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Introduction About CETANIL O TABLET
CETANIL O TABLET is a combination of Cilnidipine and Olmesartan which belongs to the group of medicines called Antihypertensive agents. It is used to manage hypertension (high blood pressure) when management with single agents is not effective.
Hypertension (also known as high blood pressure) is a medical condition in which the force of the blood exerted against the walls of the artery remains very high, and as a result it may lead to severe damage to the blood vessels supplying several vital organs, such as heart, kidney, or brain. If left unmanageed, it may cause serious complications such as heart attack, heart failure, stroke or even blindness.
Before taking CETANIL O TABLET inform your doctor if you have any heart, liver, or kidney problems. You must also inform your doctor if you have diabetes, low blood pressure or are severely dehydrated due to excessive vomiting or diarrhea.
CETANIL O TABLET is not recommended for use in patients with severe hypotension. It is also not suitable for use in pregnant or breastfeeding women as it may cause serious harm to the growing baby. Stop taking CETANIL O TABLET and inform your doctor immediately if you become pregnant while undergoing therapy with CETANIL O TABLET.
During management with CETANIL O TABLET your doctor will constantly monitor your kidney functions, blood pressure and blood sugar levels to avoid the risk of unwanted side effects.
The most common side effects of taking CETANIL O TABLET are low blood pressure, dizziness, tiredness, headache, sleepiness, swollen ankles, and flushing. Contact your doctor if any of these side effect worsens.
Uses Of CETANIL O TABLET
- Manage Hypertension (high blood pressure)
How CETANIL O TABLET Works
CETANIL O TABLET effectively controls blood pressure in patients with hypertension. It contains two medicines namely, Cilnidipine and Olmesartan. Olmesartan blocks the actions of certain hormones (angiotensin-II) in the body that causes narrowing of blood vessels and increase in blood pressure.
Cilnidipine is a vasodilator. It relaxes the blood vessels by blocking the entry of certain ions (calcium ions) within them that causes narrowing. This allows blood to flow more smoothly across the blood vessels. Collectively, they reduce the strain on the heart and helps the heart to pump blood more smoothly with less pressure.
How to use CETANIL O TABLET
Take CETANIL O TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Try to take CETANIL O TABLET at the same time each day. CETANIL O TABLET can be taken with or without food.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Continue to take CETANIL O TABLET for the stipulated duration instructed by your doctor without any interruption to achieve better results.
Side Effects Of CETANIL O TABLET
Common
- low blood pressure
- swelling of ankles and legs (edema)
- headache, dizziness
- nausea, vomiting, stomach pain, constipation, diarrhea, indigestion
- abnormal heartbeat (fast or slow)
- muscle cramps
- flushing (warmth and redness of face and neck)
- feeling tired or weak
- vision problems
- sore throat, runny nose, cough, flu-like symptoms
- back pain, joint pain
- urinary tract infections
- increased blood cholesterol levels
- increased liver enzymes levels
- increased blood urea levels
Rare
- muscle cramps
- increased blood potassium levels
- kidney problems
Stop taking CETANIL O TABLET and contact your doctor immediately if you experience any of the following side effects such as:
- signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth, or throat which can lead to difficulty in breathing or swallowing, low blood pressure which causes lightheadedness or fainting)
- severe skin reactions (such as skin rash with itching and redness, blistering and peeling of skin, skin swelling and inflammation of mucous membrane)
- chest pain, shortness of breath
How To Manage Side Effects
Nausea and vomiting:
Take CETANIL O TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Warning & Precautions
Pregnancy
CETANIL O TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing fetus. Therefore, inform your doctor before taking CETANIL O TABLET if you are pregnant, think you may be pregnant or planning to have a baby. If you become pregnant while undergoing therapy with this medicine, stop taking it and consult your doctor immediately.
Breastfeeding
CETANIL O TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
Do not drive or handle any heavy tools or machines if you experience dizziness or drowsiness after taking CETANIL O TABLET.
Alcohol
Avoid consumption of alcohol while taking CETANIL O TABLET as it might make you feel dizzier and drowsier.
Kidney
CETANIL O TABLET should be used with caution in patients with kidney problems (such as kidney transplant, narrowing of renal arteries). Therefore, consult your doctor before taking it.
