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Introduction About CICOLINE 500MG CAPSULE
CICOLINE 500MG CAPSULE contains Citicoline which belongs to a group of medicines called Psychostimulants. CICOLINE 500MG CAPSULE is used to manage cerebral insufficiency (such as dizziness, memory loss, poor circulation, disorientation) that occurs due to head trauma/brain injury in affected individuals.
CICOLINE 500MG CAPSULE is also used to manage cognitive dysfunction that occurs due to Alzheimer’s disease (brain disease that affects memory and thinking skills) and other cerebrovascular disease. It is also indicated for use in acute and recovery phase of cerebral infarction (condition that occurs due to poor blood supply to the brain) and Parkinson’s disease (age related degenerative brain condition) in affected individuals.
CICOLINE 500MG CAPSULE is not recommended for use in patients allergic to Citicoline. It is also not recommended for use in patients suffering from hypertonia (muscle overactivity).
Before taking CICOLINE 500MG CAPSULE, inform your doctor if you are scheduled for any surgery, and/or have persistent intracranial haemorrhage, kidney/liver disease.
CICOLINE 500MG CAPSULE should be used with caution in pregnant and breastfeeding women only if necessary. It is also advised to be used with caution in children and adolescents (aged below 18 years) if necessary. The medicine is also advised to be used with caution in elderly patients (aged above 65 years) after consulting the doctor.
The most common side effects of taking CICOLINE 500MG CAPSULE are nausea, vomiting, constipation, headache, low blood pressure, and/or agitation. Consult your doctor if any of these symptoms worsens.
Uses Of CICOLINE 500MG CAPSULE
- Manage cerebral insufficiency that occurs due to head trauma/brain injury
- Manage cognitive dysfunction that occurs due to Alzheimer’s disease and other cerebrovascular disease
- Manage Parkinson’s disease
- Helps in the acute and recovery phase of cerebral infarction/ischemic stroke in affected individuals
How CICOLINE 500MG CAPSULE Works
CICOLINE 500MG CAPSULE works by increasing the synthesis of phosphatidylcholine (chemical that produces acetylcholine, responsible for memory and other bodily functions) which leads to improved cerebral function and cognitive function in Alzheimer’s disease and Parkinson’s disease. It also works by repairing neuronal membranes and damaged cholinergic neurons via potentiation of acetylcholine production and reduction of free fatty acid accumulation at stroke-induced nerve damage site which results in the management neuronal cell death thus helping in the recovery phase of cerebral infarction in affected individuals.
How to use CICOLINE 500MG CAPSULE
Tablet:
Take CICOLINE 500MG CAPSULE as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Orally Disintegrating Tablet:
Take CICOLINE 500MG CAPSULE as advised by your physician. Place CICOLINE 500MG CAPSULE inside your mouth and allow it to dissolve completely. Do not swallow or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of CICOLINE 500MG CAPSULE
Common
- nausea, vomiting, constipation,
- headache
- agitation
- low blood pressure
How To Manage Side Effects
Nausea and vomiting:
Take CICOLINE 500MG CAPSULE with or just after a meal. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Inform your doctor if the condition worsens.
Constipation:
Try to eat high-fiber foods such as vegetables, cereals, fresh fruit, and drink plenty of water. Involve in regular exercise (going for a daily walk or run) and if this does not help, consult and inform your doctor for receiving alternate managements for constipation.
Headache:
If CICOLINE 500MG CAPSULE causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking CICOLINE 500MG CAPSULE. If it lasts more than a week or severe, inform your doctor.
Warning & Precautions
Pregnancy
CICOLINE 500MG CAPSULE should be used with caution during pregnancy only if it is clearly necessary. Consult your doctor before taking CICOLINE 500MG CAPSULE.
Breastfeeding
CICOLINE 500MG CAPSULE should be used with caution in breastfeeding women only if it is clearly necessary. Consult your doctor before taking CICOLINE 500MG CAPSULE.
Driving and Using Machines
Do not drive/operate machines while taking CICOLINE 500MG CAPSULE since it may affect your ability to drive/operate machines.
Kidney
CICOLINE 500MG CAPSULE should be used with caution in patients with kidney disease. Consult your doctor before taking CICOLINE 500MG CAPSULE.
Liver
CICOLINE 500MG CAPSULE should be used with caution in patients with liver disease. Consult your doctor before taking CICOLINE 500MG CAPSULE.
Allergy
Do not take CICOLINE 500MG CAPSULE if you are allergic to Citicoline, and/or any other ingredients of this medicine.
Others
CICOLINE 500MG CAPSULE is not recommended for use if you have:
- are hypertonic (muscle overactivity).
Before taking CICOLINE 500MG CAPSULE, inform your doctor if you:
- are scheduled for any surgery
- suffer from persistent intracranial haemorrhage.
CICOLINE 500MG CAPSULE should be used with caution in children and adolescents (aged below 18 years) only if it is clearly necessary. Consult your doctor before taking CICOLINE 500MG CAPSULE.
