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Introduction About CARNISURE SYRUP
CARNISURE SYRUP contains levocarnitine, which belongs to the group of medicines called amino acid derivatives. It is used to manage levocarnitine deficiency. A congenital deficiency, various metabolic disorders, end-stage kidney disease, and haemodialysis management can all cause levocarnitine deficiency.
The symptoms of levocarnitine deficiency may include muscle weakness (muscles of the hips, shoulders, neck, jaw, and even heart muscles), fatigue, low blood sugar, stomach pain, growth retardation, brain function defects, etc.
Before recommending CARNISURE SYRUP, your doctor may want you to take blood tests to check for the existing amount of levocarnitine in circulation to determine the correct dosage for you. CARNISURE SYRUP is not recommended for use in patients suffering from a history of fits or severely compromised renal function.
Before taking CARNISURE SYRUP, your doctor may want you to take blood tests to check for the existing amount of levocarnitine in circulation to determine the correct dosage for you. CARNISURE SYRUP is not recommended for use in patients suffering from a history of fits or severely compromised renal function.
CARNISURE SYRUP should be used with caution among pregnant women, breastfeeding mothers, and children; therefore, consult your doctor before taking it. The most common side effects of taking CARNISURE SYRUP are vomiting, nausea, stomach pain, diarrhea, headache, an abnormal taste, or body odour (a fishy smell). Contact the doctor if any of the symptoms get worse.
Uses Of CARNISURE SYRUP
CARNISURE SYRUP is used to manage:
- primary systemic carnitine deficiency by birth
- secondary carnitine deficiency due to certain metabolic disorders that result in the accumulation of abnormal and toxic metabolites (Ex. methyl malonic aciduria, propionic acidemia, glutaric aciduria and medium chain fatty acetyl dehydrogenase deficiency
- secondary carnitine deficiency due to hemodialysis
How CARNISURE SYRUP Works
CARNISURE SYRUP helps to manage levocarnitine deficiency which is a naturally occurring substance in the body. It is utilized in the process of energy production. This helps in sustaining the muscular activity of the heart and other muscles.
How to use CARNISURE SYRUP
CARNISURE SYRUP is to be taken as advised by the doctor. It is recommended to shake CARNISURE SYRUP well before usage. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
Side Effects Of CARNISURE SYRUP
Common
- vomiting
- nausea
- upset stomach
- diarrhea
- stomach pain
- abnormal taste
- body odour (fish-like smell)
- headache
Stop taking CARNISURE SYRUP and consult your doctor immediately if you experience any of the following:
- signs of allergic reaction such as difficulty swallowing or breathing, hives, swelling of the face, lips, tongue or throat, rash
- unexplainable muscle pain, muscle tenderness or weakness, dark brown urine (rhabdomyolysis)
- signs of increased levels of calcium such as increased thirst, frequent urination, nausea, vomiting, constipation, pain in bones, confusion and fatigue
- signs of high blood pressure such as headache, dizziness, vision problems, shortness of breath
- palpitations
- signs of decreased blood platelet count such as bleeding or bruising, fatigue and weakness
- signs of anemia such as fatigue, loss of energy, weakness, shortness of breath
- signs of bronchitis such as coughing and difficulty breathing
- low blood sugar
- fits (seizures)
- signs of dermatitis exfoliative such as rashes, redness, widespread blistering or peeling of the skin and mucosa (mouth)
How To Manage Side Effects
Headache
Stay hydrated and take rest as much as possible. Stay away from harsh lights and loud sounds. Apply a pain-relieving balm on the forehead. Consult your doctor if it persists for a long or worsens with time.
Nausea And Vomiting
Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if it persists for a long or worsens with time.
Warning & Precautions
Pregnancy
Use with CautionCARNISURE SYRUP must be used with caution in pregnant and those who are planning to get pregnant women due to a lack of safety data. Consult your doctor before taking CARNISURE SYRUP.
Breastfeeding
Use with CautionCARNISURE SYRUP must be used with caution in nursing women due to a lack of safety data. Consult your doctor before taking CARNISURE SYRUP.
Driving and Using Machines
SafeCARNISURE SYRUP is considered safe for driving or while using machinery. However, consult your doctor before taking it.
Kidney
Consult your doctorCARNISURE SYRUP is not recommended in patients with severely compromised renal function as it may lead to toxic metabolites accumulating in the kidney. This medicine must be used cautiously in patients suffering from kidney disorders and undergoing hemodialysis. Consult your doctor before taking CARNISURE SYRUP.
Allergy
ContraindicatedDo not take CARNISURE SYRUP if you are allergic to Levocarnitine.
Use In Pediatrics
Use with CautionCARNISURE SYRUP must be used with caution in pediatric patients and should be taken based on their age, body weight and disease condition. Consult your doctor before taking it.