Liver
CETANIL O TABLET is not recommended for use in patients with severe liver impairment (such as cholestasis, jaundice, biliary obstruction). It should be used with caution in patients with mild to moderate liver problems. Therefore, consult your doctor before taking it.
Allergy
Do not take CETANIL O TABLET if you are allergic to Cilnidipine or Olmesartan.
Heart Disease
CETANIL O TABLET should be used with caution in patients with heart problems (such as irregular heart rhythm, heart failure, recent heart attack, and problems with heart muscle or valves). Therefore, consult your doctor before taking it.
Others
CETANIL O TABLET is not recommended for use if you:
- have cardiogenic shock (heart cannot pump blood suddenly)
- have diabetes related kidney problems
- have severe hypotension (low blood pressure)
Before taking CETANIL O TABLET, inform your doctor if you:
- have primary hyperaldosteronism (problems in adrenal gland)
- have low blood pressure or are severely dehydrated (due to diarrhea, vomiting or excess sweating)
- have diabetes
- have hyperkalemia (high blood potassium levels)
- have narrowing of arteries
Use in pediatrics:
CETANIL O TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice.
Use in geriatrics:
CETANIL O TABLET should be used with caution in the elderly patients. Therefore, consult your doctor before taking it.
Interactions
A. Drug-Drug interactions:
Before taking CETANIL O TABLET, inform your doctor if you are taking any of the following medicines such as:
- other medicines used to manage elevated blood pressure (such as aliskiren, captopril, enalapril, lisinopril, verapamil, diltiazem, losartan, valsartan)
- lithium, St. John’s wort (medicines used to manage depression)
- potassium supplements or potassium-sparing diuretics such as spironolactone, triamterene or amiloride (used to retain or increase potassium levels in the body)
- non-steroidal anti-inflammatory drugs (used for pain relief) such as indomethacin, celecoxib, ibuprofen, aspirin
- colesevelam (a medicine used to manage high blood cholesterol levels)
- antacids (medicines used to neutralize stomach acid) Ex. aluminium hydroxide, magaldrate
- medicines used to manage mental disorders such as depression, psychosis, or anxiety (Ex. pimozide, amisulpride, haloperidol)
- aldesleukin (a medicine used to manage kidney cancer)
- quinidine (a medicine used to manage abnormal heart rhythm)
- phenytoin (a medicine used to manage epilepsy)
- rifampicin (a medicine used to manage tuberculosis)
- erythromycin (a medicine used to manage bacterial infection)
Overdosage:
If you or anyone else accidentally took more CETANIL O TABLET, consult your doctor immediately. Overdosage may cause low blood pressure, abnormal heartbeat, and dizziness.
Synopsis
| Drug | : | Cilnidipine, Olmesartan |
| Pharmacological Category | : | Calcium channel blocker, Angiotensin II Receptor Blocker |
| Therapeutic Indication | : | Hypertension |
| Dosage Forms | : | Tablet |
More Information
- Keep CETANIL O TABLET out of reach of children
- Store CETANIL O TABLET at room temperature
FAQs About CETANIL O TABLET
What are the uses of CETANIL O TABLET?
CETANIL O TABLET is used to manage hypertension in adults.
What type of a medicine is CETANIL O TABLET?
CETANIL O TABLET is an antihypertensive medicine. It is a combination of two medicines namely Cilnidipine and Olmesartan. Cilnidipine is a calcium channel blocker and Olmesartan is an angiotensin-II receptor blocker. They both reduces strain on the heart, relaxes blood vessels and makes the heart to pump more blood with lesser force.
What happens when I stop taking CETANIL O TABLET?
Do not stop taking CETANIL O TABLET without consulting your doctor as your blood pressure may raise once again. Make sure to take CETANIL O TABLET for the stipulated duration recommended by your doctor to achieve maximum results.
What is the best time to take CETANIL O TABLET?
CETANIL O TABLET can be taken with or without meals. Your doctor will decide the best time for you to take CETANIL O TABLET based on your age, body weight and disease condition.
What to do if I forgot to take a dose of CETANIL O TABLET?
If you forgot to take a dose of CETANIL O TABLET, take it as soon as you remember. However, if it is time for the next dose of CETANIL O TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of CETANIL O TABLET to compensate the missed ones.