Use in Geriatrics:
CICOLINE 500MG CAPSULE should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking the medicine.
Interactions
A. Drug - Drug interactions:
Before taking CICOLINE 500MG CAPSULE, inform your doctor if you are taking any of the following medicine:
- levodopa (medicine used to manage Parkinson’s disease)
- meclofenoxate (used as a dietary supplement to manage dementia)
Overdosage:
If you or anyone else accidentally take too much of CICOLINE 500MG CAPSULE, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Citicoline |
| Pharmacological Category | : | Pyrimidine ribonucleoside diphosphates |
| Therapeutic Indication | : | Cerebral insufficiency, Cognitive dysfunction (due to Alzheimer’s disease), Parkinson’s disease |
| Dosage Forms | : | Tablet, Injection, Syrup, Solution, Oral drops |
More Information
- Keep CICOLINE 500MG CAPSULE out of the sight and reach of children.
- Do not store CICOLINE 500MG CAPSULE above 30°C
FAQs About CICOLINE 500MG CAPSULE
What is CICOLINE 500MG CAPSULE is used for?
CICOLINE 500MG CAPSULE is used to manage cerebral insufficiency that occurs due to head trauma/brain injury in affected individuals. It is also used to manage cognitive dysfunction that occurs due to Alzheimer’s disease (brain disease that affects memory and thinking skills) and other cerebrovascular disease. It is also indicated for use in acute and recovery phase of cerebral infarction (condition that occurs due to poor blood supply to the brain) and Parkinson’s disease (age related degenerative brain condition) in affected individuals.
What are the side effects of CICOLINE 500MG CAPSULE?
The most common side effects of taking CICOLINE 500MG CAPSULE are nausea, vomiting, constipation, headache, low blood pressure, and/or agitation. Consult your doctor if any of these symptoms worsens.
How CICOLINE 500MG CAPSULE works?
CICOLINE 500MG CAPSULE works by increasing the synthesis of phosphatidylcholine (chemical that produces acetylcholine, responsible for memory and other bodily functions) which leads to improved cerebral function and cognitive function in Alzheimer’s disease and Parkinson’s disease. It also works by repairing neuronal membranes and damaged cholinergic neurons via potentiation of acetylcholine production and reduction of free fatty acid accumulation at stroke-induced nerve damage site which results in the management neuronal cell death thus helping in the recovery phase of cerebral infarction in affected individuals.
What happens if more than required dosage of CICOLINE 500MG CAPSULE is taken?
If you or anyone else accidentally take too much of CICOLINE 500MG CAPSULE, consult your doctor immediately or visit the nearby hospital to manage the overdose symptoms.
Can CICOLINE 500MG CAPSULE be used in pregnant and breastfeeding women?
Yes, CICOLINE 500MG CAPSULE can be used but with caution in pregnant and breastfeeding women only if it is clearly necessary. Consult your doctor before taking CICOLINE 500MG CAPSULE.
References
1. KD. Tripathi. CNS Stimulants and Cognition Enhancers. Essentials of medical pharmacology. Seventh edition. 2013. Page - 491.
2. Cochrane Stroke Group, Arturo J Martí-Carvajal, Claudia Valli, Cristina Elena Martí-Amarista, Ivan Solà, Joan Martí-Fàbregas, Xavier Bonfill Cosp. Citicoline for treating people with acute ischemic stroke. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in August 2020] [Accessed on 6th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406786/
3. Antonino Maria Cotroneo, Alberto Castagna, Salvatore Putignano, Roberto Lacava, Fausto Fantò, Francesco Monteleone,5 Filomena Rocca, Alba Malara, Pietro Gareri. Effectiveness and safety of citicoline in mild vascular cognitive impairment: the IDEALE study. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in February 2013] [Accessed on 6th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569046/
4. UniLab, Inc. Citicoline. [Revised in June 2015] [Accessed on 6th May 2022] https://www.unilab.com.ph/products/cholinerv
5. Vidhyasha Pharmaceuticals. Citipro 250. [Accessed on 6th May 2022] http://vidhyasha.in/tablets-capsules-approved-list/#
6. Actiza Pharmaceutical Private Limited. Citicoline Tablets. [Accessed on 6th May 2022] https://www.actizapharma.com/products/citicoline/
7. Alpha Drugs. COLCIT -500. [Accessed on 6th May 2022] https://www.alphadrug.in/product/colcit-500/
8. StayHappi Pharmacy. Citicoline Tablets IP. [Accessed on 6th May 2022] https://www.stayhappi.com/stayhappi-generics/citicoline-500-mg-tablet-10s-8708
9. Cipla Ltd. COGNOLIN 500 Tablets. [Accessed on 6th May 2022] https://www.ciplamed.com/content/cognolin-500-tablets
Useful Diagnostic Tests
- Magnetic resonance imaging (MRI)
- Dopamine transporter (DAT) scan
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