Others
CARNISURE SYRUP is not recommended for use if you:
- have a history of fits (seizure activity) as it may lead to a rise in the frequency, duration and severity of the seizures
Before taking CARNISURE SYRUP, inform your doctor if you:
- have diabetes
- are on a reduced-calorie diet
- have a disorder of kidney
- are intolerant to some sugars
Interactions
A. Drug-Drug Interactions:
Before taking CARNISURE SYRUP, inform your doctor if you are taking any of the following medicine:
- medicines used to manage blood clots (Ex. warfarin, heparin, aspirin, clopidogrel)
- medicines to manage elevated blood sugar levels (Ex. insulin, metformin etc.)
Overdosage:
If you or anyone else accidentally take too much of CARNISURE SYRUP, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are upset stomach and/or diarrhea.
Synopsis
| Drug | : | L-carnitine |
| Pharmacological Category | : | Amino acid derivatives |
| Therapeutic Indication | : | Carnitine deficiency |
| Dosage Forms | : | Tablet, Capsule, Syrup, Injection |
More Information
- Keep CARNISURE SYRUP out of reach from children
- Store at a controlled room temperature of 25°C
- Keep it safe and away from moisture and sunlight
FAQs About CARNISURE SYRUP
Q: What is CARNISURE SYRUP used for?
A: CARNISURE SYRUP is used to manage carnitine deficiency, which can occur at birth, as a result of certain metabolic disorders, or as a result of a medical procedure such as hemodialysis. This reduced level of levocarnitine results in decreased energy, leading to muscle weakness. CARNISURE SYRUP helps manage these symptoms by managing the deficiency.
Q: How should CARNISURE SYRUP be stored?
A: CARNISURE SYRUP should be stored at a controlled room temperature of 250 C. It is recommended not to store it in the refrigerator. Keep it away from humidity and sunlight. It is recommended to not store CARNISURE SYRUP after removal from the foil package.
Q: What medications should I not take before or after taking CARNISURE SYRUP?
A: Anti-diabetic medications (Ex. Insulin, Metformin), blood-thinning medications (Ex. Aspirin), and medications to manage blood clots (Ex. Heparin, Warfarin) are not recommended to be taken along with CARNISURE SYRUP as they may lead to unwanted side-effects. Inform your doctor about all the medicinal and/or surgical managements that you were, are, or will be undergoing before taking CARNISURE SYRUP.
Q: Can I drive my way back home after taking CARNISURE SYRUP?
A: Yes, you can drive after taking CARNISURE SYRUP since CARNISURE SYRUP has not been reported to cause disturbance while driving or using machinery. However, consult your doctor before taking CARNISURE SYRUP.
Q: Is it normal to experience body odour after taking CARNISURE SYRUP?
A: Yes, body odour is a common side effect usually seen after taking CARNISURE SYRUP. Apply a mild deodorant or perfume to the skin to manage it. However, it should be brought to the attention of your doctor if it worsens with time.
Q: Can I take CARNISURE SYRUP if I am pregnant?
A: Before taking CARNISURE SYRUP, it is recommended that you consult your doctor and inform him if you are pregnant or planning to become pregnant, as its effects have not been studied in pregnant women.
References
1. KD Tripathi. Miscellaneous drugs. Vitamins. Essentials of Medical Pharmacology. Seventh edition. 2013. Page 912.
2. Sakurauchi, Y., Matsumoto, Y., Shinzato, T., Takai, I., Nakamura, Y., Sato, M., Nakai, S., Miwa, M., Morita, H., Miwa, T. and Amano, I., 1998. Effects of L-carnitine supplementation on muscular symptoms in hemodialyzed patients. American journal of kidney diseases. [Available on 1st August 1998] [Accessed on 19th July 2022] https://www.ajkd.org/article/S0272-6386(98)00208-X/fulltext#relatedArticles
3. Dong, L. and Dong, J., 2016. Influence of levocarnitine on the micro-inflammatory state in hemodialysis patients with diabetic nephropathy. International Journal of Laboratory Medicine. https://pesquisa.bvsalud.org/portal/resource/pt/wpr-495705
4. Leadiant Biosciences, Inc. Levocarnitine. [Revised in November 2017] [Accessed on 15th July 2022] https://pdf.hres.ca/dpd_pm/00041980.PDF
5. sigma-tau Industrie Farmaceutiche Riunite. Electronic Medicines Compendium (EMC). [Available in May 2017] [Accessed on 18th July 2022] https://www.medicines.org.uk/emc/files/pil.5140.pdf
6. Lyne Laboratories, Inc. [Revised in December 2021] [Accessed on 18th July 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=ada35959-e317-4161-ae79-3475096c679f&type=display
7. Leadiant Biosciences, Inc. Gaithersburg. [November 2021] [Accessed on 18th July 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=b2cbc620-59fd-47b6-9e4b-7e3e31533a1c&type=display
Useful Diagnostic Tests
- Carnitine test-Blood test
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