What precautions should be followed while taking CETANIL O TABLET?
Before taking CETANIL O TABLET, inform your doctor if you have any heart, liver or kidney problems. You must also inform your doctor if you have diabetes, low blood pressure volume or are severely dehydrated. Stop taking CETANIL O TABLET and consult your doctor immediately if you become pregnant. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail.
Can I consume alcohol while taking CETANIL O TABLET?
Avoid consumption of alcohol while taking CETANIL O TABLET as it might make you feel dizzier and drowsier.
What happens if I accidentally take more CETANIL O TABLET?
If you or anyone else accidentally took more CETANIL O TABLET, consult your doctor immediately. Overdosage may cause low blood pressure, abnormal heartbeat, fainting, drowsiness, nausea, vomiting or confusion.
Can I take CETANIL O TABLET daily?
Take CETANIL O TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take CETANIL O TABLET every day or not.
Is CETANIL O TABLET safe to use in diabetic patients?
CETANIL O TABLET may alter the blood sugar levels in your body. Therefore, it is necessary to inform your doctor if you have diabetes before taking CETANIL O TABLET as a precaution. Your doctor will closely monitor you blood sugar levels to avoid the risk of side effects.
What are the side effects of CETANIL O TABLET?
The most common side effects of taking CETANIL O TABLET are low blood pressure, dizziness, tiredness, headache, sleepiness, swollen ankles, and flushing. Contact your doctor if any of these side effect worsens.
Can I stop taking CETANIL O TABLET once my symptoms subside?
No. Do not stop taking CETANIL O TABLET without consulting your doctor. As hypertension is a chronic condition, long term management may be necessary to control its symptoms. Therefore, take CETANIL O TABLET as advised by your doctor for the stipulated duration. Premature discontinuation of therapy may increase your blood pressure once again.
Can CETANIL O TABLET be taken during pregnancy?
CETANIL O TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing fetus. Therefore, inform your doctor before taking CETANIL O TABLET if you are pregnant, think you may be pregnant or planning to have a baby. If you become pregnant while undergoing therapy with CETANIL O TABLET, stop taking it and consult your doctor immediately.
Is CETANIL O TABLET safe to use in kidney disease?
CETANIL O TABLET should be used with caution in patients with kidney diseases (such as those having renal artery stenosis, kidney transplant or in those undergoing haemodialysis). Your doctor will access your health condition and suggest a suitable dose for you. Therefore, it is important to inform your doctor if you have any kidney problems before taking CETANIL O TABLET as a precaution.
Can the use of CETANIL O TABLET affect the liver?
Yes. CETANIL O TABLET may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it is strictly not recommended for use in patients with severe liver diseases. It should be used with caution in patients with other minor liver problems. Consult your doctor before taking it.
References
1. KD. Tripathi. Antihypertensive drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 561 &562.
2. Rabindra Nath Chakraborty, Deepak Langade, Shyam More, Vaibhav Revandkar, and Ashish Birla. Efficacy of Cilnidipine (L/N-type Calcium Channel Blocker) in Treatment of Hypertension: A Meta-Analysis of Randomized and Non-randomized Controlled Trials. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2021. [Accessed on 24th December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695827/#:~:text=In%20this%20study%2C%20Cilnidipine%20caused,after%20six%20months%20%5B13%5D.
3. Xiaoshen Zhang, Han Zhang, Yuxia Ma, Wenliang Che, and Michael R. Hamblin. Management of Hypertension Using Olmesartan Alone or in Combination. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. March 2017. [Accessed on 24th December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446820/
4. Centaur Pharma. CENTAPRES® Tablets. [Accessed on 24th December 2022] https://www.centaurpharma.com/downloads/CENTAPRES.pdf
5. Glenmark Pharmaceuticals Europe Limited. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 24th December 2022] https://www.medicines.org.uk/emc/files/pil.9886.pdf
6. Alkem Labs. Cilnikem OM. Cilnidipine and Olmesartan Medoxomil Tablet. [Revised in March 2017] [Accessed on 24th December 2022] https://www.alkemlabs.com/pdf/adverse/Cilnikem%20OM.pdf
Useful Diagnostic Tests
- Kidney Function Test
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