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Introduction About CETANIL CT TABLET
CETANIL CT TABLET is a combination of Chlorthalidone and Cilnidipine which belongs to the group of medicines called Antihypertensive agents. It is used to manage essential hypertension.
Hypertension also known as high or raised blood pressure, is a condition in which the blood vessels have persistently raised pressure. Blood is carried from the heart to all parts of the body in the vessels. Each time the heart beats, it pumps blood into the vessels. Blood pressure is created by the force of blood pushing against the walls of blood vessels (arteries) as it is pumped by the heart. The higher the pressure, the harder the heart has to pump.
During the course of management your doctor might regularly monitor your blood pressure, kidney function and electrolyte balance at regular intervals to avoid any untoward side effects.
CETANIL CT TABLET is not recommended for use in patients with liver, kidney, and heart disease and it should be used in caution with patient having diabetes.
CETANIL CT TABLET is not intended for use in the pregnant and breast-feeding woman. Consult your doctor before taking the medicine.
As safety and efficacy in children has not been established, consult your doctor about the risk and benefits before taking CETANIL CT TABLET.
It should be used with caution in elderly patients. The most common side effects of taking CETANIL CT TABLET are dizziness, nausea, headache, constipation, fever and chills. Consult your doctor if the above-mentioned side effects are not improving.
Uses Of CETANIL CT TABLET
- Used to manage essential hypertension (high blood pressure)
How CETANIL CT TABLET Works
CETANIL CT TABLET effectively reduces the blood pressure where Chlorthalidone acts by enhancing excretion of sodium (which is necessary for constriction of blood vessels) and water from the body causing blood vessels to relax and Cilnidipine makes the blood vessels to relax and thus lowers the blood pressure by blocking the calcium entry in blood vessels which is necessary for the smooth muscle contraction.
How to use CETANIL CT TABLET
Take CETANIL CT TABLET as advised by your physician. Swallow this medicine with a glass of water and do not crush or chew the medicine. Your doctor will decide the right dose and duration depending upon your age, body weight and disease condition.
Side Effects Of CETANIL CT TABLET
Common
- muscle weakness, muscle twitching or abnormal heartbeat
- intense joint pain, inflammation, redness (signs of high uric acid in blood)
- increase in cholesterol levels
- signs of low levels of sodium which can cause tiredness, confusion, muscle twitching or fits
- abnormal eye movements, numbness, muscle weakness
- tiredness, weakness or feeling thirsty (high blood sugar levels)
- nettle or skin rash
- low blood pressure which may make you feel dizzy when you stand up
- dizziness
- loss of appetite
- upset stomach
- impotence (in men)
Uncommon
- gout (pain and swelling in the joint)
Rare
- agitation, sore eyes, abdominal pain
- worsening of diabetes
- yellowing of the skin or eyes caused by liver or blood problems (jaundice)
- sensitivity reactions to sunlight
- irregular or fast heartbeat and fainting
- pins and needles
- headache
- stomach pain
- constipation
- reduction in blood platelets which increases the risk of bruising or bleeding
- severe reduction in the number of white blood cells which makes infection more likely
- abnormal high number of eosinophils (type of white blood cell) in the blood
- breathing problems
- loss of appetite, decreased urinary output, fatigue (kidney problems)
How To Manage Side Effects
Nausea or Vomiting:
Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks, and drinks. Try to avoid drinking too much liquid along with your meals, drink slowly in between meals. Consult your doctor for advice.
Constipation:
Eat plenty of fibre rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly.
Dizziness:
Lie, or sit down immediately when you feel dizzy. If you're feeling a severe episode of dizziness, lie in a dark and quite place with eyes closed. Discuss with your doctor.
Headache:
Apply hot or cold-water bag on your head. Try to take rest in a quiet and dark room. Drink tea or coffee. Massage the scalp or head with mild pressure. Consult your doctor for advice.
Warning & Precautions
Pregnancy
CETANIL CT TABLET is not recommended for use in pregnant woman. Consult your doctor before taking CETANIL CT TABLET.
Breastfeeding
CETANIL CT TABLET is not recommended for use in breastfeeding women as it may pass through the breastmilk to the baby. Consult your doctor for advice before taking CETANIL CT TABLET.
Driving and Using Machines
Do not drive or operate any machines if you feel dizzy after taking CETANIL CT TABLET. Consult your doctor before taking CETANIL CT TABLET.
Alcohol
Avoid alcohol consumption as it may aggravate the side effects of CETANIL CT TABLET.
Kidney
CETANIL CT TABLET is not recommended for use in patients with kidney failure. Consult your doctor before taking CETANIL CT TABLET.
Liver
CETANIL CT TABLET is not recommended for use in patients with liver failure and it should be used with caution in patients having mild to moderate liver disease. Consult your doctor before taking CETANIL CT TABLET.
