Mucosal inflammation (soreness and swelling of the digestive tract)
- Signs of bronchitis (inflammation of the lung) such as cough, shortness of breath, chest discomfort
- Oral pain, nose bleeds, upper respiratory tract infection, chest pain
- Urinary tract infection
- Sleeplessness, dizziness
- Hypoesthesia (decreased feeling of sensitivity especially in the skin)
- Tingling/numbness and swelling in hands and feet
- Low/high blood pressure
- Cough
- Pain in mouth and throat
- Rash, redness of skin
- Dysuria (pain when passing urine)
Uncommon
- Allergic reaction (hypersensitivity)
- Rejection of transplanted bone marrow
- Liver damage caused by blocking of the small veins within the liver
- Respiratory failure (impaired lung function) causing breathlessness
- Pulmonary oedema (swelling and/or fluid in the lungs)
- Inflammation of the lungs
- Bleeding from the lung (pulmonary haemorrhage)
- Hypoxia (lack of absorption of oxygen in the lung)
- Bumpy skin rash (rash maculo-papular)
- Osteoporosis (disease which causes bones to become less dense, making them weaker, more brittle and likely to break)
- Injection site reaction
Rare
- Signs of sickle cell anemia such as severe pain in the bones, chest, gut, and/or joints
- Anaphylactic reaction (sudden life-threatening allergic reaction)
- Pseudogout (pain and swelling of the joints)
- Fluid volume disturbances
- Cutaneous vasculitis (inflammation of the blood vessels in the skin)
- Plum-colored, raised, painful sores on the limbs and sometimes the face and neck with a fever (Sweets syndrome)
- Worsening of rheumatoid arthritis (joint inflammation)
- Inflammation of aorta
Stop receiving CIPLASTIM INJECTION and contact your doctor immediately if you experience any of the following side effects:
- Signs of an allergic reaction such as weakness, drop in blood pressure, difficulty breathing, swelling of the face/lips/mouth/tongue/throat, shortness of breath, red itchy welts, and/or rash
- Signs of acute respiratory distress syndrome (condition that occurs due to accumulation of fluid in air sacs) such as cough, fever, and/or difficulty in breathing (dyspnoea)
- Signs of glomerulonephritis (kidney injury) such as puffiness in your face/ankles, blood in urine/brown-coloured urine, and/or low urine output
- Signs of capillary leak syndrome (condition that occurs due to blood leakage from small blood vessels into body) such as swelling/puffiness associated with low urine output, difficulty breathing, abdominal swelling, feeling of fullness, and/or general feeling of tiredness
- Signs of sepsis (blood poisoning) such as fever, shivering, feeling very cold, high heart rate, confusion/disorientation, shortness of breath, extreme pain/discomfort, and/or clammy/sweaty skin
- Enlarged/ruptured spleen associated with symptoms such as left abdominal pain, pain below the left rib cage, and/or pain at the tip of shoulder
- Blood in urine (haematuria)
- Signs of thrombocytopenia (decreased blood platelet count) such as unusual bleeding/bruising
- Signs of aortitis (inflammation of aorta) such as fever, abdominal pain, malaise, and/or back pain
How To Manage Side Effects
Constipation
Try to eat high-fiber foods such as vegetables, cereals, fresh fruit, and drink plenty of water. Involve in regular exercise such as going for a daily walk or run). If this does not help, consult and inform your doctor for receiving alternate managements for constipation.
Diarrhea
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to manage diarrhea. Consult and inform your doctor if the symptom worsens.
Headache
If CIPLASTIM INJECTION causes headache, then take rest and drink plenty of fluids. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of receiving CIPLASTIM INJECTION. If it lasts more than a week or becomes severe, inform your doctor.
Nausea And Vomiting
Receive CIPLASTIM INJECTION with or just after a meal. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Inform your doctor if the condition worsens.
Warning & Precautions
Pregnancy
ContraindicatedCIPLASTIM INJECTION is generally not recommended for use during pregnancy. Consult your doctor before receiving CIPLASTIM INJECTION.
Breastfeeding
ContraindicatedCIPLASTIM INJECTION is generally not recommended for use in breastfeeding women. Consult your doctor before receiving CIPLASTIM INJECTION.