Allergy
Do not take CETANIL CT TABLET if you are allergic to Chlorthalidone and Cilnidipine or any other ingredients of this medicine.
Heart Disease
CETANIL CT TABLET is not recommended for patients who had cardiogenic shock, myocardial infarction (heart attack), acute unstable angina, and aortic stenosis (blocked blood supply in heart). Consult your doctor for advice.
Others
CETANIL CT TABLET is not recommended for use if you:
- have decreased levels of potassium and sodium
- have increased levels of calcium and urea
- have gout
- have addison’s disease
Before taking CETANIL CT TABLET, inform your doctor if you have:
- diabetes
Use in pediatrics:
As safety and efficacy in children has not been established, consult your doctor about the risk and benefits before taking CETANIL CT TABLET.
Use in geriatrics:
CETANIL CT TABLET should be used with caution in elderly patients of above 65 years. Before taking CETANIL CT TABLET, consult your doctor.
Interactions
A. Drug - Drug interactions:
Before taking CETANIL CT TABLET inform your doctor if you are taking any of the following medicine:
- other antihypertensive medicines (Ex. telmisartan, losartan, captopril)
- digoxin (medicine used to manage heart failure and abnormal heart rhythm)
- cimetidine (medicine used for stomach ulcer)
- rifampicin (medicine used to manage tuberculosis)
- itraconazole, miconazole (medicines used to manage fungal infections)
B. Drug - Food interaction:
Avoid drinking grapefruit juice while taking CETANIL CT TABLET as it may increase the levels of this medicine in body.
Overdosage:
If you or anyone else accidentally takes too much of CETANIL CT TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage includes low blood pressure, dizziness, nausea, sleepiness, and electrolyte disturbances associated with cardiac arrhythmias (irregular heartbeat) and muscle stiffness.
Synopsis
| Drug | : | Chlorthalidone, Cilnidipine |
| Pharmacological Category | : | Diuretics, Calcium Channel Blockers |
| Therapeutic Indication | : | High blood pressure |
| Dosage Forms | : | Tablet |
More Information
- Keep CETANIL CT TABLET out of reach of children
- Store at a temperature not exceeding 30°C
FAQs About CETANIL CT TABLET
Q: What is CETANIL CT TABLET used for?
A: CETANIL CT TABLET is a combination of Chlorthalidone and Cilnidipine. It is used in the management of essential hypertension in adults.
Q: Is CETANIL CT TABLET safe in pregnant and breast-feeding women?
A: CETANIL CT TABLET is not intended for use in pregnant and breast-feeding woman as it may pass through the breastmilk to the baby. Consult your doctor about the risk and benefits before taking it.
Q: Is CETANIL CT TABLET safe for use in elder patients?
A: CETANIL CT TABLET should be used with caution in elder patients of 65 years and above. Your doctor will decide the correct dose and duration of the management with CETANIL CT TABLET for you along with regular monitoring.
Q: Does CETANIL CT TABLET can be taken by patients with kidney and liver disease?
A: CETANIL CT TABLET is not recommended for use in patients with kidney and liver failure. It should be used with caution in patients having progressive liver disease. Consult your doctor before taking CETANIL CT TABLET.
Q: Does CETANIL CT TABLET cause dizziness?
A: Yes, it may cause dizziness. Lie, or sit down immediately when you feel dizzy. If you're feeling a severe episode of vertigo, lie in a dark and quite place with eyes closed. Talk to your doctor if the symptom does not improve.
References
1. KD. Tripathi. Diuretics. Essentials of medical pharmacology. Eighth edition. 2019. Page – 630-632.
2. Connor C. Kerndt; Jayesh B. Patel. Chlorthalidone. National Library of Medicine, National center for biotechnology information. Revised in May 2022. [Accessed 8th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK553174/#:~:text=Mechanism%20of%20Action,-Chlorthalidone%20exerts%20its&text=Chlorthalidone%20inhibits%20sodium%20reabsorption%20at,retains%20a%20higher%20sodium%20content.
3. Paul Muntner, PhD, Emily B. Levitan, PhD, Amy I. Lynch, PhD, Lara M. Simpson, PhD, Jeffrey Whittle, MD, Barry R. Davis, MD, PhD, John B. Kostis, MD, Paul K. Whelton, MD, and Suzanne Oparil, MD . Effect of Chlorthalidone, Amlodipine, and Lisinopril on Visit-to-Visit Variability of Blood Pressure: Results From the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. National Library of Medicine, National center for biotechnology information. PubMed Central. Revised in May 2014. [Accessed 8th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141643/
4. J. B. Chemicals & Pharmaceuticals Ltd. [Revised in November 2021] [Accessed 8th May 2022] https://jbpharma.com/wp-content/uploads/2021/11/CILACAR-C-12.5_PI_India_November-2021.pdf
Useful Diagnostic Tests
- Kidney function test
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