Driving and Using Machines
Use with CautionDo not drive/operate machines if you feel dizzy after receiving CIPLASTIM INJECTION.
Kidney
Use with CautionCIPLASTIM INJECTION should be used with caution in patients with kidney problems such as renal impairment. Consult your doctor before receiving the medicine.
Liver
Use with CautionCIPLASTIM INJECTION should be used with caution in patients with liver problems such as hepatic impairment. Consult your doctor before receiving the medicine.
Allergy
ContraindicatedCIPLASTIM INJECTION is not recommended for use if you are allergic (hypersensitive) to Filgrastim, and/or any other ingredients of this medicine.
Use In Pediatrics
Use with CautionCIPLASTIM INJECTION should be used with caution in children and adolescents (aged below 18 years). Consult your doctor before CIPLASTIM INJECTION is administered to the child.
Use In Geriatrics
Use with CautionCIPLASTIM INJECTION should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before receiving CIPLASTIM INJECTION.
Others
CIPLASTIM INJECTION is not recommended if you:
- Suffer from hereditary fructose intolerance (rare genetic disorder marked by inability of the body to break down fructose)
Before receiving CIPLASTIM INJECTION, inform your doctor if you:
- Have sickle cell anemia (inherited blood disorder)
- Suffer from osteoporosis (condition marked by weak and gentle bones)
- Are a stem cell donor
Interactions
A. Drug-Drug interactions:
Before receiving CIPLASTIM INJECTION, inform your doctor if you are taking any medicines, including prescription, non-prescription, and/or herbal medicines.
Overdosage:
CIPLASTIM INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Synopsis
| Drug | : | Filgrastim |
| Pharmacological Category | : | Hematopoietic agents |
| Therapeutic Indication | : | Used to manage infections after chemotherapy management and bone marrow transplant, manages infections from severe chronic neutropenia, helps to reduce risk of infections in advanced HIV patients |
| Dosage Forms | : | Injection, Pre-filled Syringe |
More Information
Storage
- Keep CIPLASTIM INJECTION out of reach of children
- Store CIPLASTIM INJECTION in a refrigerator between 2-8°C
FAQs About CIPLASTIM INJECTION
Q: What is CIPLASTIM INJECTION used for?
A: CIPLASTIM INJECTION is used to manage infections after chemotherapy management and bone marrow transplant. It is also used to manage infections in patients suffering from severe chronic neutropenia (rare blood disorder marked by abnormal white blood cell levels). The medicine is also indicated for use to reduce the risk of infections in patients with advanced HIV infection.
Q: How CIPLASTIM INJECTION works?
A: CIPLASTIM INJECTION works by stimulating the bone marrow to produce more neutrophils (type of white blood cell) which helps in fighting the microorganisms and manage the occurrence of infection after chemotherapy/bone marrow transplant in affected individuals.
Q: What are the side-effects of CIPLASTIM INJECTION?
A: The most common side effects of receiving CIPLASTIM INJECTION are anemia, headache, decreased appetite, nausea, vomiting, constipation, diarrhea, and/or unusual hair loss. Consult your doctor if any of these symptoms worsens.
Q: How CIPLASTIM INJECTION is administered?
A: CIPLASTIM INJECTION will be given to you only by a doctor or a nurse into the skin as a subcutaneous injection or into the vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Q: What happens if CIPLASTIM INJECTION is received more than its required dosage?
A: CIPLASTIM INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
References
1. Theresa A. Neumann, MaryAnn Foote. The Safety Profile of Filgrastim and Pegfilgrastim. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. 2012. [Accessed on 1st December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122905/
2. Kamel Laribi, Delphine Badinand, Philippe Janoray, Khaled Benabed, Jean-Loup Mouysset, Elizabeth Fabre, Françoise Monchecourt, Rafik Diab. Filgrastim prophylaxis in elderly cancer patients in the real-life setting: a French multicenter observational study, the TULIP study. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. 2019. [Accessed on 1st December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803566/
3. Amgen Technology (Ireland) Unlimited Company. Electronic Medicines Compendium (EMC) [Revised in July 2022] [Accessed on 1st December 2022] https://www.medicines.org.uk/emc/files/pil.3000.pdf
Useful Diagnostic Tests
- Complete Blood Count
- Peripheral Smear Examination
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